Detailed information for compound 755286

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.49 | Formula: C22H30FN3O3
  • H donors: 0 H acceptors: 2 LogP: 3.03 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)C1CCCN(C1)Cc1nc(oc1C)c1ccc(cc1F)OC)CC
  • InChi: 1S/C22H30FN3O3/c1-5-26(6-2)22(27)16-8-7-11-25(13-16)14-20-15(3)29-21(24-20)18-10-9-17(28-4)12-19(18)23/h9-10,12,16H,5-8,11,13-14H2,1-4H3
  • InChiKey: RGLTXRFAEREOPN-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1854 0.2686
Brugia malayi pyruvate kinase, muscle isozyme 0.0029 0.0184 0.0275
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0368 0.1112
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0028 0.008
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0385 0.0574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0001 0.0001
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0028 0.004
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0028 0.002
Trypanosoma brucei trypanothione reductase 0.0048 0.0385 0.1113
Trypanosoma brucei unspecified product 0.0014 0.0035 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1854 0.229
Leishmania major cathepsin L-like protease 0.0062 0.0535 0.1548
Mycobacterium leprae Probable lipase LipE 0.0152 0.147 1
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0057 0.0074
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0016 0.0021
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0057 0.0082
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1023 0.1016
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0001 0.0001
Schistosoma mansoni pyruvate kinase 0.0136 0.13 0.1883
Loa Loa (eye worm) glutaminase 0.0274 0.2745 0.4096
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.6904 0.8528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0869 0.1259
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0028 0.0041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0368 0.2357
Brugia malayi hypothetical protein 0.012 0.114 0.1701
Loa Loa (eye worm) hypothetical protein 0.012 0.114 0.1701
Entamoeba histolytica hypothetical protein 0.0328 0.3305 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Echinococcus granulosus histone acetyltransferase KAT2B 0.0131 0.1248 0.1808
Brugia malayi Cathepsin L-like precursor 0.0016 0.0057 0.0085
Trichomonas vaginalis pyruvate kinase, putative 0.0136 0.13 0.1702
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.2529 0.3774
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0869 0.1259
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0028 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0226 0.0218
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0059 0.0171
Schistosoma mansoni hypothetical protein 0.0356 0.3592 0.5203
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1135 0.1694
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0028 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0226 0.0218
Mycobacterium ulcerans esterase/lipase LipP 0.0152 0.147 0.5306
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0152 0.147 0.2193
Echinococcus granulosus pyruvate kinase 0.007 0.0612 0.0887
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0001 0.0002
Plasmodium vivax pyruvate kinase 2, putative 0.007 0.0612 0.4166
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2529 0.331
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.147 0.1923
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0059 0.0088
Onchocerca volvulus 0.0014 0.0028 0.0036
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0535 0.1548
Schistosoma mansoni pyruvate kinase 0.0136 0.13 0.1883
Brugia malayi cathepsin L-like precursor 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0368 0.0549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0025
Schistosoma mansoni bromodomain containing protein 0.0012 0.0017 0.0024
Trypanosoma brucei AAA ATPase, putative 0.0011 0.00000028146 0.00000081403
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0059 0.0171
Loa Loa (eye worm) pyruvate kinase 0.0136 0.13 0.194
Echinococcus granulosus pyruvate kinase 0.0136 0.13 0.1883
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0101 0.0125
Plasmodium falciparum pyruvate kinase 2 0.007 0.0612 0.4708
Echinococcus granulosus cpg binding protein 0.003 0.0194 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0368 0.0549
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0013 0.0019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0286 0.0827
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0368 0.1251
Plasmodium falciparum thioredoxin reductase 0.0048 0.0385 0.2959
Echinococcus multilocularis pyruvate kinase 0.007 0.0612 0.0756
Onchocerca volvulus 0.0152 0.147 0.1923
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0286 0.0827
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0057 0.0164
Schistosoma mansoni hypothetical protein 0.0328 0.3305 0.4787
Loa Loa (eye worm) hypothetical protein 0.0046 0.0368 0.0549
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0012 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0152 0.147 0.2193
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0385 0.1113
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0028 0.0036
Brugia malayi Cathepsin L-like precursor 0.0011 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0016 0.0057 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Mycobacterium ulcerans pyruvate kinase 0.0136 0.13 0.4683
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0171
Brugia malayi acetyltransferase, GNAT family protein 0.0444 0.4518 0.6742
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0286 0.0827
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0479 0.1385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Trypanosoma brucei pyruvate kinase 1 0.0136 0.13 0.3761
Loa Loa (eye worm) pyruvate kinase-PB 0.0095 0.0873 0.1302
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0286 0.0427
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Echinococcus granulosus geminin 0.0356 0.3592 0.5203
Toxoplasma gondii pyruvate kinase PyKII 0.007 0.0612 0.4166
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0563 0.0816
Loa Loa (eye worm) hypothetical protein 0.0046 0.0368 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0057 0.0074
Echinococcus multilocularis pyruvate kinase 0.0136 0.13 0.1606
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1023 0.1016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0028 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1135 0.1694
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0101 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0869 0.1259
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.1854 0.2767
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0035 0.01
Trypanosoma brucei unspecified product 0.0021 0.0101 0.0293
Loa Loa (eye worm) ctsf protein 0.0016 0.0057 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0057 0.0082
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0028 0.002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0115
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.1854 0.2767
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0171
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0563 0.0816
Schistosoma mansoni zinc finger protein 0.0012 0.0017 0.0024
Echinococcus multilocularis cpg binding protein 0.003 0.0194 0.024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0028 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.147 0.425
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0286 0.0278
Brugia malayi Pyruvate kinase, muscle isozyme 0.0136 0.13 0.194
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0086
Mycobacterium ulcerans hypothetical protein 0.0046 0.0368 0.1251
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.115 0.1143
Chlamydia trachomatis pyruvate kinase 0.0136 0.13 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0286 0.22
Plasmodium falciparum pyruvate kinase 0.0136 0.13 1
Echinococcus multilocularis pyruvate kinase 0.0136 0.13 0.1606
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0367
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0654 0.6701 1
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0028 0.008
Loa Loa (eye worm) hypothetical protein 0.0152 0.147 0.2193
Brugia malayi Cathepsin L-like precursor 0.0016 0.0057 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0368 0.0549
Echinococcus granulosus cathepsin l1 0.0016 0.0057 0.0082
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0396 0.1147
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0535 0.1548
Mycobacterium ulcerans glutaminase 0.0274 0.2745 1
Loa Loa (eye worm) pyruvate kinase 0.0029 0.0184 0.0275
Brugia malayi glutaminase DH11.1 0.0274 0.2745 0.4096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0827 0.1198
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.162 0.2121
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.147 0.1923
Schistosoma mansoni pyruvate kinase 0.007 0.0612 0.0887
Echinococcus granulosus tar DNA binding protein 0.0065 0.0563 0.0816
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0059 0.0455
Echinococcus multilocularis cysteine protease 0.0016 0.0057 0.007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0152 0.147 0.1463
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0101 0.0293
Schistosoma mansoni hypothetical protein 0.0129 0.1236 0.1791
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1714 0.2243
Giardia lamblia Histone acetyltransferase GCN5 0.012 0.1135 0.8728
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0129 0.1236 0.1791
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0131 0.1248 0.8496
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0389 0.1124
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0028 0.0189
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.147 0.1923
Mycobacterium tuberculosis Conserved protein 0.0152 0.147 0.1463
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0368 0.1112
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.3458 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0246 0.1674
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0588 0.4
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.147 0.425
Echinococcus multilocularis beta LACTamase domain containing family member 0.0152 0.147 0.1815
Brugia malayi hypothetical protein 0.0328 0.3305 0.4933
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0328 0.3305 0.4083
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0367
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0385 0.0377
Schistosoma mansoni ap endonuclease 0.0038 0.0286 0.0414
Brugia malayi hypothetical protein 0.0159 0.154 0.2299
Leishmania major cathepsin L-like protease 0.0062 0.0535 0.1548
Onchocerca volvulus Pyruvate kinase homolog 0.0136 0.13 0.1702
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0286 0.22
Loa Loa (eye worm) hypothetical protein 0.0152 0.147 0.2193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.147 0.2128
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0385 0.0557
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0059 0.0403
Plasmodium falciparum bromodomain protein 1 0.0011 0.000000040903 0.00000031455
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0057 0.007
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0368 0.0549
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0101 0.0093
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0013 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0368 0.1063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1023 0.6903
Leishmania major pyruvate kinase 0.0136 0.13 0.3761
Loa Loa (eye worm) hypothetical protein 0.0094 0.0869 0.1297
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0101 0.0293
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0059 0.0403
Echinococcus multilocularis pyruvate kinase 0.007 0.0612 0.0756
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000028146 0.00000042002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0025
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0343 0.3458 1
Onchocerca volvulus Huntingtin homolog 0.012 0.114 0.1492
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.054 0.0783
Loa Loa (eye worm) oxidoreductase 0.0014 0.0028 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0409 0.4152 0.6197
Leishmania major cathepsin L-like protease 0.0016 0.0057 0.0164
Brugia malayi Pyruvate kinase, M2 isozyme 0.0136 0.13 0.194
Brugia malayi beta-lactamase family protein 0.0152 0.147 0.2193
Brugia malayi Cathepsin L-like precursor 0.0016 0.0057 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0057 0.0172
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0869 0.5916
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0385 0.2618
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0028 0.0041
Loa Loa (eye worm) pyruvate kinase 0.0136 0.13 0.194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Onchocerca volvulus 0.0014 0.0028 0.0036
Onchocerca volvulus Huntingtin homolog 0.012 0.114 0.1492
Loa Loa (eye worm) hypothetical protein 0.0409 0.4152 0.6197
Entamoeba histolytica ankyrin repeat protein, putative 0.0011 0.000000040903 0.00000012375
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0101 0.0151
Echinococcus multilocularis zinc finger protein 0.0012 0.0017 0.0021
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0057 0.0085
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0059 0.0171
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0028 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1854 0.2686
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0368 0.1251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0368 0.1251
Onchocerca volvulus 0.0016 0.0057 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0129 0.1236 0.1791
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0059 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0368 0.1251
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.115 0.1143
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0057 0.007
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0059 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1854 0.2686
Brugia malayi hypothetical protein 0.0476 0.4844 0.7228
Loa Loa (eye worm) RNA binding protein 0.0065 0.0563 0.084
Onchocerca volvulus 0.0016 0.0057 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Schistosoma mansoni cpg binding protein 0.003 0.0194 0.0282
Brugia malayi Bromodomain containing protein 0.0012 0.0017 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2529 0.331
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0035 0.01
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0246 0.0238
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0131 0.1248 0.8496
Toxoplasma gondii cathepsin CPL 0.0016 0.0057 0.0387
Onchocerca volvulus 0.0016 0.0057 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0226 0.0218
Toxoplasma gondii hypothetical protein 0.0055 0.0463 0.3147
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0131 0.1248 0.8496
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0101 0.0147
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0028 0.008
Plasmodium vivax vivapain-2 0.0016 0.0057 0.0387
Onchocerca volvulus 0.0014 0.0028 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0563 0.0816
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0101 0.0125
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0136 0.13 0.1293
Brugia malayi Cathepsin L-like precursor 0.0011 0.0001 0.0001
Echinococcus granulosus GPCR family 2 0.0129 0.1236 0.1791
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Toxoplasma gondii exonuclease III APE 0.0038 0.0286 0.1947
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0057 0.0082
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0057 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2529 0.331
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0028 0.0041
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0028 0.0214
Giardia lamblia DINP protein human, muc B family 0.0021 0.0101 0.078
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0057 0.0437
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0409 0.4152 0.6197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Loa Loa (eye worm) hypothetical protein 0.0152 0.147 0.2193
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0286 0.0951
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Entamoeba histolytica cysteine protease, putative 0.0016 0.0057 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0535 0.1548
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0059 0.0115
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0101 0.0271
Echinococcus granulosus pyruvate kinase 0.0136 0.13 0.1883
Brugia malayi latrophilin 2 splice variant baaae 0.028 0.2803 0.4182
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0563 0.084
Entamoeba histolytica hypothetical protein 0.0328 0.3305 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0131 0.1248 0.1634
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0101 0.0293
Schistosoma mansoni hypothetical protein 0.0129 0.1236 0.1791
Leishmania major cathepsin L-like protease 0.0016 0.0057 0.0164
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0057 0.007
Schistosoma mansoni hypothetical protein 0.0129 0.1236 0.1791
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0057 0.0074
Trypanosoma brucei pyruvate kinase 1, putative 0.0136 0.13 0.3761
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Schistosoma mansoni transcription factor LCR-F1 0.0328 0.3305 0.4787
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2529 0.331
Brugia malayi Cathepsin L-like precursor 0.0016 0.0057 0.0085
Leishmania major trypanothione reductase 0.0048 0.0385 0.1113
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis dna polymerase eta 0.0021 0.0101 0.0125
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0028 0.002
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.6904 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0012 0.0017 0.0021
Onchocerca volvulus 0.0016 0.0057 0.0074
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0059 0.0171
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0152 0.147 0.1923
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.162 0.2121
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0001 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0563 0.084
Loa Loa (eye worm) pyruvate kinase 0.0136 0.13 0.194
Loa Loa (eye worm) hypothetical protein 0.028 0.2803 0.4182
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0101 0.0293
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0028 0.008
Schistosoma mansoni hypothetical protein 0.0129 0.1236 0.1791
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0444 0.4518 0.558
Mycobacterium leprae Probable pyruvate kinase PykA 0.0136 0.13 0.8827
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0086
Echinococcus multilocularis pyruvate kinase 0.0107 0.1002 0.1238
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.4844 0.7015
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0028 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0409 0.4152 0.6197
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0059 0.0115
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0367
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0057 0.0082
Schistosoma mansoni cpg binding protein 0.003 0.0194 0.0282
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0028 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0028 0.004
Leishmania major cathepsin L-like protease 0.0062 0.0535 0.1548
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0368 0.036
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0246 0.1506
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0563 0.0695
Toxoplasma gondii ABC1 family protein 0.0152 0.147 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0101 0.0293
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0286 0.0827
Echinococcus granulosus pyruvate kinase 0.007 0.0612 0.0887
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0368 0.1251
Entamoeba histolytica hypothetical protein 0.0328 0.3305 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Brugia malayi pyruvate kinase 0.0029 0.0184 0.0275
Mycobacterium tuberculosis Probable esterase LipL 0.0152 0.147 0.1463
Loa Loa (eye worm) hypothetical protein 0.0014 0.0028 0.0041
Echinococcus granulosus dna polymerase kappa 0.0021 0.0101 0.0147
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0286 0.0353
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0368 0.1112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000040903 0.00000027835
Brugia malayi Latrophilin receptor protein 2 0.0129 0.1236 0.1845
Schistosoma mansoni hypothetical protein 0.028 0.2803 0.4059
Echinococcus granulosus zinc finger protein 0.0012 0.0017 0.0024
Echinococcus multilocularis pyruvate kinase 0.007 0.0612 0.0756
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0057 0.0164
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0563 0.084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0101 0.0093
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0028 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1854 0.2686
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0028 0.008
Schistosoma mansoni hypothetical protein 0.0097 0.0898 0.13
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0057 0.0085
Trichomonas vaginalis pyruvate kinase, putative 0.0136 0.13 0.1702
Mycobacterium tuberculosis Probable lipase LipD 0.0152 0.147 0.1463
Loa Loa (eye worm) hypothetical protein 0.012 0.114 0.1701
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0226 0.0218
Leishmania major cathepsin L-like protease 0.0016 0.0057 0.0164
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0368 0.1251
Mycobacterium tuberculosis Probable lipase LipE 0.0152 0.147 0.1463
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.162 0.2121
Plasmodium vivax vivapain-2 0.0016 0.0057 0.0387
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0286 0.1947
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0057 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.162 0.2121
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0059 0.0171
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0368 0.2357
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0057 0.0437
Mycobacterium leprae conserved hypothetical protein 0.0152 0.147 1
Schistosoma mansoni hypothetical protein 0.0356 0.3592 0.5203
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1023 0.1016
Leishmania major DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0028 0.002
Giardia lamblia Pyruvate kinase 0.007 0.0612 0.4708
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Onchocerca volvulus 0.0046 0.0368 0.0481
Brugia malayi PHD-finger family protein 0.0012 0.0017 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0035 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0028 0.0189
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0246 0.0803
Echinococcus granulosus histone acetyltransferase KAT2B 0.0432 0.4388 0.6355
Schistosoma mansoni cpg binding protein 0.0028 0.0178 0.0258
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.1577 0.456
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0246 0.1892
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0101 0.0133
Mycobacterium tuberculosis Conserved hypothetical protein 0.018 0.1768 0.1761
Trichomonas vaginalis glutaminase, putative 0.0274 0.2745 0.3592
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0028 0.0041
Trichomonas vaginalis set domain proteins, putative 0.0744 0.7642 1
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0057 0.0172
Mycobacterium ulcerans beta-lactamase 0.0152 0.147 0.5306
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0898 0.134
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0011 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0028 0.008
Plasmodium vivax SET domain containing protein 0.0015 0.0042 0.0288
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0085
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0178 0.0265
Plasmodium falciparum thioredoxin reductase 0.0017 0.0059 0.0455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0129 0.1236 0.1527
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2529 0.331
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1577 0.456
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0389 0.1124
Onchocerca volvulus 0.0016 0.0057 0.0074
Loa Loa (eye worm) cysteine protease 0.0016 0.0057 0.0085
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.147 0.1923
Leishmania major hypothetical protein, conserved 0.0152 0.147 0.425
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0152 0.147 0.5306
Plasmodium falciparum glutathione reductase 0.0017 0.0059 0.0455
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0385 0.0475
Trypanosoma brucei unspecified product 0.0014 0.0035 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.147 0.2128
Plasmodium vivax SET domain protein, putative 0.0094 0.0869 0.5916
Toxoplasma gondii bromodomain-containing protein 0.0011 0.000000040903 0.00000027835
Loa Loa (eye worm) hypothetical protein 0.0152 0.147 0.2193
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0869 0.1074
Schistosoma mansoni bromodomain containing protein 0.0012 0.0017 0.0024
Loa Loa (eye worm) glutathione reductase 0.0048 0.0385 0.0574
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Plasmodium falciparum histone acetyltransferase GCN5 0.012 0.1135 0.8728
Plasmodium vivax glutathione reductase, putative 0.0048 0.0385 0.2618
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0057 0.007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1023 0.1016
Schistosoma mansoni DNA polymerase eta 0.0021 0.0101 0.0147
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.4844 0.5982
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0028 0.002
Brugia malayi CXXC zinc finger family protein 0.0028 0.0178 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1714 0.2243
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0028 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Mycobacterium ulcerans hypothetical protein 0.0152 0.147 0.5306
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0101 0.0293
Echinococcus granulosus cathepsin l1 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0744 0.7642 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0129 0.1236 0.1845
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0286 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0129 0.1236 0.1527
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0057 0.0437
Leishmania major DNA polymerase eta, putative 0.0021 0.0101 0.0293
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0028 0.008
Echinococcus multilocularis GPCR, family 2 0.0129 0.1236 0.1527
Brugia malayi Thioredoxin reductase 0.0048 0.0385 0.0574
Onchocerca volvulus 0.0159 0.154 0.2016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1854 0.229
Loa Loa (eye worm) hypothetical protein 0.0159 0.154 0.2299
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0499 0.1442
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0152 0.147 0.2193
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0059 0.0403
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0869 0.1259
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0028 0.0034
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0013 0.0016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0059 0.0171
Trypanosoma cruzi pyruvate kinase 2, putative 0.0136 0.13 0.3761
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.147 0.425
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0059 0.0455
Entamoeba histolytica acetyltransferase, GNAT family 0.012 0.1135 0.3434
Loa Loa (eye worm) acetyltransferase 0.0444 0.4518 0.6742
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.2529 0.3774
Brugia malayi MH2 domain containing protein 0.012 0.1135 0.1694
Echinococcus granulosus microtubule associated protein 2 0.0673 0.6904 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.162 0.2121
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0057 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Trypanosoma cruzi pyruvate kinase 2, putative 0.0136 0.13 0.3761
Echinococcus multilocularis geminin 0.0356 0.3592 0.4437
Brugia malayi Cathepsin L-like precursor 0.0016 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0476 0.4844 0.7228
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.162 0.2121
Loa Loa (eye worm) hypothetical protein 0.0136 0.13 0.194
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1023 0.1016
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.8096 1
Brugia malayi beta-lactamase 0.0152 0.147 0.2193
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0028 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0563 0.0816
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0286 0.0427
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0041 0.0314 0.0469
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0563 0.0816
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0028 0.002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0389 0.1124
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.115 0.7782
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0368 0.1063
Brugia malayi RNA binding protein 0.0065 0.0563 0.084
Plasmodium falciparum glutathione reductase 0.0048 0.0385 0.2959
Onchocerca volvulus Pyruvate kinase homolog 0.0136 0.13 0.1702
Brugia malayi TAR-binding protein 0.0065 0.0563 0.084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0286 0.0414
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0059 0.0077
Leishmania major cathepsin L-like protease 0.0016 0.0057 0.0164
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0328 0.3305 0.4787
Echinococcus granulosus beta LACTamase domain containing family member 0.0152 0.147 0.2128
Mycobacterium tuberculosis Conserved protein 0.0152 0.147 0.1463
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0368 0.1063
Plasmodium vivax pyruvate kinase, putative 0.0136 0.13 0.8849
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.162 0.2121
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0101 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0101 0.0271
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0012 0.0017 0.0024
Trichomonas vaginalis esterase, putative 0.0152 0.147 0.1923
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0028 0.002
Mycobacterium tuberculosis Probable hydrolase 0.0152 0.147 0.1463
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0129 0.1236 0.1845
Echinococcus multilocularis cysteine protease 0.0016 0.0057 0.007
Entamoeba histolytica hypothetical protein 0.0328 0.3305 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Onchocerca volvulus 0.0094 0.0869 0.1138
Leishmania major mitochondrial DNA polymerase beta 0.0343 0.3458 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0057 0.0074
Loa Loa (eye worm) hypothetical protein 0.0129 0.1236 0.1845
Loa Loa (eye worm) hypothetical protein 0.0095 0.0873 0.1302
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0013 0.002
Echinococcus granulosus dna polymerase eta 0.0021 0.0101 0.0147
Onchocerca volvulus 0.0014 0.0028 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.162 0.2121
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0028 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.115 0.1143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0286 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0152 0.147 0.1463
Leishmania major pyruvate kinase 0.0136 0.13 0.3761
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0028 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0869 0.1259
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0028 0.0084
Leishmania major cathepsin L-like protease 0.0016 0.0057 0.0164
Schistosoma mansoni survival motor neuron protein 0.0097 0.0898 0.13
Brugia malayi beta-lactamase family protein 0.0152 0.147 0.2193
Schistosoma mansoni glutaminase 0.0274 0.2745 0.3976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Schistosoma mansoni ap endonuclease 0.0038 0.0286 0.0414
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.3458 1
Entamoeba histolytica pyruvate kinase, putative 0.0095 0.0873 0.264
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0389 0.1124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0152 0.147 0.1463
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0101 0.0151
Onchocerca volvulus 0.0016 0.0057 0.0074
Toxoplasma gondii pyruvate kinase PyK1 0.0136 0.13 0.8849
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0444 0.4518 0.6543
Loa Loa (eye worm) fibroinase 0.0016 0.0057 0.0085
Onchocerca volvulus 0.0152 0.147 0.1923
Onchocerca volvulus 0.0097 0.0898 0.1175
Toxoplasma gondii thioredoxin reductase 0.0048 0.0385 0.2618
Trichomonas vaginalis bromodomain-containing protein, putative 0.0131 0.1248 0.1634
Giardia lamblia Pyruvate kinase 0.0136 0.13 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2529 0.331
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0535 0.1548
Brugia malayi Pre-SET motif family protein 0.0654 0.6701 1
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0059 0.0077
Mycobacterium tuberculosis Conserved protein 0.0152 0.147 0.1463
Onchocerca volvulus Pyruvate kinase homolog 0.0136 0.13 0.1702
Mycobacterium tuberculosis Probable reductase 0.0109 0.1023 0.1016
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0011 0.00000028146 0.00000034763
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0101 0.0147
Brugia malayi Pre-SET motif family protein 0.0094 0.0869 0.1297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.147 0.1923
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0368 0.1251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Brugia malayi glutathione reductase 0.0048 0.0385 0.0574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0057 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1854 0.2686
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0286 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1577 0.456
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0028 0.008
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0101 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0013 0.002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0073
Onchocerca volvulus 0.0016 0.0057 0.0074
Loa Loa (eye worm) beta-lactamase 0.0152 0.147 0.2193
Brugia malayi ATPase, AAA family protein 0.0011 0.00000028146 0.00000042002
Onchocerca volvulus 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0028 0.0178 0.0233
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0286 0.0866
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0286 0.0374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0101 0.0293
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0059 0.0455
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0059 0.0403
Loa Loa (eye worm) hypothetical protein 0.0152 0.147 0.2193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0368 0.036
Echinococcus granulosus pyruvate kinase 0.007 0.0612 0.0887
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0011 0.00000028146 0.00000040765
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0869 0.1074
Mycobacterium ulcerans lipase LipD 0.0152 0.147 0.5306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Mycobacterium ulcerans hypothetical protein 0.018 0.1768 0.6402
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0101 0.0133
Loa Loa (eye worm) glutaminase 2 0.0274 0.2745 0.4096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0535 0.1548
Plasmodium vivax hypothetical protein, conserved 0.0152 0.147 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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