Detailed information for compound 75489

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 519.682 | Formula: C29H41N7O2
  • H donors: 3 H acceptors: 5 LogP: 4.57 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)c1nnnn1C)Cc1ccccc1)O
  • InChi: 1S/C29H41N7O2/c1-3-4-14-27(37)26-20-23(19-22-10-6-5-7-11-22)15-18-36(26)17-9-16-30-29(38)31-25-13-8-12-24(21-25)28-32-33-34-35(28)2/h5-8,10-13,21,23,26-27,37H,3-4,9,14-20H2,1-2H3,(H2,30,31,38)/t23-,26-,27+/m1/s1
  • InChiKey: BAAFLUWVDPBRCL-MVNQZMKCSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0062 0.0219
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0047
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0029 0.0428
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0313 0.6805
Schistosoma mansoni smad 0.0008 0.0003 0.001
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0029 0.0068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0014 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0313 0.11
Trypanosoma brucei unspecified product 0.0029 0.0108 0.2189
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0072 0.0313 0.6805
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0029 0.0428
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0003 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.0101 0.0454 0.1613
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0282 0.1001
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.001 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0014 0.0041
Loa Loa (eye worm) Smad1 0.0017 0.0049 0.0165
Echinococcus granulosus dna polymerase kappa 0.0043 0.0172 0.0609
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0014 0.0047
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0157
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0145 0.0515
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0135 0.0125
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.12 0.4254
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.004 0.0158 0.0525
Giardia lamblia DINP protein human, muc B family 0.0043 0.0172 0.0574
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0135 0.2803
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0014 0.0004
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0062 0.0183
Plasmodium falciparum phosphodiesterase delta, putative 0.0072 0.0313 0.6805
Brugia malayi MH1 domain containing protein 0.001 0.0012 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.003
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0062 0.1158
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0014 0.0051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0238
Schistosoma mansoni smad1 5 8 and 0.0017 0.0049 0.0175
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0282 0.1001
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Brugia malayi Thioredoxin reductase 0.0101 0.0454 0.183
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0135 0.2803
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0172 0.0683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0014 0.0047
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0401
Schistosoma mansoni hypothetical protein 0.0009 0.001 0.0036
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.001 0.0036
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0072 0.0313 0.1109
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0003 0.001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0062 0.0219
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0135 0.2803
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0029 0.0428
Treponema pallidum NADH oxidase 0.0035 0.0135 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0029 0.0428
Schistosoma mansoni hypothetical protein 0.0364 0.1718 0.6097
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0108 0.2189
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0136 0.0538
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.1955 0.6938
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.001 0.0036
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0157 0.9083
Mycobacterium ulcerans hypothetical protein 0.0013 0.0029 0.0019
Loa Loa (eye worm) PDE1B protein 0.0072 0.0313 0.11
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0313 0.6805
Plasmodium vivax phosphodiesterase gamma, putative 0.0072 0.0313 0.6805
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0313 0.6805
Schistosoma mansoni hypothetical protein 0.0035 0.0136 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0047
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0157
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0157
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0032
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0313 0.6805
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0592 0.2818 1
Onchocerca volvulus 0.0029 0.0105 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0072 0.0313 0.11
Leishmania major DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.009 0.0352
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0136 0.0472
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0072 0.0313 0.1255
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0135 0.412
Entamoeba histolytica recQ family helicase, putative 0.001 0.0013 0.0141
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 0.6805
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0587 0.2794 0.2787
Echinococcus granulosus dnaJ subfamily B 0.0413 0.1955 0.6938
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0072 0.0313 0.1109
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0172 0.0609
Brugia malayi glutathione reductase 0.0101 0.0454 0.183
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0051
Plasmodium vivax glutathione reductase, putative 0.0101 0.0454 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0062 0.0219
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0158 0.4876
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0157 0.9083
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0145 0.0515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0313 0.6805
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.023 0.0783
Brugia malayi MH2 domain containing protein 0.0256 0.12 0.4852
Schistosoma mansoni smad1 5 8 and 0.0017 0.0049 0.0175
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0072 0.0313 0.1109
Plasmodium falciparum phosphodiesterase gamma, putative 0.0072 0.0313 0.6805
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0014 0.0051
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0135 0.2803
Trichomonas vaginalis pc-MYB2, putative 0.004 0.0157 0.4846
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0051
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.001 0.0036
Entamoeba histolytica hypothetical protein 0.0037 0.0145 0.8367
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0135 0.0125
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0231 0.1081 0.1495
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0014 0.0051
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0313 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0051
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0135 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0041
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2081 1 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0029 0.0068
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0014 0.1132
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0135 0.0174
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0172 0.5336
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0157 0.4846
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0014 0.0051
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0072 0.0313 0.6805
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0014 0.0041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Toxoplasma gondii thioredoxin reductase 0.0101 0.0454 0.1582
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0062 0.0238
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0014 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0029 0.0428
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0072 0.0313 0.1255
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0454 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0135 0.2803
Echinococcus granulosus GPCR family 2 0.0016 0.0044 0.0157
Loa Loa (eye worm) hypothetical protein 0.0072 0.0313 0.11
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0172 0.0609
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0172 0.0225
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0029 0.0428
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0135 0.0443
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0072 0.0313 0.1109
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0172 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0313 0.6805
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0587 0.2794 0.2787
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0072 0.0313 0.1109
Schistosoma mansoni nuclear hormone receptor 0.001 0.0014 0.0051
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0072 0.0313 0.6805
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.052 0.2471 0.8767
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0014 0.0093
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0014 0.0051
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0587 0.2794 0.3888
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0072 0.0313 0.1109
Brugia malayi glutamate synthase 0.0009 0.001 0.003
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0282 0.0992
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0014 0.0051
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.052 0.2471 0.8768
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.001 0.003
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0072 0.0313 0.6805
Trypanosoma brucei unspecified product 0.0043 0.0172 0.3631
Onchocerca volvulus 0.0009 0.001 0.0723
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0014 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi polk-prov protein 0.0013 0.0029 0.0107
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0215 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0592 0.2818 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0135 0.0478
Brugia malayi nuclear hormone receptor 0.001 0.0014 0.0047
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0049 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0029 0.0428
Schistosoma mansoni hypothetical protein 0.0413 0.1955 0.6938
Loa Loa (eye worm) RecQ helicase 0.002 0.0062 0.0209
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1158
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.001 0.0036
Loa Loa (eye worm) thioredoxin reductase 0.0101 0.0454 0.1604
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0282 0.1001
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0157 0.4846
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0135 0.2803
Mycobacterium tuberculosis Probable oxidoreductase 0.0257 0.1206 0.1669
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0051
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0049 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0051
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0072 0.0313 0.6805
Loa Loa (eye worm) hypothetical protein 0.0072 0.0313 0.11
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0135 0.0443
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0231 0.1081 0.1495
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Brugia malayi Smad1 0.0017 0.0049 0.0189
Trypanosoma brucei trypanothione reductase 0.0101 0.0454 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0108 0.2189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0157
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0072 0.0313 0.1109
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0029 0.0428
Leishmania major hypothetical protein, conserved 0.0072 0.0313 0.6805
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0313 1
Trichomonas vaginalis MYB3r3, putative 0.004 0.0157 0.4846
Schistosoma mansoni cpg binding protein 0.0029 0.0105 0.0373
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.001 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0172 0.0225
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1494 0.7171 1
Echinococcus granulosus cpg binding protein 0.0031 0.0113 0.0401
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0282 0.1001
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.009 0.0352
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0094
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0062 0.0209
Giardia lamblia hypothetical protein 0.0072 0.0313 0.1076
Plasmodium vivax thioredoxin reductase, putative 0.0101 0.0454 1
Onchocerca volvulus 0.001 0.0014 0.1132
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0072 0.0313 0.6805
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0592 0.2818 1
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0029 0.0428
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0072 0.0313 0.1109
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0044 0.0167
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0062 0.0219
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.002
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0072 0.0313 0.1109
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0257 0.1206 0.1669
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0172 0.3631
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0036
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0062 0.1158
Brugia malayi steroid hormone receptor 0.001 0.0014 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0147
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.001 0.0036
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi TAR-binding protein 0.0066 0.0282 0.1131
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0135 0.2803
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0014 0.0047
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0072 0.0313 0.6805
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0145 0.0515
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0172 0.0599
Leishmania major cAMP-specific phosphodiesterase, putative 0.0072 0.0313 0.6805
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0172 0.0161
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.001 0.003
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0003 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.12 0.4254
Brugia malayi ImpB/MucB/SamB family protein 0.0071 0.0308 0.1235
Plasmodium falciparum thioredoxin reductase 0.0035 0.0135 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0041
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0135 0.0478
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Entamoeba histolytica hypothetical protein 0.0037 0.0145 0.8367
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0072 0.0313 0.6805
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0036
Schistosoma mansoni DNA polymerase eta 0.0071 0.0308 0.1092
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0014 0.0051
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0592 0.2818 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Entamoeba histolytica recQ family helicase, putative 0.002 0.0062 0.3189
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0062 0.1702
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Plasmodium falciparum glutathione reductase 0.0035 0.0135 0.2803
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0108 0.2189
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0014 0.0051
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0029 0.0428
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0183
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0072 0.0313 0.1109
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Echinococcus multilocularis cpg binding protein 0.0031 0.0113 0.0401
Trichomonas vaginalis pc-MYB2, putative 0.004 0.0157 0.4846
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0313 0.6805
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0313 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0135 0.0443
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Echinococcus multilocularis dna polymerase eta 0.0071 0.0308 0.1092
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi hypothetical protein 0.0037 0.0145 0.0577
Echinococcus multilocularis smad 0.0017 0.0049 0.0175
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0049 0.0175
Echinococcus granulosus dna polymerase eta 0.0071 0.0308 0.1092
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0401
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0215 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 0.6805
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0157 0.4846
Mycobacterium tuberculosis Probable reductase 0.0231 0.1081 0.1495
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 0.6805
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0172 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0282 0.0992
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.001 0.0036
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0014 0.0093
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1158
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0313 0.6805
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0062 0.1702
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0157 0.9083
Schistosoma mansoni hypothetical protein 0.0037 0.0145 0.0515
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0313 0.6805
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0157 0.9083
Plasmodium falciparum thioredoxin reductase 0.0101 0.0454 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.052 0.2471 0.8768
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0072 0.0313 0.1109
Trichomonas vaginalis C-MYB, putative 0.004 0.0157 0.4846
Brugia malayi MH1 domain containing protein 0.0017 0.0049 0.0189
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0049 0.0175
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0047
Giardia lamblia DNA damage repair protein 0.0013 0.0029 0.0068
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0014 0.0051
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0135 0.2803
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0135 0.412
Trichomonas vaginalis MYB72, putative 0.004 0.0157 0.4846
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0183
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0044 0.0167
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0231 0.1081 0.1495
Echinococcus granulosus bloom syndrome protein 0.002 0.0062 0.0219
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0072 0.0313 0.1109
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.001 0.0036
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 0.6805
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0135 0.0125
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0072 0.0313 0.1255
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0072 0.0313 0.6805
Brugia malayi ecdysteroid receptor 0.001 0.0014 0.0047
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0135 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0172 0.3631
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0072 0.0313 0.6805
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0592 0.2818 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0072 0.0313 0.1109
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0135 0.2803
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.052 0.2471 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0026
Echinococcus multilocularis Smad4 0.0017 0.0049 0.0175
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0157 0.9083
Trichomonas vaginalis MYB, putative 0.004 0.0158 0.4876
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.001 0.0036
Echinococcus granulosus glutamate synthase 0.0009 0.001 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0029 0.0428
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0072 0.0313 0.1109
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1494 0.7171 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0262 0.0929
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0172 0.3631
Trichomonas vaginalis C-MYB, putative 0.004 0.0157 0.4846
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0072 0.0313 0.1109
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0215 0.0858
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Brugia malayi nuclear receptor NHR-88 0.001 0.0014 0.0047
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0072 0.0313 0.1109
Echinococcus granulosus geminin 0.0364 0.1718 0.6097
Leishmania major DNA polymerase eta, putative 0.0071 0.0308 0.6695
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0135 0.2803
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0172 0.0609
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0157
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0135 0.2803
Entamoeba histolytica hypothetical protein 0.0037 0.0145 0.8367
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0062 0.0219
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0282 0.0992
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0072 0.0313 0.1109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Echinococcus multilocularis GPCR, family 2 0.0016 0.0044 0.0157
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0587 0.2794 0.9915
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0238
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Brugia malayi MH1 domain containing protein 0.001 0.0012 0.0036
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2081 1 1
Echinococcus multilocularis glutamate synthase 0.0009 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0029 0.0428
Schistosoma mansoni coup transcription factor 0.001 0.0014 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0029 0.0428
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0013 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0047
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.001 0.0036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0014 0.0015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0231 0.1081 0.1495
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0014 0.1132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0157
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0135 0.0478
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Trypanosoma brucei DNA polymerase eta, putative 0.0071 0.0308 0.6695
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0135 0.0125
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 0.6805
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0157
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0158 0.4876
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0049 0.0175
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0014 0.0047
Loa Loa (eye worm) glutathione reductase 0.0101 0.0454 0.1604
Brugia malayi RNA binding protein 0.0066 0.0282 0.1131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Leishmania major hypothetical protein, conserved 0.0072 0.0313 0.6805
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0029 0.0104
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0135 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Leishmania major DNA polymerase eta, putative 0.0042 0.0165 0.3493
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0072 0.0313 0.1109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0135 0.2803
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0044 0.0147
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Schistosoma mansoni sulfide quinone reductase 0.0009 0.001 0.0036
Echinococcus multilocularis bloom syndrome protein 0.002 0.0062 0.0219
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0172 0.3631
Echinococcus multilocularis thioredoxin glutathione reductase 0.0101 0.0454 0.1613
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0282 0.1001
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0313 0.6805
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0051
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 0.6805
Echinococcus multilocularis geminin 0.0364 0.1718 0.6097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0014 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0014 0.0051
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0072 0.0313 0.6805
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 0.6805
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0072 0.0313 0.1255
Brugia malayi CXXC zinc finger family protein 0.0029 0.0105 0.0414
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Schistosoma mansoni smad1 5 8 and 0.0017 0.0049 0.0175
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0592 0.2818 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0014 0.1132
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0013 0.0045
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0165 0.0553
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0072 0.0313 0.1109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Schistosoma mansoni DNA helicase recq5 0.002 0.0062 0.0219
Entamoeba histolytica hypothetical protein 0.0037 0.0145 0.8367
Trypanosoma brucei unspecified product 0.0029 0.0108 0.2189
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0014 0.0051
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0049 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0313 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.001 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0051
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0072 0.0313 0.6805
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.001 0.0036
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0072 0.0313 0.1255
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0003 0.001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Brugia malayi MH2 domain containing protein 0.0017 0.0049 0.0189
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1158
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2081 1 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0157 0.4846
Leishmania major DNA damage repair protein, putative 0.0013 0.0029 0.0428
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Echinococcus granulosus Smad4 0.0017 0.0049 0.0175
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0282 0.1131
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0101 0.0454 0.062
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0215 0.0752
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0135 0.2803
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0157 0.4846
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0014 0.0051
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0072 0.0313 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0047
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0165 0.3493
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0592 0.2818 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Loa Loa (eye worm) programmed cell death 8 0.0009 0.001 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0282 0.1001
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0135 0.0125
Loa Loa (eye worm) nuclear factor I 0.001 0.0012 0.0032
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0172 0.0609
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0014 0.0051
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0014 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0172 0.0609
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0014 0.0051
Brugia malayi MH2 domain containing protein 0.0017 0.0049 0.0189
Leishmania major trypanothione reductase 0.0101 0.0454 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0257 0.1206 0.1669
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0072 0.0313 0.1109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0313 0.1076
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0172 0.5336
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0231 0.1081 0.1495
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0105 0.0363
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0157
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0308 0.1083
Echinococcus granulosus smad 0.0017 0.0049 0.0175
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0049 0.0175
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0257 0.1206 0.1669
Brugia malayi MH1 domain containing protein 0.0017 0.0049 0.0189
Leishmania major DNA polymerase kappa, putative 0.0013 0.0029 0.0428
Schistosoma mansoni Smad4 0.0008 0.0003 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3631
Schistosoma mansoni Smad4 0.0008 0.0003 0.001
Plasmodium falciparum glutathione reductase 0.0101 0.0454 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0282 0.1001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0047
Schistosoma mansoni smad 0.0017 0.0049 0.0175
Entamoeba histolytica recQ family DNA helicase 0.001 0.0014 0.0257
Schistosoma mansoni Smad4 0.0017 0.0049 0.0175
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0592 0.2818 1
Schistosoma mansoni hypothetical protein 0.0364 0.1718 0.6097
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0062 0.1702
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0072 0.0313 0.1255
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0072 0.0313 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0209
Mycobacterium tuberculosis Probable dehydrogenase 0.0231 0.1081 0.1495
Trypanosoma cruzi DNA polymerase eta, putative 0.0071 0.0308 0.6695
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0157 0.4846
Giardia lamblia Hypothetical protein 0.0072 0.0313 0.1076
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Schistosoma mansoni sulfide quinone reductase 0.0009 0.001 0.0036
Giardia lamblia Myb 1-like protein 0.004 0.0158 0.0525
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0047
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0072 0.0313 0.1109
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0051
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0072 0.0313 1
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0036

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.001 uM In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin ChEMBL. 12067561
IC50 (binding) = 0.001 uM In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin ChEMBL. 12067561

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.