TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.459 | Formula: C18H24N2O4S
H donors: 2 H acceptors: 1 LogP: 2.71 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=C1C(=NC(=S)NC1c1ccc(c(c1)OCC)OCC)C)O
InChi: 1S/C18H24N2O4S/c1-5-22-13-9-8-12(10-14(13)23-6-2)16-15(17(21)24-7-3)11(4)19-18(25)20-16/h8-10,16,21H,5-7H2,1-4H3,(H,20,25)
InChiKey: KNSOWTKKMJAMKF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0244	0.2998	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0298	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0472	0.1504
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0451	0.1433
Schistosoma mansoni	hypothetical protein	0.0041	0.0374	0.1175
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0451	0.3891
Onchocerca volvulus	Slit protein homolog	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Brugia malayi	EGF-like domain containing protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	protein jagged 1	0.0079	0.0865	0.0843
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0298	0.6617
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0045	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Brugia malayi	Peroxidasin	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0298	0.092
Echinococcus multilocularis	slit 2 protein	0.0079	0.0865	0.0843
Echinococcus granulosus	protein jagged 2	0.0079	0.0865	0.2827
Trichomonas vaginalis	rotamase, putative	0.0033	0.0269	0.6625
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0472	0.1504
Schistosoma mansoni	hypothetical protein	0.0041	0.0374	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0298	0.092
Onchocerca volvulus		0.0047	0.0451	0.1433
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0079	0.0865	0.2827
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0045	0.002
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Brugia malayi	Blistered cuticle protein 3	0.0244	0.2998	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0045	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0451	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0298	0.5
Loa Loa (eye worm)	blistered cuticle protein 3	0.0244	0.2998	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0025	0.0546
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0451	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0451	0.1433
Echinococcus multilocularis	notch	0.0079	0.0865	0.0843
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0451	1
Onchocerca volvulus	Dual oxidase homolog	0.0244	0.2998	1
Schistosoma mansoni	hypothetical protein	0.0079	0.0865	0.2827
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0451	1
Echinococcus granulosus	delta-like protein 1	0.0079	0.0865	0.2827
Echinococcus granulosus	protein jagged 1	0.0079	0.0865	0.2827
Onchocerca volvulus		0.0079	0.0865	0.2827
Onchocerca volvulus	Putative cubilin	0.0079	0.0865	0.2827
Echinococcus multilocularis	protein patched	0.0042	0.0394	0.037
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0451	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0451	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0451	1
Schistosoma mansoni	peroxidasin	0.0244	0.2998	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0374	0.1175
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.1666	0.1645
Onchocerca volvulus	Peroxidase homolog	0.0244	0.2998	1
Brugia malayi	Delta serrate ligand family protein	0.0079	0.0865	0.2827
Schistosoma mansoni	notch	0.0079	0.0865	0.2827
Schistosoma mansoni	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	neural cadherin	0.0079	0.0865	0.0843
Echinococcus granulosus	neurogenic locus protein delta	0.0079	0.0865	0.2827
Schistosoma mansoni	notch	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	neurogenic locus protein delta	0.0079	0.0865	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0279	0.69
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0079	0.0865	0.2827
Onchocerca volvulus	Peroxidasin homolog	0.0244	0.2998	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.1666	0.5521
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0298	0.092
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0451	0.1433
Onchocerca volvulus		0.0244	0.2998	1
Loa Loa (eye worm)	animal heme peroxidase	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Onchocerca volvulus	Peroxidasin homolog	0.0244	0.2998	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0033	0.0269	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0025	0.0546
Brugia malayi	EGF-like domain containing protein	0.0079	0.0865	0.2827
Trichomonas vaginalis	rotamase, putative	0.0033	0.0279	0.69
Echinococcus granulosus	neurogenic locus notch protein 4	0.0079	0.0865	0.2827
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0274	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus granulosus	protein jagged 1	0.0079	0.0865	0.2827
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0025	0.0546
Schistosoma mansoni	laminin gamma-3 chain	0.0079	0.0865	0.2827
Schistosoma mansoni	slit	0.0079	0.0865	0.2827
Schistosoma mansoni	notch	0.0079	0.0865	0.2827
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0298	0.6421
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0516	0.1654
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0451	0.1433
Onchocerca volvulus	Neurogenic locus notch homolog	0.0079	0.0865	0.2827
Onchocerca volvulus		0.0079	0.0865	0.2827
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0045	0.0069
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0451	0.1433
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Onchocerca volvulus		0.0079	0.0865	0.2827
Schistosoma mansoni	hypothetical protein	0.0015	0.0045	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0394	0.1241
Brugia malayi	EGF-like domain containing protein	0.0079	0.0865	0.2827
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0394	0.1241
Brugia malayi	Animal haem peroxidase family protein	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	notch protein	0.0079	0.0865	0.2827
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0045	0.0069
Schistosoma mansoni	peroxidasin	0.0244	0.2998	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0045	0.0069
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0025	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Schistosoma mansoni	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	expressed protein	0.0033	0.0279	0.0255
Echinococcus granulosus	peroxidasin	0.0244	0.2998	1
Brugia malayi	Muscle positioning protein 4	0.0079	0.0865	0.2827
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0025	0.0546
Schistosoma mansoni	hypothetical protein	0.0079	0.0865	0.2827
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0025	0.0546
Onchocerca volvulus		0.0079	0.0865	0.2827
Schistosoma mansoni	hypothetical protein	0.0015	0.0045	0.0069
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0394	0.1241
Brugia malayi	Cadherin domain containing protein	0.0079	0.0865	0.2827
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.112	0.3684
Brugia malayi	EGF-like domain containing protein	0.0079	0.0865	0.2827
Schistosoma mansoni	cell polarity protein	0.0079	0.0865	0.2827
Schistosoma mansoni	rotamase	0.0033	0.0279	0.0856
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0025	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0298	1
Brugia malayi	notch-like transmembrane receptor	0.0079	0.0865	0.2827
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0045	0.002
Brugia malayi	GCC2 and GCC3 family protein	0.0079	0.0865	0.2827
Onchocerca volvulus	Peroxidase homolog	0.0244	0.2998	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0394	0.037
Schistosoma mansoni	notch	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0451	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0025	0.0546
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0451	1
Loa Loa (eye worm)	animal heme peroxidase	0.0244	0.2998	1
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0279	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Brugia malayi	Cadherin domain containing protein	0.0079	0.0865	0.2827
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0394	1
Schistosoma mansoni	notch	0.0079	0.0865	0.2827
Schistosoma mansoni	notch	0.0079	0.0865	0.2827
Echinococcus granulosus	slit 2 protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.112	0.1098
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0274	0.6071
Schistosoma mansoni	hypothetical protein	0.0079	0.0865	0.2827
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0025	0.0546
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0394	0.1241
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0472	0.1504
Echinococcus multilocularis	expressed conserved protein	0.0092	0.1043	0.1021
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0033	0.0269	0.5735
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0451	1
Echinococcus granulosus	notch	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0274	0.0839
Loa Loa (eye worm)	animal heme peroxidase	0.0244	0.2998	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.0269	1
Brugia malayi	Animal haem peroxidase family protein	0.0244	0.2998	1
Echinococcus multilocularis	peroxidasin	0.0244	0.2998	0.298
Echinococcus multilocularis	protein jagged 1	0.0079	0.0865	0.0843
Brugia malayi	CHE-14 protein	0.0042	0.0394	0.1241
Brugia malayi	Animal haem peroxidase family protein	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus granulosus	neurogenic locus notch protein	0.0079	0.0865	0.2827
Brugia malayi	Animal haem peroxidase family protein	0.0244	0.2998	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0274	0.6071
Giardia lamblia	High cysteine protein	0.0079	0.0865	0.5
Echinococcus multilocularis	fibropellin Ia	0.0079	0.0865	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0298	0.092
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0451	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0079	0.0865	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Toxoplasma gondii	EGF family domain-containing protein	0.0079	0.0865	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0025	0.0546
Brugia malayi	Calcium binding EGF domain containing protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0098	0.112	0.3684
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0274	0.6071
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0033	0.0269	1
Echinococcus granulosus	neural cadherin	0.0079	0.0865	0.2827
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0045	0.002
Echinococcus granulosus	expressed protein	0.0033	0.0279	0.0856
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0451	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0045	0.0069
Onchocerca volvulus	Chorion peroxidase homolog	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0451	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0374	0.1175
Echinococcus multilocularis	neurogenic locus notch protein	0.0079	0.0865	0.0843
Schistosoma mansoni	patched 1	0.0042	0.0394	0.1241
Toxoplasma gondii	peptidylprolyl isomerase	0.0033	0.0269	0.2907
Echinococcus granulosus	expressed conserved protein	0.0092	0.1043	0.3425
Brugia malayi	Animal haem peroxidase family protein	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Onchocerca volvulus		0.0244	0.2998	1
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0471	0.0447
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0451	1
Schistosoma mansoni	septate junction protein	0.0079	0.0865	0.2827
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.112	1
Loa Loa (eye worm)	animal heme peroxidase	0.0244	0.2998	1
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0033	0.0269	0.2231
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus granulosus	GPCR family 2	0.0015	0.0045	0.0069
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0025	0.0546
Brugia malayi	Calcium binding EGF domain containing protein	0.0079	0.0865	0.2827
Echinococcus granulosus	fibropellin Ia	0.0079	0.0865	0.2827
Schistosoma mansoni	hypothetical protein	0.0015	0.0045	0.0069
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.114	0.375
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	Notch2	0.0079	0.0865	0.2827
Brugia malayi	EGF-like domain containing protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0045	0.0069
Echinococcus granulosus	protein jagged 2	0.0079	0.0865	0.2827
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.112	0.3684
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0298	0.092
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0451	1
Echinococcus granulosus	neurogenic locus notch protein	0.0079	0.0865	0.2827
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0472	0.1504
Brugia malayi	Calcium binding EGF domain containing protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Brugia malayi	EGF-like domain containing protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0279	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2998	1
Brugia malayi	hypothetical protein	0.0244	0.2998	1
Schistosoma mansoni	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	neurogenic locus notch protein	0.0079	0.0865	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Echinococcus multilocularis	protein jagged 2	0.0079	0.0865	0.0843
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0451	0.3891
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0451	0.1433
Onchocerca volvulus		0.0079	0.0865	0.2827
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0079	0.0865	0.0843
Echinococcus multilocularis	neurogenic locus protein delta	0.0079	0.0865	0.0843
Schistosoma mansoni	hypothetical protein	0.0033	0.0274	0.0839
Brugia malayi	EGF-like domain containing protein	0.0079	0.0865	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0865	0.2827
Schistosoma mansoni	hypothetical protein	0.0079	0.0865	0.2827
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0451	0.3891
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0079	0.0865	0.2827
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0274	0.6071

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 756384