Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.4534 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.4534 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.4534 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4534 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.4534 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.4534 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.4534 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.4534 | 0.4534 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.4534 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.4534 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.