Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.5856 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9714 | 0.9707 |
Echinococcus multilocularis | musashi | 0.0027 | 1 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.002 | 0.5856 | 0.4877 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0223 | 0.0381 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.5856 | 0.5761 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.002 | 0.5856 | 0.4877 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5856 | 0.4291 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.002 | 0.5856 | 0.5 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.5856 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.5856 | 0.5 |
Echinococcus multilocularis | bloom syndrome protein | 0.002 | 0.5856 | 0.4877 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.5856 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.002 | 0.5856 | 0.4877 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5856 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.5856 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.5856 | 0.5856 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.5856 | 0.5856 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.5856 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5856 | 0.4291 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1625 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0223 | 0.0000000048454 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0223 | 0.0223 |
Echinococcus multilocularis | lamin | 0.0027 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.5856 | 0.4291 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0223 | 0.0381 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.5856 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.002 | 0.5856 | 0.4877 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.5856 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5856 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.2742 | 0.2576 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.5856 | 0.5761 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1911 | 0.1727 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.5856 | 0.5761 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.002 | 0.5856 | 0.4877 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0223 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.5856 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1625 | 0.1434 |
Echinococcus granulosus | lamin | 0.0027 | 1 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0223 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.