Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.005 | 0.0621 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0075 | 0.1228 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0061 | 0.0878 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0073 | 0.1173 | 0.5551 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4836 | 0.4698 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.008 | 0.1339 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0075 | 0.1228 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0113 | 0.2113 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0063 | 0.0929 | 0.4398 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0075 | 0.1228 | 0.581 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.007 | 0.111 | 0.0872 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0075 | 0.1228 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.008 | 0.1339 | 0.6337 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.007 | 0.111 | 0.5254 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.003 | 0.0162 | 0.0765 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0049 | 0.0599 | 0.2574 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.008 | 0.1339 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0026 | 0.0053 | 0.0251 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0073 | 0.1173 | 0.5551 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2444 | 0.2242 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0063 | 0.0929 | 0.4398 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0054 | 0.0712 | 0.3708 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.008 | 0.1339 | 0.6337 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0063 | 0.0929 | 0.4398 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0113 | 0.2113 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0074 | 0.1204 | 0.0968 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.008 | 0.1339 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.008 | 0.1339 | 0.6337 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0054 | 0.0723 | 0.3424 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0143 | 0.283 | 0.1935 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0113 | 0.2113 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0061 | 0.0878 | 0.4155 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0075 | 0.1228 | 0.0132 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.005 | 0.0621 | 0.2941 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0043 | 0.0455 | 0.2155 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.008 | 0.1339 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0441 | 0.0185 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0062 | 0.0901 | 0.4267 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.008 | 0.1339 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0136 | 0.2664 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium ulcerans | thioesterase | 0.0063 | 0.0929 | 0.4398 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0113 | 0.2113 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.008 | 0.1339 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0075 | 0.1228 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0061 | 0.0878 | 0.4155 |
Onchocerca volvulus | 0.0131 | 0.2553 | 0.9285 | |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0075 | 0.1228 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.008 | 0.1339 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.005 | 0.0621 | 0.2941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.