TDR Targets

Basic information

Technical information

TDR Targets ID: 754608
Name: (3Z)-1-butyl-3-[6-oxo-2-(3,4,5-trimethoxyphen yl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-5-ylid ene]indol-2-one
MW: 496.579 | Formula: C25H28N4O5S
H donors: 0 H acceptors: 4 LogP: 4.37 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN1C(=O)/C(=C/2\SC3N(C2=O)NC(N3)c2cc(OC)c(c(c2)OC)OC)/c2c1cccc2
InChi: 1S/C25H24N4O5S/c1-5-6-11-28-16-10-8-7-9-15(16)19(23(28)30)21-24(31)29-25(35-21)26-22(27-29)14-12-17(32-2)20(34-4)18(13-14)33-3/h7-10,12-13H,5-6,11H2,1-4H3/b21-19-
InChiKey: OHXSDTBVGFAYDV-VZCXRCSSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3Z)-1-butyl-3-[6-oxo-2-(3,4,5-trimethoxyphenyl)thiazolo[2,3-e][1,2,4]triazol-5-ylidene]indolin-2-one
(3Z)-1-butyl-3-[6-oxo-2-(3,4,5-trimethoxyphenyl)-5-thiazolo[2,3-e][1,2,4]triazolylidene]-2-indolinone
(3Z)-1-butyl-3-[6-keto-2-(3,4,5-trimethoxyphenyl)thiazolo[2,3-e][1,2,4]triazol-5-ylidene]oxindole
STOCK4S-15123

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0035	0.0035
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0035	0.0035
Schistosoma mansoni	apoferritin-2	0.0026	0.0067	0.0067
Schistosoma mansoni	apoferritin-2	0.0026	0.0067	0.0067
Brugia malayi	beta-lactamase family protein	0.0175	0.1156	0.1156
Brugia malayi	Animal haem peroxidase family protein	0.139	1	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1156	0.1156
Entamoeba histolytica	hypothetical protein	0.0073	0.041	1
Schistosoma mansoni	hypothetical protein	0.0388	0.2709	0.2709
Onchocerca volvulus	Putative cubilin	0.0388	0.2709	0.2709
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0035	0.0035
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0035	0.0035
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0035	0.0035
Schistosoma mansoni	cellular tumor antigen P53	0.01	0.0609	0.0609
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Leishmania major	cathepsin L-like protease	0.0062	0.0335	0.2896
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0035	0.0035
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0035	0.0035
Trypanosoma cruzi	hypothetical protein, conserved	0.0175	0.1156	1
Onchocerca volvulus		0.01	0.0609	0.0609
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Onchocerca volvulus		0.0175	0.1156	0.1156
Brugia malayi	mothers against decapentaplegic homolog 3	0.0018	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0035	0.0035
Brugia malayi	EGF-like domain containing protein	0.0388	0.2709	0.2709
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0351	0.0351
Onchocerca volvulus		0.139	1	1
Echinococcus multilocularis	fibropellin Ia	0.0388	0.2709	0.2709
Onchocerca volvulus	Chorion peroxidase homolog	0.139	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.0735	0.6129
Onchocerca volvulus		0.0388	0.2709	0.2709
Schistosoma mansoni	laminin gamma-3 chain	0.0388	0.2709	0.2709
Trypanosoma brucei	trypanothione reductase	0.0046	0.0218	0.1426
Loa Loa (eye worm)	Smad1	0.0041	0.0179	0.0179
Schistosoma mansoni	hypothetical protein	0.0079	0.0459	0.0459
Brugia malayi	Bromodomain containing protein	0.0077	0.0438	0.0438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Brugia malayi	Peroxidasin	0.139	1	1
Brugia malayi	MH2 domain containing protein	0.0041	0.0179	0.0179
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0388	0.2709	0.2709
Echinococcus multilocularis	notch	0.0388	0.2709	0.2709
Mycobacterium ulcerans	esterase/lipase LipP	0.0175	0.1156	1
Brugia malayi	Fli-1 protein	0.0216	0.1457	0.1457
Mycobacterium tuberculosis	Probable esterase LipL	0.0175	0.1156	0.1368
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0035	0.0035
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0035	0.0035
Schistosoma mansoni	ap endonuclease	0.0038	0.0156	0.0156
Mycobacterium tuberculosis	Conserved protein	0.0175	0.1156	0.1368
Brugia malayi	EGF-like domain containing protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0062	0.2826
Loa Loa (eye worm)	TAR-binding protein	0.0124	0.0783	0.0783
Trichomonas vaginalis	ferritin, putative	0.0026	0.0067	0.013
Brugia malayi	beta-lactamase family protein	0.0175	0.1156	0.1156
Schistosoma mansoni	peroxidasin	0.139	1	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0325	0.0325
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0324	0.0324
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0073	0.0073
Brugia malayi	Calcium binding EGF domain containing protein	0.0388	0.2709	0.2709
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.0783	0.0783
Mycobacterium ulcerans	beta-lactamase	0.0175	0.1156	1
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0388	0.2709	0.2709
Toxoplasma gondii	EGF family domain-containing protein	0.0388	0.2709	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0227	0.0227
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0035	0.0035
Brugia malayi	MH1 domain containing protein	0.0023	0.0046	0.0046
Entamoeba histolytica	hypothetical protein	0.0073	0.041	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0089	0.0525	0.0525
Schistosoma mansoni	thyroid hormone receptor	0.0285	0.1959	0.1959
Onchocerca volvulus		0.0175	0.1156	0.1156
Brugia malayi	Delta serrate ligand family protein	0.0388	0.2709	0.2709
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0035	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0035	0.0035
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0156	0.0861
Loa Loa (eye worm)	fli-1 protein	0.0216	0.1457	0.1457
Plasmodium vivax	SET domain protein, putative	0.0092	0.055	0.4757
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0175	0.1156	0.1368
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0035	0.0035
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0035	0.0035
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1119	0.803	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.0649	0.073
Brugia malayi	GCC2 and GCC3 family protein	0.0388	0.2709	0.2709
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0156	0.1348
Onchocerca volvulus	Peroxidasin homolog	0.139	1	1
Schistosoma mansoni	ferritin light chain	0.0026	0.0067	0.0067
Schistosoma mansoni	septate junction protein	0.0388	0.2709	0.2709
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0035	0.0035
Plasmodium falciparum	glutathione reductase	0.0046	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0609	0.0609
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0035	0.0035
Brugia malayi	MH2 domain containing protein	0.0018	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0156	0.0812
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Echinococcus multilocularis	lamin dm0	0.0026	0.0073	0.0073
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.041	0.041
Loa Loa (eye worm)	MH2 domain-containing protein	0.0602	0.4264	0.4264
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0018	0.0014	0.0014
Schistosoma mansoni	ets-related	0.0216	0.1457	0.1457
Echinococcus granulosus	mothers against decapentaplegic 6	0.0018	0.0014	0.0014
Schistosoma mansoni	Smad4	0.0018	0.0014	0.0014
Schistosoma mansoni	smad	0.0041	0.0179	0.0179
Echinococcus granulosus	GPCR family 2	0.0079	0.0459	0.0459
Loa Loa (eye worm)	transcription factor SMAD2	0.0602	0.4264	0.4264
Echinococcus granulosus	mothers against decapentaplegic 5	0.0041	0.0179	0.0179
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0041	0.0179	0.0179
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.0649	0.073
Onchocerca volvulus		0.0026	0.0073	0.0073
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Brugia malayi	hypothetical protein	0.0025	0.0062	0.0062
Loa Loa (eye worm)	animal heme peroxidase	0.139	1	1
Echinococcus multilocularis	zinc finger protein	0.002	0.0026	0.0026
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0035	0.0035
Brugia malayi	EGF-like domain containing protein	0.0388	0.2709	0.2709
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Schistosoma mansoni	lamin	0.0026	0.0073	0.0073
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0109	0.0677	0.0677
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0156	0.0156
Echinococcus granulosus	beta LACTamase domain containing family member	0.0175	0.1156	0.1156
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0175	0.1156	0.1156
Echinococcus multilocularis	ferritin	0.0026	0.0067	0.0067
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0014	0.0014
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1707	0.1707
Schistosoma mansoni	hypothetical protein	0.0079	0.0459	0.0459
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.0783	0.0783
Brugia malayi	Pre-SET motif family protein	0.0641	0.4547	0.4547
Echinococcus multilocularis	musashi	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus multilocularis	neurogenic locus notch protein	0.0388	0.2709	0.2709
Brugia malayi	RNA binding protein	0.0124	0.0783	0.0783
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0335	0.2896
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.0783	0.0783
Echinococcus granulosus	neural cadherin	0.0388	0.2709	0.2709
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.04	0.04
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0218	0.0218
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0238	0.2056
Toxoplasma gondii	exonuclease III APE	0.0038	0.0156	0.0575
Brugia malayi	TAR-binding protein	0.0124	0.0783	0.0783
Echinococcus granulosus	Smad4	0.0041	0.0179	0.0179
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1156	0.1156
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.1576	0.1576
Trichomonas vaginalis	set domain proteins, putative	0.0729	0.5192	1
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Echinococcus granulosus	zinc finger protein	0.002	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Brugia malayi	latrophilin 2 splice variant baaae	0.0171	0.1129	0.1129
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0079	0.0459	0.0459
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0035	0.0035
Echinococcus multilocularis	protein jagged 1	0.0388	0.2709	0.2709
Schistosoma mansoni	hypothetical protein	0.0073	0.041	0.041
Brugia malayi	hypothetical protein	0.0073	0.041	0.041
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus granulosus	smad	0.0041	0.0179	0.0179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Loa Loa (eye worm)	nuclear factor I	0.0023	0.0046	0.0046
Brugia malayi	Blistered cuticle protein 3	0.139	1	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1156	0.1156
Echinococcus granulosus	protein jagged 1	0.0388	0.2709	0.2709
Schistosoma mansoni	Smad4	0.0041	0.0179	0.0179
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0285	0.1959	0.1959
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0041	0.0179	0.0179
Brugia malayi	notch-like transmembrane receptor	0.0388	0.2709	0.2709
Schistosoma mansoni	hypothetical protein	0.0171	0.1129	0.1129
Brugia malayi	MH1 domain containing protein	0.0041	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Onchocerca volvulus		0.0175	0.1156	0.1156
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0079	0.0459	0.0459
Mycobacterium leprae	conserved hypothetical protein	0.0175	0.1156	1
Mycobacterium leprae	Probable lipase LipE	0.0175	0.1156	1
Onchocerca volvulus		0.139	1	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus granulosus	protein jagged 2	0.0388	0.2709	0.2709
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0218	0.0189
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0062	0.0227
Mycobacterium tuberculosis	Probable reductase	0.0106	0.0649	0.073
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0179	0.0179
Brugia malayi	PHD-finger family protein	0.0025	0.0066	0.0066
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0014	0.0014
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0062	0.0062
Brugia malayi	EGF-like domain containing protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Schistosoma mansoni	notch	0.0388	0.2709	0.2709
Brugia malayi	Bromodomain containing protein	0.0039	0.0165	0.0165
Echinococcus granulosus	tumor protein p63	0.0683	0.4855	0.4855
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.0783	0.0783
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.0649	0.073
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0124	0.0783	0.0783
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0079	0.0459	0.0459
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0079	0.0459	0.0459
Schistosoma mansoni	microtubule-associated protein tau	0.0672	0.4774	0.4774
Brugia malayi	MH2 domain containing protein	0.0041	0.0179	0.0179
Echinococcus multilocularis	peroxidasin	0.139	1	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0218	0.1882
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0264	0.1805	0.1805
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0264	0.1805	0.1805
Echinococcus granulosus	mothers against decapentaplegic 2	0.0018	0.0014	0.0014
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0035	0.0035
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0324	0.0324
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0062	0.0532
Trypanosoma brucei	hypothetical protein, conserved	0.0175	0.1156	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0335	0.2896
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0184	0.0184
Echinococcus multilocularis	tar DNA binding protein	0.0124	0.0783	0.0783
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Brugia malayi	Thioredoxin reductase	0.0046	0.0218	0.0218
Schistosoma mansoni	hypothetical protein	0.0264	0.1805	0.1805
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0079	0.0459	0.0459
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0092	0.055	0.2031
Loa Loa (eye worm)	beta-lactamase	0.0175	0.1156	0.1156
Brugia malayi	Ets-domain containing protein	0.0071	0.04	0.04
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0035	0.0035
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0035	0.0035
Echinococcus granulosus	neurogenic locus protein delta	0.0388	0.2709	0.2709
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0062	0.2826
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Brugia malayi	Animal haem peroxidase family protein	0.139	1	1
Onchocerca volvulus		0.139	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0035	0.0035
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0218	0.1882
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Schistosoma mansoni	coup transcription factor	0.0021	0.0035	0.0035
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0156	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus granulosus	geminin	0.0166	0.1088	0.1088
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0069	0.0069
Onchocerca volvulus		0.0388	0.2709	0.2709
Trichomonas vaginalis	penicillin-binding protein, putative	0.0175	0.1156	0.2227
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0035	0.0035
Toxoplasma gondii	ABC1 family protein	0.0175	0.1156	0.4269
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.0735	0.0838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Echinococcus multilocularis	neurogenic locus notch protein	0.0388	0.2709	0.2709
Echinococcus multilocularis	slit 2 protein	0.0388	0.2709	0.2709
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0035	0.0035
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0035	0.0035
Brugia malayi	Animal haem peroxidase family protein	0.139	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Echinococcus granulosus	histone lysine methyltransferase setb	0.0109	0.0677	0.0677
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0041	0.0179	0.0179
Mycobacterium ulcerans	lipase LipD	0.0175	0.1156	1
Leishmania major	cathepsin L-like protease	0.0062	0.0335	0.2896
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.04	0.04
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.0649	0.073
Schistosoma mansoni	gabp alpha	0.0071	0.04	0.04
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0175	0.1156	0.1156
Onchocerca volvulus	Slit protein homolog	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Brugia malayi	glutathione reductase	0.0046	0.0218	0.0218
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0109	0.0677	0.0677
Schistosoma mansoni	ferritin	0.0026	0.0067	0.0067
Schistosoma mansoni	hypothetical protein	0.0047	0.0227	0.0227
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.0649	0.073
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0459	0.0459
Brugia malayi	RNA recognition motif domain containing protein	0.0124	0.0783	0.0783
Mycobacterium tuberculosis	Probable hydrolase	0.0175	0.1156	0.1368
Onchocerca volvulus	Peroxidasin homolog	0.139	1	1
Echinococcus granulosus	lamin dm0	0.0026	0.0073	0.0073
Onchocerca volvulus		0.0092	0.055	0.055
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0035	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0035	0.0035
Echinococcus granulosus	notch	0.0388	0.2709	0.2709
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0175	0.1156	0.1156
Brugia malayi	steroid hormone receptor	0.0021	0.0035	0.0035
Onchocerca volvulus	Peroxidase homolog	0.139	1	1
Onchocerca volvulus		0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0156	0.3799
Schistosoma mansoni	notch	0.0388	0.2709	0.2709
Echinococcus granulosus	intermediate filament protein	0.0026	0.0073	0.0073
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0073	0.0073
Echinococcus multilocularis	geminin	0.0166	0.1088	0.1088
Echinococcus multilocularis	neurogenic locus protein delta	0.0388	0.2709	0.2709
Schistosoma mansoni	slit	0.0388	0.2709	0.2709
Brugia malayi	Cadherin domain containing protein	0.0388	0.2709	0.2709
Schistosoma mansoni	notch	0.0388	0.2709	0.2709
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0079	0.0459	0.0459
Brugia malayi	Ets-domain containing protein	0.0071	0.04	0.04
Mycobacterium tuberculosis	Conserved protein	0.0175	0.1156	0.1368
Schistosoma mansoni	ferritin	0.0026	0.0067	0.0067
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0073	0.0073
Schistosoma mansoni	hypothetical protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Mycobacterium tuberculosis	Conserved protein	0.0175	0.1156	0.1368
Brugia malayi	ecdysteroid receptor	0.0021	0.0035	0.0035
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0175	0.1156	0.1368
Loa Loa (eye worm)	animal heme peroxidase	0.139	1	1
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0218	0.0803
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0034	0.0034
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0251	0.1707	0.1707
Loa Loa (eye worm)	animal heme peroxidase	0.139	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0035	0.0035
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0035	0.0035
Schistosoma mansoni	cell polarity protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1576	0.1576
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0035	0.0035
Brugia malayi	Animal haem peroxidase family protein	0.139	1	1
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Brugia malayi	beta-lactamase	0.0175	0.1156	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1156	0.1156
Loa Loa (eye worm)	animal heme peroxidase	0.139	1	1
Echinococcus granulosus	neurogenic locus notch protein	0.0388	0.2709	0.2709
Brugia malayi	MH2 domain containing protein	0.0602	0.4264	0.4264
Schistosoma mansoni	notch	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0046	0.0046
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0035	0.0035
Brugia malayi	hypothetical protein	0.0233	0.1576	0.1576
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0156	0.0111
Echinococcus granulosus	protein jagged 1	0.0388	0.2709	0.2709
Entamoeba histolytica	hypothetical protein	0.0073	0.041	1
Loa Loa (eye worm)	Notch2	0.0388	0.2709	0.2709
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0218	0.1882
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0035	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Echinococcus granulosus	fibropellin Ia	0.0388	0.2709	0.2709
Echinococcus granulosus	tar DNA binding protein	0.0124	0.0783	0.0783
Brugia malayi	intermediate filament protein	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0035	0.0035
Schistosoma mansoni	thyroid hormone receptor	0.0285	0.1959	0.1959
Schistosoma mansoni	hypothetical protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1156	0.1156
Schistosoma mansoni	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0092	0.055	0.055
Brugia malayi	Latrophilin receptor protein 2	0.0079	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Brugia malayi	Calcium binding EGF domain containing protein	0.0388	0.2709	0.2709
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0156	1
Echinococcus multilocularis	tumor protein p63	0.0683	0.4855	0.4855
Leishmania major	hypothetical protein, conserved	0.0025	0.0062	0.0532
Echinococcus multilocularis	lamin	0.0026	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1129	0.1129
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0335	0.2896
Echinococcus granulosus	neurogenic locus notch protein	0.0388	0.2709	0.2709
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.0735	0.0838
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0218	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0166	0.0166
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0388	0.2709	0.2709
Schistosoma mansoni	lamin	0.0026	0.0073	0.0073
Onchocerca volvulus		0.0047	0.0227	0.0227
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0018	0.0014	0.0014
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.055	0.055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0035	0.0035
Brugia malayi	Smad1	0.0041	0.0179	0.0179
Brugia malayi	Animal haem peroxidase family protein	0.139	1	1
Schistosoma mansoni	hypothetical protein	0.0166	0.1088	0.1088
Echinococcus multilocularis	protein jagged 1	0.0388	0.2709	0.2709
Echinococcus granulosus	microtubule associated protein 2	0.0672	0.4774	0.4774
Brugia malayi	Pre-SET motif family protein	0.0092	0.055	0.055
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0035	0.0035
Trichomonas vaginalis	D-aminoacylase, putative	0.0175	0.1156	0.2227
Schistosoma mansoni	hypothetical protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0218	0.0218
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0251	0.1707	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0073	0.0073
Mycobacterium ulcerans	hypothetical protein	0.0175	0.1156	1
Leishmania major	hypothetical protein, conserved	0.0175	0.1156	1
Schistosoma mansoni	hypothetical protein	0.0388	0.2709	0.2709
Schistosoma mansoni	hypothetical protein	0.0079	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Brugia malayi	MH1 domain containing protein	0.0023	0.0046	0.0046
Trichomonas vaginalis	penicillin-binding protein, putative	0.0175	0.1156	0.2227
Loa Loa (eye worm)	notch protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0641	0.4547	0.4547
Entamoeba histolytica	hypothetical protein	0.0073	0.041	1
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.1576	0.1576
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0156	0.1348
Schistosoma mansoni	hypothetical protein	0.0021	0.0034	0.0034
Giardia lamblia	High cysteine protein	0.0388	0.2709	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0035	0.0035
Loa Loa (eye worm)	blistered cuticle protein 3	0.139	1	1
Onchocerca volvulus		0.0388	0.2709	0.2709
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0175	0.1156	0.1156
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0035	0.0035
Schistosoma mansoni	hypothetical protein	0.0079	0.0459	0.0459
Schistosoma mansoni	ferritin	0.0026	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Loa Loa (eye worm)	RNA binding protein	0.0124	0.0783	0.0783
Mycobacterium tuberculosis	Probable lipase LipD	0.0175	0.1156	0.1368
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0295	0.2555
Brugia malayi	nuclear hormone receptor	0.0021	0.0035	0.0035
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0035	0.0035
Onchocerca volvulus	Neurogenic locus notch homolog	0.0388	0.2709	0.2709
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0218	0.0218
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0148	0.0148
Leishmania major	cathepsin L-like protease	0.0062	0.0335	0.2896
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0035	0.0035
Echinococcus multilocularis	Smad4	0.0041	0.0179	0.0179
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0179	0.0179
Onchocerca volvulus	Peroxidase homolog	0.139	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0198	0.0198
Schistosoma mansoni	notch	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0018	0.0014	0.0014
Schistosoma mansoni	zinc finger protein	0.002	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Loa Loa (eye worm)	MH1 domain-containing protein	0.0041	0.0179	0.0179
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0035	0.0035
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0012	0.0012
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0175	0.1156	0.1156
Brugia malayi	EGF-like domain containing protein	0.0388	0.2709	0.2709
Onchocerca volvulus		0.0388	0.2709	0.2709
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0156	0.03
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0677	0.0677
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0035	0.0035
Trichomonas vaginalis	esterase, putative	0.0175	0.1156	0.2227
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Onchocerca volvulus	Dual oxidase homolog	0.139	1	1
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0175	0.1156	0.2227
Loa Loa (eye worm)	MH2 domain-containing protein	0.0041	0.0179	0.0179
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0035	0.0035
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0035	0.0035
Brugia malayi	EGF-like domain containing protein	0.0388	0.2709	0.2709
Schistosoma mansoni	ferritin light chain	0.0026	0.0067	0.0067
Onchocerca volvulus		0.0729	0.5192	0.5192
Mycobacterium tuberculosis	Probable lipase LipE	0.0175	0.1156	0.1368
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0035	0.0035
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0062	0.0532
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0388	0.2709	0.2709
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0109	0.0677	0.0677
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0251	0.1707	0.1707
Brugia malayi	Calcium binding EGF domain containing protein	0.0388	0.2709	0.2709
Leishmania major	trypanothione reductase	0.0046	0.0218	0.1882
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.0735	0.0838
Schistosoma mansoni	smad1 5 8 and	0.0041	0.0179	0.0179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Schistosoma mansoni	hypothetical protein	0.0388	0.2709	0.2709
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.0649	0.5342
Schistosoma mansoni	ferritin	0.0026	0.0067	0.0067
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0092	0.055	0.055
Echinococcus multilocularis	GPCR, family 2	0.0079	0.0459	0.0459
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0041	0.0179	0.0179
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0008	0.0008
Echinococcus multilocularis	neurogenic locus protein delta	0.0388	0.2709	0.2709
Echinococcus granulosus	neurogenic locus notch protein 4	0.0388	0.2709	0.2709
Plasmodium vivax	hypothetical protein, conserved	0.0175	0.1156	1
Schistosoma mansoni	hypothetical protein	0.0166	0.1088	0.1088
Brugia malayi	Muscle positioning protein 4	0.0388	0.2709	0.2709
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0048	0.0048
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.041	0.041
Schistosoma mansoni	notch	0.0388	0.2709	0.2709
Echinococcus multilocularis	neural cadherin	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0014	0.0014
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0406	0.0406
Echinococcus granulosus	slit 2 protein	0.0388	0.2709	0.2709
Schistosoma mansoni	Smad4	0.0018	0.0014	0.0014
Brugia malayi	Cadherin domain containing protein	0.0388	0.2709	0.2709
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0175	0.1156	0.1368
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0156	0.1348
Brugia malayi	EGF-like domain containing protein	0.0388	0.2709	0.2709
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0156	0.1348
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0073	0.0073
Schistosoma mansoni	peroxidasin	0.139	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0175	0.1156	1
Onchocerca volvulus		0.0021	0.0035	0.0035
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0035	0.0035
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.04	0.04
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.041	0.041
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1156	0.1156
Brugia malayi	MH1 domain containing protein	0.0041	0.0179	0.0179
Schistosoma mansoni	smad	0.0018	0.0014	0.0014
Echinococcus multilocularis	expressed protein	0.0026	0.0067	0.0067
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.0783	0.0783
Echinococcus granulosus	expressed protein	0.0026	0.0067	0.0067
Onchocerca volvulus		0.0026	0.0073	0.0073
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0008	0.0008
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0335	0.2896
Echinococcus multilocularis	protein jagged 2	0.0388	0.2709	0.2709
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0008	0.0008
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0175	0.1156	1
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0388	0.2709	0.2709
Echinococcus granulosus	lamin	0.0026	0.0073	0.0073
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0335	0.2497
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0035	0.0035
Schistosoma mansoni	ap endonuclease	0.0038	0.0156	0.0156
Echinococcus granulosus	ferritin	0.0026	0.0067	0.0067
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0048	0.0048
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0062	0.0532
Echinococcus granulosus	peroxidasin	0.139	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0035	0.0035
Echinococcus granulosus	delta-like protein 1	0.0388	0.2709	0.2709
Trichomonas vaginalis	D-aminoacylase, putative	0.0175	0.1156	0.2227
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0156	0.716
Loa Loa (eye worm)	hypothetical protein	0.0388	0.2709	0.2709
Echinococcus multilocularis	microtubule associated protein 2	0.0672	0.4774	0.4774
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0156	0.03
Loa Loa (eye worm)	hypothetical protein	0.139	1	1
Echinococcus granulosus	protein jagged 2	0.0388	0.2709	0.2709
Echinococcus multilocularis	smad	0.0041	0.0179	0.0179

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 754608