Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Histamine H2 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | IPR000276,Rhodopsin-like GPCR superfamily,domain-containing | Histamine H2 receptor | 359 aa | 291 aa | 20.6 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Histamine H2 receptor | 359 aa | 319 aa | 25.1 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Histamine H2 receptor | 359 aa | 348 aa | 32.5 % |
Echinococcus granulosus | orexin receptor type 2 | Histamine H2 receptor | 359 aa | 296 aa | 22.6 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Histamine H2 receptor | 359 aa | 318 aa | 24.8 % |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | Histamine H2 receptor | 359 aa | 325 aa | 24.0 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H2 receptor | 359 aa | 311 aa | 23.8 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H2 receptor | 359 aa | 296 aa | 27.4 % |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 325 aa | 24.3 % | |
Brugia malayi | hypothetical protein | Histamine H2 receptor | 359 aa | 292 aa | 20.9 % |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 330 aa | 32.1 % | |
Echinococcus granulosus | allatostatin A receptor | Histamine H2 receptor | 359 aa | 328 aa | 25.0 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Histamine H2 receptor | 359 aa | 301 aa | 28.6 % |
Echinococcus multilocularis | allatostatin A receptor | Histamine H2 receptor | 359 aa | 351 aa | 25.4 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Histamine H2 receptor | 359 aa | 305 aa | 24.3 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Histamine H2 receptor | 359 aa | 310 aa | 25.2 % |
Schistosoma mansoni | neuropeptide F-like receptor | Histamine H2 receptor | 359 aa | 302 aa | 21.5 % |
Schistosoma mansoni | adenoreceptor | Histamine H2 receptor | 359 aa | 309 aa | 27.2 % |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 296 aa | 22.3 % | |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 342 aa | 21.6 % | |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 289 aa | 26.0 % | |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 291 aa | 18.2 % | |
Onchocerca volvulus | Cyclin-dependent kinase 20 homolog | Histamine H2 receptor | 359 aa | 362 aa | 21.8 % |
Echinococcus multilocularis | orexin receptor type 2 | Histamine H2 receptor | 359 aa | 293 aa | 23.2 % |
Brugia malayi | GnHR receptor homolog | Histamine H2 receptor | 359 aa | 295 aa | 21.4 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Histamine H2 receptor | 359 aa | 353 aa | 32.9 % |
Loa Loa (eye worm) | neuropeptide F receptor | Histamine H2 receptor | 359 aa | 289 aa | 23.5 % |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 319 aa | 26.0 % | |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Histamine H2 receptor | 359 aa | 393 aa | 20.1 % |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Histamine H2 receptor | 359 aa | 370 aa | 20.3 % |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 303 aa | 23.4 % | |
Schistosoma japonicum | Rhodopsin, putative | Histamine H2 receptor | 359 aa | 319 aa | 20.1 % |
Onchocerca volvulus | Histamine H2 receptor | 359 aa | 311 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0091 | 0.0291 | 0.5 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0196 | 0.2797 | 0.4122 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0091 | 0.0291 | 0.0291 |
Brugia malayi | Hr1 repeat family protein | 0.0091 | 0.0291 | 0.0454 |
Brugia malayi | protein kinase C II. | 0.0301 | 0.5297 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0139 | 0.1432 | 0.2072 |
Schistosoma mansoni | atypical protein kinase C | 0.0156 | 0.1825 | 0.239 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0296 | 0.5174 | 0.7695 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0091 | 0.0291 | 0.0291 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2027 | 0.2706 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.0291 | 0.0454 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0091 | 0.0291 | 0.0291 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0091 | 0.0291 | 0.0358 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0228 | 0.3555 | 0.5261 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2027 | 0.2706 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0196 | 0.2797 | 0.4122 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0091 | 0.0291 | 0.0358 |
Echinococcus granulosus | geminin | 0.0164 | 0.2027 | 0.2967 |
Onchocerca volvulus | 0.0408 | 0.783 | 0.5 | |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0301 | 0.5297 | 0.5297 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.0291 | 0.0454 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0139 | 0.1432 | 1 |
Toxoplasma gondii | AGC kinase | 0.0091 | 0.0291 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0296 | 0.5174 | 0.7695 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0091 | 0.0291 | 0.0291 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0301 | 0.5297 | 0.7879 |
Echinococcus multilocularis | geminin | 0.0164 | 0.2027 | 0.2967 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0301 | 0.5297 | 0.7801 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0091 | 0.0291 | 0.0454 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0091 | 0.0291 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.783 | 0.783 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0091 | 0.0291 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.783 | 0.783 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0091 | 0.0291 | 0.0454 |
Echinococcus granulosus | NDR protein kinase | 0.0091 | 0.0291 | 0.0358 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.2797 | 0.2797 |
Echinococcus multilocularis | protein kinase c iota type | 0.0156 | 0.1825 | 0.2662 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.9364 | 0.9364 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0091 | 0.0291 | 0.0291 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0091 | 0.0291 | 0.0358 |
Schistosoma mansoni | amine GPCR | 0.0203 | 0.2952 | 0.4146 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.4331 | 0.4331 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0196 | 0.2797 | 0.4122 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0091 | 0.0291 | 0.0358 |
Brugia malayi | Protein kinase c protein 2 | 0.0271 | 0.4586 | 0.8643 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0091 | 0.0291 | 0.0358 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0091 | 0.0291 | 0.0358 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0091 | 0.0291 | 0.0358 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0091 | 0.0291 | 0.0358 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0301 | 0.5297 | 0.7879 |
Echinococcus granulosus | protein kinase c iota type | 0.0156 | 0.1825 | 0.2662 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0361 | 0.6708 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0361 | 0.6708 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0361 | 0.6708 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0361 | 0.6708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.783 | 0.783 |
Trichomonas vaginalis | AGC family protein kinase | 0.0091 | 0.0291 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0207 | 0.3052 | 0.3052 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0091 | 0.0291 | 0.0291 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.48 ug ml-1 | Histamine H2 receptor antagonistic activity | ChEMBL. | No reference |
IC50 (functional) | = 0.48 ug ml-1 | Histamine H2 receptor antagonistic activity | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Compound was tested for inhibitory activity against Helicobacter pylori No. 9470 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.