TDR Targets

Basic information

Technical information

TDR Targets ID: 754727
Name: 2-[4-[5-[(4-chloro-3,5-dimethylphenoxy)methyl ]-1,2,4-oxadiazol-3-yl]phenoxy]acetamide
MW: 387.817 | Formula: C19H18ClN3O4
H donors: 1 H acceptors: 3 LogP: 3.58 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)COc1ccc(cc1)c1noc(n1)COc1cc(C)c(c(c1)C)Cl
InChi: 1S/C19H18ClN3O4/c1-11-7-15(8-12(2)18(11)20)26-10-17-22-19(23-27-17)13-3-5-14(6-4-13)25-9-16(21)24/h3-8H,9-10H2,1-2H3,(H2,21,24)
InChiKey: UGDZLJUPPXCDIB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[5-[(4-chloro-3,5-dimethyl-phenoxy)methyl]-1,2,4-oxadiazol-3-yl]phenoxy]acetamide
2-[4-[5-[(4-chloro-3,5-dimethyl-phenoxy)methyl]-1,2,4-oxadiazol-3-yl]phenoxy]ethanamide
IDI1_024057
ChemDiv3_006147

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Intermediate filament tail domain containing protein	0.0058	0.0456	0.0802
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0522	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0083	0.0162
Echinococcus multilocularis	geminin	0.0684	1	1
Echinococcus granulosus	tar DNA binding protein	0.0136	0.1644	0.1644
Brugia malayi	Animal haem peroxidase family protein	0.0365	0.5145	1
Loa Loa (eye worm)	RNA binding protein	0.0136	0.1644	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Entamoeba histolytica	hypothetical protein	0.0077	0.075	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0047	0.0091
Echinococcus multilocularis	peroxidasin	0.0365	0.5145	0.5145
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1894	0.3681
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0058	0.0456	0.0886
Onchocerca volvulus	Peroxidase homolog	0.0365	0.5145	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0319	0.062
Brugia malayi	intermediate filament protein	0.0058	0.0456	0.0802
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0295	0.0487
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0522	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1644	0.1574
Onchocerca volvulus	Peroxidase homolog	0.0365	0.5145	1
Schistosoma mansoni	lamin	0.0058	0.0456	0.0376
Loa Loa (eye worm)	animal heme peroxidase	0.0365	0.5145	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.044	0.0855
Brugia malayi	hypothetical protein	0.0077	0.075	0.138
Schistosoma mansoni	lamin	0.0058	0.0456	0.0376
Schistosoma mansoni	peroxidasin	0.0365	0.5145	0.5104
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1644	0.1574
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.096	0.1792
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.096	0.096
Brugia malayi	hypothetical protein	0.0365	0.5145	1
Loa Loa (eye worm)	intermediate filament protein	0.0058	0.0456	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0319	0.0534
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0295	0.0213
Onchocerca volvulus		0.0152	0.1894	0.3297
Schistosoma mansoni	hypothetical protein	0.0047	0.0295	0.0213
Onchocerca volvulus		0.0365	0.5145	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0522	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.3105	0.3105
Echinococcus granulosus	peroxidasin	0.0365	0.5145	0.5145
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.096	0.096
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.096	0.0884
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.3105	0.3105
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0522	0.0442
Onchocerca volvulus		0.0058	0.0456	0.0332
Entamoeba histolytica	hypothetical protein	0.0077	0.075	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0522	0.5
Onchocerca volvulus	Chorion peroxidase homolog	0.0365	0.5145	1
Brugia malayi	Animal haem peroxidase family protein	0.0365	0.5145	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.096	0.096
Echinococcus granulosus	lamin dm0	0.0058	0.0456	0.0456
Echinococcus multilocularis	lamin	0.0058	0.0456	0.0456
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.096	0.096
Echinococcus multilocularis	lamin dm0	0.0058	0.0456	0.0456
Echinococcus granulosus	lamin	0.0058	0.0456	0.0456
Brugia malayi	TAR-binding protein	0.0136	0.1644	0.3133
Brugia malayi	Peroxidasin	0.0365	0.5145	1
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1644	0.1574
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.096	0.0884
Entamoeba histolytica	hypothetical protein	0.0077	0.075	0.5
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Schistosoma mansoni	hypothetical protein	0.0684	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.096	0.1866
Onchocerca volvulus	Dual oxidase homolog	0.0365	0.5145	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0456	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0522	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0365	0.5145	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.075	0.0672
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1644	0.1574
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0522	0.5
Brugia malayi	RNA binding protein	0.0136	0.1644	0.3133
Loa Loa (eye worm)	TAR-binding protein	0.0136	0.1644	0.3195
Brugia malayi	hypothetical protein	0.0231	0.3105	0.5999
Brugia malayi	Animal haem peroxidase family protein	0.0365	0.5145	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0083	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0319	0.062
Brugia malayi	Animal haem peroxidase family protein	0.0365	0.5145	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Schistosoma mansoni	peroxidasin	0.0365	0.5145	0.5104
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Onchocerca volvulus		0.0365	0.5145	1
Onchocerca volvulus		0.0365	0.5145	1
Onchocerca volvulus	Peroxidasin homolog	0.0365	0.5145	1
Brugia malayi	Animal haem peroxidase family protein	0.0365	0.5145	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.075	0.075
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.075	0.075
Onchocerca volvulus	Peroxidasin homolog	0.0365	0.5145	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0522	0.0522
Onchocerca volvulus		0.0058	0.0456	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3105	0.6035
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0319	0.0534
Echinococcus multilocularis	musashi	0.0058	0.0456	0.0456
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.096	0.0884
Echinococcus granulosus	intermediate filament protein	0.0058	0.0456	0.0456
Loa Loa (eye worm)	animal heme peroxidase	0.0365	0.5145	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0365	0.5145	1
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.1644	0.1574
Schistosoma mansoni	hypothetical protein	0.0684	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0136	0.1644	0.1644
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0136	0.1644	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Schistosoma mansoni	hypothetical protein	0.0077	0.075	0.0672
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0522	0.0442
Brugia malayi	hypothetical protein	0.0152	0.1894	0.3623
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0522	0.0522
Brugia malayi	RNA recognition motif domain containing protein	0.0136	0.1644	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Brugia malayi	Blistered cuticle protein 3	0.0365	0.5145	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5145	1
Schistosoma mansoni	intermediate filament proteins	0.0058	0.0456	0.0376
Loa Loa (eye worm)	animal heme peroxidase	0.0365	0.5145	1
Entamoeba histolytica	hypothetical protein	0.0077	0.075	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 754727