TDR Targets

Basic information

Technical information

TDR Targets ID: 756341
Name: N-(4-fluorophenyl)-2,1,3-benzothiadiazole-7-s ulfonamide
MW: 309.339 | Formula: C12H8FN3O2S2
H donors: 1 H acceptors: 4 LogP: 2.42 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)NS(=O)(=O)c1cccc2c1nsn2
InChi: 1S/C12H8FN3O2S2/c13-8-4-6-9(7-5-8)16-20(17,18)11-3-1-2-10-12(11)15-19-14-10/h1-7,16H
InChiKey: YMIVXUJRALYRJG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-fluorophenyl)piazthiole-4-sulfonamide
Benzo[1,2,5]thiadiazole-4-sulfonic acid (4-fluoro-phenyl)-amide
AG-690/36951089
ZINC00114142
BAS 00499969

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	EGF-like domain containing protein	0.0054	0.2343	0.2343
Echinococcus granulosus	protein jagged 1	0.0054	0.2343	0.1681
Schistosoma mansoni	laminin gamma-3 chain	0.0054	0.2343	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Brugia malayi	intermediate filament protein	0.0028	0.0796	0.0796
Echinococcus granulosus	slit 2 protein	0.0054	0.2343	0.1681
Brugia malayi	EGF-like domain containing protein	0.0054	0.2343	0.2343
Onchocerca volvulus	Putative cubilin	0.0054	0.2343	0.1846
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0054	0.2343	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Echinococcus granulosus	neural cadherin	0.0054	0.2343	0.1681
Schistosoma mansoni	notch	0.0054	0.2343	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	blistered cuticle protein 3	0.0167	0.9177	0.9177
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0054	0.2343	0.1846
Echinococcus multilocularis	protein jagged 2	0.0054	0.2343	0.1681
Brugia malayi	Calcium binding EGF domain containing protein	0.0054	0.2343	0.2343
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0643	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Onchocerca volvulus		0.0054	0.2343	0.1846
Brugia malayi	Animal haem peroxidase family protein	0.0167	0.9177	0.9177
Echinococcus multilocularis	protein jagged 1	0.0054	0.2343	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Brugia malayi	EGF-like domain containing protein	0.0054	0.2343	0.2343
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0054	0.2343	0.1846
Brugia malayi	Animal haem peroxidase family protein	0.0167	0.9177	0.9177
Schistosoma mansoni	notch	0.0054	0.2343	0.1846
Schistosoma mansoni	notch	0.0054	0.2343	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.018	1	1
Onchocerca volvulus	Dual oxidase homolog	0.0167	0.9177	1
Onchocerca volvulus		0.0167	0.9177	1
Echinococcus granulosus	fibropellin Ia	0.0054	0.2343	0.1681
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0643	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0643	0.5
Echinococcus multilocularis	peroxidasin	0.0167	0.9177	0.9106
Schistosoma mansoni	notch	0.0054	0.2343	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0796	0.0796
Onchocerca volvulus	Chorion peroxidase homolog	0.0167	0.9177	1
Brugia malayi	Blistered cuticle protein 3	0.0167	0.9177	0.9177
Onchocerca volvulus		0.0054	0.2343	0.1846
Brugia malayi	hypothetical protein	0.0026	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Schistosoma mansoni	slit	0.0054	0.2343	0.1846
Brugia malayi	Calcium binding EGF domain containing protein	0.0054	0.2343	0.2343
Echinococcus granulosus	delta-like protein 1	0.0054	0.2343	0.1681
Echinococcus multilocularis	slit 2 protein	0.0054	0.2343	0.1681
Schistosoma mansoni	peroxidasin	0.0167	0.9177	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0643	0.5
Schistosoma mansoni	hypothetical protein	0.0054	0.2343	0.1846
Loa Loa (eye worm)	animal heme peroxidase	0.0167	0.9177	0.9177
Onchocerca volvulus		0.0054	0.2343	0.1846
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0054	0.2343	0.1681
Brugia malayi	Animal haem peroxidase family protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Echinococcus multilocularis	notch	0.0054	0.2343	0.1681
Loa Loa (eye worm)	Notch2	0.0054	0.2343	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Echinococcus multilocularis	muscleblind protein 1	0.018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0054	0.2343	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0796	0.0796
Onchocerca volvulus	Neurogenic locus notch homolog	0.0054	0.2343	0.1846
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0796	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Echinococcus granulosus	protein jagged 2	0.0054	0.2343	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Schistosoma mansoni	hypothetical protein	0.0054	0.2343	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Toxoplasma gondii	EGF family domain-containing protein	0.0054	0.2343	1
Brugia malayi	Peroxidasin	0.0167	0.9177	0.9177
Echinococcus granulosus	notch	0.0054	0.2343	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Brugia malayi	hypothetical protein	0.0017	0.009	0.009
Brugia malayi	notch-like transmembrane receptor	0.0054	0.2343	0.2343
Echinococcus granulosus	neurogenic locus notch protein	0.0054	0.2343	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Schistosoma mansoni	hypothetical protein	0.0054	0.2343	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Brugia malayi	EGF-like domain containing protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Brugia malayi	EGF-like domain containing protein	0.0054	0.2343	0.2343
Echinococcus granulosus	protein jagged 1	0.0054	0.2343	0.1681
Schistosoma mansoni	notch	0.0054	0.2343	0.1846
Echinococcus granulosus	neurogenic locus notch protein 4	0.0054	0.2343	0.1681
Echinococcus granulosus	muscleblind protein	0.018	1	1
Onchocerca volvulus	Peroxidasin homolog	0.0167	0.9177	1
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Onchocerca volvulus		0.0054	0.2343	0.1846
Loa Loa (eye worm)	animal heme peroxidase	0.0167	0.9177	0.9177
Schistosoma mansoni	cell polarity protein	0.0054	0.2343	0.1846
Brugia malayi	Cadherin domain containing protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Brugia malayi	EGF-like domain containing protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0796	0.0796
Brugia malayi	EGF-like domain containing protein	0.0054	0.2343	0.2343
Schistosoma mansoni	hypothetical protein	0.0054	0.2343	0.1846
Schistosoma mansoni	hypothetical protein	0.0054	0.2343	0.1846
Schistosoma mansoni	hypothetical protein	0.0054	0.2343	0.1846
Echinococcus multilocularis	neural cadherin	0.0054	0.2343	0.1681
Echinococcus multilocularis	neurogenic locus notch protein	0.0054	0.2343	0.1681
Echinococcus multilocularis	neurogenic locus notch protein	0.0054	0.2343	0.1681
Brugia malayi	Cadherin domain containing protein	0.0054	0.2343	0.2343
Onchocerca volvulus	Peroxidase homolog	0.0167	0.9177	1
Echinococcus granulosus	peroxidasin	0.0167	0.9177	0.9106
Echinococcus granulosus	protein jagged 2	0.0054	0.2343	0.1681
Brugia malayi	Animal haem peroxidase family protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.018	1	1
Onchocerca volvulus	Peroxidasin homolog	0.0167	0.9177	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Echinococcus multilocularis	fibropellin Ia	0.0054	0.2343	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Echinococcus multilocularis	neurogenic locus protein delta	0.0054	0.2343	0.1681
Giardia lamblia	High cysteine protein	0.0054	0.2343	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Echinococcus granulosus	neurogenic locus protein delta	0.0054	0.2343	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0764	0.0764
Brugia malayi	Delta serrate ligand family protein	0.0054	0.2343	0.2343
Brugia malayi	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Schistosoma mansoni	septate junction protein	0.0054	0.2343	0.1846
Brugia malayi	Muscle positioning protein 4	0.0054	0.2343	0.2343
Echinococcus multilocularis	muscleblind protein	0.018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Onchocerca volvulus	Slit protein homolog	0.0054	0.2343	0.1846
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0643	0.5
Onchocerca volvulus		0.0054	0.2343	0.1846
Onchocerca volvulus	Peroxidase homolog	0.0167	0.9177	1
Onchocerca volvulus		0.0167	0.9177	1
Loa Loa (eye worm)	animal heme peroxidase	0.0167	0.9177	0.9177
Brugia malayi	Animal haem peroxidase family protein	0.0167	0.9177	0.9177
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Brugia malayi	GCC2 and GCC3 family protein	0.0054	0.2343	0.2343
Schistosoma mansoni	peroxidasin	0.0167	0.9177	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0643	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2343	0.2343
Loa Loa (eye worm)	notch protein	0.0054	0.2343	0.2343
Echinococcus granulosus	neurogenic locus notch protein	0.0054	0.2343	0.1681
Echinococcus multilocularis	protein jagged 1	0.0054	0.2343	0.1681
Loa Loa (eye worm)	animal heme peroxidase	0.0167	0.9177	0.9177
Echinococcus multilocularis	neurogenic locus protein delta	0.0054	0.2343	0.1681
Schistosoma mansoni	hypothetical protein	0.0054	0.2343	0.1846
Brugia malayi	Calcium binding EGF domain containing protein	0.0054	0.2343	0.2343
Schistosoma mansoni	notch	0.0054	0.2343	0.1846
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0643	0.5
Onchocerca volvulus		0.0167	0.9177	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.2239 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (binding)	15.8489 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1308333
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Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 756341