Detailed information for compound 75315

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 518.284 | Formula: C24H26Br2N2O--
  • H donors: 1 H acceptors: 1 LogP: 6.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1cccc(c1)CC(c1ccccc1)N1CCN(CC1)c1ccccc1.[Br-].[Br-]
  • InChi: 1S/C24H26N2O.2BrH/c27-23-13-7-8-20(18-23)19-24(21-9-3-1-4-10-21)26-16-14-25(15-17-26)22-11-5-2-6-12-22;;/h1-13,18,24,27H,14-17,19H2;2*1H/p-2
  • InChiKey: QXARGNODKWLMGS-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2028 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0111 0.0651 0.1656
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0064 0.0315
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0005
Loa Loa (eye worm) AGC/PKN protein kinase 0.0111 0.0651 0.1656
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0651 0.1368
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.017 0.0655
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.008 0.0429 0.1092
Onchocerca volvulus 0.0057 0.0265 0.0833
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.0073 0.0184
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.051 0.0509
Echinococcus granulosus RNA directed DNA polymerase 0.0261 0.1741 0.1741
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0054 0.045
Echinococcus granulosus sodium channel protein 0.0148 0.0923 0.0923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0064 0.0357
Mycobacterium ulcerans esterase/lipase LipP 0.0187 0.1204 0.6119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Echinococcus granulosus protein kinase c epsilon type 0.0353 0.2402 0.2401
Brugia malayi Protein kinase domain containing protein 0.0111 0.0651 0.2515
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0078 0.0416 0.1059
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0064 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Loa Loa (eye worm) RNA binding protein 0.0255 0.1695 0.4313
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0073 0.0072
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.0073 0.0184
Onchocerca volvulus 0.0078 0.0416 0.1316
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Echinococcus multilocularis raf serine:threonine protein kinase 0.0078 0.0416 0.0416
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.0073 0.0072
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0073 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0215
Brugia malayi Cathepsin L-like precursor 0.0038 0.0128 0.0494
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Mycobacterium tuberculosis Probable esterase LipL 0.0187 0.1204 0.112
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0434 0.0911
Brugia malayi RNA binding protein 0.0255 0.1695 0.6551
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0077
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Schistosoma mansoni hypothetical protein 0.0031 0.0076 0.0158
Brugia malayi Cathepsin L-like precursor 0.0057 0.0265 0.1025
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.051 0.0509
Echinococcus granulosus geminin 0.0678 0.4755 0.4755
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0111 0.0651 0.0651
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.0073 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0651 0.1368
Mycobacterium ulcerans glutaminase 0.0268 0.1787 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0104 0.0511
Mycobacterium tuberculosis Probable lipase LipE 0.0187 0.1204 0.112
Onchocerca volvulus 0.0187 0.1204 0.3836
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Schistosoma mansoni hypothetical protein 0.0031 0.0076 0.0158
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Onchocerca volvulus 0.0031 0.0073 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Echinococcus multilocularis Diacylglycerol kinase theta 0.0078 0.0416 0.0416
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0057 0.0265 0.0265
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0057 0.0265 0.0265
Brugia malayi bZIP transcription factor family protein 0.0084 0.0456 0.1761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Loa Loa (eye worm) hypothetical protein 0.0187 0.1204 0.3062
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0456 0.0456
Loa Loa (eye worm) raf kinase 0.0078 0.0416 0.1059
Echinococcus multilocularis smad 0.0026 0.0037 0.0037
Echinococcus granulosus cathepsin L cysteine protease 0.003 0.0064 0.0064
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0078 0.0416 0.1059
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.1204 0.5933
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0227 0.0577
Loa Loa (eye worm) hypothetical protein 0.0187 0.1204 0.3062
Schistosoma mansoni hypothetical protein 0.0267 0.1779 0.3741
Loa Loa (eye worm) hypothetical protein 0.0086 0.0475 0.1208
Schistosoma mansoni nAChR subunit 0.0031 0.0073 0.0152
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.008 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Echinococcus granulosus GPCR family 2 0.0031 0.0076 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0012
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.0073 0.0072
Toxoplasma gondii diacylglycerol kinase, putative 0.0078 0.0416 0.346
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.0073 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.0123
Echinococcus granulosus Smad4 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0005 0.0019
Echinococcus multilocularis lamin 0.0082 0.0447 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0019
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0057 0.0265 1
Entamoeba histolytica protein kinase, putative 0.0111 0.0651 0.6698
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0073 0.0184
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0037 0.0093
Loa Loa (eye worm) hypothetical protein 0.004 0.0138 0.0351
Brugia malayi Cation transporter family protein 0.0101 0.0577 0.2231
Mycobacterium tuberculosis Conserved protein 0.0187 0.1204 0.112
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0073 0.0152
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0089 0.0497 0.0496
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1695 0.3564
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0169 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0073 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0012
Schistosoma mansoni diacylglycerol kinase theta 0.0078 0.0416 0.0875
Schistosoma mansoni importin beta-1 0.0028 0.0054 0.0113
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.017 0.0432
Schistosoma mansoni thyroid hormone receptor 0.0288 0.1934 0.4066
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0064 0.0657
Loa Loa (eye worm) hypothetical protein 0.0067 0.0337 0.0857
Loa Loa (eye worm) hypothetical protein 0.0453 0.3129 0.7962
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Brugia malayi beta-lactamase 0.0187 0.1204 0.465
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0073 0.0072
Mycobacterium ulcerans hypothetical protein 0.0187 0.1204 0.6119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0562 0.143
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0081 0.0434 0.1675
Entamoeba histolytica diacylglycerol kinase, putative 0.0078 0.0416 0.4283
Echinococcus multilocularis sodium channel protein 0.0148 0.0923 0.0923
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0283 0.1396
Echinococcus multilocularis jun protein 0.0084 0.0456 0.0456
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0353 0.2402 0.6111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0128 0.0715
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Schistosoma mansoni coup transcription factor 0.0021 0.0005 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0181 0.1159 0.1159
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0111 0.0651 0.0651
Brugia malayi RhoGAP domain containing protein 0.0078 0.0416 0.1608
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0019
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0104 0.0511
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0019
Brugia malayi Variant SH3 domain containing protein 0.0078 0.0416 0.1608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0169 0.0943
Schistosoma mansoni atypical protein kinase C 0.0189 0.1217 0.2559
Plasmodium vivax unspecified product 0.003 0.0064 0.053
Onchocerca volvulus 0.0057 0.0265 0.0833
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.0073 0.028
Loa Loa (eye worm) hypothetical protein 0.0532 0.3695 0.9403
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0881 0.4343
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0148 0.0923 0.4551
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0283 0.0283
Plasmodium vivax vivapain-1 0.003 0.0064 0.053
Loa Loa (eye worm) glutaminase 2 0.0268 0.1787 0.4547
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.008 0.0429 0.0429
Brugia malayi Ras association domain family 1 isoform A 0.0078 0.0416 0.1608
Schistosoma mansoni intermediate filament proteins 0.0082 0.0447 0.0939
Echinococcus granulosus unc 13 munc13 0.0089 0.0497 0.0496
Toxoplasma gondii ABC1 family protein 0.0187 0.1204 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Schistosoma mansoni protein kinase C 0.0089 0.0497 0.1044
Trichomonas vaginalis glutaminase, putative 0.0268 0.1787 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Echinococcus granulosus tar DNA binding protein 0.0255 0.1695 0.1695
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0224 0.1101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0158 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0104 0.0578
Plasmodium vivax importin-beta 2, putative 0.0028 0.0054 0.0447
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0227 0.0876
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0057 0.0265 0.1483
Echinococcus multilocularis GPCR, family 2 0.0031 0.0076 0.0075
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0447 0.1136
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0227 0.0876
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0187 0.1204 0.112
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0064 0.0315
Schistosoma mansoni hypothetical protein 0.0068 0.0343 0.072
Mycobacterium leprae conserved hypothetical protein 0.0187 0.1204 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0073 0.0072
Echinococcus multilocularis cathepsin L cysteine protease 0.0057 0.0265 0.0265
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Echinococcus granulosus serine:threonine protein kinase N2 0.0155 0.0972 0.0972
Loa Loa (eye worm) hypothetical protein 0.0081 0.0439 0.1117
Brugia malayi nuclear hormone receptor 0.0021 0.0005 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0073 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0169 0.0943
Echinococcus granulosus Rac GTPase activating protein 1 0.0078 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Echinococcus multilocularis protein kinase c iota type 0.0189 0.1217 0.1217
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.1204 0.253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0012
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0078 0.0416 0.1059
Loa Loa (eye worm) hypothetical protein 0.0089 0.0497 0.1263
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.1204 0.6734
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Brugia malayi Hr1 repeat family protein 0.0111 0.0651 0.2515
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0073 0.0072
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Echinococcus granulosus cathepsin l cysteine peptidase 0.0057 0.0265 0.0265
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0078 0.0416 0.0875
Brugia malayi Protein kinase domain containing protein 0.0111 0.0651 0.2515
Loa Loa (eye worm) hypothetical protein 0.034 0.2308 0.5871
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.0073 0.0072
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.0073 0.0072
Schistosoma mansoni unc-13 (munc13) 0.0089 0.0497 0.1044
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0001 0.0003
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0227 0.0577
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0016 0.0085
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0265 0.1025
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.1646 0.6361
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0057 0.0265 0.1483
Echinococcus granulosus beta LACTamase domain containing family member 0.0187 0.1204 0.1203
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0169 0.1733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0225
Onchocerca volvulus 0.0052 0.0227 0.071
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0111 0.0651 0.1656
Brugia malayi p70 ribosomal S6 kinase beta 0.0111 0.0651 0.2515
Onchocerca volvulus 0.0057 0.0265 0.0833
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.2028 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Schistosoma mansoni protein kinase C mu 0.0078 0.0416 0.0875
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.1204 0.6734
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.0073 0.028
Entamoeba histolytica cysteine proteinase 2 0.003 0.0064 0.0657
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.1204 0.6734
Entamoeba histolytica diacylglycerol kinase, putative 0.0078 0.0416 0.4283
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0283 0.0595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Echinococcus multilocularis Rac GTPase activating protein 1 0.0078 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0057 0.0265 0.0675
Echinococcus granulosus snurportin 1 0.0301 0.2026 0.2026
Mycobacterium tuberculosis Probable hydrolase 0.0187 0.1204 0.112
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.2026 0.5155
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0187 0.1204 0.6119
Echinococcus multilocularis lamin dm0 0.0082 0.0447 0.0447
Brugia malayi diacylglycerol kinase 0.0078 0.0416 0.1608
Echinococcus multilocularis tar DNA binding protein 0.0255 0.1695 0.1695
Brugia malayi nuclear receptor NHR-88 0.0021 0.0005 0.0019
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0054 0.0054
Onchocerca volvulus 0.0038 0.0128 0.0394
Schistosoma mansoni nAChR subunit 0.0031 0.0073 0.0152
Brugia malayi MH2 domain containing protein 0.0026 0.0037 0.0141
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0227 0.071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.0486
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0005
Brugia malayi protein kinase C3,putative 0.0081 0.0434 0.1675
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0227 0.071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0005 0.001
Toxoplasma gondii hypothetical protein 0.0049 0.0202 0.1675
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Schistosoma mansoni diacylglycerol kinase theta 0.0078 0.0416 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0128 0.0715
Loa Loa (eye worm) transcription factor SMAD2 0.0378 0.2588 0.6584
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0037 0.0077
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0073 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0005
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.0073 0.028
Loa Loa (eye worm) hypothetical protein 0.0082 0.0447 0.1136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0157 0.077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.1204 0.253
Brugia malayi beta-lactamase family protein 0.0187 0.1204 0.465
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0169 0.0354
Echinococcus granulosus N chimaerin 0.0078 0.0416 0.0416
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0005
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.051 0.0509
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0005 0.001
Plasmodium vivax vivapain-2 0.0057 0.0265 0.2203
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0169 0.083
Brugia malayi Cathepsin L-like precursor 0.0057 0.0265 0.1025
Onchocerca volvulus Putative nachr subunit 0.0031 0.0073 0.0216
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0227 0.0577
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0064 0.0657
Brugia malayi MH2 domain containing protein 0.0378 0.2588 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0111 0.0651 0.1656
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0073 0.028
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0005 0.0019
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0325
Schistosoma mansoni hypothetical protein 0.0031 0.0076 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.1204 0.6734
Brugia malayi Cation transporter family protein 0.0031 0.0073 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0104 0.0578
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.0073 0.0072
Onchocerca volvulus 0.0057 0.0265 0.0833
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0111 0.0651 0.0651
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0073 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0019
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Echinococcus granulosus importin subunit beta 1 0.0028 0.0054 0.0054
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0073 0.0072
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0997 0.0869
Onchocerca volvulus 0.0082 0.0447 0.1414
Onchocerca volvulus 0.0057 0.0265 0.0833
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0283 0.2355
Loa Loa (eye worm) MH2 domain-containing protein 0.0378 0.2588 0.6584
Entamoeba histolytica hypothetical protein 0.0043 0.0158 0.1628
Leishmania major cysteine peptidase A (CPA) 0.0057 0.0265 0.1307
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0076 0.0291
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0157 0.077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Brugia malayi TAR-binding protein 0.0255 0.1695 0.6551
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0169 0.083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0323
Brugia malayi Smad1 0.0026 0.0037 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.3189 0.6705
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0255 0.1695 0.4313
Echinococcus multilocularis peroxidasin 0.0052 0.0227 0.0227
Brugia malayi Cathepsin L-like precursor 0.0057 0.0265 0.1025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0325
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0037 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0005 0.001
Schistosoma mansoni lamin 0.0082 0.0447 0.0939
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0073 0.0072
Onchocerca volvulus 0.0057 0.0265 0.0833
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0261 0.1741 0.4431
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0073 0.0072
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0005 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Echinococcus granulosus protein kinase c eta type 0.0078 0.0416 0.0416
Loa Loa (eye worm) cysteine protease 0.0057 0.0265 0.0675
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0054 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.0486
Toxoplasma gondii AGC kinase 0.0111 0.0651 0.5409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.0486
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Trypanosoma cruzi cysteine protease, putative 0.003 0.0064 0.0315
Onchocerca volvulus 0.0078 0.0416 0.1316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.0121
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0037 0.0037
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0169 0.0168
Echinococcus multilocularis serine:threonine protein kinase N2 0.0263 0.1755 0.1755
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0005 0.0019
Leishmania major cathepsin L-like protease 0.0057 0.0265 0.1307
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.2028 1
Schistosoma mansoni hypothetical protein 0.0678 0.4755 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.0073 0.0184
Schistosoma mansoni smad 0.0026 0.0037 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0104 0.0578
Schistosoma mansoni nAChR subunit 0.0031 0.0073 0.0152
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0227 0.0876
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0434 0.0911
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0157 0.077
Schistosoma mansoni peroxidasin 0.0052 0.0227 0.0477
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0283 0.0283
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0128 0.0494
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Loa Loa (eye worm) beta-lactamase 0.0187 0.1204 0.3062
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2028 1
Onchocerca volvulus 0.0187 0.1204 0.3836
Echinococcus granulosus lamin 0.0082 0.0447 0.0447
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0275 0.1839 0.4679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Onchocerca volvulus Peroxidase homolog 0.0052 0.0227 0.071
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0169 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.0121
Echinococcus granulosus NDR protein kinase 0.0111 0.0651 0.0651
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0169 0.083
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Schistosoma mansoni protein kinase C mu 0.0081 0.0434 0.0911
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0181 0.1159 0.1159
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0019
Echinococcus granulosus cathepsin l1 0.0038 0.0128 0.0128
Echinococcus granulosus cathepsin L 0.003 0.0064 0.0064
Loa Loa (eye worm) AGC/NDR protein kinase 0.0111 0.0651 0.1656
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.0073 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0076 0.0291
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0081 0.0434 0.1103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0081 0.0434 0.1103
Echinococcus granulosus smad 0.0026 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0064 0.0356
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0057 0.0265 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Brugia malayi intermediate filament protein 0.0082 0.0447 0.1726
Echinococcus multilocularis cathepsin L 0.003 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0041 0.0225
Onchocerca volvulus Cathepsin L homolog 0.0057 0.0265 0.0833
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Echinococcus multilocularis musashi 0.0082 0.0447 0.0447
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0337 0.1301
Plasmodium falciparum importin beta, putative 0.0028 0.0054 0.203
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0881 0.4343
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0073 0.028
Echinococcus granulosus lamin dm0 0.0082 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0248 0.1646 0.4188
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0128 0.1316
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Mycobacterium ulcerans lipase LipD 0.0187 0.1204 0.6119
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.0073 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0064 0.0315
Onchocerca volvulus 0.0453 0.3129 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0019
Echinococcus granulosus serine:threonine protein kinase N2 0.0111 0.0651 0.0651
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.0073 0.0072
Echinococcus granulosus cathepsin l1 0.0057 0.0265 0.0265
Schistosoma mansoni glutaminase 0.0268 0.1787 0.3758
Schistosoma mansoni peroxidasin 0.0052 0.0227 0.0477
Plasmodium vivax vivapain-3 0.003 0.0064 0.053
Trypanosoma cruzi major cysteine proteinase, putative 0.0172 0.1093 0.539
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0022 0.0007 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0265 0.2728
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0227 0.0577
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0073 0.0152
Echinococcus granulosus protein kinase C gamma type 0.0383 0.2622 0.2622
Echinococcus granulosus Protein kinase C brain isozyme 0.0461 0.3189 0.3188
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0101 0.0577 0.1214
Loa Loa (eye worm) hypothetical protein 0.0101 0.0577 0.1469
Echinococcus multilocularis nAChR subunit 0.0031 0.0073 0.0072
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Loa Loa (eye worm) TAR-binding protein 0.0255 0.1695 0.4313
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Onchocerca volvulus 0.0082 0.0447 0.1414
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0169 0.0429
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0111 0.0651 0.0651
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.1204 0.6734
Mycobacterium ulcerans hypothetical protein 0.0159 0.0997 0.4748
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0104 0.0578
Brugia malayi Pleckstrin Homology Domain 0.0078 0.0416 0.1608
Giardia lamblia GTOR 0.0044 0.0169 0.3306
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0037 0.0093
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0265 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0104 0.0578
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.0486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Loa Loa (eye worm) hypothetical protein 0.0205 0.1336 0.3399
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0057 0.0265 0.0675
Echinococcus multilocularis cysteine protease 0.0057 0.0265 0.0265
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0128 0.0269
Echinococcus multilocularis thyroid hormone receptor alpha 0.0288 0.1934 0.1934
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0416 0.0875
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0283 0.0595
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0005 0.001
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.0265 0.2728
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.0073 0.028
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0077
Onchocerca volvulus 0.0187 0.1204 0.3836
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Schistosoma mansoni hypothetical protein 0.0043 0.0158 0.0333
Brugia malayi Cathepsin L-like precursor 0.0038 0.0128 0.0494
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0019
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Echinococcus multilocularis unc 13 (munc13) 0.0089 0.0497 0.0496
Onchocerca volvulus 0.0031 0.0073 0.0216
Schistosoma mansoni thyroid hormone receptor 0.0288 0.1934 0.4066
Schistosoma mansoni serine/threonine kinase 0.0111 0.0651 0.1368
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0064 0.0134
Onchocerca volvulus Cathepsin L homolog 0.0057 0.0265 0.0833
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Echinococcus multilocularis serine threonine protein kinase 0.0383 0.2622 0.2622
Onchocerca volvulus Cathepsin F homolog 0.0057 0.0265 0.0833
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0073 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0064 0.0315
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0267 0.1779 0.1779
Brugia malayi RNA recognition motif domain containing protein 0.0255 0.1695 0.6551
Loa Loa (eye worm) ctsf protein 0.0057 0.0265 0.0675
Onchocerca volvulus 0.0205 0.1336 0.426
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0101 0.0577 0.1214
Entamoeba histolytica hypothetical protein 0.0043 0.0158 0.1628
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1195 0.8496 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0085
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0227 0.071
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0169 0.083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0073 0.028
Leishmania major cathepsin L-like protease 0.0057 0.0265 0.1307
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0031 0.0073 0.0152
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0073 0.0072
Schistosoma mansoni vav2 0.0078 0.0416 0.0875
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0227 0.0577
Trypanosoma cruzi cysteine peptidase, putative 0.0219 0.1432 0.7059
Echinococcus multilocularis serine:threonine protein kinase N2 0.0111 0.0651 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0019
Echinococcus multilocularis protein kinase c epsilon type 0.0353 0.2402 0.2401
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0054 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.1204 0.5933
Brugia malayi MH1 domain containing protein 0.0026 0.0037 0.0141
Loa Loa (eye worm) hypothetical protein 0.0031 0.0076 0.0191
Echinococcus granulosus nAChR subunit 0.0031 0.0073 0.0072
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0078 0.0416 0.0875
Plasmodium falciparum cysteine proteinase falcipain 3 0.0057 0.0265 1
Onchocerca volvulus 0.0089 0.0497 0.1573
Brugia malayi MH1 domain containing protein 0.0026 0.0037 0.0141
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0057 0.0317
Brugia malayi Cathepsin L-like precursor 0.0057 0.0265 0.1025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0085
Schistosoma mansoni nAChR subunit 0.0031 0.0073 0.0152
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0265 0.0557
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.0486
Brugia malayi Cation transporter family protein 0.0031 0.0073 0.028
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0005 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0005 0.0005
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0111 0.0651 0.0651
Echinococcus multilocularis protein kinase c eta type 0.0078 0.0416 0.0416
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.0123
Onchocerca volvulus 0.0052 0.0227 0.071
Schistosoma mansoni rac gtpase activating protein 0.0078 0.0416 0.0875
Onchocerca volvulus 0.0101 0.0577 0.1832
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.0073 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.3189 0.6705
Toxoplasma gondii cathepsin CPL 0.0057 0.0265 0.2205
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0005 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0076 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1695 0.3564
Echinococcus multilocularis cysteine protease 0.0057 0.0265 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0064 0.0357
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0261 0.1741 0.1741
Loa Loa (eye worm) AGC/AKT protein kinase 0.0111 0.0651 0.1656
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0187 0.1204 0.112
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0087 0.0724
Echinococcus multilocularis N chimaerin 0.0078 0.0416 0.0416
Leishmania major cathepsin L-like protease 0.0219 0.1432 0.7059
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0104 0.0511
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Echinococcus granulosus myotubularin protein 13 0.0078 0.0416 0.0416
Brugia malayi Importin beta-1 subunit 0.0028 0.0054 0.0208
Brugia malayi Peroxidasin 0.0052 0.0227 0.0876
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0187 0.1204 1
Brugia malayi MH2 domain containing protein 0.0026 0.0037 0.0141
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0073 0.0072
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0091 0.051 0.1071
Echinococcus multilocularis beta LACTamase domain containing family member 0.0187 0.1204 0.1203
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.0073 0.0184
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0562 0.2172
Mycobacterium ulcerans beta-lactamase 0.0187 0.1204 0.6119
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.0073 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Onchocerca volvulus Peroxidase homolog 0.0052 0.0227 0.071
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0064 0.0657
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0227 0.071
Echinococcus multilocularis Smad4 0.0026 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0187 0.1204 0.3062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0005 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0064 0.0247
Echinococcus multilocularis geminin 0.0678 0.4755 0.4755
Leishmania major cathepsin L-like protease 0.0219 0.1432 0.7059
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0111 0.0651 0.2515
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0005 0.001
Echinococcus multilocularis RNA directed DNA polymerase 0.0261 0.1741 0.1741
Loa Loa (eye worm) hypothetical protein 0.0453 0.3129 0.7962
Leishmania major importin beta-1 subunit, putative 0.0023 0.0016 0.0075
Trypanosoma brucei rac serine-threonine kinase, putative 0.0111 0.0651 0.3209
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0016 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0137
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0461 0.3189 0.3188
Brugia malayi hypothetical protein 0.0052 0.0227 0.0876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0122 0.0682
Brugia malayi Protein kinase c protein 2 0.0353 0.2405 0.9295
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0111 0.0651 0.1656
Entamoeba histolytica hypothetical protein 0.0043 0.0158 0.1628
Brugia malayi ecdysteroid receptor 0.0021 0.0005 0.0019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0157 0.077
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0138 0.0138
Entamoeba histolytica protein kinase, putative 0.0111 0.0651 0.6698
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0138 0.0138
Onchocerca volvulus 0.0066 0.0326 0.1027
Schistosoma mansoni hypothetical protein 0.0678 0.4755 1
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0651 0.1368
Schistosoma mansoni hypothetical protein 0.0031 0.0076 0.0158
Leishmania major cathepsin L-like protease 0.0057 0.0265 0.1307
Echinococcus granulosus protein kinase c iota type 0.0189 0.1217 0.1217
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Brugia malayi RhoGEF domain containing protein 0.0078 0.0416 0.1608
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0073 0.028
Leishmania major cathepsin L-like protease 0.0057 0.0265 0.1307
Loa Loa (eye worm) Smad1 0.0026 0.0037 0.0093
Loa Loa (eye worm) hypothetical protein 0.0187 0.1204 0.3062
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0078 0.0416 0.0416
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1695 0.3564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0073 0.0184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Loa Loa (eye worm) hypothetical protein 0.0091 0.051 0.1296
Onchocerca volvulus 0.0052 0.0227 0.071
Echinococcus multilocularis cathepsin L cysteine protease 0.0057 0.0265 0.0265
Brugia malayi Cathepsin L-like precursor 0.0057 0.0265 0.1025
Leishmania major cathepsin L-like protease 0.0219 0.1432 0.7059
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Trichomonas vaginalis esterase, putative 0.0187 0.1204 0.6734
Brugia malayi Blistered cuticle protein 3 0.0052 0.0227 0.0876
Loa Loa (eye worm) hypothetical protein 0.0187 0.1204 0.3062
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0073 0.0072
Schistosoma mansoni hypothetical protein 0.0301 0.2026 0.426
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0169 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0651 0.1368
Loa Loa (eye worm) hypothetical protein 0.0187 0.1204 0.3062
Entamoeba histolytica cysteine protease, putative 0.003 0.0064 0.0657
Schistosoma mansoni nAChR subunit 0.0031 0.0073 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0019
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0111 0.0651 0.0651
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0158 0.0158
Entamoeba histolytica hypothetical protein 0.0043 0.0158 0.1628
Schistosoma mansoni serine/threonine protein kinase 0.0353 0.2402 0.505
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0081 0.0434 0.0433
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.0265 0.0557
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0089 0.0497 0.0496
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.008 0.0429 0.1658
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0073 0.028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0447 0.1136
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0019
Brugia malayi RhoGAP domain containing protein 0.0078 0.0416 0.1608
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0073 0.0072
Brugia malayi hypothetical protein 0.0066 0.0326 0.1259
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0447 0.1726
Echinococcus multilocularis tumor protein p63 0.1403 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.1204 0.5933
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0108 0.0634 0.3545
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.0265 0.1307
Mycobacterium tuberculosis Conserved protein 0.0187 0.1204 0.112
Echinococcus multilocularis myotubularin protein 13 0.0078 0.0416 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.0123
Echinococcus granulosus intermediate filament protein 0.0082 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0005 0.001
Entamoeba histolytica protein kinase, putative 0.0111 0.0651 0.6698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.0121
Brugia malayi diacylglycerol kinase 0.0078 0.0416 0.1608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0265 0.1483
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0064 0.0247
Schistosoma mansoni lamin 0.0082 0.0447 0.0939
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0078 0.0416 0.0416
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0064 0.0134
Leishmania major hypothetical protein, conserved 0.0187 0.1204 0.5933
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0187 0.1204 0.3062
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0064 0.0315
Echinococcus multilocularis snurportin 1 0.0301 0.2026 0.2026
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0227 0.0876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0169 0.0943
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.02 0.1294 0.6382
Brugia malayi Cathepsin L-like precursor 0.0057 0.0265 0.1025
Entamoeba histolytica hypothetical protein 0.0078 0.0416 0.4283
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0579 0.4812
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0169 0.1733
Mycobacterium leprae Probable lipase LipE 0.0187 0.1204 0.5
Loa Loa (eye worm) hypothetical protein 0.0453 0.3129 0.7962
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0073 0.0152
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.003 0.0064 0.0315
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0187 0.1204 0.112
Onchocerca volvulus 0.0057 0.0265 0.0833
Brugia malayi hypothetical protein 0.0043 0.0158 0.0611
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0267 0.1779 0.1779
Entamoeba histolytica PH domain containing protein kinase, putative 0.0155 0.0972 1
Entamoeba histolytica protein kinase, putative 0.0111 0.0651 0.6698
Echinococcus granulosus Diacylglycerol kinase theta 0.0078 0.0416 0.0416
Onchocerca volvulus 0.0101 0.0577 0.1832
Echinococcus granulosus cysteine protease 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0564 0.393 1
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0227 0.0876
Brugia malayi RNA, U transporter 1 0.008 0.043 0.166
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0019
Loa Loa (eye worm) LGC-31 protein 0.0031 0.0073 0.0184
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0651 0.3642
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0076 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0076 0.0191
Echinococcus granulosus cathepsin L cysteine proteinase 0.0057 0.0265 0.0265
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0073 0.028
Onchocerca volvulus 0.0101 0.0577 0.1832
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.0073 0.028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0881 0.4343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0219 0.1432 0.7059
Plasmodium falciparum cysteine proteinase falcipain 1 0.003 0.0064 0.2408
Entamoeba histolytica cysteine protease, putative 0.0057 0.0265 0.2728
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0081 0.0434 0.0433
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0005 0.001
Brugia malayi glutaminase DH11.1 0.0268 0.1787 0.6906
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0187 0.1204 0.112
Loa Loa (eye worm) hypothetical protein 0.0101 0.0577 0.1469
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0169 0.0651
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0073 0.028
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0091 0.051 1
Brugia malayi protein kinase C II. 0.0353 0.2402 0.9282
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0064 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0087 0.0486
Echinococcus granulosus peroxidasin 0.0052 0.0227 0.0227
Onchocerca volvulus 0.0031 0.0073 0.0216
Brugia malayi C1-like domain containing protein 0.0081 0.0434 0.1675
Plasmodium vivax vivapain-2 0.0057 0.0265 0.2203
Loa Loa (eye worm) hypothetical protein 0.0078 0.0416 0.1059
Schistosoma mansoni hypothetical protein 0.0067 0.0337 0.0708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Schistosoma mansoni nAChR subunit 0.0031 0.0073 0.0152
Mycobacterium tuberculosis Probable lipase LipD 0.0187 0.1204 0.112
Schistosoma mansoni nAChR subunit 0.0031 0.0073 0.0152
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0005 0.001
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.051 0.0509
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.0073 0.028
Echinococcus granulosus jun protein 0.0084 0.0456 0.0456
Loa Loa (eye worm) RasGEF domain-containing protein 0.0078 0.0416 0.1059
Schistosoma mansoni cellular tumor antigen P53 0.0205 0.1336 0.2809
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Loa Loa (eye worm) hypothetical protein 0.0052 0.0227 0.0577
Brugia malayi beta-lactamase family protein 0.0187 0.1204 0.465
Loa Loa (eye worm) hypothetical protein 0.0081 0.0436 0.1109
Loa Loa (eye worm) glutaminase 0.0268 0.1787 0.4547
Loa Loa (eye worm) fibroinase 0.0057 0.0265 0.0675
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1695 0.3564
Brugia malayi Protein kinase domain containing protein 0.0081 0.0434 0.1675
Trypanosoma cruzi cysteine peptidase, putative 0.0219 0.1432 0.7059
Brugia malayi steroid hormone receptor 0.0021 0.0005 0.0019
Schistosoma mansoni Smad4 0.0026 0.0037 0.0077
Echinococcus multilocularis serine:threonine protein kinase 38 0.0111 0.0651 0.0651
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0148 0.0923 0.0923
Trypanosoma cruzi cysteine peptidase, putative 0.0219 0.1432 0.7059
Schistosoma mansoni hypothetical protein 0.0078 0.0416 0.0875
Brugia malayi cathepsin L-like precursor 0.0038 0.0128 0.0494
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0187 0.1204 0.465
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0325
Leishmania major cathepsin L-like protease 0.0057 0.0265 0.1307
Schistosoma mansoni unc-13 (munc13) 0.0089 0.0497 0.1044
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0005 0.0019
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.0073 0.028
Schistosoma mansoni jun-related protein 0.0068 0.0343 0.072
Schistosoma mansoni tar DNA-binding protein 0.0255 0.1695 0.3564
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0323
Echinococcus granulosus raf serine:threonine protein kinase 0.0078 0.0416 0.0416
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0073 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0265 0.1483
Entamoeba histolytica cysteine proteinase 1, putative 0.003 0.0064 0.0657
Trypanosoma cruzi cruzipain precursor, putative 0.0219 0.1432 0.7059

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.649 mg kg-1 Analgesic activity measured in mice in the tail-flick test by subcutaneous administration. ChEMBL. 3656354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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