Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | < 20 % | Agonistic efficacy relative to progesterone (100%) on Human Progesterone receptor B isoform in cotransfected CV-1 cell lines. | ChEMBL. | 8627601 |
Efficacy (functional) | < 20 % | Agonistic efficacy relative to progesterone (100%) on Human Progesterone receptor B isoform in cotransfected CV-1 cell lines. | ChEMBL. | 8627601 |
IC50 (functional) | = 775 nM | Antagonistic potency to the human progesterone receptor measured in the T-47D alkaline phospatase assay | ChEMBL. | 8627601 |
IC50 (functional) | = 775 nM | Antagonistic potency to the human progesterone receptor measured in the T-47D alkaline phospatase assay | ChEMBL. | 8627601 |
IC50 (binding) | = 1950 nM | Concentration required to give half-maximal inhibition against human Progesterone receptor B isoform in cotransfected CV-1 cell lines. | ChEMBL. | 8627601 |
IC50 (binding) | = 1950 nM | Concentration required to give half-maximal inhibition against human Progesterone receptor B isoform in cotransfected CV-1 cell lines. | ChEMBL. | 8627601 |
Ki (binding) | nM | Binding affinity determined for human estrogen receptor; ND = Not determined | ChEMBL. | 8627601 |
Ki (binding) | 0 nM | Binding affinity determined for human estrogen receptor; ND = Not determined | ChEMBL. | 8627601 |
Ki (binding) | = 88 nM | Binding affinity determined for human Progesterone receptor A isoform | ChEMBL. | 8627601 |
Ki (binding) | = 88 nM | Binding affinity determined for human Progesterone receptor A isoform | ChEMBL. | 8627601 |
Ki (binding) | = 8356 nM | Binding affinity was determined for human glucocorticoid receptor(hGR). | ChEMBL. | 8627601 |
Ki (binding) | = 8356.00000000001 nM | Binding affinity was determined for human glucocorticoid receptor(hGR). | ChEMBL. | 8627601 |
Ki (binding) | > 10000 nM | Binding affinity determined against human Androgen receptor | ChEMBL. | 8627601 |
Ki (binding) | > 10000 nM | Binding affinity determined against human Androgen receptor | ChEMBL. | 8627601 |
Max inhibition (functional) | = 71 % | Antagonistic efficacy to the progesterone receptor measured in the T-47D alkaline phospatase assay | ChEMBL. | 8627601 |
Max inhibition (functional) | = 71 % | Antagonistic efficacy to the progesterone receptor measured in the T-47D alkaline phospatase assay | ChEMBL. | 8627601 |
Max inhibition (functional) | = 72 % | Antagonistic efficacy against Human Progesterone receptor B isoform in cotransfected CV-1 cell lines. | ChEMBL. | 8627601 |
Max inhibition (functional) | = 72 % | Antagonistic efficacy against Human Progesterone receptor B isoform in cotransfected CV-1 cell lines. | ChEMBL. | 8627601 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.