Detailed information for compound 75395

Basic information

Technical information
  • TDR Targets ID: 75395
  • Name: 11-Aminomethyl-20-(RS)-Camptothecin
  • MW: 377.393 | Formula: C21H19N3O4
  • H donors: 2 H acceptors: 4 LogP: -0.16 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(O)C(=O)OCc2c1cc1c3nc4cc(CN)ccc4cc3Cn1c2=O
  • InChi: 1S/C21H19N3O4/c1-2-21(27)15-7-17-18-13(6-12-4-3-11(8-22)5-16(12)23-18)9-24(17)19(25)14(15)10-28-20(21)26/h3-7,27H,2,8-10,22H2,1H3
  • InChiKey: VOIZNGXMCGYCRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NSC609955

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0036 0.0036 0.023
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.008 0.0506
Brugia malayi hypothetical protein 0.0159 0.0488 0.3083
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0055 0.0464
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0214 0.3432
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0086 0.1384
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0086 0.0944
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0162 0.1777
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0086 0.0545
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0162 0.3185
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0086 0.0545
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.3839
Echinococcus multilocularis Squalene phytoene synthase 0.0079 0.0192 0.3084
Brugia malayi Cytochrome P450 family protein 0.0048 0.008 0.0506
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0048 0.5
Schistosoma mansoni ATP-citrate synthase 0.0136 0.0403 0.4405
Loa Loa (eye worm) hypothetical protein 0.0079 0.0192 0.1214
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0086 0.1384
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0031 0.0018 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Mycobacterium ulcerans phytoene synthase, CrtB 0.0079 0.0192 0.016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0196 0.0624 1
Loa Loa (eye worm) glutaminase 0.0275 0.0914 0.5772
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.0018 0.0111
Schistosoma mansoni carbonic anhydrase 0.0031 0.0018 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0086 0.0545
Echinococcus multilocularis carbonic anhydrase II 0.0031 0.0018 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi glutaminase DH11.1 0.0275 0.0914 0.5772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0086 0.0545
Brugia malayi polk-prov protein 0.0031 0.0018 0.0116
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Echinococcus granulosus carbonic anhydrase II 0.0031 0.0018 0.0399
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0091 0.0239 0.3839
Schistosoma mansoni jun-related protein 0.0069 0.0156 0.1704
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0282
Trypanosoma brucei squalene synthase, putative 0.0252 0.083 1
Brugia malayi bZIP transcription factor family protein 0.0085 0.0214 0.135
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0091 0.0239 0.4875
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0061 0.0067
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0086 0.0944
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0086 0.0545
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0032 0.052
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0399
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0086 0.1384
Loa Loa (eye worm) acetyltransferase 0.0146 0.0439 0.2774
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0086 0.1958
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0055 0.0023
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2747 1 1
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0399
Brugia malayi nuclear hormone receptor 0.005 0.0086 0.0545
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0086 0.1958
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0032 0.0205
Brugia malayi ecdysteroid receptor 0.005 0.0086 0.0545
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.1584 1
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0086 0.0944
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0086 0.1384
Brugia malayi hypothetical protein 0.0066 0.0147 0.093
Echinococcus multilocularis jun protein 0.0085 0.0214 0.3432
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0078 0.085
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0036 0.0398
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.0018 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0086 0.0545
Schistosoma mansoni thyroid hormone receptor 0.0196 0.0624 0.6819
Loa Loa (eye worm) glutaminase 2 0.0275 0.0914 0.5772
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0091 0.0239 0.5432
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0086 0.1958
Toxoplasma gondii ATP-citrate lyase, putative 0.0155 0.0473 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0086 0.0545
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0086 0.0944
Plasmodium falciparum fructose-bisphosphate aldolase 0.0091 0.0239 1
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0086 0.0944
Echinococcus granulosus single minded 2 0.0035 0.0032 0.0736
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0031 0.0018 0.0111
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0029 0.018
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0091 0.0239 0.1511
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0086 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0018 0.0009
Schistosoma mansoni hypothetical protein 0.0146 0.0441 0.4819
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.0441 1
Trypanosoma cruzi squalene synthase, putative 0.0252 0.083 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0086 0.0545
Schistosoma mansoni hypothetical protein 0.0034 0.0029 0.0312
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.018
Echinococcus granulosus dna polymerase kappa 0.0041 0.0055 0.1254
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.5432
Brugia malayi steroid hormone receptor 0.005 0.0086 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi ATP-citrate synthase 0.0155 0.0473 0.2983
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0086 0.3367
Onchocerca volvulus 0.0066 0.0147 0.7182
Brugia malayi nuclear receptor NHR-88 0.005 0.0086 0.0545
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0398
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0546
Echinococcus granulosus jun protein 0.0085 0.0214 0.4856
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2747 1 1
Brugia malayi PAS domain containing protein 0.0047 0.0078 0.0491
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0086 0.1958
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0086 0.3367
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0086 0.0545
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0086 0.0545
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0399
Loa Loa (eye worm) ATP-citrate synthase 0.0155 0.0473 0.2983
Trichomonas vaginalis glutaminase, putative 0.0275 0.0914 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0048 0.1367
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0018 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0086 0.1958
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0048 1
Schistosoma mansoni coup transcription factor 0.005 0.0086 0.0944
Brugia malayi follicle stimulating hormone receptor 0.0457 0.1584 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0086 0.0944
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0162 0.1777
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0162 0.3688
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0424 0.9632
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0055 0.0464
Echinococcus granulosus Squalene phytoene synthase 0.0079 0.0192 0.4365
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0086 0.0545
Brugia malayi hypoxia-induced factor 1 0.0147 0.0443 0.2797
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.4875
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Trypanosoma cruzi phytoene synthase, putative 0.0079 0.0192 0.215
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0086 0.0545
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0091 0.0239 0.1511
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0031 0.0018 0.0111
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0079 0.0192 0.003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0061 0.1385
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0086 0.0545
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0086 0.0545
Leishmania major squalene synthase, putative 0.0252 0.083 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0086 0.1958
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0036 0.0827
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0091 0.0239 1
Schistosoma mansoni single-minded 0.0047 0.0078 0.085
Schistosoma mansoni hypothetical protein 0.0079 0.0192 0.2103
Trypanosoma brucei unspecified product 0.0035 0.0031 0.0163
Brugia malayi fructose-bisphosphate aldolase 2 0.0091 0.0239 0.1511
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.3839
Echinococcus granulosus FTZ F1 alpha 0.005 0.0086 0.1958
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0086 0.0546
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0079 0.0192 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0162 0.1783
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0439 0.4806
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0086 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0086 0.0545
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0091 0.0239 0.2618
Schistosoma mansoni hypothetical protein 0.0069 0.0156 0.1704
Leishmania major fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.2729
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0031 0.0018 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0086 0.0545
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0086 0.0546
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0086 0.1958
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0055 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0214 0.4856
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0086 0.1958
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0055 0.0886
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0443 0.2797
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0116
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0086 0.3367
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0031 0.0163
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0086 0.0944
Trypanosoma cruzi squalene synthase, putative 0.0252 0.083 1
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Loa Loa (eye worm) carbonic anhydrase 3 0.0031 0.0018 0.0111
Schistosoma mansoni glutaminase 0.0275 0.0914 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0086 0.1384
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0086 0.0545
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0086 0.1384
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0086 0.0545
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0086 0.1384
Schistosoma mansoni nuclear hormone receptor 0.005 0.0086 0.0944
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.5432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0086 0.0545
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0086 0.0546
Schistosoma mansoni hypothetical protein 0.0031 0.0018 0.0192
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0282
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi fructose-bisphosphate aldolase 1 0.0091 0.0239 0.1511
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0091 0.0239 0.2618
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0162 0.2606
Onchocerca volvulus 0.005 0.0086 0.3367
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0086 0.1384
Loa Loa (eye worm) hypothetical protein 0.0159 0.0488 0.3083
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Schistosoma mansoni thyroid hormone receptor 0.0196 0.0624 0.6819
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0086 0.0944
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.5432
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0061 0.0955
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0036 0.0584
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.4875
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0086 0.0545
Mycobacterium ulcerans glutaminase 0.0275 0.0914 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0086 0.0545
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.3839
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0439 0.2774
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.0441 0.7067
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0031 0.0018 0.0192
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0086 0.0545
Leishmania major hypothetical protein, conserved 0.0079 0.0192 0.215
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0061 0.0955
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.0082 0.0205 0.1297
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0439 0.7048

Activities

Activity type Activity value Assay description Source Reference
Active dose range (functional) 0 mg kg-1 Active dose range of the compound for antileukemic activity against L1210 mouse leukemia cells was reported ; ND means no data ChEMBL. 3656353
ED50 (functional) = 2 ug ml-1 In vitro cytotoxic activity against KB cell culture. ChEMBL. 3656353
No. of cures (functional) In vivo antileukemic activity against L-1210 mouse leukemia cells given as number of animals cured out of 6 ; ND means no data ChEMBL. 3656353
No. of cures (functional) 0 In vivo antileukemic activity against L-1210 mouse leukemia cells given as number of animals cured out of 6 ; ND means no data ChEMBL. 3656353
T/C (functional) % In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as % T/C (median survival time of treated/control animals) x 100 ; IA means inactive ChEMBL. 3656353
T/C (functional) % In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as KE (log10 of initial tumor cell population minus log10 of tumor cell population at end of treatment); ND means no data ChEMBL. 3656353
T/C (functional) 0 % In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as % T/C (median survival time of treated/control animals) x 100 ; IA means inactive ChEMBL. 3656353
T/C (functional) 0 % In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as KE (log10 of initial tumor cell population minus log10 of tumor cell population at end of treatment); ND means no data ChEMBL. 3656353
Toxic dose (ADMET) 0 mg kg-1 Toxic dose of the compound against L1210 mouse leukemia cells was determined; ND means no data ChEMBL. 3656353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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