Detailed information for compound 755360

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 390.559 | Formula: C23H38N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.99 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1CC1CCCCC1)Cc1ccc(c(c1)OCC)OC
  • InChi: 1S/C23H38N2O3/c1-3-28-23-15-20(9-10-22(23)27-2)16-24-12-13-25(21(18-24)11-14-26)17-19-7-5-4-6-8-19/h9-10,15,19,21,26H,3-8,11-14,16-18H2,1-2H3
  • InChiKey: KIFINVMXDBRZLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus microtubule associated protein 2 0.0674 0.5469 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0795 0.0767
Trypanosoma brucei pyruvate kinase 1 0.021 0.1628 0.5846
Echinococcus multilocularis beta LACTamase domain containing family member 0.0191 0.1476 0.2291
Brugia malayi Latrophilin receptor protein 2 0.0134 0.1 0.1363
Brugia malayi latrophilin 2 splice variant baaae 0.0289 0.2283 0.3138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0958 0.1751
Brugia malayi acetyltransferase, GNAT family protein 0.046 0.3699 0.5096
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0129 0.0396
Schistosoma mansoni hypothetical protein 0.0134 0.1 0.1829
Brugia malayi Importin beta-1 subunit 0.0028 0.0129 0.0159
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0076 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1267 0.1533
Loa Loa (eye worm) pyruvate kinase 0.021 0.1628 0.2232
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0958 0.1478
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0378 0.3019 0.5509
Brugia malayi hypothetical protein 0.0483 0.3885 0.5354
Schistosoma mansoni Smad4 0.0017 0.0034 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1267 0.1533
Mycobacterium tuberculosis Probable reductase 0.0109 0.0795 0.0767
Schistosoma mansoni transcription factor LCR-F1 0.0378 0.3019 0.5521
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.0131
Trypanosoma brucei unspecified product 0.0022 0.0076 0.0205
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1267 0.1533
Plasmodium vivax hypothetical protein, conserved 0.0191 0.1476 0.9051
Schistosoma mansoni cpg binding protein 0.0059 0.0386 0.0705
Schistosoma mansoni smad1 5 8 and 0.0017 0.0034 0.0062
Brugia malayi hypothetical protein 0.0018 0.0045 0.0042
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0038 0.004
Trypanosoma brucei trypanothione reductase 0.0048 0.0289 0.0978
Loa Loa (eye worm) pyruvate kinase 0.021 0.1628 0.2232
Loa Loa (eye worm) pyruvate kinase 0.021 0.1628 0.2232
Mycobacterium leprae Probable lipase LipE 0.0191 0.1476 0.9017
Echinococcus granulosus importin subunit beta 1 0.0028 0.0129 0.021
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0085 0.0195
Entamoeba histolytica hypothetical protein 0.0378 0.3019 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0224 0.029
Mycobacterium tuberculosis Probable lipase LipD 0.0191 0.1476 0.1451
Brugia malayi beta-lactamase family protein 0.0191 0.1476 0.2022
Brugia malayi Thioredoxin reductase 0.0048 0.0289 0.038
Mycobacterium tuberculosis Probable hydrolase 0.0191 0.1476 0.1451
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0299 0.1014
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1987 0.2404
Brugia malayi Pyruvate kinase, muscle isozyme 0.021 0.1628 0.2232
Onchocerca volvulus Pyruvate kinase homolog 0.021 0.1628 0.1886
Toxoplasma gondii pyruvate kinase PyK1 0.021 0.1628 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0086 0.0235
Plasmodium vivax glutathione reductase, putative 0.0048 0.0289 0.1615
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0085 0.0101
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.277 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.1476 0.2022
Schistosoma mansoni hypothetical protein 0.0358 0.2855 0.522
Loa Loa (eye worm) hypothetical protein 0.012 0.0887 0.1207
Trichomonas vaginalis penicillin-binding protein, putative 0.0191 0.1476 0.1786
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0067 0.0224
Toxoplasma gondii pyruvate kinase PyKII 0.0108 0.0784 0.4716
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1987 0.2404
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0135 0.1013 0.1226
Loa Loa (eye worm) hypothetical protein 0.0151 0.1144 0.1563
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Brugia malayi hypothetical protein 0.0028 0.0127 0.0156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0191 0.1476 0.2699
Loa Loa (eye worm) hypothetical protein 0.0146 0.1103 0.1506
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0889 0.7245 1
Brugia malayi MH2 domain containing protein 0.0017 0.0034 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0076 0.0047
Brugia malayi Pyruvate kinase, M2 isozyme 0.021 0.1628 0.2232
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0031 0.0036
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1256 0.447
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0135 0.1013 0.6151
Loa Loa (eye worm) pyruvate kinase 0.0044 0.026 0.034
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0076 0.0165
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0135 0.1013 0.6151
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0134 0.1 0.1807
Schistosoma mansoni hypothetical protein 0.0358 0.2855 0.522
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0032
Echinococcus granulosus histone acetyltransferase KAT2B 0.0135 0.1013 0.1832
Trichomonas vaginalis penicillin-binding protein, putative 0.0191 0.1476 0.1786
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0034 0.0062
Loa Loa (eye worm) hypothetical protein 0.0134 0.1 0.1363
Schistosoma mansoni bromodomain containing protein 0.0014 0.0014 0.0026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0134 0.1 0.1545
Entamoeba histolytica hypothetical protein 0.0378 0.3019 1
Giardia lamblia DINP protein human, muc B family 0.0022 0.0076 0.0283
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0063 0.0419 0.056
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0224 0.027
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0795 0.0767
Schistosoma mansoni cpg binding protein 0.0056 0.0359 0.0657
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0224 0.0704
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1987 0.2404
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Trypanosoma cruzi pyruvate kinase 2, putative 0.021 0.1628 0.5829
Mycobacterium tuberculosis Conserved protein 0.0191 0.1476 0.1451
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0038 0.004
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0031 0.0036
Loa Loa (eye worm) pyruvate kinase-PB 0.0146 0.1103 0.1506
Schistosoma mansoni ap endonuclease 0.004 0.0224 0.041
Trichomonas vaginalis D-aminoacylase, putative 0.0191 0.1476 0.1786
Echinococcus granulosus tar DNA binding protein 0.0066 0.0439 0.0779
Schistosoma mansoni smad 0.0017 0.0034 0.0062
Loa Loa (eye worm) glutathione reductase 0.0048 0.0289 0.038
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0086 0.02
Schistosoma mansoni hypothetical protein 0.0098 0.0709 0.1296
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0895 0.5246
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0077 0.0115
Echinococcus granulosus smad 0.0017 0.0034 0.0035
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0034 0.0027
Schistosoma mansoni ran 0.0021 0.0067 0.0123
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0224 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0423 0.3389 0.4667
Plasmodium vivax SET domain protein, putative 0.0129 0.0958 0.5802
Trichomonas vaginalis D-aminoacylase, putative 0.0191 0.1476 0.1786
Trichomonas vaginalis D-aminoacylase, putative 0.0191 0.1476 0.1786
Trypanosoma cruzi hypothetical protein, conserved 0.0191 0.1476 0.5276
Echinococcus multilocularis geminin 0.0358 0.2855 0.4452
Brugia malayi Smad1 0.0017 0.0034 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0423 0.3389 0.4667
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0127 0.0349
Loa Loa (eye worm) RNA binding protein 0.0066 0.0439 0.0588
Onchocerca volvulus 0.0098 0.0709 0.0762
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0127 0.0598
Trichomonas vaginalis set domain proteins, putative 0.1012 0.8259 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0191 0.1476 0.2699
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0958 0.1751
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0439 0.0588
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0076 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Trichomonas vaginalis esterase, putative 0.0191 0.1476 0.1786
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0224 0.0704
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0439 0.0803
Echinococcus granulosus Smad4 0.0017 0.0034 0.0035
Plasmodium vivax importin-beta 2, putative 0.0028 0.0129 0.0612
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0191 0.1476 0.1451
Echinococcus multilocularis GPCR, family 2 0.0134 0.1 0.1545
Brugia malayi pyruvate kinase 0.0044 0.026 0.034
Loa Loa (eye worm) hypothetical protein 0.0191 0.1476 0.2022
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0031 0.0024
Schistosoma mansoni hypothetical protein 0.0289 0.2283 0.4175
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0191 0.1476 0.1451
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1267 0.1533
Plasmodium falciparum thioredoxin reductase 0.0048 0.0289 0.1615
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0086 0.0235
Giardia lamblia Histone acetyltransferase GCN5 0.0124 0.092 0.5567
Loa Loa (eye worm) hypothetical protein 0.0423 0.3389 0.4667
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.5469 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0034 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0076 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0299 0.0977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.2174 0.3975
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0032
Echinococcus multilocularis pyruvate kinase 0.021 0.1628 0.2529
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0076 0.0086
Leishmania major trypanothione reductase 0.0048 0.0289 0.0941
Brugia malayi MH2 domain containing protein 0.0017 0.0034 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.1256 0.4492
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0909 0.164
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.046 0.3699 0.5775
Echinococcus multilocularis smad 0.0017 0.0034 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0134 0.1 0.1545
Echinococcus granulosus pyruvate kinase 0.021 0.1628 0.2958
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0191 0.1476 0.1451
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0077 0.0098
Mycobacterium tuberculosis Probable esterase LipL 0.0191 0.1476 0.1451
Schistosoma mansoni survival motor neuron protein 0.0098 0.0709 0.1296
Echinococcus multilocularis dna polymerase eta 0.0022 0.0076 0.0097
Schistosoma mansoni cpg binding protein 0.0059 0.0386 0.0705
Leishmania major importin beta-1 subunit, putative 0.0023 0.0085 0.0195
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0191 0.1476 0.6207
Loa Loa (eye worm) glutaminase 0.0298 0.2359 0.3243
Entamoeba histolytica acetyltransferase, GNAT family 0.0124 0.092 0.2889
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.2174 0.3975
Onchocerca volvulus Huntingtin homolog 0.012 0.0887 0.098
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0086 0.0056
Schistosoma mansoni hypothetical protein 0.0378 0.3019 0.5521
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0289 0.026
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0086 0.0099
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0086 0.0235
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.1256 0.447
Schistosoma mansoni hypothetical protein 0.0134 0.1 0.1829
Loa Loa (eye worm) hypothetical protein 0.021 0.1628 0.2232
Loa Loa (eye worm) hypothetical protein 0.0483 0.3885 0.5354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.2174 0.3959
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0076 0.0205
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0907 0.5483
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0224
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0076 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1267 0.1533
Giardia lamblia Pyruvate kinase 0.021 0.1628 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0086 0.0235
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0439 0.0588
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0895 0.0868
Brugia malayi Pre-SET motif family protein 0.0889 0.7245 1
Echinococcus multilocularis pyruvate kinase 0.0108 0.0784 0.1207
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0076 0.0205
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0224 0.0532
Onchocerca volvulus Pyruvate kinase homolog 0.021 0.1628 0.1886
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0067 0.0083
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0067 0.0224
Mycobacterium leprae Probable pyruvate kinase PykA 0.021 0.1628 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0359 0.0477
Brugia malayi glutaminase DH11.1 0.0298 0.2359 0.3243
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0076 0.0097
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.1987 0.2728
Echinococcus multilocularis cpg binding protein 0.0059 0.0386 0.0582
Schistosoma mansoni pyruvate kinase 0.021 0.1628 0.2977
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0387 0.13
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0289 0.0504
Schistosoma mansoni DNA polymerase eta 0.0022 0.0076 0.014
Echinococcus multilocularis Smad4 0.0017 0.0034 0.003
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0127 0.0598
Loa Loa (eye worm) hypothetical protein 0.0289 0.2283 0.3138
Leishmania major DNA polymerase kappa, putative 0.0022 0.0076 0.0165
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0127 0.0598
Mycobacterium ulcerans beta-lactamase 0.0191 0.1476 0.6207
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0077 0.0087
Entamoeba histolytica hypothetical protein 0.0378 0.3019 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0127 0.0598
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1987 0.2404
Schistosoma mansoni smad1 5 8 and 0.0017 0.0034 0.0062
Brugia malayi MH1 domain containing protein 0.0017 0.0034 0.0027
Entamoeba histolytica pyruvate kinase, putative 0.0146 0.1103 0.351
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1267 0.1533
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0289 0.038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0032
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0076 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0439 0.0803
Trypanosoma cruzi hypothetical protein, conserved 0.0191 0.1476 0.5276
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0076 0.0194
Plasmodium falciparum pyruvate kinase 0.021 0.1628 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0135 0.1013 0.6151
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0958 0.1478
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0049 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0439 0.0803
Mycobacterium ulcerans hypothetical protein 0.0183 0.1409 0.5919
Leishmania major GTP-binding protein, putative 0.0021 0.0067 0.0131
Loa Loa (eye worm) hypothetical protein 0.0028 0.0127 0.0156
Trichomonas vaginalis pyruvate kinase, putative 0.021 0.1628 0.197
Leishmania major pyruvate kinase 0.021 0.1628 0.5829
Mycobacterium ulcerans pyruvate kinase 0.021 0.1628 0.6858
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0224 0.0195
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.277 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0224
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0795 0.0767
Echinococcus granulosus snurportin 1 0.0303 0.2397 0.4368
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0439 0.0803
Onchocerca volvulus 0.0191 0.1476 0.1701
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0076 0.0205
Brugia malayi RNA binding protein 0.0066 0.0439 0.0588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0086 0.0056
Echinococcus granulosus dna polymerase eta 0.0022 0.0076 0.0114
Plasmodium vivax pyruvate kinase, putative 0.021 0.1628 1
Brugia malayi hypothetical protein 0.012 0.0887 0.1207
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0276 0.2174 0.2986
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.0099
Loa Loa (eye worm) hypothetical protein 0.0191 0.1476 0.2022
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0224 0.1208
Mycobacterium ulcerans esterase/lipase LipP 0.0191 0.1476 0.6207
Schistosoma mansoni pyruvate kinase 0.0108 0.0784 0.1434
Schistosoma mansoni importin beta-1 0.0028 0.0129 0.0236
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0086 0.02
Onchocerca volvulus 0.0129 0.0958 0.1066
Brugia malayi hypothetical protein 0.0378 0.3019 0.4156
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0031 0.0001
Echinococcus granulosus geminin 0.0358 0.2855 0.5208
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0086 0.02
Loa Loa (eye worm) latrophilin receptor protein 2 0.0134 0.1 0.1363
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0134 0.1 0.1363
Onchocerca volvulus 0.0151 0.1144 0.1295
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0038 0.0027
Toxoplasma gondii hypothetical protein 0.0056 0.0358 0.2049
Echinococcus granulosus cpg binding protein 0.0059 0.0386 0.0681
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0439 0.0666
Mycobacterium ulcerans hypothetical protein 0.0023 0.0086 0.0235
Plasmodium vivax SET domain containing protein 0.0017 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0191 0.1476 0.2022
Echinococcus granulosus beta LACTamase domain containing family member 0.0191 0.1476 0.268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0276 0.2174 0.3975
Brugia malayi CXXC zinc finger family protein 0.0056 0.0359 0.0477
Schistosoma mansoni ap endonuclease 0.004 0.0224 0.041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0085 0.0101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0076 0.0165
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0038 0.0008
Onchocerca volvulus Huntingtin homolog 0.012 0.0887 0.098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0423 0.3389 0.4667
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.6395 1
Brugia malayi Pre-SET motif family protein 0.0129 0.0958 0.1305
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1267 0.1445
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.2397 0.3295
Echinococcus multilocularis survival motor neuron protein 1 0.0483 0.3885 0.6067
Loa Loa (eye worm) hypothetical protein 0.0129 0.0958 0.1305
Echinococcus multilocularis pyruvate kinase 0.0166 0.1263 0.1957
Brugia malayi RNA, U transporter 1 0.0081 0.0561 0.0756
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0224 0.0828
Loa Loa (eye worm) transcription factor SMAD2 0.0247 0.1935 0.2657
Mycobacterium tuberculosis Conserved protein 0.0191 0.1476 0.1451
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.2174 0.3384
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0086 0.0099
Brugia malayi glutathione reductase 0.0048 0.0289 0.038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.046 0.3699 0.6763
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0289 0.1615
Brugia malayi hypothetical protein 0.0151 0.1144 0.1563
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0076 0.0165
Echinococcus multilocularis snurportin 1 0.0303 0.2397 0.3734
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0224 0.0704
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0086 0.0235
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0034 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0086 0.0064
Echinococcus granulosus pyruvate kinase 0.021 0.1628 0.2958
Echinococcus multilocularis pyruvate kinase 0.0108 0.0784 0.1207
Brugia malayi pyruvate kinase, muscle isozyme 0.0044 0.026 0.034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.0099
Loa Loa (eye worm) MH2 domain-containing protein 0.0247 0.1935 0.2657
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0224 0.0385
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.021 0.1628 0.1603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0919 0.168
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.1987 0.2728
Loa Loa (eye worm) beta-lactamase 0.0191 0.1476 0.2022
Leishmania major hypothetical protein, conserved 0.0191 0.1476 0.5276
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0031 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0709 0.096
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0034 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0958 0.5802
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0191 0.1476 0.2022
Mycobacterium tuberculosis Probable lipase LipE 0.0191 0.1476 0.1451
Loa Loa (eye worm) hypothetical protein 0.0028 0.0129 0.0159
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0086 0.0064
Plasmodium vivax pyruvate kinase 2, putative 0.0108 0.0784 0.4716
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0034 0.0035
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0129 0.0612
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0299 0.0977
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0795 0.4595
Leishmania major hypothetical protein, conserved 0.0028 0.0127 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1267 0.1533
Schistosoma mansoni hypothetical protein 0.0134 0.1 0.1829
Schistosoma mansoni hypothetical protein 0.0303 0.2397 0.4383
Echinococcus granulosus pyruvate kinase 0.0108 0.0784 0.1412
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0086 0.0099
Echinococcus granulosus dna polymerase kappa 0.0022 0.0076 0.0114
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.277 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0191 0.1476 0.2022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0224 0.1208
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0086 0.0235
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.0171
Mycobacterium leprae conserved hypothetical protein 0.0191 0.1476 0.9017
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0076 0.014
Mycobacterium ulcerans glutaminase 0.0298 0.2359 1
Echinococcus granulosus pyruvate kinase 0.0108 0.0784 0.1412
Mycobacterium ulcerans lipase LipD 0.0191 0.1476 0.6207
Plasmodium falciparum histone acetyltransferase GCN5 0.0124 0.092 0.5567
Echinococcus multilocularis pyruvate kinase 0.021 0.1628 0.2529
Schistosoma mansoni zinc finger protein 0.0014 0.0014 0.0026
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0795 0.0767
Onchocerca volvulus 0.1012 0.8259 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0276 0.2174 0.2986
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0067 0.0097
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0049 0.0054
Leishmania major DNA polymerase eta, putative 0.0022 0.0076 0.0165
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0038 0.004
Loa Loa (eye worm) Smad1 0.0017 0.0034 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0076 0.0086
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0224 0.1208
Loa Loa (eye worm) hypothetical protein 0.0023 0.0086 0.0099
Trichomonas vaginalis pyruvate kinase, putative 0.021 0.1628 0.197
Plasmodium falciparum pyruvate kinase 2 0.0108 0.0784 0.4716
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Echinococcus granulosus histone acetyltransferase KAT2B 0.0447 0.3592 0.6559
Loa Loa (eye worm) glutaminase 2 0.0298 0.2359 0.3243
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0076 0.0165
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0076 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1987 0.2404
Schistosoma mansoni hypothetical protein 0.0134 0.1 0.1829
Trypanosoma brucei hypothetical protein, conserved 0.0191 0.1476 0.5295
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0958 0.1751
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0895 0.0868
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0224 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0076 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1341 0.1623
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0299 0.0977
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0439 0.0803
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0129 0.018
Echinococcus multilocularis pyruvate kinase 0.0108 0.0784 0.1207
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0076 0.0165
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0085 0.0101
Giardia lamblia Pyruvate kinase 0.0108 0.0784 0.4716
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0076 0.0047
Entamoeba histolytica hypothetical protein 0.0378 0.3019 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0086 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.0205
Trichomonas vaginalis ran, putative 0.0021 0.0067 0.008
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0224 0.027
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0224 0.0329
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.277 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0032
Brugia malayi MH2 domain containing protein 0.0247 0.1935 0.2657
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0127 0.0349
Loa Loa (eye worm) acetyltransferase 0.046 0.3699 0.5096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0958 0.1751
Mycobacterium tuberculosis Conserved protein 0.0191 0.1476 0.1451
Schistosoma mansoni ran 0.0021 0.0067 0.0123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0378 0.3019 0.471
Schistosoma mansoni smad1 5 8 and 0.0017 0.0034 0.0062
Schistosoma mansoni bromodomain containing protein 0.0014 0.0014 0.0026
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0224 0.029
Mycobacterium ulcerans hypothetical protein 0.0191 0.1476 0.6207
Onchocerca volvulus 0.0191 0.1476 0.1701
Echinococcus granulosus survival motor neuron protein 1 0.0483 0.3885 0.7097
Trichomonas vaginalis glutaminase, putative 0.0298 0.2359 0.2856
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0075 0.0084
Onchocerca volvulus 0.0056 0.0359 0.0334
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0289 0.0431
Brugia malayi TAR-binding protein 0.0066 0.0439 0.0588
Echinococcus granulosus pyruvate kinase 0.0108 0.0784 0.1412
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0076 0.0165
Leishmania major pyruvate kinase 0.021 0.1628 0.5829
Onchocerca volvulus Pyruvate kinase homolog 0.021 0.1628 0.1886
Schistosoma mansoni glutaminase 0.0298 0.2359 0.4314
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0795 0.0767
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1987 0.2404
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0086
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0076 0.014
Loa Loa (eye worm) hypothetical protein 0.0191 0.1476 0.2022
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0289 0.0941
Echinococcus granulosus GPCR family 2 0.0134 0.1 0.1807
Toxoplasma gondii exonuclease III APE 0.004 0.0224 0.1208
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0134 0.1 0.1807
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0031 0.0041
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.0131
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0224 0.0742
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0958 0.1729
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0129 0.0396
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0031 0.0057
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0034 0.0035
Schistosoma mansoni pyruvate kinase 0.021 0.1628 0.2977
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.5469 0.8549
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0086 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1341 0.1623
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.1409 0.1384
Plasmodium falciparum importin beta, putative 0.0028 0.0129 0.0612
Toxoplasma gondii thioredoxin reductase 0.0048 0.0289 0.1615
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0049 0.0089
Trypanosoma brucei pyruvate kinase 1, putative 0.021 0.1628 0.5846
Entamoeba histolytica hypothetical protein 0.0023 0.0085 0.0059
Brugia malayi beta-lactamase family protein 0.0191 0.1476 0.2022
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0439 0.0588
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0049 0.0063
Brugia malayi beta-lactamase 0.0191 0.1476 0.2022
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0127 0.0388
Trypanosoma cruzi pyruvate kinase 2, putative 0.021 0.1628 0.5829
Loa Loa (eye worm) hypothetical protein 0.012 0.0887 0.1207
Onchocerca volvulus 0.0191 0.1476 0.1701
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0895 0.0868
Toxoplasma gondii ABC1 family protein 0.0191 0.1476 0.9051
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0076 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0276 0.2174 0.3384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0276 0.2174 0.3959
Trichomonas vaginalis bromodomain-containing protein, putative 0.0135 0.1013 0.1226
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0049 0.0063
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0191 0.1476 0.2022
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0073
Plasmodium falciparum glutathione reductase 0.0048 0.0289 0.1615
Chlamydia trachomatis pyruvate kinase 0.021 0.1628 1
Brugia malayi MH1 domain containing protein 0.0017 0.0034 0.0027

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.