Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.003 | 1 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.8054 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.8054 | 0.5 |
Schistosoma mansoni | lamin | 0.003 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.9606 | 0.9606 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.8054 | 0.5 |
Onchocerca volvulus | 0.003 | 1 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.003 | 1 | 0.5 |
Echinococcus multilocularis | musashi | 0.003 | 1 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.8054 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.8054 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.8054 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.8054 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.8054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.8054 | 0.8054 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.111 | 0.111 |
Echinococcus granulosus | lamin | 0.003 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0.8054 | 0.8054 |
Echinococcus multilocularis | lamin | 0.003 | 1 | 0.5 |
Onchocerca volvulus | 0.003 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.