Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0259 | 0.539 | 0.539 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0453 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0079 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0079 | 1 |
Onchocerca volvulus | 0.0259 | 0.539 | 1 | |
Onchocerca volvulus | 0.0259 | 0.539 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.038 | 0.038 |
Onchocerca volvulus | 0.0035 | 0.0079 | 0.0146 | |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Trichomonas vaginalis | set domain proteins, putative | 0.0255 | 0.5309 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0079 | 0.0079 |
Echinococcus multilocularis | muscleblind protein | 0.0453 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Brugia malayi | Animal haem peroxidase family protein | 0.0259 | 0.539 | 0.539 |
Brugia malayi | Animal haem peroxidase family protein | 0.0259 | 0.539 | 0.539 |
Onchocerca volvulus | 0.0255 | 0.5309 | 0.9849 | |
Onchocerca volvulus | 0.0259 | 0.539 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0259 | 0.539 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0259 | 0.539 | 0.539 |
Onchocerca volvulus | 0.0035 | 0.0079 | 0.0146 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0259 | 0.539 | 0.539 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0079 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0079 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0079 | 0.0079 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0018 | 0.0018 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0079 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0259 | 0.539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0079 | 0.5 |
Brugia malayi | Peroxidasin | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.038 | 0.038 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0079 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0079 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0259 | 0.539 | 0.539 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.038 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0079 | 0.0079 |
Echinococcus granulosus | muscleblind protein | 0.0453 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Onchocerca volvulus | 0.0035 | 0.0079 | 0.0146 | |
Echinococcus granulosus | peroxidasin | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0079 | 0.0079 |
Brugia malayi | Animal haem peroxidase family protein | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0259 | 0.539 | 0.539 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0079 | 0.0079 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Echinococcus multilocularis | peroxidasin | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Onchocerca volvulus | Peroxidase homolog | 0.0259 | 0.539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0079 | 0.0079 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0079 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0259 | 0.539 | 1 |
Schistosoma mansoni | peroxidasin | 0.0259 | 0.539 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0018 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Schistosoma mansoni | peroxidasin | 0.0259 | 0.539 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.038 | 0.038 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0079 | 0.0079 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0079 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0079 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Onchocerca volvulus | Dual oxidase homolog | 0.0259 | 0.539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.4627 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0079 | 0.0146 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0224 | 0.4571 | 0.4571 |
Onchocerca volvulus | Peroxidase homolog | 0.0259 | 0.539 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0224 | 0.4571 | 0.4571 |
Brugia malayi | Animal haem peroxidase family protein | 0.0259 | 0.539 | 0.539 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0079 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Brugia malayi | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.539 | 0.539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.