Detailed information for compound 754982

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.366 | Formula: C17H22F2N2O2
  • H donors: 0 H acceptors: 1 LogP: 3.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN(C(C)C)Cc1nc(oc1C)c1ccc(cc1F)F
  • InChi: 1S/C17H22F2N2O2/c1-11(2)21(7-8-22-4)10-16-12(3)23-17(20-16)14-6-5-13(18)9-15(14)19/h5-6,9,11H,7-8,10H2,1-4H3
  • InChiKey: LLJQFNIZKYGPMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.1452 0.8456
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0395 0.0732
Echinococcus granulosus histone lysine methyltransferase setb 0.0121 0.1161 0.2153
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0061 0.036
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0395 0.045
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.007
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0283 0.0337
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0144 0.1408 0.2611
Schistosoma mansoni hypothetical protein 0.0144 0.1408 0.2606
Echinococcus granulosus geminin 0.0521 0.5395 1
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0238 0.1393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Onchocerca volvulus Pyruvate kinase homolog 0.0172 0.1706 0.1703
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0254 0.2576 0.3073
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0011 0.0007 0.0003
Echinococcus granulosus tar DNA binding protein 0.0062 0.0543 0.1007
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0543 0.1001
Schistosoma mansoni hypothetical protein 0.0099 0.0935 0.1728
Schistosoma mansoni jumonji domain containing protein 0.008 0.0737 0.1361
Leishmania major importin beta-1 subunit, putative 0.0027 0.0171 0.0968
Entamoeba histolytica hypothetical protein 0.0254 0.2576 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.0946 0.1078
Trichomonas vaginalis pyruvate kinase, putative 0.0172 0.1706 0.1703
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.1683 0.168
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2396 0.4437
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0061 0.0073
Plasmodium vivax vivapain-2 0.0017 0.0061 0.036
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0063 0.033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0085 0.0501
Giardia lamblia PHD finger protein 15 0.0031 0.0214 0.1217
Schistosoma mansoni synaptojanin 0.0011 0.0007 0.0006
Leishmania major DNA polymerase eta, putative 0.0019 0.0085 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1683 0.168
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0342 0.0408
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.1452 0.1656
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Echinococcus multilocularis smad 0.0026 0.0158 0.0189
Plasmodium vivax SET domain containing protein 0.0015 0.0047 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0411 0.0408
Schistosoma mansoni pyruvate kinase 0.0088 0.0821 0.1515
Mycobacterium tuberculosis Conserved protein 0.0148 0.1452 0.1463
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1046 0.1051
Onchocerca volvulus 0.0017 0.0061 0.0058
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0063 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.1161 0.2147
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0007 0.0041
Schistosoma mansoni DNA polymerase eta 0.0019 0.0085 0.0152
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0016 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0946 0.1747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2396 0.4437
Schistosoma mansoni smad1 5 8 and 0.0026 0.0158 0.0286
Onchocerca volvulus 0.0017 0.0061 0.0058
Toxoplasma gondii exonuclease III APE 0.0056 0.0481 0.2822
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0041
Echinococcus granulosus peregrin 0.0042 0.0327 0.0606
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0011 0.0007 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0004 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2625 0.2622
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0061 0.0058
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0148 0.1452 0.1656
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0085 0.0152
Loa Loa (eye worm) hypothetical protein 0.0486 0.5026 0.5729
Onchocerca volvulus 0.0148 0.1452 0.1449
Brugia malayi MH1 domain containing protein 0.0014 0.0037 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0481 0.2792
Schistosoma mansoni Smad4 0.0011 0.0008 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0369
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.032
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0946 0.0942
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0283 0.0517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Schistosoma mansoni hypothetical protein 0.0144 0.1408 0.2606
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0543 0.0619
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Loa Loa (eye worm) MH2 domain-containing protein 0.0377 0.3865 0.4406
Schistosoma mansoni survival motor neuron protein 0.0099 0.0935 0.1728
Loa Loa (eye worm) Smad1 0.0026 0.0158 0.018
Loa Loa (eye worm) hypothetical protein 0.0033 0.0238 0.0271
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0041
Mycobacterium ulcerans hypothetical protein 0.0148 0.1452 0.8456
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0085 0.0102
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.1452 0.1733
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0008
Brugia malayi MH1 domain containing protein 0.0026 0.0158 0.018
Brugia malayi RNA, U transporter 1 0.0094 0.0884 0.1008
Brugia malayi PHD-finger family protein 0.0031 0.0214 0.0244
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0007 0.0008
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0395 0.2315
Echinococcus granulosus importin subunit beta 1 0.0033 0.0238 0.0441
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0007 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0481 0.0549
Echinococcus granulosus pyruvate kinase 0.0088 0.0821 0.1521
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1683 0.168
Loa Loa (eye worm) glutathione reductase 0.0048 0.0395 0.045
Onchocerca volvulus 0.0099 0.0935 0.0932
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.1452 0.2692
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.1452 0.1463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0462
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0041
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0935 0.1066
Brugia malayi hypothetical protein 0.0254 0.2576 0.2936
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0061 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0543 0.1001
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0011 0.0007 0.0041
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0007 0.0041
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0041
Echinococcus granulosus GPCR family 2 0.0144 0.1408 0.2611
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0395 0.0393
Loa Loa (eye worm) hypothetical protein 0.0311 0.3174 0.3618
Schistosoma mansoni cript-related 0.0011 0.0007 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.1161 0.2147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.1161 0.2147
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0007 0.0008
Brugia malayi TAR-binding protein 0.0062 0.0543 0.0619
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0128 0.1244 0.7289
Plasmodium vivax importin-beta 2, putative 0.0033 0.0238 0.1393
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0007 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.2396 0.444
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0946 0.3672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0063 0.0369
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0214 0.039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0009
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.1452 0.8456
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0214 0.1253
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1452 0.1449
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0085 0.0158
Entamoeba histolytica acetyltransferase, GNAT family 0.0118 0.1131 0.439
Brugia malayi MH2 domain containing protein 0.0377 0.3865 0.4406
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0481 0.2792
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0171 0.0168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.2396 0.2858
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0543 0.0619
Schistosoma mansoni smad 0.0011 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0061 0.032
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0481 0.048
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0016 0.0013
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0042
Leishmania major hypothetical protein, conserved 0.0148 0.1452 0.8507
Onchocerca volvulus 0.0017 0.0061 0.0058
Schistosoma mansoni carbon catabolite repressor protein 0.0011 0.0007 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.178 0.1777
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0946 0.0942
Schistosoma mansoni Smad4 0.0026 0.0158 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Schistosoma mansoni kinase 0.0051 0.0425 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Giardia lamblia Histone acetyltransferase GCN5 0.0118 0.1131 0.6613
Entamoeba histolytica hypothetical protein 0.0254 0.2576 1
Schistosoma mansoni hypothetical protein 0.0144 0.1408 0.2606
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.8382 1
Treponema pallidum NADH oxidase 0.0017 0.0063 0.1181
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0011 0.0007 0.0041
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0011 0.0007 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0237 0.2396 0.2731
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0027
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0063 0.0369
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0481 0.0892
Schistosoma mansoni hypothetical protein 0.0311 0.3174 0.5881
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0145 0.0851
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0158 0.018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0063 0.0072
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0841 0.8772 1
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0011 0.0007 0.0006
Plasmodium vivax exodeoxyribonuclease III, putative 0.0011 0.0007 0.0041
Plasmodium falciparum glutathione reductase 0.0017 0.0063 0.0369
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Leishmania major cathepsin L-like protease 0.0063 0.0551 0.3204
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0085 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1683 0.168
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0011 0.0007 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0283 0.0524
Trypanosoma brucei unspecified product 0.0019 0.0085 0.0501
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2625 0.2622
Echinococcus granulosus smad 0.0026 0.0158 0.0293
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.1452 0.1656
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0551 0.3204
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2625 0.2622
Trichomonas vaginalis bromodomain-containing protein, putative 0.0128 0.1244 0.1241
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0061 0.0073
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0061 0.036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0144 0.1408 0.168
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0007 0.0008
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0027
Echinococcus multilocularis Smad4 0.0026 0.0158 0.0189
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.1452 0.1463
Onchocerca volvulus Huntingtin homolog 0.0123 0.1186 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0061 0.0058
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0063 0.0369
Echinococcus granulosus histone acetyltransferase KAT2B 0.0128 0.1244 0.2305
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0145 0.0165
Trypanosoma brucei unspecified product 0.0013 0.0024 0.014
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0007 0.0041
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0007 0.0003
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0008 0.001
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0121 0.1161 0.1386
Plasmodium vivax pyruvate kinase 2, putative 0.0088 0.0821 0.481
Echinococcus granulosus Smad4 0.0026 0.0158 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1452 0.8507
Brugia malayi pyruvate kinase 0.0036 0.027 0.0308
Brugia malayi MH2 domain containing protein 0.0026 0.0158 0.018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0063 0.0369
Loa Loa (eye worm) ctsf protein 0.0017 0.0061 0.007
Loa Loa (eye worm) acetyltransferase 0.0437 0.4501 0.5131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0061 0.036
Loa Loa (eye worm) cysteine protease 0.0017 0.0061 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.2396 0.444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Echinococcus multilocularis geminin 0.0521 0.5395 0.6436
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0085 0.0501
Loa Loa (eye worm) hypothetical protein 0.0179 0.1778 0.2027
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.032
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0145 0.0851
Leishmania major cathepsin L-like protease 0.0063 0.0551 0.3204
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0016 0.0013
Schistosoma mansoni importin beta-1 0.0033 0.0238 0.0434
Onchocerca volvulus Alhambra homolog 0.0031 0.0214 0.021
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.2396 0.2858
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0543 0.1001
Echinococcus multilocularis pyruvate kinase 0.0136 0.1323 0.1578
Echinococcus granulosus cathepsin l1 0.0017 0.0061 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0061 0.0238
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0007 0.0013
Chlamydia trachomatis pyruvate kinase 0.0172 0.1706 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0481 0.2822
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0061 0.0107
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.007
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0052 0.0437 0.0499
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0128 0.1244 0.7289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Echinococcus multilocularis dna polymerase eta 0.0019 0.0085 0.0102
Echinococcus granulosus dna polymerase kappa 0.0019 0.0085 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Loa Loa (eye worm) hypothetical protein 0.0121 0.1161 0.1324
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0063 0.0369
Leishmania major trypanothione reductase 0.0048 0.0395 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Trypanosoma brucei RNA editing exonuclease 2 0.0011 0.0007 0.0041
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0011 0.0007 0.0027
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0437 0.4501 0.5369
Schistosoma mansoni smad1 5 8 and 0.0026 0.0158 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0063 0.033
Loa Loa (eye worm) fibroinase 0.0017 0.0061 0.007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Brugia malayi beta-lactamase family protein 0.0148 0.1452 0.1656
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0061 0.0073
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.1452 0.1463
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0481 0.2822
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0946 0.5525
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0437 0.4501 0.8341
Loa Loa (eye worm) hypothetical protein 0.012 0.1156 0.1317
Onchocerca volvulus Putative neutral sphingomyelinase 0.0011 0.0007 0.0003
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0007 0.0008
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0008 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0061 0.0058
Leishmania major DNA polymerase kappa, putative 0.0019 0.0085 0.0462
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0145 0.0813
Mycobacterium leprae conserved hypothetical protein 0.0148 0.1452 0.6157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0063 0.033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.1452 0.1463
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0481 0.0574
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0085 0.0501
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0063 0.0057
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0.0007 0.0041
Plasmodium falciparum glutathione reductase 0.0048 0.0395 0.2315
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1452 0.1449
Trypanosoma brucei pyruvate kinase 1 0.0172 0.1706 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1046 0.1051
Loa Loa (eye worm) hypothetical protein 0.0148 0.1452 0.1656
Trypanosoma brucei polo-like protein kinase 0.01 0.0946 0.5543
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0145 0.0269
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0395 0.2283
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Trypanosoma brucei trypanothione reductase 0.0048 0.0395 0.2315
Schistosoma mansoni Smad4 0.0011 0.0008 0.0008
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0008 0.0015
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0354 0.3632 0.414
Loa Loa (eye worm) pyruvate kinase-PB 0.012 0.1156 0.1317
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0145 0.0813
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0085 0.0102
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.0946 0.1128
Loa Loa (eye worm) hypothetical protein 0.0148 0.1452 0.1656
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0158 0.0293
Loa Loa (eye worm) hypothetical protein 0.0123 0.1186 0.1352
Echinococcus granulosus pyruvate kinase 0.0172 0.1706 0.3163
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0369
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.1175 0.1958
Echinococcus multilocularis GPCR, family 2 0.0144 0.1408 0.168
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.1161 0.1386
Toxoplasma gondii ABC1 family protein 0.0148 0.1452 0.8513
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0007 0.0003
Trypanosoma brucei unspecified product 0.0013 0.0024 0.014
Mycobacterium leprae Probable lipase LipE 0.0148 0.1452 0.6157
Schistosoma mansoni hypothetical protein 0.0354 0.3632 0.6729
Loa Loa (eye worm) hypothetical protein 0.0053 0.0447 0.051
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0238 0.1393
Loa Loa (eye worm) RNA binding protein 0.0062 0.0543 0.0619
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0238 0.1393
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0543 0.1001
Onchocerca volvulus Pyruvate kinase homolog 0.0172 0.1706 0.1703
Brugia malayi pyruvate kinase, muscle isozyme 0.0036 0.027 0.0308
Echinococcus granulosus pyruvate kinase 0.0088 0.0821 0.1521
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1452 0.1449
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.2625 0.2992
Loa Loa (eye worm) beta-lactamase 0.0148 0.1452 0.1656
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2625 0.2622
Plasmodium vivax SET domain protein, putative 0.0121 0.1161 0.6807
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0481 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0481 0.2792
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0097
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0027
Echinococcus multilocularis cysteine protease 0.0017 0.0061 0.0073
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1046 0.1051
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0008 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0486 0.5026 0.9316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0085 0.0462
Schistosoma mansoni smad1 5 8 and 0.0026 0.0158 0.0286
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0171 0.0168
Trichomonas vaginalis pyruvate kinase, putative 0.0172 0.1706 0.1703
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0041 0.0046
Onchocerca volvulus Huntingtin homolog 0.0123 0.1186 0.1182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2396 0.4437
Trichomonas vaginalis Phospholipase C precursor, putative 0.0011 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Leishmania major pyruvate kinase 0.0172 0.1706 1
Schistosoma mansoni ap endonuclease 0.0056 0.0481 0.0886
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0148 0.1452 0.1656
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0061 0.0114
Schistosoma mansoni pyruvate kinase 0.0172 0.1706 0.3158
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0007 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0494 0.2864
Plasmodium vivax hypothetical protein, conserved 0.0148 0.1452 0.8513
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.0946 0.1078
Brugia malayi CCR4 0.0011 0.0007 0.0008
Brugia malayi MH1 domain containing protein 0.0014 0.0037 0.0042
Brugia malayi beta-lactamase family protein 0.0148 0.1452 0.1656
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.0946 0.5525
Schistosoma mansoni nocturnin 0.0011 0.0007 0.0006
Mycobacterium tuberculosis Conserved protein 0.0148 0.1452 0.1463
Echinococcus multilocularis pyruvate kinase 0.0172 0.1706 0.2036
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0214 0.0396
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0007 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0455 0.4696 0.5353
Brugia malayi MH2 domain containing protein 0.0026 0.0158 0.018
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0011 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.014
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0158 0.0286
Trypanosoma brucei pyruvate kinase 1, putative 0.0172 0.1706 1
Entamoeba histolytica hypothetical protein 0.0254 0.2576 1
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.032
Mycobacterium tuberculosis Probable reductase 0.011 0.1046 0.1051
Brugia malayi Pyruvate kinase, M2 isozyme 0.0172 0.1706 0.1945
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0947 0.9889 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0085 0.0501
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0004 0.0004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0063 0.011
Schistosoma mansoni ran 0.0024 0.0145 0.0262
Plasmodium vivax vivapain-2 0.0017 0.0061 0.036
Onchocerca volvulus 0.0017 0.0061 0.0058
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0171 0.0968
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0481 0.2792
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0085 0.0097
Leishmania major pyruvate kinase 0.0172 0.1706 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.1115 0.2066
Entamoeba histolytica cysteine protease, putative 0.0017 0.0061 0.0238
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0007 0.0027
Brugia malayi beta-lactamase 0.0148 0.1452 0.1656
Echinococcus granulosus histone acetyltransferase KAT2B 0.0424 0.4371 0.8102
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0007 0.0027
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0409 0.2367
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0007 0.0008
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0008 0.0015
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0145 0.0851
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.007
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.0946 0.1753
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0462
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0015 0.0047 0.0275
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0145 0.0173
Schistosoma mansoni hypothetical protein 0.0031 0.0214 0.039
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.007
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1778 0.1775
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0063 0.033
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0007 0.0008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0957 0.1142
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.014
Onchocerca volvulus 0.0017 0.0061 0.0058
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0158 0.0189
Echinococcus multilocularis pyruvate kinase 0.0088 0.0821 0.0979
Trichomonas vaginalis esterase, putative 0.0148 0.1452 0.1449
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.1452 0.1463
Entamoeba histolytica pyruvate kinase, putative 0.012 0.1156 0.4487
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0063 0.0059
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0063 0.0369
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0214 0.0255
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0481 0.2546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Onchocerca volvulus Pyruvate kinase homolog 0.0172 0.1706 0.1703
Loa Loa (eye worm) pyruvate kinase 0.0172 0.1706 0.1945
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0117
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0238 0.0284
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2625 0.2622
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0214 0.0244
Entamoeba histolytica hypothetical protein 0.0027 0.0171 0.0665
Brugia malayi glutathione reductase 0.0048 0.0395 0.045
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0158 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0283 0.0517
Onchocerca volvulus 0.0148 0.1452 0.1449
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0063 0.033
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0061 0.032
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0011 0.0007 0.0041
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0061 0.0114
Toxoplasma gondii thioredoxin reductase 0.0048 0.0395 0.2315
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.1175 0.1182
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2625 0.2622
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0011 0.0007 0.0041
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.0946 0.5525
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0061 0.007
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0214 0.1253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0041 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0551 0.3204
Leishmania major cathepsin L-like protease 0.0063 0.0551 0.3204
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0011 0.0007 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Plasmodium vivax pyruvate kinase, putative 0.0172 0.1706 1
Leishmania major GTP-binding protein, putative 0.0024 0.0145 0.0813
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0011 0.0007 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0411 0.0408
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0214 0.1253
Echinococcus multilocularis synaptojanin 1 0.0011 0.0007 0.0008
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0008 0.001
Brugia malayi Bromodomain containing protein 0.0042 0.0327 0.0373
Echinococcus granulosus pyruvate kinase 0.0088 0.0821 0.1521
Loa Loa (eye worm) hypothetical protein 0.0172 0.1706 0.1945
Toxoplasma gondii pyruvate kinase PyKII 0.0088 0.0821 0.481
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0.0007 0.0041
Schistosoma mansoni hypothetical protein 0.0144 0.1408 0.2606
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0085 0.0097
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0007 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.1452 0.1463
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0007 0.0008
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0063 0.0369
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0128 0.1244 0.1241
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0455 0.4696 0.5353
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Entamoeba histolytica hypothetical protein 0.0254 0.2576 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0145 0.085
Loa Loa (eye worm) nuclear factor I 0.0014 0.0037 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.1452 0.8513
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0007 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0085 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Plasmodium falciparum phd finger protein, putative 0.0031 0.0214 0.1253
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1046 0.1051
Brugia malayi hypothetical protein 0.0486 0.5026 0.5729
Brugia malayi acetyltransferase, GNAT family protein 0.0437 0.4501 0.5131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Echinococcus granulosus synaptojanin 1 0.0011 0.0007 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Plasmodium vivax glutathione reductase, putative 0.0048 0.0395 0.2315
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0085 0.0462
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1452 0.2687
Onchocerca volvulus 0.0011 0.0007 0.0003
Plasmodium falciparum DNase I-like protein, putative 0.0011 0.0007 0.0041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0171 0.0168
Echinococcus multilocularis peregrin 0.0042 0.0327 0.039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0395 0.0471
Mycobacterium ulcerans pyruvate kinase 0.0172 0.1706 1
Plasmodium falciparum pyruvate kinase 2 0.0088 0.0821 0.481
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0007 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0946 0.0942
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0085 0.0501
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0085 0.0082
Echinococcus granulosus pyruvate kinase 0.0172 0.1706 0.3163
Brugia malayi MH1 domain containing protein 0.0026 0.0158 0.018
Schistosoma mansoni hypothetical protein 0.0254 0.2576 0.4771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1683 0.168
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0027
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0172 0.1706 0.172
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0551 0.3204
Plasmodium falciparum histone acetyltransferase GCN5 0.0118 0.1131 0.6627
Schistosoma mansoni pyruvate kinase 0.0172 0.1706 0.3158
Brugia malayi Latrophilin receptor protein 2 0.0144 0.1408 0.1606
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0085 0.0082
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.0946 0.0942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0481 0.0478
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1683 0.168
Onchocerca volvulus 0.0017 0.0061 0.0058
Schistosoma mansoni neutral sphingomyelinase 0.0011 0.0007 0.0006
Toxoplasma gondii cathepsin CPL 0.0017 0.0061 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.178 0.1777
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0342 0.0633
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0481 0.0549
Brugia malayi Pyruvate kinase, muscle isozyme 0.0172 0.1706 0.1945
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0007 0.0013
Brugia malayi Smad1 0.0026 0.0158 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0543 0.0648
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0085 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0462
Mycobacterium leprae Probable pyruvate kinase PykA 0.0172 0.1706 1
Giardia lamblia Kinase, PLK 0.01 0.0946 0.5525
Mycobacterium ulcerans lipase LipD 0.0148 0.1452 0.8456
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0011 0.0007 0.0003
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0041
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0061 0.0073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0455 0.4696 0.5353
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1683 0.168
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0158 0.0189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Schistosoma mansoni ap endonuclease 0.0056 0.0481 0.0886
Loa Loa (eye worm) latrophilin receptor protein 2 0.0144 0.1408 0.1606
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1452 0.8507
Schistosoma mansoni transcription factor LCR-F1 0.0254 0.2576 0.4771
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0008 0.0009
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0957 0.1774
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0085 0.0079
Schistosoma mansoni hypothetical protein 0.0521 0.5395 1
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0006
Schistosoma mansoni synaptojanin 0.0011 0.0007 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0543 0.1001
Trypanosoma cruzi pyruvate kinase 2, putative 0.0172 0.1706 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0061 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.1161 0.2147
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0946 0.0942
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Trichomonas vaginalis ran, putative 0.0024 0.0145 0.0141
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0144 0.1408 0.1606
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0058
Loa Loa (eye worm) pyruvate kinase 0.0036 0.027 0.0308
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0007 0.0003
Plasmodium falciparum pyruvate kinase 0.0172 0.1706 1
Echinococcus multilocularis cysteine protease 0.0017 0.0061 0.0073
Brugia malayi jmjC domain containing protein 0.0101 0.0957 0.1091
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1452 0.1449
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0254 0.2576 0.4774
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0551 0.3204
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.014
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0946 0.0942
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0008
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0007 0.0008
Echinococcus granulosus snurportin 1 0.0354 0.3632 0.6731
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0011 0.0007 0.0041
Brugia malayi Importin beta-1 subunit 0.0033 0.0238 0.0271
Trypanosoma cruzi pyruvate kinase 2, putative 0.0172 0.1706 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0145 0.0165
Schistosoma mansoni smad 0.0026 0.0158 0.0286
Mycobacterium ulcerans beta-lactamase 0.0148 0.1452 0.8456
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0008 0.0009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0085 0.0332
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0007 0.0008
Onchocerca volvulus 0.0148 0.1452 0.1449
Loa Loa (eye worm) hypothetical protein 0.0123 0.1186 0.1352
Onchocerca volvulus 0.0017 0.0061 0.0058
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.2625 0.2992
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.033
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.1452 0.1463
Echinococcus multilocularis snurportin 1 0.0354 0.3632 0.4332
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0158 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0551 0.3231
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0063 0.033
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0061 0.007
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.1175 0.1182
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0543 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0946 0.0942
Plasmodium falciparum thioredoxin reductase 0.0048 0.0395 0.2315
Echinococcus multilocularis pyruvate kinase 0.0088 0.0821 0.0979
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0016 0.0019
Entamoeba histolytica Ran family GTPase 0.0024 0.0145 0.0563
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1046 0.1051
Trichomonas vaginalis set domain proteins, putative 0.0957 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1452 0.1449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0058
Echinococcus multilocularis pyruvate kinase 0.0088 0.0821 0.0979
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0283 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0562 0.064
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0481 0.1869
Loa Loa (eye worm) hypothetical protein 0.0148 0.1452 0.1656
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0481 0.2822
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.1161 0.6807
Brugia malayi Thioredoxin reductase 0.0048 0.0395 0.045
Plasmodium falciparum importin beta, putative 0.0033 0.0238 0.1393
Giardia lamblia Pyruvate kinase 0.0088 0.0821 0.4789
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0004
Brugia malayi cathepsin L-like precursor 0.0011 0.0004 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0481 1
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.032
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0085 0.0136
Brugia malayi latrophilin 2 splice variant baaae 0.0311 0.3174 0.3618
Brugia malayi MH2 domain containing protein 0.0011 0.0008 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1452 0.2687
Mycobacterium tuberculosis Conserved protein 0.0148 0.1452 0.1463
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0144 0.1408 0.1606
Echinococcus granulosus dna polymerase eta 0.0019 0.0085 0.0158
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0085 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1683 0.168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0237 0.2396 0.2731
Onchocerca volvulus 0.0121 0.1161 0.1158
Loa Loa (eye worm) pyruvate kinase 0.0172 0.1706 0.1945
Schistosoma mansoni hypothetical protein 0.0521 0.5395 1
Brugia malayi Pre-SET motif family protein 0.0121 0.1161 0.1324
Loa Loa (eye worm) hypothetical protein 0.0455 0.4696 0.5353
Echinococcus multilocularis survival motor neuron protein 1 0.0486 0.5026 0.5996
Giardia lamblia DINP protein human, muc B family 0.0019 0.0085 0.0462
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0007 0.0008
Giardia lamblia Pyruvate kinase 0.0172 0.1706 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0144 0.1408 0.168
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0144 0.1408 0.2611
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0063 0.0369
Loa Loa (eye worm) transcription factor SMAD2 0.0377 0.3865 0.4406
Brugia malayi Pre-SET motif family protein 0.0841 0.8772 1
Brugia malayi hypothetical protein 0.0123 0.1186 0.1352
Brugia malayi jmjC domain containing protein 0.0037 0.0283 0.0322
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0061 0.007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0128 0.1244 0.7289
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0061 0.0058
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0075
Loa Loa (eye worm) pyruvate kinase 0.0172 0.1706 0.1945
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0145 0.0813
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0007 0.0041
Schistosoma mansoni ran 0.0024 0.0145 0.0262
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0061 0.0238
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0481 0.0478
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.1175 0.1182
Echinococcus multilocularis pyruvate kinase 0.0172 0.1706 0.2036
Brugia malayi RNA binding protein 0.0062 0.0543 0.0619
Brugia malayi N-terminal motif family protein 0.0179 0.1778 0.2027
Toxoplasma gondii pyruvate kinase PyK1 0.0172 0.1706 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1452 0.1656
Echinococcus granulosus cathepsin l1 0.0011 0.0004 0.0007
Onchocerca volvulus 0.0011 0.0007 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0085 0.0462
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0946 0.0942
Plasmodium falciparum thioredoxin reductase 0.0017 0.0063 0.0369

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.