Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Bos taurus | Alpha-2a adrenergic receptor | Starlite/ChEMBL | References |
Bos taurus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Bos taurus | Alpha-1a adrenergic receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1b (5-HT1b) receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000000004 M | Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000000004 M | Binding affinity against 5-hydroxytryptamine 1A (5-HT1A) receptor in rat hippocampus membranes | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00000004 M | Binding affinity against D2 receptor in calf caudate nucleus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00000004 M | Binding affinity against D2 receptor in calf caudate nucleus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.0000004 M | Binding affinity against alpha-2 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.0000004 M | Binding affinity against alpha-2 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000006 M | Binding affinity towards 5-hydroxytryptamine 2 receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000006 M | Binding affinity against alpha-1 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000006 M | Binding affinity towards 5-hydroxytryptamine 2 receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.000006 M | Binding affinity against alpha-1 adrenergic receptor in calf frontal cortex | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00001 M | Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00001 M | Binding affinity for 5-hydroxytryptamine 1B receptor in rat cortex, striatum and globus pallidus | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00008 M | Binding affinity towards dopamine receptor D1 in calf striatum | ChEMBL. | 7912735 |
IC50 (binding) | = 0.00008 M | Binding affinity towards dopamine receptor D1 in calf striatum | ChEMBL. | 7912735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.