Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0066 | 0.0468 | 0.1182 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0823 | 0.2077 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0164 | 0.1514 | 0.1514 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0031 | 0.0095 | 0.0095 |
Schistosoma mansoni | hypothetical protein | 0.0392 | 0.3961 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0059 | 0.0389 | 0.0883 |
Loa Loa (eye worm) | fli-1 protein | 0.022 | 0.2115 | 0.4304 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0389 | 0.0982 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0243 | 0.5 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0077 | 0.058 | 0.1219 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0059 | 0.0389 | 0.4646 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0045 | 0.0243 | 0.1725 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.0535 | 0.1216 |
Echinococcus multilocularis | hypothetical protein | 0.0101 | 0.0837 | 1 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0066 | 0.0468 | 0.0984 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0348 | 0.3486 | 1 |
Brugia malayi | Melibiase family protein | 0.0066 | 0.0468 | 0.1064 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0134 | 0.1199 | 0.1199 |
Schistosoma mansoni | gabp alpha | 0.0072 | 0.0535 | 0.1351 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0227 | 0.2189 | 0.4488 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.041 | 0.4152 | 0.9379 |
Schistosoma mansoni | DNA polymerase gamma | 0.0101 | 0.0837 | 0.2112 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0134 | 0.1199 | 0.1199 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0072 | 0.0535 | 0.6393 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0024 | 0.002 | 0.002 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0823 | 0.2077 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0056 | 0.0356 | 0.4256 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0072 | 0.0535 | 0.0364 |
Toxoplasma gondii | melibiase subfamily protein | 0.0099 | 0.0823 | 0.5833 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0059 | 0.0389 | 0.2756 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0955 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0066 | 0.0468 | 0.1182 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0101 | 0.0837 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0823 | 0.2077 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.0535 | 0.1216 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0243 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0503 | 0.5153 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0059 | 0.0389 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0422 | 0.0084 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0099 | 0.0823 | 0.9833 |
Brugia malayi | hypothetical protein | 0.0122 | 0.1072 | 0.2436 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0031 | 0.0095 | 0.0095 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0099 | 0.0823 | 0.9833 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0031 | 0.0095 | 0.0095 |
Toxoplasma gondii | hypothetical protein | 0.0154 | 0.141 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0955 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0452 | 0.4606 | 0.4606 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0296 | 0.0747 |
Brugia malayi | Fli-1 protein | 0.022 | 0.2115 | 0.4807 |
Brugia malayi | Pre-SET motif family protein | 0.041 | 0.4152 | 0.9434 |
Loa Loa (eye worm) | camk/mapkapk/mnk protein kinase | 0.0433 | 0.4401 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0392 | 0.3961 | 0.3961 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0389 | 0.0982 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0243 | 0.5 |
Brugia malayi | DNA polymerase I family protein | 0.0101 | 0.0837 | 0.1901 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.3181 | 0.696 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0823 | 0.2077 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0099 | 0.0823 | 0.9833 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0955 | 1 | 1 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0056 | 0.0356 | 0.0899 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0243 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0348 | 0.3486 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0059 | 0.0389 | 0.0982 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0059 | 0.0389 | 0.4646 |
Brugia malayi | follicle stimulating hormone receptor | 0.0227 | 0.2189 | 0.4975 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0348 | 0.3486 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0059 | 0.0389 | 0.0982 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0031 | 0.0095 | 0.0095 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0024 | 0.002 | 0.002 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0243 | 0.5 |
Schistosoma mansoni | ets-related | 0.022 | 0.2115 | 0.5341 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0134 | 0.1199 | 0.1199 |
Onchocerca volvulus | 0.0059 | 0.0389 | 0.0817 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0468 | 0.0198 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0452 | 0.4606 | 0.4606 |
Onchocerca volvulus | 0.0466 | 0.4758 | 1 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0452 | 0.4606 | 0.4606 |
Trichomonas vaginalis | set domain proteins, putative | 0.0466 | 0.4758 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0503 | 0.5153 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0348 | 0.3486 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0837 | 0.1116 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0056 | 0.0356 | 0.4256 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0024 | 0.002 | 0.0041 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0059 | 0.0389 | 0.4646 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0072 | 0.0535 | 0.6393 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.058 | 0.0476 |
Brugia malayi | Protein kinase domain containing protein | 0.0433 | 0.4401 | 1 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0047 | 0.0264 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0057 | 0.0366 | 0.4369 |
Trypanosoma brucei | unspecified product | 0.0031 | 0.0095 | 0.0095 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0045 | 0.0243 | 0.0553 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0024 | 0.002 | 0.0041 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0134 | 0.1199 | 0.1199 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0024 | 0.002 | 0.002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | ug ml-1 | Antimicrobial activity of the compound against Candida albicans; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | ug ml-1 | Antimicrobial activity of the compound against Cryptococcus neoformans; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | ug ml-1 | Antimicrobial activity of the compound against Escherichia coli; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Cryptococcus neoformans; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Candida albicans; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Staphylococcus aureus; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Streptococcus pneumoniae; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Enterococcus faecali; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Escherichia coli; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Enterobacter cloacae; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Stenotrophomonas maltophilia; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | 0 ug ml-1 | Antimicrobial activity of the compound against Neisseria gonorrhoeae; No inhibition at 64 ug/mL | ChEMBL. | 15027869 |
Activity (functional) | = 64 ug ml-1 | Antimicrobial activity of the compound against Micrococcus luteus | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of murine leukemia P388 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of pancreatic BXPC-3 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of breast MCF-7 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of CNS SF-268 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of lung NCI-H460 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of colon KM20L2 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of prostate DU-145 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of murine leukemia P388 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of pancreatic BXPC-3 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of breast MCF-7 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of CNS SF-268 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of lung NCI-H460 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of colon KM20L2 cell proliferation | ChEMBL. | 15027869 |
ED50 (functional) | > 10 ug ml-1 | Inhibition of prostate DU-145 cell proliferation | ChEMBL. | 15027869 |
Inhibition (binding) | = 19.5 % | Inhibition of PKC alpha at 30 FM | ChEMBL. | 15027869 |
Inhibition (binding) | = 19.5 % | Inhibition of PKC alpha at 30 FM | ChEMBL. | 15027869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.