Detailed information for compound 753958

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.208 | Formula: C16H16BrNO
  • H donors: 1 H acceptors: 1 LogP: 4.65 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C=Nc2cc(C)ccc2C)c(c(c1)Br)O
  • InChi: 1S/C16H16BrNO/c1-10-4-5-12(3)15(8-10)18-9-13-6-11(2)7-14(17)16(13)19/h4-9,19H,1-3H3/b18-9+
  • InChiKey: HFPPVAXCZXDBHC-GIJQJNRQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-glucosidase 0.0149 0.0976 0.0976
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0191 0.0174
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0314 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0314 0.1321
Schistosoma mansoni coup transcription factor 0.0045 0.0215 0.0215
Schistosoma mansoni lamin 0.0086 0.0514 0.0514
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0086 0.0513 0.0497
Brugia malayi CXXC zinc finger family protein 0.0098 0.06 0.0676
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0024 0.0007
Loa Loa (eye worm) hypothetical protein 0.0086 0.0513 0.0567
Echinococcus multilocularis snurportin 1 0.0307 0.212 0.2107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0215 0.0215
Schistosoma mansoni ap endonuclease 0.0058 0.0314 0.0314
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.0485
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0191 0.0174
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.228 0.228
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0681 0.295
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.0485
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0681 0.4114
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0215 0.0215
Echinococcus granulosus sodium bile acid cotransporter 0.1203 0.8635 0.8632
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0402 0.1709
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0224 0.0921
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.017 0.0681
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0694 0.494 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.0044 0.0044
Schistosoma mansoni nuclear receptor 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Mycobacterium tuberculosis Conserved protein 0.0109 0.0681 0.1348
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0224 0.0921
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.0804 0.35
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.0008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0314 0.3715
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0044 0.0119
Loa Loa (eye worm) hypothetical protein 0.0109 0.0681 0.0762
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0123 0.0106
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.0008
Brugia malayi Trypsin family protein 0.0086 0.0513 0.0575
Schistosoma mansoni hypothetical protein 0.0086 0.0513 0.0513
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0681 0.4114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0123 0.0123
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.0662 0.5264
Onchocerca volvulus 0.0109 0.0681 0.0762
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0062 0.0044
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0681 0.1348
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0357 0.1512
Toxoplasma gondii cathepsin CPL 0.0018 0.0024 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0152 0.0135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0215 0.0199
Onchocerca volvulus 0.0086 0.0514 0.0568
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0044 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0215 0.023
Schistosoma mansoni hypothetical protein 0.054 0.3818 0.3818
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0681 0.1348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Brugia malayi hypothetical protein 0.0036 0.0152 0.0157
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0215 0.0215
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.017 0.0178
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0099 0.0669
Schistosoma mansoni importin beta-1 0.0029 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0109 0.0681 0.0762
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0215 0.0222
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0215 0.0222
Brugia malayi isocitrate dehydrogenase 0.0032 0.0126 0.0127
Mycobacterium tuberculosis Probable reductase 0.0115 0.0726 0.1439
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0118 0.0101
Schistosoma mansoni hypothetical protein 0.139 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.0804 0.35
Plasmodium vivax vivapain-2 0.0018 0.0024 0.011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0726 0.1439
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0126 0.0804 0.0804
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.017 0.0153
Toxoplasma gondii thioredoxin reductase 0.005 0.0256 0.1952
Brugia malayi beta-lactamase family protein 0.0109 0.0681 0.077
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.0662 0.9726
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0126 0.0804 0.35
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0681 0.0762
Brugia malayi steroid hormone receptor 0.0045 0.0215 0.023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Leishmania major protein kinase, putative 0.0052 0.0269 0.112
Brugia malayi hypothetical protein 0.0154 0.1012 0.1155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0123 0.0123
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0044 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0215 0.023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0123 0.0123
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0215 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0314 0.3773
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0215 0.0199
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Plasmodium falciparum importin beta, putative 0.0029 0.0099 0.1271
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0269 0.3135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.017 0.0949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Schistosoma mansoni cpg binding protein 0.0098 0.06 0.06
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0099 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0215 0.0222
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0327 0.2266 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1152 0.1137
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0126 0.0804 0.0788
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0314 0.1842
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0051 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0024 0.0045
Brugia malayi tailless protein 0.0021 0.0044 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0109
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0314 0.0603
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0513 0.0513
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0215 0.0222
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0726 0.3258
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0044 0.0027
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0314 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0215 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0062 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0329 0.228 0.2267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0185 0.1236 0.1407
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0804 0.4881
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.017 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1015 0.4435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0215 0.023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.142 0.1621
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0314 0.2641
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0044 0.0044
Mycobacterium tuberculosis Conserved protein 0.0109 0.0681 0.1348
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0086 0.0513 0.0575
Brugia malayi nuclear hormone receptor 0.0021 0.0044 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0215 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0215 0.0199
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0256 0.3607
Leishmania major trypanothione reductase 0.005 0.0256 0.1064
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0075 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0329 0.228 0.2267
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0118 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0681 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0044 0.0022
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0109
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1015 0.4435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Onchocerca volvulus 0.0086 0.0514 0.0568
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0126 0.0126
Onchocerca volvulus 0.0154 0.1012 0.1147
Schistosoma mansoni hypothetical protein 0.054 0.3818 0.3818
Trichomonas vaginalis set domain proteins, putative 0.0239 0.163 1
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0126 0.089
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0024 0.0032
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0681 0.1348
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0123 0.0106
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.017 0.0169
Brugia malayi ecdysone receptor 0.0021 0.0044 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Brugia malayi nuclear receptor NHR-67 0.0021 0.0044 0.0031
Loa Loa (eye worm) hypothetical protein 0.0271 0.1858 0.213
Trypanosoma brucei trypanothione reductase 0.005 0.0256 0.1064
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0062 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0662 0.287
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.0237 0.022
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.0237 0.022
Trypanosoma brucei protein kinase, putative 0.0052 0.0269 0.112
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0681 0.1348
Brugia malayi hypothetical protein 0.0024 0.0062 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0681 0.295
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0292 0.1223
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0314 0.1321
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0726 0.1439
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0123 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0681 0.295
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0051 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0662 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0099 0.0365
Brugia malayi hypothetical protein 0.0021 0.0044 0.0031
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0246 0.0257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0681 0.1348
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0681 0.0681
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0126 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0215 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0215 0.0222
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0224 0.0232
Brugia malayi nuclear receptor NHR-88 0.0021 0.0044 0.0031
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0215 0.023
Brugia malayi hypothetical protein 0.0069 0.0389 0.0431
Brugia malayi nuclear receptor RXR 0.0021 0.0044 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0109
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0256 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0126 0.0804 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0086 0.0513 0.0497
Loa Loa (eye worm) hypothetical protein 0.0084 0.0502 0.0555
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0681 0.4114
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0126 0.1645
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0126 0.0804 0.35
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0681 0.0665
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0726 0.1439
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0126 0.0485
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0819 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0024 0.0024
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0044 0.0219
Onchocerca volvulus 0.0109 0.0681 0.0762
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.1799 0.2061
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0024 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0662 0.287
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0126 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.017 0.0949
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.018 0.018
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0662 1
Brugia malayi hypothetical protein 0.0024 0.0062 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0314 0.1321
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.017 0.0949
Echinococcus granulosus sodium bile acid cotransporter 0.1203 0.8635 0.8632
Brugia malayi Sodium Bile acid symporter family protein 0.1203 0.8635 1
Echinococcus granulosus lamin dm0 0.0086 0.0514 0.0498
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0314 0.1321
Echinococcus granulosus lysosomal alpha glucosidase 0.0174 0.1152 0.1137
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0681 0.0665
Schistosoma mansoni nuclear receptor 0.0021 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0086 0.0513 0.0567
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0075 0.0058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Onchocerca volvulus 0.0239 0.163 0.1864
Plasmodium vivax glutathione reductase, putative 0.005 0.0256 0.3607
Loa Loa (eye worm) hypothetical protein 0.0109 0.0681 0.0762
Loa Loa (eye worm) glutathione reductase 0.005 0.0256 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Brugia malayi Thioredoxin reductase 0.005 0.0256 0.0278
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0024 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0215 0.023
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0681 0.59
Echinococcus granulosus intermediate filament protein 0.0086 0.0514 0.0498
Echinococcus multilocularis GPCR, family 2 0.0086 0.0513 0.0497
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0044 0.0031
Schistosoma mansoni hypothetical protein 0.0086 0.0513 0.0513
Echinococcus granulosus sodium bile acid cotransporter 0.1203 0.8635 0.8632
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0224 0.0921
Onchocerca volvulus 0.01 0.062 0.0692
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0681 0.4114
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0681 0.4114
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.0662 0.287
Loa Loa (eye worm) CXXC zinc finger family protein 0.0098 0.06 0.0669
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0215 0.0199
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0314 0.0345
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0126 0.0127
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.0485
Echinococcus multilocularis ubiquitin specific protease 41 0.0126 0.0804 0.0788
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0215 0.0199
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0819 0.1629
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0269 0.3135
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.212 0.2434
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0215 0.023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0044
Brugia malayi beta-lactamase family protein 0.0109 0.0681 0.077
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0075 0.0058
Entamoeba histolytica Ran family GTPase 0.0021 0.0044 0.0251
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0126 0.0804 0.0788
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1637
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0044
Brugia malayi ecdysteroid receptor 0.0045 0.0215 0.023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1637
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0215 0.0215
Schistosoma mansoni ran 0.0021 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.1142 0.2284
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0513 0.0513
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0215 0.0199
Leishmania major importin beta-1 subunit, putative 0.0023 0.006 0.0189
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0314 0.0297
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0314 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0215 0.023
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0044 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.017 0.0949
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0314 0.4477
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0051 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0126 0.0804 0.4881
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0514 0.0568
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0329 0.228 0.2626
Schistosoma mansoni hypothetical protein 0.0048 0.0237 0.0237
Echinococcus granulosus cathepsin l1 0.0018 0.0024 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0271 0.1858 0.213
Schistosoma mansoni alpha-glucosidase 0.0149 0.0976 0.0976
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1637
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0024 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0681 0.1348
Loa Loa (eye worm) DR-78 0.0021 0.0044 0.0022
Echinococcus multilocularis cysteine protease 0.0018 0.0024 0.0007
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0174 0.1152 0.131
Onchocerca volvulus 0.1203 0.8635 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0126 0.0804 0.0804
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0044 0.0022
Onchocerca volvulus 0.0075 0.0433 0.0475
Echinococcus multilocularis sodium bile acid cotransporter 0.1203 0.8635 0.8632
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.1637
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.017 0.1249
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0402 0.1709
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0062 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0215 0.0222
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0726 0.1439
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0024 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Loa Loa (eye worm) hypothetical protein 0.0109 0.0681 0.0762
Loa Loa (eye worm) hypothetical protein 0.0041 0.0191 0.0194
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0115 0.0114
Brugia malayi nuclear receptor NHR-88 0.0045 0.0215 0.023
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0024 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0024 0.0113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0215 0.0199
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0044 0.0027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0726 0.1439
Brugia malayi beta-lactamase 0.0109 0.0681 0.077
Schistosoma mansoni ap endonuclease 0.0058 0.0314 0.0314
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0215 0.0199
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0256 0.1064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0051 0.021
Leishmania major cathepsin L-like protease 0.007 0.0402 0.1709
Loa Loa (eye worm) hypothetical protein 0.0154 0.1012 0.1147
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0044 0.0405
Trichomonas vaginalis importin beta-1, putative 0.0023 0.006 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Brugia malayi Pre-SET motif family protein 0.0032 0.0123 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Echinococcus granulosus geminin 0.054 0.3818 0.3808
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0215 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0329 0.228 0.2267
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0256 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.228 0.228
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0819 0.1629
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0215 0.023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0215 0.0199
Onchocerca volvulus 0.0032 0.0123 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Loa Loa (eye worm) hypothetical protein 0.0126 0.0804 0.0906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Brugia malayi hypothetical protein 0.0021 0.0044 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0215 0.0215
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0044 0.0119
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0032
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0044 0.0027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0215 0.0222
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0514 0.0576
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0024 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0051 0.021
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0681 0.59
Schistosoma mansoni sodium-bile acid cotransporter 0.0715 0.5089 0.5089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Echinococcus multilocularis lamin 0.0086 0.0514 0.0498
Plasmodium vivax SET domain protein, putative 0.0032 0.0123 0.1596
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0086 0.0514 0.0568
Echinococcus multilocularis sodium bile acid cotransporter 0.1203 0.8635 0.8632
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0099 0.0365
Trypanosoma brucei eukaryotic translation initiation factor 2-alpha kinase 1, putative 0.0052 0.0269 0.112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0051 0.021
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0044 0.0119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.017 0.0949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0087
Mycobacterium ulcerans hypothetical protein 0.0109 0.0681 0.59
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0215 0.0199
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.006 0.0189
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0215 0.0199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0215 0.023
Schistosoma mansoni ran 0.0021 0.0044 0.0044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0044 0.0027
Leishmania major GTP-binding protein, putative 0.0021 0.0044 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0215 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0271 0.1858 0.2137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0044
Entamoeba histolytica hypothetical protein 0.0023 0.006 0.0451
Trichomonas vaginalis ran, putative 0.0021 0.0044 0.0166
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0224 0.0921
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0024 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.006 0.0264
Echinococcus multilocularis sodium bile acid cotransporter 0.1203 0.8635 0.8632
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.2266 1
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0106 0.0662 0.0741
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0126 0.0804 0.0788
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0828 0.5912 0.5905
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0329 0.228 0.2267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.1015 0.4435
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0215 0.0215
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 0.0341
Brugia malayi latrophilin 2 splice variant baaae 0.0185 0.1236 0.1414
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0215 0.0199
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.017 0.0949
Echinococcus multilocularis cpg binding protein 0.0103 0.0641 0.0624
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0126 0.0804 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0329 0.228 0.262
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0044 0.0027
Brugia malayi Cytochrome P450 family protein 0.0049 0.0246 0.0266
Loa Loa (eye worm) hypothetical protein 0.1203 0.8635 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0051 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0044 0.0031
Schistosoma mansoni sodium-bile acid cotransporter related 0.0488 0.3436 0.3436
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.0008
Schistosoma mansoni hypothetical protein 0.0036 0.0152 0.0152
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0024 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Loa Loa (eye worm) beta-lactamase 0.0109 0.0681 0.0762
Schistosoma mansoni hypothetical protein 0.0086 0.0513 0.0513
Leishmania major hypothetical protein, conserved 0.0109 0.0681 0.295
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 0.0023
Brugia malayi intermediate filament protein 0.0086 0.0514 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Echinococcus granulosus cpg binding protein 0.0103 0.0641 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Schistosoma mansoni sodium-bile acid cotransporter related 0.1203 0.8635 0.8635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Brugia malayi Importin beta-1 subunit 0.0029 0.0099 0.0095
Plasmodium falciparum thioredoxin reductase 0.005 0.0256 0.3709
Brugia malayi RNA, U transporter 1 0.0082 0.0484 0.0542
Loa Loa (eye worm) hypothetical protein 0.0086 0.0513 0.0567
Leishmania major mitochondrial DNA polymerase beta 0.0327 0.2266 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Brugia malayi Pre-SET motif family protein 0.021 0.142 0.1628
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0126 0.0804 0.0913
Schistosoma mansoni alpha glucosidase 0.0039 0.017 0.017
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0044 0.0044
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.017 0.0949
Echinococcus granulosus eukaryotic translation initiation factor 2 alpha 0.0052 0.0269 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0051 0.021
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0044 0.0031
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0215 0.0215
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0681 0.1348
Echinococcus multilocularis lysosomal alpha glucosidase 0.0174 0.1152 0.1137
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.017 0.0681
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.017 0.0681
Brugia malayi hypothetical protein 0.0052 0.0269 0.0292
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0126 0.0109
Brugia malayi hypothetical protein 0.0106 0.0662 0.0749
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.228 0.228
Plasmodium vivax vivapain-2 0.0018 0.0024 0.011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0215 0.0215
Trypanosoma brucei glucosidase, putative 0.0039 0.017 0.0681
Onchocerca volvulus 0.0109 0.0681 0.0762
Loa Loa (eye worm) hypothetical protein 0.0109 0.0681 0.0762
Mycobacterium ulcerans lipase LipD 0.0109 0.0681 0.59
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0215 0.0222
Onchocerca volvulus 0.0098 0.06 0.0669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0086 0.0513 0.0497
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 0.0031
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0152 0.0152
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0215 0.0215
Leishmania major cathepsin L-like protease 0.007 0.0402 0.1709
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0044 0.0027
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.017 0.0949
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0314 0.4603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0024 0.0045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0514 0.0568
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0126 0.0804 0.0788
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0126 0.0222
Echinococcus granulosus lamin 0.0086 0.0514 0.0498
Onchocerca volvulus 0.0045 0.0215 0.0222
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0152 0.0135
Leishmania major hypothetical protein, conserved 0.0106 0.0662 0.287
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.017 0.0949
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0024 0.0045
Schistosoma mansoni hypothetical protein 0.0086 0.0513 0.0513
Leishmania major cathepsin L-like protease 0.007 0.0402 0.1709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0044 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0086 0.0513 0.0567
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0024 0.0008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0044 0.0027
Plasmodium vivax importin-beta 2, putative 0.0029 0.0099 0.1236
Echinococcus multilocularis eukaryotic translation initiation factor 2 alpha 0.0052 0.0269 0.0252
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0126 0.0109
Onchocerca volvulus 0.0086 0.0513 0.0567
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0075 0.0058
Loa Loa (eye worm) hypothetical protein 0.0109 0.0681 0.0762
Echinococcus multilocularis musashi 0.0086 0.0514 0.0498
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0185 0.1236 0.1236
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0327 0.2266 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0044 0.0022
Schistosoma mansoni cpg binding protein 0.0103 0.0641 0.0641
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0126 0.0804 0.4881
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0314 0.0297
Mycobacterium ulcerans hypothetical protein 0.0172 0.1142 1
Mycobacterium tuberculosis Conserved protein 0.0109 0.0681 0.1348
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0044 0.0031
Plasmodium falciparum glutathione reductase 0.005 0.0256 0.3709
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0044 0.0031
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0215 0.0215
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0215 0.0199
Brugia malayi Glycosyl hydrolases family 31 protein 0.0174 0.1152 0.1317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0186 0.1243 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0126 0.1691
Toxoplasma gondii exonuclease III APE 0.0058 0.0314 0.2423
Brugia malayi follicle stimulating hormone receptor 0.0263 0.1799 0.2068
Echinococcus granulosus ubiquitin specific protease 41 0.0126 0.0804 0.0788
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0215 0.0215
Echinococcus multilocularis geminin 0.054 0.3818 0.3808
Loa Loa (eye worm) PEK/HRI protein kinase 0.0052 0.0269 0.0284
Schistosoma mansoni hypothetical protein 0.0307 0.212 0.212
Brugia malayi nuclear hormone receptor 0.0045 0.0215 0.023
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Mycobacterium ulcerans beta-lactamase 0.0109 0.0681 0.59
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0215 0.023
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0099 0.0082
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0314 0.1842
Echinococcus granulosus GPCR family 2 0.0086 0.0513 0.0497
Echinococcus granulosus importin subunit beta 1 0.0029 0.0099 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0271 0.1858 0.2137
Loa Loa (eye worm) hypothetical protein 0.0045 0.0215 0.0222
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0086 0.0513 0.0497
Brugia malayi Latrophilin receptor protein 2 0.0086 0.0513 0.0575
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0044 0.0027
Schistosoma mansoni intermediate filament proteins 0.0086 0.0514 0.0514
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0681 0.077
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0819 0.1629
Onchocerca volvulus 0.0021 0.0044 0.0022
Brugia malayi nuclear receptor RXR 0.0024 0.0062 0.0052
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0126 0.089
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0024 0.0007
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0032
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0215 0.0199
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0256 0.0269
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0062 0.0045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.017 0.187
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0017 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.017 0.187
Brugia malayi conserved hypotetical protein 0.0021 0.0044 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0215 0.0199
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0044 0.0027
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0044 0.0031
Echinococcus granulosus snurportin 1 0.0307 0.212 0.2107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0215 0.0222
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0044
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0044 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0402 0.1709
Echinococcus multilocularis lamin dm0 0.0086 0.0514 0.0498
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0062 0.0045
Trichomonas vaginalis helicase, putative 0.0022 0.0051 0.021
Loa Loa (eye worm) hypothetical protein 0.004 0.018 0.018
Schistosoma mansoni zinc finger protein 0.0021 0.0044 0.0044
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0224 0.024
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.0008
Toxoplasma gondii ABC1 family protein 0.0109 0.0681 0.5412
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0215 0.023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0215 0.0199
Onchocerca volvulus 0.0021 0.0044 0.0022
Trichomonas vaginalis esterase, putative 0.0109 0.0681 0.4114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0402 0.1709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0215 0.0222
Toxoplasma gondii hypothetical protein 0.0053 0.0273 0.209
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0051 0.021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0044 0.0416
Echinococcus multilocularis cysteine protease 0.0018 0.0024 0.0007
Brugia malayi Cathepsin L-like precursor 0.0018 0.0024 0.0008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.006 0.0264
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0123 0.0863
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0256 0.024
Leishmania major cathepsin L-like protease 0.0018 0.0024 0.0032
Echinococcus multilocularis dnaJ subfamily B 0.139 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0062 0.0052
Schistosoma mansoni lamin 0.0086 0.0514 0.0514
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0118 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0123 0.0123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0215 0.0199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0208 0.1404 0.1404
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0402 0.1709
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0044 0.0027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0297 0.1246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0024 0.0045
Schistosoma mansoni cpg binding protein 0.0103 0.0641 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0215 0.023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0022
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0109
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0044
Brugia malayi glutathione reductase 0.005 0.0256 0.0278
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0044 0.0027

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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