Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1606 | 0.2801 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0851 | 0.1173 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0996 | 0.1406 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0464 | 0.5733 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.051 | 0.6329 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0288 | 0.0266 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0137 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0464 | 0.5733 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0288 | 0.0167 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0288 | 0.0167 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0464 | 0.5733 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0464 | 0.5733 | 0.568 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0288 | 0.0266 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0034 | 0.0123 | 0.0215 |
Toxoplasma gondii | NAC domain-containing protein | 0.0034 | 0.0123 | 0.0211 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0137 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0236 | 0.2761 | 0.4816 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1652 | 0.2881 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0288 | 0.0503 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0487 | 0.0849 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0473 | 0.5842 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0473 | 0.5842 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0473 | 0.5842 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0473 | 0.5842 | 1 |
Echinococcus granulosus | geminin | 0.051 | 0.6329 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0464 | 0.5733 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.0996 | 0.1737 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0288 | 0.0266 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0487 | 0.0586 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0288 | 0.0167 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0473 | 0.5842 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0851 | 0.1173 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0288 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0137 | 0.024 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.0123 | 0.0215 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0137 | 0.0023 |
Brugia malayi | beta-NAC-like protein | 0.0034 | 0.0123 | 0.0215 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0149 | 0.1627 | 0.2837 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0034 | 0.0123 | 0.0211 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0487 | 0.0586 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0851 | 0.1173 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0161 | 0.1779 | 0.5 |
Loa Loa (eye worm) | ICD-1 protein | 0.0034 | 0.0123 | 0.0215 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0464 | 0.5733 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0288 | 0.0503 |
Brugia malayi | MH2 domain containing protein | 0.0236 | 0.2761 | 0.4816 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0288 | 0.0266 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0137 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0851 | 0.1173 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0288 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0137 | 0.0023 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0464 | 0.5733 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.1606 | 0.2801 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0487 | 0.0849 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0487 | 0.0368 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0487 | 0.0586 |
Onchocerca volvulus | 0.0151 | 0.1652 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0487 | 0.0586 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0303 | 0.3633 | 0.6219 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0464 | 0.5733 | 0.904 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.1606 | 0.2801 |
Brugia malayi | hypothetical protein | 0.0151 | 0.1652 | 0.2881 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0034 | 0.0123 | 0.0211 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0487 | 0.0849 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.0851 | 0.1485 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0288 | 0.0266 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0487 | 0.0849 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.0851 | 0.1485 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0487 | 0.0849 |
Echinococcus multilocularis | geminin | 0.051 | 0.6329 | 0.6284 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0487 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0996 | 0.1737 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0851 | 0.1173 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0487 | 0.0586 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0473 | 0.5842 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0288 | 0.0503 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0137 | 0.0014 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0487 | 0.0849 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0851 | 0.0737 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.1606 | 0.2801 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0034 | 0.0123 | 0.0215 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0851 | 0.0737 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0154 | 0.1685 | 0.2938 |
Leishmania major | basic transcription factor 3a, putative | 0.0034 | 0.0123 | 0.0215 |
Schistosoma mansoni | hypothetical protein | 0.051 | 0.6329 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0473 | 0.5842 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0137 | 0.0023 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0236 | 0.2761 | 0.4816 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0464 | 0.5733 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0464 | 0.5733 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0464 | 0.5733 | 0.904 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0288 | 0.0503 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0137 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.