Detailed information for compound 756255

Basic information

Technical information
  • TDR Targets ID: 756255
  • Name: 5-[(3-bromo-5-ethoxy-4-methoxyphenyl)methylid ene]-3-[(4-chlorophenyl)methyl]-1,3-thiazolid ine-2,4-dione
  • MW: 482.775 | Formula: C20H17BrClNO4S
  • H donors: 0 H acceptors: 2 LogP: 5.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=C2SC(=O)N(C2=O)Cc2ccc(cc2)Cl)cc(c1OC)Br
  • InChi: 1S/C20H17BrClNO4S/c1-3-27-16-9-13(8-15(21)18(16)26-2)10-17-19(24)23(20(25)28-17)11-12-4-6-14(22)7-5-12/h4-10H,3,11H2,1-2H3/b17-10-
  • InChiKey: OPOQTSADTXINTL-YVLHZVERSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-5-[(3-bromo-5-ethoxy-4-methoxyphenyl)methylidene]-3-[(4-chlorophenyl)methyl]-1,3-thiazolidine-2,4-dione
  • 5-[(3-bromo-5-ethoxy-4-methoxy-phenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
  • (5Z)-5-[(3-bromo-5-ethoxy-4-methoxy-phenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
  • 5-[(3-bromo-5-ethoxy-4-methoxyphenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
  • (5Z)-5-[(3-bromo-5-ethoxy-4-methoxyphenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
  • 5-(3-bromo-5-ethoxy-4-methoxy-benzylidene)-3-(4-chlorobenzyl)thiazolidine-2,4-quinone
  • (5Z)-5-(3-bromo-5-ethoxy-4-methoxy-benzylidene)-3-(4-chlorobenzyl)thiazolidine-2,4-quinone
  • 5-[(3-bromo-5-ethoxy-4-methoxy-phenyl)methylidene]-3-[(4-chlorophenyl)methyl]-1,3-thiazolidine-2,4-dione
  • (5Z)-5-[(3-bromo-5-ethoxy-4-methoxy-phenyl)methylidene]-3-[(4-chlorophenyl)methyl]-1,3-thiazolidine-2,4-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Loa Loa (eye worm) glutaminase 0.0266 0.4674 0.4674
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0668 0.0561
Trichomonas vaginalis glucosylceramidase, putative 0.0516 1 1
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0668 0.5
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0668 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0668 1
Onchocerca volvulus 0.0378 0.705 1
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0668 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0668 0.0561
Brugia malayi Animal haem peroxidase family protein 0.0378 0.705 0.6917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0935 0.1206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0935 0.1206
Onchocerca volvulus Peroxidasin homolog 0.0378 0.705 1
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.6221 0.6051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0935 0.0763
Loa Loa (eye worm) pyruvate kinase 0.0067 0.043 0.043
Onchocerca volvulus 0.0378 0.705 1
Leishmania major pyruvate kinase 0.0067 0.043 0.5
Brugia malayi Animal haem peroxidase family protein 0.0378 0.705 0.6917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0935 0.1206
Loa Loa (eye worm) animal heme peroxidase 0.0378 0.705 0.705
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0935 0.0528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0935 0.0763
Onchocerca volvulus 0.0378 0.705 1
Echinococcus granulosus peroxidasin 0.0378 0.705 1
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.6609 0.6457
Loa Loa (eye worm) pyruvate kinase 0.0067 0.043 0.043
Brugia malayi hypothetical protein 0.0378 0.705 0.6917
Echinococcus multilocularis pyruvate kinase 0.0067 0.043 0.0479
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0935 0.1206
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0668 1
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.6609 0.6457
Trichomonas vaginalis glucosylceramidase, putative 0.0516 1 1
Brugia malayi Peroxidasin 0.0378 0.705 0.6917
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.6221 0.6051
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.043 0.5832
Loa Loa (eye worm) glutaminase 2 0.0266 0.4674 0.4674
Echinococcus multilocularis pyruvate kinase 0.0067 0.043 0.0479
Loa Loa (eye worm) animal heme peroxidase 0.0378 0.705 0.705
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0668 1
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.6221 0.6051
Brugia malayi Animal haem peroxidase family protein 0.0378 0.705 0.6917
Schistosoma mansoni glutaminase 0.0266 0.4674 0.6412
Brugia malayi Probable ClpP-like protease 0.0078 0.0668 0.0249
Onchocerca volvulus Glucosylceramidase homolog 0.0339 0.6221 0.8748
Onchocerca volvulus Peroxidasin homolog 0.0378 0.705 1
Giardia lamblia Pyruvate kinase 0.0067 0.043 0.5
Schistosoma mansoni peroxidasin 0.0378 0.705 1
Trichomonas vaginalis glucosylceramidase, putative 0.0516 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0516 1 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.043 1
Leishmania major pyruvate kinase 0.0067 0.043 0.5
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0668 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0516 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.6221 0.6051
Brugia malayi glutaminase DH11.1 0.0266 0.4674 0.4435
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0668 0.0821
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Loa Loa (eye worm) blistered cuticle protein 3 0.0378 0.705 0.705
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.043 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.0668 0.0668
Brugia malayi Animal haem peroxidase family protein 0.0378 0.705 0.6917
Echinococcus multilocularis peroxidasin 0.0378 0.705 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.043 0.5
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Mycobacterium ulcerans glutaminase 0.0266 0.4674 1
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Onchocerca volvulus Dual oxidase homolog 0.0378 0.705 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0668 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.6221 0.6051
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0668 0.0821
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.6221 0.6051
Echinococcus granulosus pyruvate kinase 0.0067 0.043 0.0479
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Onchocerca volvulus Peroxidase homolog 0.0378 0.705 1
Onchocerca volvulus Chorion peroxidase homolog 0.0378 0.705 1
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Schistosoma mansoni peroxidasin 0.0378 0.705 1
Entamoeba histolytica pyruvate kinase, putative 0.0047 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Loa Loa (eye worm) animal heme peroxidase 0.0378 0.705 0.705
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.6221 0.6051
Trichomonas vaginalis glucosylceramidase, putative 0.0516 1 1
Loa Loa (eye worm) hypothetical protein 0.0378 0.705 0.705
Trypanosoma brucei pyruvate kinase 1 0.0067 0.043 0.5
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0668 0.5
Onchocerca volvulus Peroxidase homolog 0.0378 0.705 1
Trichomonas vaginalis glucosylceramidase, putative 0.0516 1 1
Trichomonas vaginalis glutaminase, putative 0.0266 0.4674 0.4435
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0935 0.0763
Brugia malayi Animal haem peroxidase family protein 0.0378 0.705 0.6917
Echinococcus multilocularis pyruvate kinase 0.0053 0.013 0.0049
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.043 0.5
Loa Loa (eye worm) pyruvate kinase 0.0067 0.043 0.043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0935 0.0935
Loa Loa (eye worm) hypothetical protein 0.0067 0.043 0.043
Echinococcus granulosus pyruvate kinase 0.0067 0.043 0.0479
Brugia malayi Blistered cuticle protein 3 0.0378 0.705 0.6917
Loa Loa (eye worm) animal heme peroxidase 0.0378 0.705 0.705

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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