TDR Targets

Basic information

Technical information

TDR Targets ID: 756376
Name: 5-[(5-bromo-2-ethoxyphenyl)methylidene]-3-[(4 -chlorophenyl)methyl]-1,3-thiazolidine-2,4-di one
MW: 452.749 | Formula: C19H15BrClNO3S
H donors: 0 H acceptors: 2 LogP: 5.53 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1C=C1SC(=O)N(C1=O)Cc1ccc(cc1)Cl)Br
InChi: 1S/C19H15BrClNO3S/c1-2-25-16-8-5-14(20)9-13(16)10-17-18(23)22(19(24)26-17)11-12-3-6-15(21)7-4-12/h3-10H,2,11H2,1H3/b17-10-
InChiKey: MOERWHPQZBGOMZ-YVLHZVERSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(5Z)-5-[(5-bromo-2-ethoxyphenyl)methylidene]-3-[(4-chlorophenyl)methyl]-1,3-thiazolidine-2,4-dione
5-[(5-bromo-2-ethoxy-phenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
(5Z)-5-[(5-bromo-2-ethoxy-phenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
5-[(5-bromo-2-ethoxyphenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
(5Z)-5-[(5-bromo-2-ethoxyphenyl)methylene]-3-[(4-chlorophenyl)methyl]thiazolidine-2,4-dione
5-(5-bromo-2-ethoxy-benzylidene)-3-(4-chlorobenzyl)thiazolidine-2,4-quinone
(5Z)-5-(5-bromo-2-ethoxy-benzylidene)-3-(4-chlorobenzyl)thiazolidine-2,4-quinone
(5Z)-5-[(5-bromo-2-ethoxy-phenyl)methylidene]-3-[(4-chlorophenyl)methyl]-1,3-thiazolidine-2,4-dione
5-[(5-bromo-2-ethoxy-phenyl)methylidene]-3-[(4-chlorophenyl)methyl]-1,3-thiazolidine-2,4-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	c-Jun N-terminal kinases	0.0224	0.2386	0.3255
Brugia malayi	GCC2 and GCC3 family protein	0.0143	0.1293	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.2751	1
Onchocerca volvulus	Peroxidasin homolog	0.0442	0.5339	1
Loa Loa (eye worm)	animal heme peroxidase	0.0442	0.5339	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1705	0.1027
Onchocerca volvulus	Chorion peroxidase homolog	0.0442	0.5339	1
Brugia malayi	EGF-like domain containing protein	0.0143	0.1293	0.2423
Brugia malayi	Delta serrate ligand family protein	0.0143	0.1293	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0143	0.1293	0.0367
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0961	0.5
Brugia malayi	EGF-like domain containing protein	0.0143	0.1293	0.2423
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.0961	0.1801
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Schistosoma mansoni	slit	0.0143	0.1293	0.2423
Schistosoma mansoni	notch	0.0143	0.1293	0.2423
Schistosoma mansoni	laminin gamma-3 chain	0.0143	0.1293	0.2423
Schistosoma mansoni	notch	0.0143	0.1293	0.2423
Schistosoma mansoni	peroxidasin	0.0442	0.5339	1
Schistosoma mansoni	notch	0.0143	0.1293	0.2423
Echinococcus granulosus	neurogenic locus notch protein 4	0.0143	0.1293	0.0758
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0143	0.1293	0.2423
Echinococcus granulosus	slit 2 protein	0.0143	0.1293	0.0758
Onchocerca volvulus	Peroxidase homolog	0.0442	0.5339	1
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0224	0.2386	0.2702
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Onchocerca volvulus		0.0442	0.5339	1
Echinococcus multilocularis	neural cadherin	0.0143	0.1293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.1586	0.297
Echinococcus multilocularis	notch	0.0143	0.1293	0.0367
Echinococcus granulosus	protein jagged 2	0.0143	0.1293	0.0758
Schistosoma mansoni	serine/threonine protein kinase	0.0224	0.2386	0.447
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0961	0.5
Echinococcus granulosus	fibropellin Ia	0.0143	0.1293	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0143	0.1293	0.2423
Loa Loa (eye worm)	animal heme peroxidase	0.0442	0.5339	1
Brugia malayi	EGF-like domain containing protein	0.0143	0.1293	0.2423
Echinococcus granulosus	peroxidasin	0.0442	0.5339	1
Brugia malayi	hypothetical protein	0.0231	0.2487	0.4658
Echinococcus multilocularis	protein jagged 2	0.0143	0.1293	0.0367
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.2751	0.3602
Echinococcus granulosus	protein jagged 1	0.0143	0.1293	0.0758
Schistosoma mansoni	hypothetical protein	0.0143	0.1293	0.2423
Brugia malayi	Animal haem peroxidase family protein	0.0442	0.5339	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1705	0.1027
Schistosoma mansoni	hypothetical protein	0.0143	0.1293	0.2423
Onchocerca volvulus	Slit protein homolog	0.0143	0.1293	0.2423
Brugia malayi	Animal haem peroxidase family protein	0.0442	0.5339	1
Schistosoma mansoni	hypothetical protein	0.0143	0.1293	0.2423
Onchocerca volvulus		0.0143	0.1293	0.2423
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0224	0.2386	0.1576
Echinococcus multilocularis	peroxidasin	0.0442	0.5339	0.4843
Schistosoma mansoni	notch	0.0143	0.1293	0.2423
Onchocerca volvulus		0.0143	0.1293	0.2423
Brugia malayi	EGF-like domain containing protein	0.0143	0.1293	0.2423
Echinococcus multilocularis	neurogenic locus notch protein	0.0143	0.1293	0.0367
Brugia malayi	EGF-like domain containing protein	0.0143	0.1293	0.2423
Brugia malayi	Peroxidasin	0.0442	0.5339	1
Toxoplasma gondii	EGF family domain-containing protein	0.0143	0.1293	1
Giardia lamblia	High cysteine protein	0.0143	0.1293	0.5
Brugia malayi	EGF-like domain containing protein	0.0143	0.1293	0.2423
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.1336	0.0415
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.2751	1
Echinococcus granulosus	protein jagged 1	0.0143	0.1293	0.0758
Onchocerca volvulus		0.0442	0.5339	1
Onchocerca volvulus	Putative cubilin	0.0143	0.1293	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Schistosoma mansoni	peroxidasin	0.0442	0.5339	1
Schistosoma mansoni	notch	0.0143	0.1293	0.2423
Schistosoma mansoni	hypothetical protein	0.0143	0.1293	0.2423
Echinococcus multilocularis	slit 2 protein	0.0143	0.1293	0.0367
Brugia malayi	follicle stimulating hormone receptor	0.0225	0.2401	0.4498
Onchocerca volvulus		0.0143	0.1293	0.2423
Schistosoma mansoni	cell polarity protein	0.0143	0.1293	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Brugia malayi	Animal haem peroxidase family protein	0.0442	0.5339	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0118	0.0961	0.5
Brugia malayi	Blistered cuticle protein 3	0.0442	0.5339	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0143	0.1293	0.0367
Echinococcus granulosus	notch	0.0143	0.1293	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.2487	0.3484
Echinococcus granulosus	neural cadherin	0.0143	0.1293	0.0758
Echinococcus multilocularis	fibropellin Ia	0.0143	0.1293	0.0367
Loa Loa (eye worm)	animal heme peroxidase	0.0442	0.5339	1
Onchocerca volvulus	Peroxidase homolog	0.0442	0.5339	1
Loa Loa (eye worm)	animal heme peroxidase	0.0442	0.5339	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1336	0.0106
Brugia malayi	Muscle positioning protein 4	0.0143	0.1293	0.2423
Onchocerca volvulus	Peroxidasin homolog	0.0442	0.5339	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.0961	0.1801
Echinococcus multilocularis	protein jagged 1	0.0143	0.1293	0.0367
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0143	0.1293	0.2423
Brugia malayi	EGF-like domain containing protein	0.0143	0.1293	0.2423
Brugia malayi	Cadherin domain containing protein	0.0143	0.1293	0.2423
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.2751	1
Schistosoma mansoni	hypothetical protein	0.0143	0.1293	0.2423
Brugia malayi	notch-like transmembrane receptor	0.0143	0.1293	0.2423
Echinococcus granulosus	neurogenic locus notch protein	0.0143	0.1293	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.2751	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0143	0.1293	0.2423
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.2751	1
Echinococcus multilocularis	protein jagged 1	0.0143	0.1293	0.0367
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.2751	1
Echinococcus granulosus	neurogenic locus notch protein	0.0143	0.1293	0.0758
Schistosoma mansoni	hypothetical protein	0.0143	0.1293	0.2423
Onchocerca volvulus		0.0143	0.1293	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Echinococcus granulosus	delta-like protein 1	0.0143	0.1293	0.0758
Brugia malayi	Cadherin domain containing protein	0.0143	0.1293	0.2423
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0143	0.1293	0.0367
Brugia malayi	Muscleblind-like protein	0.0146	0.1336	0.2503
Schistosoma mansoni	notch	0.0143	0.1293	0.2423
Brugia malayi	hypothetical protein	0.0442	0.5339	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0225	0.2401	0.2738
Schistosoma mansoni	septate junction protein	0.0143	0.1293	0.2423
Echinococcus multilocularis	muscleblind protein	0.0146	0.1336	0.0415
Brugia malayi	Calcium binding EGF domain containing protein	0.0143	0.1293	0.2423
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.2487	0.1687
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0118	0.0961	0.5
Schistosoma mansoni	hypothetical protein	0.0143	0.1293	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0442	0.5339	1
Onchocerca volvulus		0.0143	0.1293	0.2423
Onchocerca volvulus	Neurogenic locus notch homolog	0.0143	0.1293	0.2423
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Onchocerca volvulus		0.0442	0.5339	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0143	0.1293	0.0367
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0143	0.1293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0442	0.5339	1
Brugia malayi	Animal haem peroxidase family protein	0.0442	0.5339	1
Echinococcus granulosus	neurogenic locus protein delta	0.0143	0.1293	0.0758
Echinococcus granulosus	protein jagged 2	0.0143	0.1293	0.0758
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0143	0.1293	0.2423
Brugia malayi	Animal haem peroxidase family protein	0.0442	0.5339	1
Onchocerca volvulus	Dual oxidase homolog	0.0442	0.5339	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.0961	0.5
Brugia malayi	Stress-activated protein kinase jnk-1	0.0224	0.2386	0.447
Echinococcus granulosus	muscleblind protein	0.0146	0.1336	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2487	0.295
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1336	0.0106
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.2751	0.5152

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 756376