Detailed information for compound 754128

Basic information

Technical information
  • TDR Targets ID: 754128
  • Name: (3aR,4S,9bS)-N-(4-ethoxyphenyl)-4-(4-nitrophe nyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]qui noline-8-sulfonamide
  • MW: 491.559 | Formula: C26H25N3O5S
  • H donors: 2 H acceptors: 4 LogP: 5.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NS(=O)(=O)c1ccc2c(c1)[C@H]1C=CC[C@H]1[C@@H](N2)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C26H25N3O5S/c1-2-34-20-12-8-18(9-13-20)28-35(32,33)21-14-15-25-24(16-21)22-4-3-5-23(22)26(27-25)17-6-10-19(11-7-17)29(30)31/h3-4,6-16,22-23,26-28H,2,5H2,1H3/t22-,23+,26+/m0/s1
  • InChiKey: HRNHLSMYFXVRRX-PPJWLVRDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • UNM000000675801
  • UNM000011067701

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.1367 0.1361
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0219 0.057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.3344 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0065 0.0053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0072 0.1802 0.1792
Onchocerca volvulus Huntingtin homolog 0.0121 0.3419 0.6159
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.034 0.1833
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0796 0.4382
Echinococcus granulosus neutral alpha glucosidase AB 0.0072 0.1802 0.1797
Loa Loa (eye worm) hypothetical protein 0.0068 0.1673 0.1663
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0528 0.2059
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0219 0.0623
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0528 0.1502
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1043 0.1035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.1802 0.1792
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0209 0.0539
Schistosoma mansoni hypothetical protein 0.0035 0.0606 0.0647
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0219 0.057
Trypanosoma brucei trypanothione reductase 0.0094 0.2519 1
Plasmodium falciparum thioredoxin reductase 0.0032 0.0528 0.2059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Loa Loa (eye worm) hypothetical protein 0.0149 0.434 0.4333
Schistosoma mansoni ap endonuclease 0.0018 0.0065 0.0058
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.2772 0.3008
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0209 0.0592
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0219 0.0305
Trichomonas vaginalis sucrase-isomaltase, putative 0.0072 0.1802 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.1802 0.1792
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0209 0.3588
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.3344 0.3631
Plasmodium falciparum thioredoxin reductase 0.0094 0.2519 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.034 0.1833
Echinococcus multilocularis lysosomal alpha glucosidase 0.0322 0.9969 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0268 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1802 0.7139
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1802 1
Onchocerca volvulus 0.0023 0.0219 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0703 0.386
Loa Loa (eye worm) glutathione reductase 0.0094 0.2519 0.251
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0528 0.155
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0528 0.155
Loa Loa (eye worm) hypothetical protein 0.008 0.2091 0.2082
Schistosoma mansoni alpha-glucosidase 0.0277 0.8507 0.9259
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0606 0.0596
Entamoeba histolytica hypothetical protein 0.0023 0.0209 0.0197
Schistosoma mansoni hypothetical protein 0.0168 0.4931 0.5361
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.2772 0.2772
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.034 0.1309
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0209 0.029
Leishmania major cathepsin L-like protease 0.0063 0.1527 0.4549
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.3344 0.3346
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0528 0.0734
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1043 0.1032
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0268 0.102
Loa Loa (eye worm) hypothetical protein 0.0229 0.6921 0.6918
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.1673 0.181
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0528 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1367 0.1357
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0528 1
Entamoeba histolytica hypothetical protein 0.0035 0.0606 0.0595
Schistosoma mansoni alpha glucosidase 0.0072 0.1802 0.1951
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0219 0.0208
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0209 0.0592
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.2772 0.2772
Mycobacterium tuberculosis Probable reductase 0.0213 0.6422 0.8923
Brugia malayi Glycosyl hydrolases family 31 protein 0.0322 0.9969 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0528 0.2059
Toxoplasma gondii melibiase subfamily protein 0.0101 0.2772 0.8284
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0992 0.0984
Entamoeba histolytica hypothetical protein 0.0035 0.0606 0.0595
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0065 0.0053
Echinococcus granulosus chromobox protein 1 0.0067 0.1667 0.1662
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.2059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0065 0.0212
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.1367 0.1361
Schistosoma mansoni jumonji domain containing protein 0.0058 0.1367 0.1477
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0065 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0219 0.057
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0248 0.0237
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0219 0.0623
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0323 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1527 0.6046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.2059
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.6422 0.8923
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0219 0.057
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1527 0.6046
Brugia malayi Heterochromatin protein 1 0.0067 0.1667 0.1662
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1367 0.1477
Onchocerca volvulus 0.0149 0.434 0.7825
Toxoplasma gondii exonuclease III APE 0.0018 0.0065 0.0159
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0528 0.1888
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.6422 0.889
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0268 0.0767
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.034 0.1833
Onchocerca volvulus 0.0018 0.006 0.0086
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.1667 0.1657
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0219 0.0623
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0546 0.0536
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.1367 0.1477
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0065 0.0053
Toxoplasma gondii thioredoxin reductase 0.0094 0.2519 0.7524
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.2091 0.2089
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.034 0.1833
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0209 0.0787
Plasmodium falciparum glutathione reductase 0.0032 0.0528 0.2059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0219 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.2059
Echinococcus multilocularis geminin 0.0168 0.4931 0.494
Leishmania major cathepsin L-like protease 0.0063 0.1527 0.4549
Loa Loa (eye worm) hypothetical protein 0.0121 0.3419 0.3411
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0528 0.0519
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.2059
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0528 0.1502
Entamoeba histolytica hypothetical protein 0.0035 0.0606 0.0595
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0065 0.0212
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0528 0.1502
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1802 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.2519 0.2518
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0528 0.2059
Loa Loa (eye worm) hypothetical protein 0.0033 0.0546 0.0535
Echinococcus granulosus lysosomal alpha glucosidase 0.0322 0.9969 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0528 0.2885
Loa Loa (eye worm) hypothetical protein 0.0121 0.3419 0.3411
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1527 0.6046
Onchocerca volvulus Huntingtin homolog 0.0121 0.3419 0.6159
Echinococcus multilocularis chromobox protein 1 0.0067 0.1667 0.1662
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.034 0.1309
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0268 0.102
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1802 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0219 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0209 0.0539
Brugia malayi glutathione reductase 0.0094 0.2519 0.2518
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0219 0.0015
Echinococcus multilocularis neutral alpha glucosidase AB 0.0072 0.1802 0.1797
Leishmania major alpha glucosidase II subunit, putative 0.0072 0.1802 0.5372
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0019
Schistosoma mansoni hypothetical protein 0.0168 0.4931 0.5361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1527 0.6046
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0072 0.1802 0.5372
Echinococcus granulosus chromobox protein 1 0.0067 0.1667 0.1662
Trypanosoma brucei glucosidase, putative 0.0072 0.1802 0.7077
Schistosoma mansoni ap endonuclease 0.0018 0.0065 0.0058
Brugia malayi hypothetical protein 0.0035 0.0606 0.0596
Onchocerca volvulus 0.0047 0.0992 0.1772
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0219 0.057
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0703 0.1249
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.6422 0.8923
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0343 0.1853
Entamoeba histolytica hypothetical protein 0.0035 0.0606 0.0595
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.2091 0.2089
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.155
Echinococcus granulosus geminin 0.0168 0.4931 0.494
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.7197 1
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.6921 0.6939
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0528 0.1888
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.034 0.1833
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0322 0.9969 0.9969
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.2091 0.2089
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0528 0.1888
Brugia malayi jmjC domain containing protein 0.0058 0.1367 0.1361
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.2772 0.3008
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0528 0.155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0065 0.0159
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.1802 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.2772 0.3008
Brugia malayi Thioredoxin reductase 0.0094 0.2519 0.2518
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0528 0.2885
Leishmania major cathepsin L-like protease 0.0063 0.1527 0.4549
Loa Loa (eye worm) hypothetical protein 0.003 0.0437 0.0426
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1667 0.9248
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.1349 0.5334
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.1673 0.928
Loa Loa (eye worm) hypothetical protein 0.0027 0.034 0.0329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Mycobacterium ulcerans hypothetical protein 0.0023 0.0219 0.057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0219 0.0208
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1802 0.7139
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1802 1
Schistosoma mansoni alpha-glucosidase 0.0277 0.8507 0.9259
Loa Loa (eye worm) hypothetical protein 0.0038 0.0703 0.0692
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0796 0.4382
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0528 0.155
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.2059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0065 0.0212
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1043 0.1035
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0528 0.2059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0219 0.0208
Brugia malayi Melibiase family protein 0.0068 0.1673 0.1668
Onchocerca volvulus 0.008 0.2091 0.376
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.034 0.1833
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.2519 0.2518
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.3344 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0219 0.057
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.034 0.1833
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0219 0.0015
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0209 0.3112
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.7197 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.3344 0.3346
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.6422 0.8923
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0065 0.0212
Schistosoma mansoni chromobox protein 0.0067 0.1667 0.1804
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.7197 1
Treponema pallidum NADH oxidase 0.0032 0.0528 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.1367 0.1361
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.3344 1
Leishmania major trypanothione reductase 0.0094 0.2519 0.7524
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0065 0.0053
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0065 0.0053
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0268 0.102
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.6422 0.8923
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0796 0.1418
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0219 0.0208
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0219 0.057
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.034 0.0593
Onchocerca volvulus 0.003 0.0437 0.0768
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.003 0.0074
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.3344 0.4646
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.2519 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0528 0.1888
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.1088 0.4291
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0528 0.0519
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0268 0.0826
Brugia malayi hypothetical protein 0.0229 0.6921 0.6939
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.003 0.0074
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.1802 1
Leishmania major glycosyl hydrolase-like protein 0.0027 0.034 0.0985
Plasmodium vivax glutathione reductase, putative 0.0094 0.2519 1
Loa Loa (eye worm) hypothetical protein 0.0323 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0528 0.2059
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.1802 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.2772 0.3008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.034 0.1833
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Echinococcus multilocularis chromobox protein 1 0.0067 0.1667 0.1662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.003 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0343 0.1853
Brugia malayi hypothetical protein 0.0121 0.3419 0.3422
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.034 0.0329
Brugia malayi chromobox protein homolog 3 0.0038 0.0703 0.0694
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0528 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.3344 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0209 0.0592
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0268 0.102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.2059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Schistosoma mansoni survival motor neuron protein 0.0047 0.0992 0.1068
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.1367 0.1361
Brugia malayi jmjC domain containing protein 0.0058 0.1367 0.1361
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0248 0.0237
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0528 0.0563
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.2519 0.35
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.2091 0.2266
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.1802 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.1673 0.181
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0268 0.102
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0065 0.0104
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0065 0.0296
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.3344 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0209 0.3112
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.6921 0.6939
Schistosoma mansoni hypothetical protein 0.0033 0.0546 0.0582
Loa Loa (eye worm) hypothetical protein 0.0023 0.0219 0.0208
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1667 0.9248
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.2519 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0703 0.386
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0065 0.0296
Brugia malayi hypothetical protein 0.0024 0.0268 0.0257
Plasmodium falciparum glutathione reductase 0.0094 0.2519 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0322 0.9969 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.6422 0.8923
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.3344 0.3631
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0528 0.2059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.7197 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0606 0.0596
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0528 0.0519
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0019
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.034 0.1121
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0219 0.0208
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.2519 0.251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1527 0.596
Loa Loa (eye worm) hypothetical protein 0.0048 0.1043 0.1032
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0209 0.0588
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0606 0.0647
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0219 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0219 0.0208
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0528 0.155
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0528 0.2059
Brugia malayi hypothetical protein 0.0149 0.434 0.4347
Onchocerca volvulus 0.0186 0.5543 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0528 1
Leishmania major hypothetical protein, conserved 0.0024 0.0268 0.0767
Schistosoma mansoni chromobox protein 0.0067 0.1667 0.1804
Schistosoma mansoni hypothetical protein 0.0047 0.0992 0.1068
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0019
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.1802 0.1797
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0209 0.0787
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.034 0.033
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.2772 0.2772

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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