Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1521 | 0.1305 |
Echinococcus multilocularis | nephrin | 0.0078 | 0.5863 | 0.5758 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0041 | 0.0941 | 0.0941 |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0102 | 0.8923 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.011 | 1 | 1 |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0041 | 0.0941 | 0.1055 |
Trypanosoma brucei | protein kinase, putative | 0.0102 | 0.8923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2705 | 0.2705 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0102 | 0.8923 | 0.8896 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0102 | 0.8923 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1521 | 0.1704 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1521 | 0.1704 |
Plasmodium vivax | apical sushi protein, putative | 0.0041 | 0.0941 | 0.5 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0041 | 0.0941 | 0.0711 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.2495 | 0.2796 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.01 | 0.8738 | 0.8738 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0054 | 0.2705 | 0.2705 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.5863 | 0.657 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0102 | 0.8923 | 0.5 |
Echinococcus multilocularis | irregular chiasm roughest protein immunoglobulin set domain containing protein | 0.0078 | 0.5863 | 0.5758 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0102 | 0.8923 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0102 | 0.8923 | 0.8923 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.01 | 0.8738 | 0.8738 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0102 | 0.8923 | 0.8896 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0102 | 0.8923 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Echinococcus granulosus | Immunoglobulin | 0.0078 | 0.5863 | 0.5758 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2056 | 0.2056 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0248 | 0.0277 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0102 | 0.8923 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0248 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1521 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0102 | 0.8923 | 0.8896 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0102 | 0.8923 | 1 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0041 | 0.0941 | 0.0711 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2056 | 0.2056 |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1521 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1885 | 0.1885 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0102 | 0.8923 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1521 | 0.1305 |
Brugia malayi | hypothetical protein | 0.01 | 0.8738 | 0.8738 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.8923 | 1 |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0102 | 0.8923 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0102 | 0.8923 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.01 | 0.8738 | 0.8738 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.011 | 1 | 1 |
Brugia malayi | Sushi domain | 0.0041 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1521 | 0.1521 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0102 | 0.8923 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1521 | 0.1704 |
Echinococcus multilocularis | Immunoglobulin | 0.0078 | 0.5863 | 0.5758 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.2995 | 0.3356 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2056 | 0.2056 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0041 | 0.0941 | 0.0711 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0248 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.5863 | 0.657 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Plasmodium falciparum | apical sushi protein | 0.0041 | 0.0941 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0078 | 0.5863 | 0.5758 |
Echinococcus granulosus | nephrin | 0.0078 | 0.5863 | 0.5758 |
Brugia malayi | MAP kinase sur-1 | 0.0102 | 0.8923 | 0.8923 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0248 | 0.0277 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0041 | 0.0941 | 0.0941 |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0102 | 0.8923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Echinococcus granulosus | irregular chiasm roughest protein | 0.0078 | 0.5863 | 0.5758 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2056 | 0.2056 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0102 | 0.8923 | 0.8896 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.2495 | 0.2304 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0102 | 0.8923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Echinococcus granulosus | nephrin | 0.0078 | 0.5863 | 0.5758 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0248 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0941 | 0.0941 |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.0941 | 0.5 | |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.2495 | 0.2304 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0248 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0248 | 0.0248 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0041 | 0.0941 | 0.0711 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.01 | 0.8738 | 0.8738 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.2495 | 0.2495 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Active dose range (functional) | 0 mg kg-1 | Active dose range of the compound for antileukemic activity against L1210 mouse leukemia cells was reported ; ND means no data | ChEMBL. | 3656353 |
ED50 (functional) | = 0.3 ug ml-1 | In vitro cytotoxic activity against KB cell culture. | ChEMBL. | 3656353 |
GI50 (functional) | -5.849 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.814 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.683 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.59 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.544 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.511 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.419 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.344 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.788 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
No. of cures (functional) | In vivo antileukemic activity against L-1210 mouse leukemia cells given as number of animals cured out of 6 ; ND means no data | ChEMBL. | 3656353 | |
No. of cures (functional) | 0 | In vivo antileukemic activity against L-1210 mouse leukemia cells given as number of animals cured out of 6 ; ND means no data | ChEMBL. | 3656353 |
T/C (functional) | % | In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as % T/C (median survival time of treated/control animals) x 100 ; IA means inactive | ChEMBL. | 3656353 |
T/C (functional) | % | In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as KE (log10 of initial tumor cell population minus log10 of tumor cell population at end of treatment); ND means no data | ChEMBL. | 3656353 |
T/C (functional) | 0 % | In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as % T/C (median survival time of treated/control animals) x 100 ; IA means inactive | ChEMBL. | 3656353 |
T/C (functional) | 0 % | In vivo antileukemic activity against L-1210 mouse leukemia cells expressed as KE (log10 of initial tumor cell population minus log10 of tumor cell population at end of treatment); ND means no data | ChEMBL. | 3656353 |
Toxic dose (ADMET) | 0 mg kg-1 | Toxic dose of the compound against L1210 mouse leukemia cells was determined; ND means no data | ChEMBL. | 3656353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.