Detailed information for compound 75243

Basic information

Technical information
  • TDR Targets ID: 75243
  • Name: 3-[2-(4-amino-5-fluoro-2-oxopyrimidin-1-yl)et hyl]-2-(hydroxymethyl)-1,3-thiazolidin-4-one
  • MW: 288.299 | Formula: C10H13FN4O3S
  • H donors: 2 H acceptors: 3 LogP: -1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(=O)n(cc1F)CCN1C(CO)SCC1=O
  • InChi: 1S/C10H13FN4O3S/c11-6-3-14(10(18)13-9(6)12)1-2-15-7(17)5-19-8(15)4-16/h3,8,16H,1-2,4-5H2,(H2,12,13,18)
  • InChiKey: KIBYNOSVQCZDBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(4-amino-5-fluoro-2-oxo-pyrimidin-1-yl)ethyl]-2-(hydroxymethyl)thiazolidin-4-one
  • 3-[2-(4-amino-5-fluoro-2-oxo-1-pyrimidinyl)ethyl]-2-(hydroxymethyl)-4-thiazolidinone
  • 3-[2-(4-azanyl-5-fluoro-2-oxo-pyrimidin-1-yl)ethyl]-2-(hydroxymethyl)-1,3-thiazolidin-4-one
  • 3-[2-(4-amino-5-fluoro-2-keto-pyrimidin-1-yl)ethyl]-2-methylol-thiazolidin-4-one
  • 4-amino-5-fluoro-1-[2-[2-(hydroxymethyl)-4-oxo-1,3-thiazolidin-3-yl]ethyl]pyrimidin-2-one
  • 4-amino-5-fluoro-1-[2-[2-(hydroxymethyl)-4-oxo-thiazolidin-3-yl]ethyl]pyrimidin-2-one
  • 4-amino-5-fluoro-1-[2-[2-(hydroxymethyl)-4-oxo-3-thiazolidinyl]ethyl]-2-pyrimidinone
  • 4-amino-5-fluoro-1-[2-(4-keto-2-methylol-thiazolidin-3-yl)ethyl]pyrimidin-2-one
  • 181507-37-9
  • 1-((2-BnOMe-4-oxo-3-thiazol)Et)cytosine
  • 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(2-(hydroxymethyl)-4-oxo-3-thiazolidinyl)ethyl)-
  • 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-[2-(hydroxymethyl)-4-oxo-3-thiazolidinyl]ethyl]-
  • AIDS-043359
  • AIDS043359

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0134 0.1598
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0326 0.1919 0.1916
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Schistosoma mansoni sodium/chloride dependent transporter 0.0036 0.0129 0.0125
Trichomonas vaginalis ran, putative 0.0043 0.0176 0.0999
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0117 0.0867
Brugia malayi Cathepsin L-like precursor 0.0036 0.0128 0.0361
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Trichomonas vaginalis cation-transporting ATPase, putative 0.0022 0.0046 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Schistosoma mansoni retinoic acid receptor RXR 0.029 0.1697 0.1694
Entamoeba histolytica hypothetical protein 0.0022 0.0043 0.0488
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0344 0.0341
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0046 0.0042
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0128 0.4256
Echinococcus multilocularis conserved hypothetical protein 0.0799 0.4842 0.484
Trypanosoma cruzi cyclin 6, putative 0.0046 0.019 0.1415
Leishmania major importin beta-1 subunit, putative 0.0048 0.0203 0.1401
Brugia malayi follicle stimulating hormone receptor 0.053 0.3179 0.9134
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0046 0.019 0.13
Brugia malayi Ets-domain containing protein 0.0082 0.0416 0.1188
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0188 0.0498
Brugia malayi orphan nuclear receptor NR2E1 0.0088 0.045 0.1286
Trypanosoma cruzi UDP-galactopyranose mutase 0.0024 0.0058 0.0418
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0117 0.0114
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0004 0.001
Trypanosoma brucei pteridine reductase 1 0.019 0.1082 0.8146
Echinococcus multilocularis sodium and chloride dependent glycine 0.0036 0.0129 0.0125
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0134 0.0131
Schistosoma mansoni ap endonuclease 0.0038 0.0141 0.0137
Echinococcus granulosus dna polymerase kappa 0.0039 0.0147 0.0143
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0176 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0186 0.1056 0.303
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0188 0.1404
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0113 0.0832
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0036 0.0129 0.0125
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0141 0.098
Brugia malayi Nuclear hormone receptor-like 1 0.0186 0.1056 0.303
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0203 0.1515
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.0745 0.5611
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0035 0.0124 0.0918
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0231
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0213 0.0605
Toxoplasma gondii hypothetical protein 0.0036 0.0129 0.0952
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0186 0.1056 0.1053
Loa Loa (eye worm) cyclin domain-containing protein 0.0019 0.0026 0.0068
Echinococcus multilocularis nuclear receptor nhr 48 0.0088 0.045 0.0447
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Echinococcus multilocularis nervana 2 0.053 0.318 0.3177
Brugia malayi nuclear hormone receptor 0.0088 0.045 0.1286
Trichomonas vaginalis penicillin-binding protein, putative 0.023 0.1326 0.8445
Leishmania major cathepsin L-like protease 0.0136 0.0745 0.5552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Trypanosoma cruzi CYC2-like cyclin, putative 0.0046 0.019 0.1415
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0188 0.1289
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Echinococcus granulosus dna polymerase eta 0.0039 0.0147 0.0143
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0416 0.1098
Loa Loa (eye worm) hypothetical protein 0.053 0.318 0.8398
Echinococcus multilocularis Galectin, carbohydrate recognition domain 0.0123 0.0668 0.0665
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.0362
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.023 0.0227
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0128 0.4256
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0105 0.0278
Echinococcus granulosus lysine specific histone demethylase 1A 0.0024 0.0058 0.0055
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0009 0.0005
Trypanosoma brucei unspecified product 0.0039 0.0147 0.1027
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0033 0.0029
Mycobacterium tuberculosis Probable esterase LipL 0.023 0.1326 0.1427
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.053 0.318 0.3177
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.023 0.1326 0.3502
Schistosoma mansoni alpha-glucosidase 0.0142 0.0783 0.078
Schistosoma mansoni galectin 0.0123 0.0668 0.0665
Echinococcus granulosus Galectin carbohydrate recognition domain 0.0123 0.0668 0.0665
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.0321
Schistosoma mansoni nuclear hormone receptor 0.0088 0.045 0.0447
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.053 0.318 0.3177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus granulosus heat shock protein 0.0033 0.0113 0.0109
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Brugia malayi Sodium:neurotransmitter symporter family protein 0.021 0.1205 0.3457
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0017 0.0012 0.007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0141 0.0137
Schistosoma mansoni ran 0.0043 0.0176 0.0172
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0113
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0235 0.0232
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0272 0.1978
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.1447 0.1444
Brugia malayi Protein kinase domain containing protein 0.0016 0.0007 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0186 0.1056 0.1053
Loa Loa (eye worm) DR-78 0.0088 0.045 0.1188
Schistosoma mansoni sodium/chloride dependent transporter 0.021 0.1205 0.1202
Echinococcus granulosus cyclin b3 0.0019 0.0026 0.0022
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Brugia malayi hypoxia-induced factor 1 0.0161 0.0904 0.2591
Brugia malayi TAR-binding protein 0.0064 0.0304 0.0865
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0129 0.082
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0137
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.039 0.2929
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0186 0.1056 0.279
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0147 0.1027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0473 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0153
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0395 0.0392
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0925 0.0921
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0028 0.0081 0.0593
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0128 0.1526
Brugia malayi PXA domain containing protein 0.0022 0.0043 0.0115
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0147 0.0414
Schistosoma mansoni lamin 0.0032 0.0105 0.0102
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0242 0.0238
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0058 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0304 0.03
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0681 0.5061
Schistosoma mansoni smad1 5 8 and 0.0016 0.0009 0.0005
Echinococcus granulosus cathepsin l1 0.0036 0.0128 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0056 0.0219
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0043 0.0039
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0036 0.0129 0.0125
Brugia malayi Cathepsin L-like precursor 0.0036 0.0128 0.0361
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0044 0.0178 0.0174
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.021 0.1205 0.1202
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0395 0.0392
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0073 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0134 0.0992
Giardia lamblia DINP protein human, muc B family 0.0039 0.0147 0.331
Brugia malayi Serotonin receptor 0.0544 0.3269 0.9393
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0123 0.0668 0.1764
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.034
Brugia malayi Cyclin, N-terminal domain containing protein 0.0046 0.019 0.0538
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0035 0.0124 0.1478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0242 0.0238
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.034
Onchocerca volvulus Galectin homolog 0.0579 0.348 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0043 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0473 0.047
Loa Loa (eye worm) hypothetical protein 0.0046 0.019 0.0502
Onchocerca volvulus 0.0032 0.0105 0.0238
Loa Loa (eye worm) hypothetical protein 0.0054 0.0242 0.0639
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0033 0.0029
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0128 0.0125
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0272 0.2034
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0035 0.0124 0.0918
Brugia malayi cell division control protein 2 homolog 0.0045 0.0188 0.0534
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0098 0.0515 0.0512
Loa Loa (eye worm) TK protein kinase 0.0035 0.0125 0.0329
Leishmania major cathepsin L-like protease 0.0036 0.0128 0.0827
Brugia malayi Fli-1 protein 0.025 0.1449 0.4158
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0085 0.0434 0.1147
Schistosoma mansoni transmemberane protein 0.053 0.318 0.3177
Trichomonas vaginalis cyclin B, putative 0.0046 0.019 0.109
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0745 0.5611
Brugia malayi Galactoside-binding lectin family protein 0.0123 0.0668 0.1913
Brugia malayi photoreceptor-specific nuclear receptor 0.0186 0.1056 0.303
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0186 0.1056 0.2988
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0272 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0098 0.0515 0.1473
Schistosoma mansoni hypothetical protein 0.0628 0.3786 0.3784
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0022 0.0018
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0141 0.3144
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0043 0.0039
Onchocerca volvulus 0.053 0.318 0.9131
Entamoeba histolytica hypothetical protein 0.0022 0.0043 0.0488
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0141 0.0771
Brugia malayi nuclear receptor NHR-88 0.0088 0.045 0.1286
Brugia malayi Pre-SET motif family protein 0.0034 0.0117 0.033
Echinococcus multilocularis Smad4 0.0016 0.0009 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0113
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.0321
Echinococcus multilocularis protoporphyrinogen oxidase 0.0024 0.0058 0.0055
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0022 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0134 0.0727
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.0178 0.0174
Trichomonas vaginalis cyclin D, putative 0.0019 0.0026 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0202 0.1158 0.3323
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0035 0.0124 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0043 0.0113
Toxoplasma gondii histone lysine-specific demethylase 0.0024 0.0058 0.0418
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0017 0.0011 0.0007
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0176 0.6166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.034
Loa Loa (eye worm) hypothetical protein 0.0087 0.0448 0.1184
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0147 0.0184
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0128 0.0125
Brugia malayi Nuclear hormone receptor E75 0.0088 0.045 0.1286
Schistosoma mansoni nephrin 0.0016 0.0005 0.0001
Leishmania major cathepsin L-like protease 0.0136 0.0745 0.5552
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Loa Loa (eye worm) nuclear hormone receptor 0.0088 0.045 0.1188
Brugia malayi Death domain containing protein 0.0015 0.0004 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0304 0.03
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Plasmodium falciparum heat shock protein 90 0.0033 0.0113 0.3643
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0134 0.0727
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0188 0.108
Onchocerca volvulus 0.0036 0.0128 0.0304
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0203 0.1175
Echinococcus granulosus calcium transporting atpase 0.0028 0.0081 0.0078
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0004 0.0000042662
Schistosoma mansoni thyroid hormone receptor 0.0321 0.1888 0.1885
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0304 0.03
Echinococcus multilocularis endoplasmin 0.0026 0.0071 0.0068
Plasmodium vivax hypothetical protein, conserved 0.023 0.1326 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0058 0.1454
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Echinococcus granulosus roundabout 2 0.002 0.003 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0825 0.0821
Leishmania major P-type H -ATPase, putative 0.0022 0.0046 0.0196
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0681 0.1252
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0043 0.0115
Schistosoma mansoni ap endonuclease 0.0038 0.0141 0.0137
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0269
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.023 0.1326 0.3805
Schistosoma mansoni zinc finger protein 0.0088 0.045 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0186 0.1056 0.303
Brugia malayi nuclear hormone receptor family member nhr-6 0.0088 0.045 0.1286
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0188 0.1404
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0036 0.0129 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Loa Loa (eye worm) fibroinase 0.0036 0.0128 0.0339
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0202 0.1158 0.3059
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0186 0.1056 0.303
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0188 0.1343
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0007
Plasmodium falciparum calcium-transporting ATPase 0.0028 0.0081 0.2377
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.032 0.1882 0.2051
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Loa Loa (eye worm) calcium ATPase 0.002 0.003 0.0079
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0043 0.0039
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Onchocerca volvulus 0.023 0.1326 0.3768
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0043 0.0039
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0022 0.0054
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0176 0.4106
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0123 0.0668 0.1764
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.0178 0.0174
Trypanosoma cruzi ISWI complex protein 0.0018 0.002 0.0132
Leishmania major cathepsin L-like protease 0.0036 0.0128 0.0827
Schistosoma mansoni zinc finger protein 0.0018 0.002 0.0017
Toxoplasma gondii hypothetical protein 0.0036 0.0129 0.0952
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0098 0.0515 0.136
Echinococcus granulosus smad 0.0016 0.0009 0.0005
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0036 0.0129 0.0125
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0056 0.0152
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0043 0.0115
Trichomonas vaginalis penicillin-binding protein, putative 0.023 0.1326 0.8445
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0178 0.0174
Echinococcus multilocularis nervana 2 0.0326 0.1919 0.1916
Brugia malayi Steroid receptor seven-up type 2 0.0186 0.1056 0.303
Schistosoma mansoni hypothetical protein 0.0051 0.0222 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0681 0.1252
Loa Loa (eye worm) hypothetical protein 0.0039 0.0147 0.0388
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0017 0.0012 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0113 0.059
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0147 0.1089
Plasmodium vivax calcium-transporting ATPase, putative 0.0035 0.0124 0.0786
Loa Loa (eye worm) follicle stimulating hormone receptor 0.053 0.3179 0.8396
Entamoeba histolytica hypothetical protein 0.0022 0.0043 0.0488
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.0464 0.046
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0058 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0186 0.1056 0.303
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0147 0.1089
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0128 0.0948
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.0362
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0171 0.0167
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0171 0.0167
Plasmodium vivax P-type ATPase4, putative 0.0035 0.0124 0.0786
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0188 0.0185
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0001
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0326 0.1919 0.1916
Loa Loa (eye worm) hypothetical protein 0.023 0.1326 0.3502
Schistosoma mansoni endoplasmin 0.0033 0.0113 0.0109
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0128 0.0304
Mycobacterium tuberculosis Probable hydrolase 0.023 0.1326 0.1427
Schistosoma mansoni ATPase 0.0035 0.0124 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0473 0.047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.023 0.1326 0.1323
Brugia malayi hypothetical protein 0.0036 0.0129 0.0362
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0153
Brugia malayi hypothetical protein 0.0088 0.045 0.1286
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0192
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.0664
Echinococcus granulosus jun protein 0.009 0.0464 0.046
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Brugia malayi Na,K-ATPase alpha subunit 0.0085 0.0434 0.1241
Entamoeba histolytica hypothetical protein 0.0148 0.0825 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0141 0.0913
Onchocerca volvulus 0.0034 0.0117 0.0273
Loa Loa (eye worm) hypothetical protein 0.021 0.1205 0.3182
Trypanosoma cruzi ISWI complex protein 0.0018 0.002 0.0132
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0147 0.0143
Schistosoma mansoni nuclear receptor 0.0088 0.045 0.0447
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0134 0.0727
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0134 0.0354
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0028 0.0081 0.1512
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0043 0.0039
Echinococcus multilocularis musashi 0.0032 0.0105 0.0102
Echinococcus granulosus zinc finger protein 0.0023 0.0051 0.0048
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0043 0.0039
Trichomonas vaginalis cyclins, putative 0.0019 0.0026 0.0027
Mycobacterium ulcerans lipase LipD 0.023 0.1326 0.2541
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0222 0.0631
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.0664
Loa Loa (eye worm) TK protein kinase 0.0039 0.0152 0.04
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0178 0.0174
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Onchocerca volvulus 0.0036 0.0128 0.0304
Schistosoma mansoni gabp alpha 0.0082 0.0416 0.0412
Onchocerca volvulus 0.0186 0.1056 0.2988
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0028
Schistosoma mansoni tyrosine kinase 0.0044 0.0178 0.0174
Echinococcus granulosus ecdysone induced protein 78C 0.0186 0.1056 0.1053
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0188 0.4449
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0681 0.0678
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0153
Brugia malayi MH1 domain containing protein 0.0016 0.0009 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0147 0.0811
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Trichomonas vaginalis cyclin D, putative 0.0019 0.0026 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0186 0.1056 0.1053
Echinococcus granulosus nervana 2 0.0326 0.1919 0.1916
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Schistosoma mansoni hypothetical protein 0.0111 0.0591 0.0587
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.045 0.0447
Schistosoma mansoni single-minded 0.0052 0.023 0.0227
Echinococcus multilocularis zinc finger protein 0.0023 0.0051 0.0048
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0628 0.3786 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0147 0.0143
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0147 0.1027
Loa Loa (eye worm) hypothetical protein 0.021 0.1205 0.3182
Schistosoma mansoni netrin receptor unc5 0.0019 0.0029 0.0025
Trypanosoma brucei unspecified product 0.0027 0.0073 0.0464
Brugia malayi galectin 0.0123 0.0668 0.1913
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Trypanosoma brucei P-type H+-ATPase, putative 0.0022 0.0046 0.0257
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0085 0.0434 0.0431
Trypanosoma brucei glucosidase, putative 0.0037 0.0134 0.0929
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1383 0.3652
Echinococcus multilocularis cyclin B3 1 0.0019 0.0026 0.0022
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0123 0.0668 0.1764
Brugia malayi nuclear hormone receptor family member odr-7 0.0088 0.045 0.1286
Trichomonas vaginalis cyclin B, putative 0.0046 0.019 0.109
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0043 0.0039
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0028 0.0081 0.0078
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Echinococcus granulosus tyrosine protein kinase Blk 0.0039 0.0152 0.0148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0186 0.1056 0.303
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0022 0.0143
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0135 0.0741 0.0737
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.1478
Mycobacterium tuberculosis Conserved protein 0.023 0.1326 0.1427
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0128 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0137
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0681 0.0678
Echinococcus granulosus tumor protein p63 0.0362 0.2142 0.2139
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Schistosoma mansoni ets-related 0.025 0.1449 0.1446
Schistosoma mansoni jun-related protein 0.0073 0.036 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Onchocerca volvulus 0.0185 0.1049 0.2967
Echinococcus granulosus tyrosine kinase 0.0039 0.0152 0.0148
Entamoeba histolytica hypothetical protein 0.0148 0.0825 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0473 0.047
Trypanosoma cruzi hypothetical protein, conserved 0.023 0.1326 1
Brugia malayi ecdysone receptor 0.0088 0.045 0.1286
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0153
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0147 0.0143
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0113
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0071 0.0391
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.0464 0.046
Brugia malayi Bromodomain containing protein 0.0045 0.0188 0.0533
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0176 0.0172
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0135 0.0741 0.0737
Brugia malayi RNA, U transporter 1 0.0167 0.0942 0.27
Brugia malayi hypothetical protein 0.0071 0.0344 0.0983
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0147 0.097
Onchocerca volvulus 0.023 0.1326 0.3768
Plasmodium falciparum transporter, putative 0.0036 0.0129 0.4276
Trichomonas vaginalis set domain proteins, putative 0.0269 0.1566 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.0664
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0009 0.0005
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0028 0.0081 0.0526
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0019 0.0026 0.0022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0186 0.1056 0.1053
Brugia malayi hypothetical protein 0.0098 0.0515 0.1473
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0024 0.0058 0.0055
Brugia malayi Cyclin, N-terminal domain containing protein 0.0046 0.019 0.0538
Schistosoma mansoni steroid hormone receptor ad4bp 0.0186 0.1056 0.1053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0032
Echinococcus granulosus cyclin B 0.0046 0.019 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.0186 0.1056 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0186 0.1056 0.303
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0043 0.0113
Trypanosoma brucei mitotic cyclin 6 0.0046 0.019 0.1355
Plasmodium vivax amine transporter, putative 0.0036 0.0129 0.082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0186 0.1056 0.303
Echinococcus multilocularis gamma secretase subunit aph 1 0.0246 0.1424 0.1421
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0035 0.0124 0.0796
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0113 0.0298
Loa Loa (eye worm) hypothetical protein 0.0059 0.0272 0.0718
Echinococcus multilocularis cysteine protease 0.0036 0.0128 0.0125
Echinococcus granulosus microtubule associated protein 2 0.0697 0.4212 0.421
Echinococcus granulosus snurportin 1 0.0628 0.3786 0.3784
Plasmodium vivax vivapain-2 0.0036 0.0128 0.0816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0186 0.1056 0.279
Echinococcus granulosus gamma secretase subunit aph 1 0.0246 0.1424 0.1421
Echinococcus multilocularis cysteine protease 0.0036 0.0128 0.0125
Mycobacterium ulcerans proteasome PrcA 0.0834 0.5056 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0013
Loa Loa (eye worm) steroid hormone receptor 0.0186 0.1056 0.279
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0326 0.1919 0.1916
Toxoplasma gondii ABC1 family protein 0.023 0.1326 1
Echinococcus granulosus heat shock protein 90 0.0033 0.0113 0.0109
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0304 0.0802
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0186 0.1056 0.303
Mycobacterium ulcerans beta-lactamase 0.023 0.1326 0.2541
Loa Loa (eye worm) beta-lactamase 0.023 0.1326 0.3502
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0147 0.0388
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0098 0.0515 0.0512
Echinococcus multilocularis dna polymerase eta 0.0039 0.0147 0.0143
Echinococcus multilocularis cathepsin L 0.0018 0.0022 0.0018
Leishmania major calcium motive p-type ATPase, putative 0.0028 0.0081 0.0467
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Entamoeba histolytica protein kinase, putative 0.0035 0.0125 0.1483
Schistosoma mansoni nuclear receptor 0.0088 0.045 0.0447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0473 0.047
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.0952
Loa Loa (eye worm) solute carrier family 6 member 4 0.021 0.1205 0.3182
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0098 0.0515 0.0511
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0128 0.0361
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0044 0.0178 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Schistosoma mansoni hypothetical protein 0.1635 1 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.039 0.4716
Entamoeba histolytica Ran family GTPase 0.0043 0.0176 0.2107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Echinococcus multilocularis jun protein 0.009 0.0464 0.046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0058 0.0279
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0028 0.0081 0.0225
Trichomonas vaginalis heat shock protein, putative 0.002 0.0034 0.0079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0186 0.1056 0.1053
Leishmania major cyclin 0.0046 0.019 0.13
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0203 0.1175
Echinococcus granulosus nervana 2 0.053 0.318 0.3177
Brugia malayi SRC-1 0.0044 0.0178 0.0503
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0144 0.014
Echinococcus granulosus cathepsin l1 0.0024 0.0056 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0219 0.0578
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.053 0.318 0.3177
Brugia malayi Importin beta-1 subunit 0.0059 0.0272 0.0774
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0024 0.0058 0.1454
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0071 0.0518
Brugia malayi MH2 domain containing protein 0.0016 0.0009 0.0018
Toxoplasma gondii exonuclease III APE 0.0038 0.0141 0.1043
Loa Loa (eye worm) hypothetical protein 0.021 0.1205 0.3182
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0416 0.0412
Schistosoma mansoni gamma-secretase subunit aph-1 0.0246 0.1424 0.1421
Echinococcus granulosus tyrosine protein kinase Src64B 0.0044 0.0178 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.045 0.0447
Toxoplasma gondii cathepsin CPL 0.0036 0.0128 0.0948
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0071 0.1241
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0188 0.0185
Brugia malayi hypothetical protein 0.0148 0.0825 0.2363
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0043 0.0039
Echinococcus granulosus Na:K ATPase alpha subunit 0.0078 0.0391 0.0388
Onchocerca volvulus 0.0095 0.0496 0.1368
Mycobacterium ulcerans hypothetical protein 0.023 0.1326 0.2541
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0134 0.0727
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0188 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0073 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0186 0.1056 0.279
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0128 0.0125
Entamoeba histolytica cyclin family protein 0.0019 0.0026 0.0282
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.1447 0.1444
Echinococcus multilocularis calcium transporting atpase 0.0028 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0098 0.0515 0.136
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0074 0.0365 0.0965
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0009 0.0024
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.002 0.003 0.0332
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0187 0.0184
Leishmania major DNA polymerase eta, putative 0.0039 0.0147 0.097
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0304 0.03
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.0952
Schistosoma mansoni hypothetical protein 0.1635 1 1
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0035 0.0124 0.0918
Echinococcus multilocularis cyclin b3 0.0019 0.0026 0.0022
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0176 0.1183
Echinococcus multilocularis lamin dm0 0.0032 0.0105 0.0102
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0088 0.045 0.1188
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0043 0.0039
Echinococcus multilocularis GPCR, family 2 0.0016 0.0005 0.0001
Brugia malayi Pre-SET motif family protein 0.0236 0.1365 0.3917
Schistosoma mansoni DNA polymerase eta 0.0039 0.0147 0.0143
Onchocerca volvulus Protein ultraspiracle homolog 0.0186 0.1056 0.2988
Trichomonas vaginalis D-aminoacylase, putative 0.023 0.1326 0.8445
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0176 0.1248
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0147 0.0103
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.011 0.0106
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Loa Loa (eye worm) hypothetical protein 0.0175 0.0991 0.2618
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0113 0.0832
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0123 0.0668 0.1764
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0304 0.03
Trypanosoma brucei hypothetical protein, conserved 0.023 0.1326 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0036 0.0132 0.0128
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0046 0.0121
Onchocerca volvulus 0.023 0.1326 0.3768
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1383 0.3652
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0188 0.1289
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.0566 0.4258
Loa Loa (eye worm) hypothetical protein 0.0061 0.0287 0.0758
Echinococcus granulosus death domain containing protein 0.0015 0.0004 0.000004252
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0186 0.1056 0.1053
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0035 0.0124 0.0918
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0044 0.0178 0.0174
Plasmodium vivax endoplasmin, putative 0.0033 0.0113 0.0699
Loa Loa (eye worm) cysteine protease 0.0036 0.0128 0.0339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0078 0.0391 0.0388
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.0178 0.0174
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.4212 0.421
Brugia malayi Uncoordinated protein 44 0.0015 0.0004 0.0002
Onchocerca volvulus 0.0039 0.0147 0.0357
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0186 0.1056 0.1053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0141 0.0372
Brugia malayi nuclear receptor RXR 0.0098 0.0515 0.1473
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0123 0.0668 0.1764
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Loa Loa (eye worm) hypothetical protein 0.0579 0.348 0.9191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0186 0.1056 0.1053
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0014 0.0032
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0035 0.0124 0.0138
Brugia malayi Fibroblast growth factor family protein 0.0061 0.0287 0.0817
Giardia lamblia Grp94/Hsp90 0.0026 0.0071 0.1241
Brugia malayi intermediate filament protein 0.0032 0.0105 0.0295
Plasmodium vivax vivapain-2 0.0036 0.0128 0.0816
Plasmodium vivax importin-beta 2, putative 0.0059 0.0272 0.1918
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0012
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0192 0.1091 0.1088
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0078 0.0391 0.0388
Echinococcus granulosus expressed protein 0.0424 0.2524 0.2521
Loa Loa (eye worm) Smad1 0.0016 0.0009 0.0024
Echinococcus multilocularis tyrosine protein kinase Srms 0.0039 0.0152 0.0148
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Leishmania major UDP-galactopyranose mutase 0.0024 0.0058 0.029
Schistosoma mansoni nuclear hormone receptor 0.0186 0.1056 0.1053
Loa Loa (eye worm) hypothetical protein 0.0046 0.019 0.0502
Onchocerca volvulus 0.0036 0.0129 0.0305
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0141 0.168
Onchocerca volvulus 0.0024 0.0058 0.0101
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0113 0.0832
Trichomonas vaginalis D-aminoacylase, putative 0.023 0.1326 0.8445
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0304 0.0865
Echinococcus multilocularis 0.0024 0.0058 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0186 0.1056 0.303
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0035 0.0124 0.0121
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0825 0.0821
Onchocerca volvulus 0.0036 0.0128 0.0304
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0088 0.045 0.0447
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.0499 0.3752
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0128 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.039 0.0387
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0141 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0147 0.0184
Schistosoma mansoni smad 0.0016 0.0009 0.0005
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.1478
Leishmania major cathepsin L-like protease 0.0036 0.0128 0.0827
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0681 0.5126
Loa Loa (eye worm) SRC-1 0.0044 0.0178 0.0469
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0046 0.0325
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0113
Loa Loa (eye worm) hypoxia-induced factor 1 0.0161 0.0904 0.2387
Brugia malayi galectin 0.0426 0.2536 0.7284
Brugia malayi hypothetical protein 0.0022 0.0043 0.0115
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0022 0.0143
Entamoeba histolytica hypothetical protein 0.0048 0.0203 0.2438
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0043 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.0178 0.0174
Echinococcus granulosus neuroglian 0.0016 0.0005 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.023 0.1326 0.2541
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0117 0.0114
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0028 0.0081 0.0078
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0088 0.045 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Schistosoma mansoni cyclins 0.0019 0.0026 0.0022
Brugia malayi PXA domain containing protein 0.0022 0.0043 0.0115
Trichomonas vaginalis cyclin B, putative 0.0046 0.019 0.109
Schistosoma mansoni nuclear hormone receptor 0.0088 0.045 0.0447
Plasmodium vivax protein kinase Crk2 0.0045 0.0188 0.1279
Schistosoma mansoni zinc finger protein 0.0023 0.0051 0.0048
Brugia malayi gamma-secretase subunit aph-1 0.0246 0.1424 0.4087
Loa Loa (eye worm) hypothetical protein 0.0098 0.0515 0.136
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0105 0.0278
Echinococcus granulosus sodium and chloride dependent glycine 0.0036 0.0129 0.0125
Echinococcus multilocularis FTZ F1 alpha 0.0186 0.1056 0.1053
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0176 0.1309
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0141 0.0771
Schistosoma mansoni ATPase 0.0035 0.0124 0.0121
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0188 0.0185
Trichomonas vaginalis cyclins, putative 0.0031 0.0101 0.0513
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0188 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0186 0.1056 0.303
Brugia malayi Galactoside-binding lectin family protein 0.0123 0.0668 0.1913
Leishmania major calcium-transporting ATPase, putative 0.0028 0.0081 0.0467
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0024 0.0058 0.0418
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0088 0.045 0.0447
Leishmania major cathepsin L-like protease 0.0036 0.0128 0.0827
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.039 0.0387
Echinococcus granulosus cysteine protease 0.0018 0.0022 0.0018
Giardia lamblia G2/mitotic-specific cyclin B 0.0046 0.019 0.449
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Onchocerca volvulus 0.0326 0.1919 0.5485
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0044 0.0178 0.0174
Plasmodium falciparum protein kinase 5 0.0045 0.0188 0.6667
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0117 0.0328
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0017
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0028 0.0081 0.0593
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0105 0.0295
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.045 0.0447
Onchocerca volvulus 0.0036 0.0128 0.0304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Entamoeba histolytica cysteine protease, putative 0.0036 0.0128 0.1526
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0147 0.1089
Echinococcus granulosus FTZ F1 alpha 0.0186 0.1056 0.1053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0153
Echinococcus granulosus lamin 0.0032 0.0105 0.0102
Schistosoma mansoni endoplasmin 0.0033 0.0113 0.0109
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0416 0.0412
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0188 0.0498
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0043 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0186 0.1056 0.1053
Leishmania major pteridine reductase 1 0.0193 0.1098 0.8253
Trichomonas vaginalis cyclins, putative 0.0046 0.019 0.109
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0141 0.0171
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0134 0.0872
Loa Loa (eye worm) hypothetical protein 0.0085 0.0434 0.1147
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0242 0.0238
Onchocerca volvulus 0.021 0.1205 0.3418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Loa Loa (eye worm) galectin 0.0426 0.2536 0.6697
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0043 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0344 0.0341
Plasmodium falciparum endoplasmin, putative 0.002 0.0034 0.0487
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0144 0.014
Trichomonas vaginalis cyclins, putative 0.0046 0.019 0.109
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0304 0.0802
Trypanosoma brucei ISWI complex protein 0.0018 0.002 0.0063
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0035 0.0124 0.2691
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0056 0.0052
Trichomonas vaginalis endoplasmin, putative 0.002 0.0034 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0073 0.0464
Echinococcus granulosus cathepsin L 0.0018 0.0022 0.0018
Brugia malayi Cathepsin L-like precursor 0.0036 0.0128 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0137
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1467 0.8963 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0188 0.226
Onchocerca volvulus 0.0088 0.045 0.1234
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0036 0.0129 0.0125
Echinococcus granulosus nervana 2 0.0326 0.1919 0.1916
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0141 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0073 0.0464
Echinococcus granulosus lysine specific histone demethylase 1A 0.0024 0.0058 0.0055
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0188 0.0185
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.053 0.318 0.3177
Brugia malayi hypothetical protein 0.0088 0.045 0.1286
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.1365 0.3604
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.045 0.0447
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0024 0.0058 0.0006
Echinococcus multilocularis neuroglian 0.0016 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0098 0.0515 0.136
Echinococcus multilocularis beta LACTamase domain containing family member 0.023 0.1326 0.1323
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0186 0.1056 0.303
Schistosoma mansoni coup transcription factor 0.0186 0.1056 0.1053
Plasmodium falciparum amino acid transporter, putative 0.0036 0.0129 0.4276
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0022 0.0143
Schistosoma mansoni lamin 0.0032 0.0105 0.0102
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0028 0.0081 0.0078
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.0952
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0113
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0043 0.0115
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Echinococcus granulosus nervana 2 0.053 0.318 0.3177
Echinococcus granulosus single minded 2 0.0039 0.0147 0.0143
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0043 0.0039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0473 0.125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0117 0.0114
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0033 0.0029
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0035 0.0124 0.0854
Echinococcus multilocularis serotonin transporter 0.021 0.1205 0.1202
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0001
Brugia malayi beta-lactamase family protein 0.023 0.1326 0.3805
Loa Loa (eye worm) hypothetical protein 0.023 0.1326 0.3502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Brugia malayi Bromodomain containing protein 0.0089 0.0456 0.1303
Plasmodium falciparum cyclin 0.0019 0.0026 0.0167
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0043 0.0039
Onchocerca volvulus Galectin homolog 0.0123 0.0668 0.1865
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0017 0.0012 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0186 0.1056 0.303
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0059 0.0156
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.034
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0113 0.0832
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0113 0.0832
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0187 0.0184
Schistosoma mansoni amine oxidase 0.0024 0.0058 0.0054
Trichomonas vaginalis cyclin B, putative 0.0046 0.019 0.109
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0043 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0272 0.1978
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0074 0.0365 0.1042
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0213 0.0563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0186 0.1056 0.279
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Schistosoma mansoni sodium-dependent amino acid transporter 0.0036 0.0129 0.0125
Onchocerca volvulus Bile acid receptor homolog 0.0186 0.1056 0.2988
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0001
Leishmania major P-type H -ATPase, putative 0.0022 0.0046 0.0196
Trichomonas vaginalis esterase, putative 0.023 0.1326 0.8445
Echinococcus granulosus serotonin transporter 0.021 0.1205 0.1202
Loa Loa (eye worm) hypothetical protein 0.0053 0.0235 0.0622
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0035 0.0124 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0044 0.0178 0.0174
Leishmania major cathepsin L-like protease 0.0136 0.0745 0.5552
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.045 0.0447
Echinococcus granulosus heat shock protein 90 0.0026 0.0071 0.0068
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0134 0.0131
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0147 0.0811
Brugia malayi cathepsin L-like precursor 0.0024 0.0056 0.0152
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0186 0.1056 0.1053
Brugia malayi amine oxidase, flavin-containing family protein 0.0024 0.0058 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0015 0.0003 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0745 0.5611
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0028 0.0081 0.0385
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0005 0.0006
Schistosoma mansoni importin beta-1 0.0059 0.0272 0.0268
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0113
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0128 0.0339
Brugia malayi Smad1 0.0016 0.0009 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0186 0.1056 0.1053
Trichomonas vaginalis cyclin B3, putative 0.0019 0.0026 0.0027
Onchocerca volvulus 0.0046 0.019 0.0482
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0188 0.108
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0098 0.0515 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus granulosus endoplasmin 0.0026 0.0071 0.0068
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0134 0.0992
Schistosoma mansoni nuclear receptor nhr-48 0.0088 0.045 0.0447
Entamoeba histolytica hypothetical protein 0.0148 0.0825 1
Brugia malayi Nuclear hormone receptor E75 0.0088 0.045 0.1286
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0128 0.0125
Trichomonas vaginalis cation-transporting ATPase, putative 0.0035 0.0124 0.0664
Brugia malayi hypothetical protein 0.0022 0.0043 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0203 0.1175
Leishmania major GTP-binding protein, putative 0.0043 0.0176 0.1193
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0147 0.1089
Trichomonas vaginalis D-aminoacylase, putative 0.023 0.1326 0.8445
Brugia malayi SWIRM domain containing protein 0.0024 0.0058 0.0159
Loa Loa (eye worm) norepinephrine transporter 0.021 0.1205 0.3182
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0147
Onchocerca volvulus 0.0071 0.0344 0.0929
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.0321
Schistosoma mansoni survival motor neuron protein 0.0051 0.0222 0.0219
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0134 0.0727
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0009 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0231
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0147 0.1027
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0128 0.1526
Loa Loa (eye worm) hypothetical protein 0.0098 0.0515 0.136
Loa Loa (eye worm) hypothetical protein 0.005 0.022 0.0581
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Brugia malayi PHD-finger family protein 0.0029 0.009 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0137
Echinococcus multilocularis smad 0.0016 0.0009 0.0005
Echinococcus multilocularis roundabout 2 0.002 0.003 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0321 0.1888 0.1885
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0925 0.2651
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0019 0.0026 0.0022
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0035 0.0124 0.0121
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Onchocerca volvulus 0.0036 0.0129 0.0305
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0176 0.0172
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.039 0.0387
Onchocerca volvulus 0.0032 0.0105 0.0238
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0186 0.1056 0.279
Schistosoma mansoni cyclin B 0.0046 0.019 0.0186
Echinococcus multilocularis ecdysone induced protein 78C 0.0186 0.1056 0.1053
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0071 0.0068
Toxoplasma gondii P-type ATPase4, putative 0.0035 0.0124 0.0918
Trypanosoma brucei calcium-translocating P-type ATPase 0.0028 0.0081 0.0526
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0043 0.0039
Schistosoma mansoni alpha-glucosidase 0.0142 0.0783 0.078
Trichomonas vaginalis cation-transporting ATPase, putative 0.0035 0.0124 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.0499 0.3752
Echinococcus granulosus lamin dm0 0.0032 0.0105 0.0102
Loa Loa (eye worm) serotonin transporter b 0.021 0.1205 0.3182
Echinococcus granulosus beta LACTamase domain containing family member 0.023 0.1326 0.1323
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0043 0.0115
Leishmania major P-type ATPase, putative 0.0028 0.0081 0.0467
Echinococcus granulosus Ankyrin 0.0016 0.0004 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0304 0.03
Brugia malayi hypothetical protein 0.0024 0.0058 0.0159
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0309
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0153
Trypanosoma cruzi UDP-galactopyranose mutase 0.0024 0.0058 0.0418
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0056 0.0643
Toxoplasma gondii P-type ATPase PMA1 0.0022 0.0046 0.0325
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0188 0.1404
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0028 0.0081 0.0078
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0113 0.1339
Brugia malayi MH2 domain containing protein 0.0239 0.1383 0.3968
Onchocerca volvulus 0.0036 0.0129 0.0305
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0925 0.0921
Echinococcus multilocularis tumor protein p63 0.0362 0.2142 0.2139
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0113 0.0832
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0113 0.0767
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Plasmodium falciparum protoporphyrinogen oxidase 0.0024 0.0058 0.1454
Trichomonas vaginalis cation-transporting ATPase, putative 0.0035 0.0124 0.0664
Brugia malayi Galactoside-binding lectin family protein 0.0123 0.0668 0.1913
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0344 0.2031 0.3952
Brugia malayi Cathepsin L-like precursor 0.0024 0.0056 0.0152
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.0125 0.0121
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0141 0.0923
Echinococcus granulosus hypothetical protein 0.0811 0.4913 0.4911
Loa Loa (eye worm) hypothetical protein 0.0045 0.0189 0.0498
Brugia malayi nuclear hormone receptor 0.0186 0.1056 0.303
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0473 0.047
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0213 0.0605
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0043 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0473 0.047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0186 0.1056 0.1053
Loa Loa (eye worm) hypothetical protein 0.007 0.0342 0.0904
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.001
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0028 0.0081 0.0593
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0834 0.5056 1
Echinococcus multilocularis expressed protein 0.0424 0.2524 0.2521
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0147 0.1754
Onchocerca volvulus 0.0024 0.0056 0.0094
Trypanosoma brucei Aph-1 protein, putative 0.0096 0.0499 0.3708
Echinococcus granulosus tyrosine protein kinase Lyn 0.0044 0.0181 0.0177
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0035 0.0124 0.0664
Loa Loa (eye worm) hypothetical protein 0.0084 0.0425 0.1122
Brugia malayi hypothetical protein 0.0175 0.0987 0.2831
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0681 0.0678
Brugia malayi Cathepsin L-like precursor 0.0036 0.0128 0.0361
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0001
Entamoeba histolytica cyclin, putative 0.0046 0.019 0.2278
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0043 0.0039
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0036 0.0129 0.0125
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0176 0.1309
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0134 0.0727
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0188 0.0498
Loa Loa (eye worm) galectin 0.0123 0.0668 0.1764
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0024 0.0058 0.0279
Brugia malayi protein-tyrosine kinase 0.0039 0.0152 0.0428
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Schistosoma mansoni thyroid hormone receptor 0.0321 0.1888 0.1885
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0147 0.0103
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0035 0.0124 0.0121
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.053 0.318 0.3177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0186 0.1056 0.279
Loa Loa (eye worm) RNA binding protein 0.0064 0.0304 0.0802
Loa Loa (eye worm) nuclear receptor NHR-67 0.0088 0.045 0.1188
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0044 0.0178 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0186 0.1056 0.303
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0141 0.1043
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0188 0.0185
Brugia malayi Protein kinase domain containing protein 0.0176 0.0994 0.2851
Brugia malayi Endoplasmin precursor 0.0033 0.0113 0.0317
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0134 0.0727
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0088 0.045 0.0447
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0022 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0056 0.0219
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0035 0.0124 0.0854
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.034
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0128 0.0304
Mycobacterium ulcerans oxidoreductase 0.0024 0.0058 0.0006
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0681 0.1252
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0005 0.0001
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0022 0.0231
Schistosoma mansoni Smad4 0.0016 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0148 0.0825 0.0821
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0147 0.1089
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0022 0.0054
Schistosoma mansoni hypothetical protein 0.0073 0.036 0.0356
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0004 0.000000014262
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0825 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus granulosus Smad4 0.0016 0.0009 0.0005
Echinococcus granulosus GPCR family 2 0.0016 0.0005 0.0001
Entamoeba histolytica hypothetical protein 0.0148 0.0825 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0124 0.0328
Brugia malayi hypothetical protein 0.0098 0.0515 0.1473
Echinococcus multilocularis tyrosine protein kinase Blk 0.0039 0.0152 0.0148
Plasmodium vivax SET domain protein, putative 0.0034 0.0117 0.0734
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.1478
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0043 0.0039
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0176 0.0465
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.034
Brugia malayi MH2 domain containing protein 0.0016 0.0009 0.0018
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0071 0.0518
Treponema pallidum sodium- and chloride- dependent transporter 0.021 0.1205 1
Giardia lamblia Hypothetical protein 0.0061 0.0287 0.7143
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0147
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0046 0.0121
Loa Loa (eye worm) endoplasmin 0.0033 0.0113 0.0298
Brugia malayi Cathepsin L-like precursor 0.0024 0.0056 0.0152
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0028 0.0081 0.0078
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.053 0.318 0.3177
Onchocerca volvulus 0.0036 0.0128 0.0304
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0046 0.0124
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0141 0.0614
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0113 0.0832
Loa Loa (eye worm) hypothetical protein 0.0175 0.0987 0.2607
Echinococcus multilocularis heat shock protein 0.0033 0.0113 0.0109
Schistosoma mansoni ran 0.0043 0.0176 0.0172
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0681 0.0703
Loa Loa (eye worm) ctsf protein 0.0036 0.0128 0.0339
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0344 0.2031 0.3952
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0186 0.1056 0.1053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0029 0.0075
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.023 0.1326 0.1427
Brugia malayi tailless protein 0.0088 0.045 0.1286
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0028 0.0081 0.0078
Brugia malayi nuclear receptor NHR-88 0.0186 0.1056 0.303
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0231
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0246 0.1424 0.3761
Entamoeba histolytica cyclin family protein 0.0019 0.0026 0.0282
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.034
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0029 0.0199
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0834 0.5056 0.5614
Loa Loa (eye worm) hypothetical protein 0.0063 0.0297 0.0785
Schistosoma mansoni hypothetical protein 0.0024 0.0059 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0141 0.4761
Brugia malayi ecdysteroid receptor 0.0186 0.1056 0.303
Echinococcus granulosus netrin receptor unc 5 0.0019 0.0029 0.0025
Brugia malayi steroid hormone receptor 0.0186 0.1056 0.303
Echinococcus granulosus cyclin B3 1 0.0019 0.0026 0.0022
Trypanosoma cruzi cyclin, putative 0.0046 0.019 0.1415
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.023 0.1326 0.1323
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0035 0.0124 0.0121
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0028 0.0081 0.0078
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0186 0.1056 0.1053
Schistosoma mansoni bromodomain containing protein 0.0075 0.037 0.0367
Brugia malayi beta-lactamase 0.023 0.1326 0.3805
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0113 0.2379
Plasmodium falciparum importin beta, putative 0.0059 0.0272 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0043 0.0039
Schistosoma mansoni tyrosine kinase 0.0044 0.0178 0.0174
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Echinococcus multilocularis heat shock protein 90 0.0026 0.0071 0.0068
Echinococcus multilocularis lamin 0.0032 0.0105 0.0102
Onchocerca volvulus 0.0269 0.1567 0.4465
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Trypanosoma brucei P-type H+-ATPase, putative 0.0022 0.0046 0.0257
Trichomonas vaginalis cyclin A, putative 0.0046 0.019 0.109
Mycobacterium leprae conserved hypothetical protein 0.023 0.1326 0.2537
Loa Loa (eye worm) hypothetical protein 0.0098 0.0515 0.136
Echinococcus multilocularis cyclin B 0.0046 0.019 0.0186
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0128 0.0125
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0074 0.0365 0.0615
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0925 0.0921
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0014 0.0037
Mycobacterium tuberculosis Probable conserved lipoprotein 0.023 0.1326 0.1427
Loa Loa (eye worm) hypothetical protein 0.0186 0.1056 0.279
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0134 0.0727
Mycobacterium leprae Probable lipase LipE 0.023 0.1326 0.2537
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0113 0.0767
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.045 0.1234
Echinococcus granulosus twitchin 0.0016 0.0008 0.0005
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0038 0.0099
Brugia malayi RNA binding protein 0.0064 0.0304 0.0865
Schistosoma mansoni intermediate filament proteins 0.0032 0.0105 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0137
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Mycobacterium tuberculosis Conserved protein 0.023 0.1326 0.1427
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0147 0.0414
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0078 0.0391 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.0061 0.0287 0.0758
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0043 0.0039
Brugia malayi Cyclin, N-terminal domain containing protein 0.0019 0.0026 0.0067
Echinococcus multilocularis sodium and chloride dependent glycine 0.0036 0.0129 0.0125
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.0178 0.0174
Schistosoma mansoni hypothetical protein 0.0034 0.0117 0.0113
Echinococcus granulosus intermediate filament protein 0.0032 0.0105 0.0102
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.0664
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0124 0.0673 0.5062
Mycobacterium tuberculosis Probable lipase LipE 0.023 0.1326 0.1427
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.023 0.1326 0.1427
Echinococcus multilocularis heat shock protein 90 0.0033 0.0113 0.0109
Schistosoma mansoni smad1 5 8 and 0.0016 0.0009 0.0005
Leishmania major calcium-translocating P-type ATPase 0.0035 0.0124 0.0796
Chlamydia trachomatis protoporphyrinogen oxidase 0.0024 0.0058 0.2564
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0188 0.4449
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0071 0.0018
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.039 0.2929
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0147 0.0414
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.039 0.1115
Brugia malayi beta-lactamase family protein 0.023 0.1326 0.3805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Trypanosoma cruzi cyclin, putative 0.0046 0.019 0.1415
Brugia malayi Membrane calcium atpase protein 3 0.0028 0.0081 0.0225
Brugia malayi nuclear receptor RXR 0.0088 0.045 0.1286
Echinococcus multilocularis geminin 0.1635 1 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.053 0.318 0.3177
Trichomonas vaginalis cyclins, putative 0.0046 0.019 0.109
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0009 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0134 0.0727
Schistosoma mansoni cyclin B3 0.0019 0.0026 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0022 0.0231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0128 0.0689
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Schistosoma mansoni amine oxidase 0.0024 0.0058 0.0054
Echinococcus multilocularis netrin receptor unc 5 0.0019 0.0029 0.0025
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0147 0.0143
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0036 0.0129 0.0362
Echinococcus granulosus importin subunit beta 1 0.0059 0.0272 0.0268
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0147 0.0143
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Mycobacterium ulcerans dehydrogenase 0.0024 0.0058 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.053 0.318 0.8398
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0036 0.0129 0.0125
Loa Loa (eye worm) hypothetical protein 0.0049 0.0213 0.0563
Brugia malayi Fibroblast growth factor family protein 0.0061 0.0287 0.0817
Onchocerca volvulus 0.0036 0.0128 0.0304
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0147 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0036 0.0129 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0186 0.1056 0.1053
Brugia malayi Nuclear hormone receptor-like 1 0.0098 0.0515 0.1473
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Brugia malayi conserved hypotetical protein 0.0088 0.045 0.1286
Mycobacterium ulcerans esterase/lipase LipP 0.023 0.1326 0.2541
Brugia malayi heat shock protein 90 0.0033 0.0113 0.0317
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0925 0.2442
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0005 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0681 0.0678
Brugia malayi Ets-domain containing protein 0.0082 0.0416 0.1188
Schistosoma mansoni hypothetical protein 0.0135 0.0741 0.0737
Loa Loa (eye worm) hypothetical protein 0.023 0.1326 0.3502
Echinococcus granulosus sodium and chloride dependent glycine 0.0036 0.0129 0.0125
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.002 0.003 0.0079
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0186 0.1056 0.1053
Loa Loa (eye worm) hypothetical protein 0.023 0.1326 0.3502
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0147 0.1027
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.008
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0088 0.045 0.0447
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0035 0.0124 0.4098
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.0125 0.0121
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.039 0.2835
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0178 0.0174
Echinococcus granulosus cyclins 0.0019 0.0026 0.0022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0128 0.0125
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.039 0.1031
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0128 0.0304
Brugia malayi Cathepsin L-like precursor 0.0036 0.0128 0.0361
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0188 0.226
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0134 0.0992
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Brugia malayi MH1 domain containing protein 0.0016 0.0009 0.0018
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0035 0.0124 0.0796
Onchocerca volvulus 0.0036 0.0128 0.0304
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.053 0.318 0.3177
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0134 0.1598
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0043 0.0137
Loa Loa (eye worm) hypothetical protein 0.0036 0.0128 0.0339
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0022 0.0018
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0043 0.0039
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Onchocerca volvulus 0.0053 0.0235 0.0614
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.039 0.2879
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0188 0.108
Brugia malayi E1-E2 ATPase family protein 0.0022 0.0046 0.0124
Echinococcus granulosus tar DNA binding protein 0.0064 0.0304 0.03
Mycobacterium ulcerans monoamine oxidase 0.0024 0.0058 0.0006
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0022 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.023 0.1326 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0186 0.1056 0.1053
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Loa Loa (eye worm) hypothetical protein 0.0048 0.0206 0.0544
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0326 0.1919 0.1916
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.045 0.1234
Loa Loa (eye worm) fli-1 protein 0.025 0.1449 0.3826
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0035 0.0124 0.0854
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0033 0.0029
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0141 0.0397
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0035 0.0124 0.0918
Brugia malayi Galactoside-binding lectin family protein 0.0579 0.348 1
Schistosoma mansoni cell adhesion molecule 0.0017 0.0011 0.0007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0141 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0088 0.045 0.0447
Mycobacterium tuberculosis Probable lipase LipD 0.023 0.1326 0.1427
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0022 0.0143
Loa Loa (eye worm) hypothetical protein 0.023 0.1326 0.3502
Leishmania major cathepsin L-like protease 0.0036 0.0128 0.0827
Schistosoma mansoni alpha glucosidase 0.0037 0.0134 0.013
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0188 0.1404
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0129 0.034
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0028 0.0081 0.0078
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0147
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0046 0.0325
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0141 0.1043
Echinococcus multilocularis nervana 2 0.0326 0.1919 0.1916
Echinococcus multilocularis Ankyrin 0.0016 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.008
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0028 0.0081 0.0078
Brugia malayi hypothetical protein 0.0249 0.1447 0.4152
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.002 0.003 0.0332
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0085 0.0434 0.0759
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0043 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0022 0.0074
Trypanosoma brucei unspecified product 0.0027 0.0073 0.0464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0242 0.0238
Brugia malayi Cathepsin L-like precursor 0.0036 0.0128 0.0361
Loa Loa (eye worm) hypothetical protein 0.0061 0.0287 0.0758
Schistosoma mansoni heat shock protein 0.0033 0.0113 0.0109
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0124 0.0664
Schistosoma mansoni smad1 5 8 and 0.0016 0.0009 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0043 0.0039
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0188 0.0185
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.4212 0.421
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0071 0.0032
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0004 0.0001
Echinococcus granulosus nuclear receptor nhr 48 0.0088 0.045 0.0447
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0073 0.007
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0152 0.0148
Schistosoma mansoni heat shock protein 0.0033 0.0113 0.0109
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0004 0.0000042662
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0176 0.1309
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0278
Echinococcus multilocularis snurportin 1 0.0628 0.3786 0.3784
Mycobacterium tuberculosis Possible oxidoreductase 0.0024 0.0058 0.0003
Leishmania major DNA polymerase kappa, putative 0.0039 0.0147 0.097
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0113 0.0767
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0113 0.1339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0039 0.0152 0.0148
Loa Loa (eye worm) hypothetical protein 0.0249 0.1447 0.3821
Loa Loa (eye worm) E1-E2 ATPase 0.0022 0.0046 0.0121
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0024 0.0058 0.0054
Brugia malayi nuclear receptor NHR-67 0.0088 0.045 0.1286
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0134 0.0378
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0128 0.4256
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0024 0.0058 0.0054
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0036 0.0129 0.0125
Mycobacterium tuberculosis Conserved protein 0.023 0.1326 0.1427
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0745 0.5611
Trypanosoma brucei heat shock protein, putative 0.0033 0.0113 0.0767
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0044 0.0178 0.0174
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0188 0.0185
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0147 0.1027
Leishmania major heat shock protein 83-1 0.0033 0.0113 0.0709
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0186 0.1056 0.1053
Echinococcus multilocularis cyclins 0.0019 0.0026 0.0022
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0128 0.0339
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0043 0.0039
Trichomonas vaginalis cyclin B, putative 0.0019 0.0026 0.0027
Brugia malayi bZIP transcription factor family protein 0.009 0.0464 0.1325
Trichomonas vaginalis cyclins, putative 0.0046 0.019 0.109
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0147 0.0143
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0036 0.0129 0.0362
Onchocerca volvulus 0.0085 0.0434 0.1189
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0022 0.0143
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0473 0.1353
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.045 0.0447
Echinococcus multilocularis nervana 2 0.053 0.318 0.3177
Entamoeba histolytica cysteine protease, putative 0.0018 0.0022 0.0231
Leishmania major hypothetical protein, conserved 0.023 0.1326 1
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0188 0.1343
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0071 0.0026
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0128 0.0827
Onchocerca volvulus 0.0051 0.0222 0.0576
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.1188
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0024 0.0058 0.0279
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0188 0.1404
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0005 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0186 0.1056 0.279
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0043 0.0113
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.023 0.1326 0.3502
Onchocerca volvulus Tyrosine kinase homolog 0.0189 0.1076 0.3045
Onchocerca volvulus 0.0088 0.045 0.1234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0745 0.558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0128 0.0689
Brugia malayi PAS domain containing protein 0.0052 0.023 0.0654
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0113 0.0699
Echinococcus granulosus retinoic acid receptor rxr beta a 0.029 0.1697 0.1695
Entamoeba histolytica cyclin, putative 0.0019 0.0026 0.0282

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 100 uM Compound was tested for its cytotoxicity against HIV-1 infected MT-4 cell lines ChEMBL. No reference
CC50 (functional) = 100 uM Compound was tested for its cytotoxicity against HIV-1 infected MT-4 cell lines ChEMBL. No reference
CC50 (functional) = 150 uM Compound was tested for its cytotoxicity against against duck hepatitis B virus in duck fetal hepatocytes culture ChEMBL. No reference
IC50 (functional) = 2 uM Compound was tested for its antiviral activity against hepatitis B virus(DHBV) in duck fetal hepatocytes culture ChEMBL. No reference
IC50 (functional) = 10 uM Compound was tested to inhibit HIV-1 replication in MT-4 cell lines ; value may range from 1 - 10 ChEMBL. No reference
IC50 (functional) = 10 uM Compound was tested to inhibit HIV-1 replication in MT-4 cell lines ; value may range from 1 - 10 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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