Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ferredoxin--NADP reductase | 0.0016 | 0.022 | 0.0495 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.001 | 0.0056 | 0.015 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0012 | 0.0116 | 0.0092 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0046 | 0.1102 | 0.2965 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0615 | 0.0615 |
Leishmania major | cytochrome P450 reductase, putative | 0.0122 | 0.3268 | 0.8793 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0116 | 0.0313 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1767 | 0.4755 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0116 | 0.0313 |
Mycobacterium ulcerans | hydrolase | 0.001 | 0.0049 | 0.0131 |
Onchocerca volvulus | 0.0035 | 0.0759 | 0.0965 | |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Schistosoma mansoni | chromobox protein | 0.0013 | 0.0139 | 0.0375 |
Brugia malayi | SRC-1 | 0.001 | 0.0056 | 0.0076 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0016 | 0.022 | 0.0301 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.0417 | 0.1122 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0009 | 0.0038 | 0.0102 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0015 | 0.0203 | 0.1173 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0056 | 0.0076 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0015 | 0.0208 | 0.0191 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0018 | 0.0281 | 0.0756 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0734 | 0.1976 |
Trichomonas vaginalis | chromobox protein, putative | 0.0013 | 0.0139 | 0.0124 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.1031 | 0.1335 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0615 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0139 | 0.0139 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.0056 | 0.015 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0038 | 0.022 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0016 | 0.022 | 0.0593 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0053 | 0.1281 | 0.3446 |
Brugia malayi | hypothetical protein | 0.001 | 0.0049 | 0.0066 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0068 | 0.1729 | 1 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0016 | 0.022 | 0.0593 |
Echinococcus multilocularis | methionine synthase reductase | 0.0085 | 0.2207 | 0.594 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.2018 | 0.5431 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0139 | 0.0139 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.034 | 0.0916 |
Onchocerca volvulus | 0.0267 | 0.7409 | 1 | |
Leishmania major | cytochrome-b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.034 | 0.0396 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0053 | 0.1281 | 0.7157 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.001 | 0.0056 | 0.015 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.034 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0138 | 0.3716 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Entamoeba histolytica | hypothetical protein | 0.0013 | 0.0139 | 0.0489 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.001 | 0.0056 | 0.015 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Echinococcus granulosus | chromobox protein 1 | 0.0079 | 0.2018 | 0.5431 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0734 | 0.1663 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0013 | 0.0139 | 0.0375 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Brugia malayi | diaphorase | 0.0016 | 0.022 | 0.0301 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Echinococcus multilocularis | c src tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0734 | 0.1976 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0009 | 0.0038 | 0.0102 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1767 | 0.4755 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0927 | 0.2494 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0056 | 0.0076 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Toxoplasma gondii | chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 | 0.0013 | 0.0139 | 0.0807 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0286 | 0.0286 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Giardia lamblia | Hypothetical protein | 0.0122 | 0.3268 | 1 |
Echinococcus granulosus | chromobox protein 2 | 0.0013 | 0.0139 | 0.0375 |
Brugia malayi | Heterochromatin protein 1 | 0.0079 | 0.2018 | 0.2759 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0013 | 0.0139 | 0.0375 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0138 | 0.3716 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.001 | 0.0056 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.001 | |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0016 | 0.022 | 0.0593 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Brugia malayi | SET domain containing protein | 0.0014 | 0.0175 | 0.0239 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0927 | 0.2494 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0138 | 0.3716 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | chromobox protein, putative | 0.0013 | 0.0139 | 0.0124 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.001 | 0.0056 | 0.015 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.2018 | 0.5431 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.1767 | 0.2415 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.1767 | 1 |
Onchocerca volvulus | 0.0046 | 0.1102 | 0.1431 | |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0016 | 0.022 | 0.0593 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.034 | 0.034 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.0417 | 0.05 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.034 | 0.0916 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.001 | 0.0056 | 0.015 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Onchocerca volvulus | 0.0013 | 0.0139 | 0.0124 | |
Brugia malayi | Type III restriction enzyme, res subunit family protein | 0.0013 | 0.0139 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.3716 | 0.3716 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Mycobacterium ulcerans | oxidoreductase | 0.0016 | 0.022 | 0.0593 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.0056 | 0.015 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0069 | 0.1759 | 0.4733 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0016 | 0.022 | 0.1274 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0053 | 0.1281 | 0.3446 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.001 | 0.0056 | 0.0076 |
Brugia malayi | CHD4 protein | 0.0013 | 0.0139 | 0.0191 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0734 | 0.1976 |
Loa Loa (eye worm) | TK protein kinase | 0.001 | 0.0056 | 0.0056 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.034 | 0.0916 |
Echinococcus granulosus | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | Chromobox protein 3 | 0.0013 | 0.0139 | 0.0375 |
Entamoeba histolytica | hypothetical protein | 0.0013 | 0.0139 | 0.0489 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.1031 | 0.1335 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0013 | 0.0139 | 0.0807 |
Brugia malayi | Pre-SET motif family protein | 0.0235 | 0.6482 | 0.886 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0264 | 0.7316 | 0.7316 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0016 | 0.022 | 0.6472 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0016 | 0.022 | 0.0593 |
Mycobacterium ulcerans | arylsulfatase, AslA | 0.001 | 0.0049 | 0.0131 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.001 | 0.0056 | 0.015 |
Plasmodium vivax | ferredoxin--NADP reductase, putative | 0.0016 | 0.022 | 0.0226 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.001 | 0.0056 | 0.015 |
Trypanosoma cruzi | reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0663 | 0.0835 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0068 | 0.1729 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0016 | 0.022 | 0.6472 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.034 | 0.0936 |
Brugia malayi | Protein cec-1. | 0.0013 | 0.0139 | 0.0191 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0013 | 0.0139 | 0.0375 |
Brugia malayi | flavodoxin family protein | 0.0138 | 0.3716 | 0.508 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0016 | 0.022 | 0.0593 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0038 | 0.0052 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.034 | 0.0916 |
Schistosoma mansoni | chromobox protein-related (chromobox 1) (heterochromatin 1) | 0.0013 | 0.0139 | 0.0375 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.034 | 0.0916 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.0417 | 0.0417 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.034 | 0.1968 |
Brugia malayi | Sulfatase family protein | 0.001 | 0.0049 | 0.0066 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0013 | 0.0139 | 0.0276 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.1767 | 0.4755 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0122 | 0.3268 | 0.8746 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0016 | 0.022 | 0.6472 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0009 | 0.0038 | 0.0038 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0489 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1767 | 0.4755 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0016 | 0.022 | 0.0593 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1767 | 0.4755 |
Entamoeba histolytica | hypothetical protein | 0.0013 | 0.0139 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0056 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0085 | 0.2207 | 0.594 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0013 | 0.0139 | 0.0375 |
Trichomonas vaginalis | hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 1 | 0.0013 | 0.0139 | 0.0375 |
Loa Loa (eye worm) | diaphorase | 0.0016 | 0.022 | 0.022 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.1031 | 0.1409 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0016 | 0.022 | 0.6472 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.034 | 0.0916 |
Schistosoma mansoni | chromobox protein | 0.0079 | 0.2018 | 0.5431 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Leishmania major | nitrate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 1 | 0.0013 | 0.0139 | 0.0375 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0016 | 0.022 | 0.0593 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0053 | 0.1281 | 0.7157 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0138 | 0.3716 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.1767 | 0.4755 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0053 | 0.1281 | 0.3446 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0138 | 0.3716 | 1 |
Giardia lamblia | Hypothetical protein | 0.001 | 0.0049 | 0.0032 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0016 | 0.022 | 0.022 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.001 | 0.0056 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0139 | 0.0139 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.034 | 0.1132 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.001 | 0.0056 | 0.015 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0734 | 0.1004 |
Brugia malayi | hypothetical protein | 0.001 | 0.0056 | 0.0076 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.034 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.034 | 0.0465 |
Echinococcus granulosus | Chromo domain | 0.0013 | 0.0139 | 0.0375 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.2018 | 0.5431 |
Echinococcus multilocularis | chromobox protein 2 | 0.0013 | 0.0139 | 0.0375 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.1127 | 0.1465 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.001 | |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0016 | 0.022 | 0.0593 |
Leishmania major | reductase, putative | 0.0016 | 0.022 | 0.0593 |
Echinococcus granulosus | methionine synthase reductase | 0.0085 | 0.2207 | 0.594 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0013 | 0.0139 | 0.0807 |
Plasmodium vivax | oxidoreductase NAD-binding domain containing protein | 0.0016 | 0.022 | 0.0226 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Brugia malayi | Associated with TFs and helicases family protein | 0.0013 | 0.0139 | 0.0191 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.1767 | 0.4755 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0138 | 0.3716 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.0338 | 0.0817 |
Mycobacterium ulcerans | flavodoxin reductase Hmp | 0.0016 | 0.022 | 0.0593 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.1031 | 0.1335 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.1127 | 0.1465 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.0663 | 0.0835 |
Plasmodium falciparum | chromodomain-helicase-DNA-binding protein 1 homolog, putative | 0.0013 | 0.0139 | 0.0276 |
Schistosoma mansoni | chromobox protein | 0.0013 | 0.0139 | 0.0375 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0734 | 0.4247 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0759 | 0.0759 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0116 | 0.0313 |
Giardia lamblia | Hypothetical protein | 0.001 | 0.0049 | 0.0032 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0138 | 0.3716 | 1 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0489 |
Schistosoma mansoni | cytochrome B5 | 0.0016 | 0.022 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0139 | 0.0139 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.001 | 0.0056 | 0.015 |
Leishmania major | p450 reductase, putative | 0.0138 | 0.3716 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Brugia malayi | M-phase phosphoprotein, mpp8 | 0.0013 | 0.0139 | 0.0191 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0053 | 0.1281 | 0.7157 |
Plasmodium vivax | hypothetical protein, conserved | 0.0053 | 0.1281 | 0.319 |
Mycobacterium ulcerans | arylsulfatase AtsD | 0.001 | 0.0049 | 0.0131 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0009 | 0.0038 | 0.0102 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0053 | 0.1281 | 0.3446 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.001 | 0.0056 | 0.015 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.2018 | 0.2676 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0139 | 0.0139 |
Brugia malayi | SH2 domain containing protein | 0.001 | 0.0056 | 0.0076 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0734 | 0.1976 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0734 | 0.1976 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Trichomonas vaginalis | chromobox protein, putative | 0.0013 | 0.0139 | 0.0124 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0053 | 0.1281 | 0.1674 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0053 | 0.1281 | 0.1281 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.034 | 0.0396 |
Plasmodium falciparum | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0495 |
Trichomonas vaginalis | chromobox protein, putative | 0.0079 | 0.2018 | 0.2676 |
Trichomonas vaginalis | set domain proteins, putative | 0.0267 | 0.7409 | 1 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma brucei | nitrate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.001 | |
Leishmania major | oxidoreductase-like protein | 0.0016 | 0.022 | 0.0593 |
Mycobacterium tuberculosis | Possible hydrolase | 0.001 | 0.0049 | 0.1427 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0122 | 0.3268 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.034 | 0.1663 |
Echinococcus multilocularis | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0139 | 0.0375 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.001 | |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.034 | 0.0916 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0009 | 0.0038 | 0.0102 |
Mycobacterium ulcerans | oxygenase | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.0417 | 0.05 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.001 | 0.0056 | 0.015 |
Mycobacterium tuberculosis | Probable sulfatase | 0.001 | 0.0049 | 0.1427 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.001 | 0.0056 | 0.015 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0122 | 0.3268 | 0.4374 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Mycobacterium ulcerans | arylsulfatase AtsB | 0.001 | 0.0049 | 0.0131 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.034 | 0.0916 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0053 | 0.1281 | 0.7157 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1031 | 0.1031 |
Echinococcus multilocularis | Chromo domain | 0.0013 | 0.0139 | 0.0375 |
Entamoeba histolytica | recQ family helicase, putative | 0.0012 | 0.0116 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0139 | 0.0139 |
Giardia lamblia | Flavohemoprotein lateral transfer candidate | 0.0016 | 0.022 | 0.0564 |
Mycobacterium leprae | putative cytochrome p450 | 0.0008 | 0 | 0.5 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0138 | 0.3716 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.1281 | 0.3446 |
Plasmodium falciparum | heterochromatin protein 1 | 0.0013 | 0.0139 | 0.0276 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.001 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0734 | 0.0734 |
Brugia malayi | SH2 domain containing protein | 0.001 | 0.0056 | 0.0076 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0038 | 0.022 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0138 | 0.3716 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.034 | 0.0916 |
Trypanosoma cruzi | p450 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Mycobacterium tuberculosis | Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) | 0.001 | 0.0049 | 0.1427 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0053 | 0.1281 | 0.1674 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0699 | 0.1881 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0056 | 0.0076 |
Onchocerca volvulus | 0.0016 | 0.022 | 0.0233 | |
Mycobacterium tuberculosis | Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) | 0.001 | 0.0049 | 0.1427 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0138 | 0.3716 | 0.4983 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0138 | 0.3716 | 1 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0013 | 0.0139 | 0.0375 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.034 | 0.0822 |
Brugia malayi | FAD binding domain containing protein | 0.0138 | 0.3716 | 0.508 |
Mycobacterium ulcerans | flavodoxin oxidoreductase | 0.0016 | 0.022 | 0.0593 |
Brugia malayi | protein-tyrosine kinase | 0.001 | 0.0056 | 0.0076 |
Brugia malayi | hypothetical protein | 0.0137 | 0.3696 | 0.5053 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0053 | 0.1281 | 0.1674 |
Schistosoma mansoni | DNA helicase recq5 | 0.0009 | 0.0038 | 0.0102 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Mycobacterium ulcerans | monooxygenase | 0.0016 | 0.022 | 0.0593 |
Onchocerca volvulus | 0.0013 | 0.0139 | 0.0124 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0734 | 0.1976 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0053 | 0.1281 | 0.7157 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0038 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0038 | 0.0038 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0139 | 0.0124 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | c src tyrosine kinase | 0.001 | 0.0056 | 0.015 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0138 | 0.3716 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0085 | 0.2207 | 0.2207 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.001 | 0.0056 | 0.0056 |
Entamoeba histolytica | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0489 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0013 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0138 | 0.3716 | 0.3716 |
Brugia malayi | Valyl-tRNA synthetase | 0.0013 | 0.0139 | 0.0191 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0139 | 0.0191 |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0056 | 0.0076 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0138 | 0.3716 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0138 | 0.3716 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.034 | 0.0561 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0053 | 0.1281 | 0.1674 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0139 | 0.0139 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0053 | 0.1281 | 0.3378 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0138 | 0.3716 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.1127 | 0.1465 |
Brugia malayi | follicle stimulating hormone receptor | 0.0264 | 0.7316 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0009 | 0.0038 | 0.0102 |
Trypanosoma cruzi | p450 reductase, putative | 0.0138 | 0.3716 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0085 | 0.2207 | 0.3017 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.1767 | 0.1767 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.001 | 0.0056 | 0.015 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.0417 | 0.1122 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.001 | 0.0056 | 0.015 |
Loa Loa (eye worm) | SRC-1 | 0.001 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0235 | 0.6482 | 0.6482 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0013 | 0.0139 | 0.0375 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.001 | 0.0056 | 0.015 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0138 | 0.3716 | 1 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0016 | 0.022 | 0.0593 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0016 | 0.022 | 0.0593 |
Loa Loa (eye worm) | helicase | 0.0013 | 0.0139 | 0.0139 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0016 | 0.022 | 0.6472 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0016 | 0.022 | 0.0593 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0079 | 0.2018 | 0.2018 |
Treponema pallidum | flavodoxin | 0.0053 | 0.1281 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.001 | 0.0056 | 0.015 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0016 | 0.022 | 0.1274 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.001 | |
Brugia malayi | Protein kinase domain containing protein | 0.001 | 0.0056 | 0.0076 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.001 | 0.0056 | 0.015 |
Brugia malayi | flavodoxin family protein | 0.0053 | 0.1281 | 0.175 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0053 | 0.1281 | 0.3378 |
Echinococcus multilocularis | chromobox protein 1 | 0.0079 | 0.2018 | 0.5431 |
Plasmodium vivax | hypothetical protein, conserved | 0.0013 | 0.0139 | 0.00000000030694 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.0417 | 0.057 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0138 | 0.3716 | 1 |
Mycobacterium ulcerans | arylsulfatase AtsD | 0.001 | 0.0049 | 0.0131 |
Chlamydia trachomatis | sulfite reductase | 0.0085 | 0.2207 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0139 | 0.0124 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.001 | |
Mycobacterium ulcerans | sulfatase | 0.001 | 0.0049 | 0.0131 |
Trichomonas vaginalis | Heterochromatin protein, putative | 0.0013 | 0.0139 | 0.0124 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0068 | 0.1729 | 0.4653 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0016 | 0.022 | 0.0593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.00000051 M | Histamine H2 receptor antagonist activity (chronotropic response to histamine) in guinea pig right atrium | ChEMBL. | 2888895 |
ED50 (functional) | = 0.00000051 M | Histamine H2 receptor antagonist activity (chronotropic response to histamine) in guinea pig right atrium | ChEMBL. | 2888895 |
ED50 (functional) | = 0.0191 mg kg-1 | Reduction in gastric acid secretion under histamine[160 ug/(kg h)] stimulation in anesthetized dogs after intravenous administration | ChEMBL. | 2888895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.