TDR Targets

Basic information

Technical information

TDR Targets ID: 756461
Name: 2-morpholin-4-yl-5-[(4-prop-2-enoxyphenyl)met hylidene]-1,3-thiazol-4-one
MW: 330.401 | Formula: C17H18N2O3S
H donors: 0 H acceptors: 1 LogP: 2.7 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: C=CCOc1ccc(cc1)/C=C\1/SC(=NC1=O)N1CCOCC1
InChi: 1S/C17H18N2O3S/c1-2-9-22-14-5-3-13(4-6-14)12-15-16(20)18-17(23-15)19-7-10-21-11-8-19/h2-6,12H,1,7-11H2/b15-12+
InChiKey: XLRRVVKABWCRIT-NTCAYCPXSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(5E)-2-morpholin-4-yl-5-[(4-prop-2-enoxyphenyl)methylidene]-1,3-thiazol-4-one
(5E)-5-[(4-allyloxyphenyl)methylene]-2-morpholino-thiazol-4-one
5-[(4-allyloxyphenyl)methylene]-2-morpholino-thiazol-4-one
(5E)-5-[(4-allyloxyphenyl)methylene]-2-morpholino-4-thiazolone
5-[(4-allyloxyphenyl)methylene]-2-morpholino-4-thiazolone
(5E)-5-(4-allyloxybenzylidene)-2-morpholino-thiazol-4-one
5-(4-allyloxybenzylidene)-2-morpholino-thiazol-4-one
ZINC02295056
AF-399/40640769

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.1109	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0229	0.0471
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0395	0.0857
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.1427	0.129
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0215	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1114	0.2287
Schistosoma mansoni	hypothetical protein	0.0148	0.4515	0.9789
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0836	0.1851
Brugia malayi	PHD-finger family protein	0.0029	0.0593	0.1218
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0149	0.455	0.4463
Schistosoma mansoni	hypothetical protein	0.0021	0.0333	0.0721
Brugia malayi	MH2 domain containing protein	0.0134	0.4033	0.8283
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0424	0.0461
Schistosoma mansoni	bromodomain containing protein	0.0067	0.1855	0.4022
Echinococcus multilocularis	protein patched	0.0042	0.1027	0.2226
Schistosoma mansoni	ferritin	0.0027	0.0538	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0109	0.3219	0.6611
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0159	0.4869	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.4226	0.9161
Echinococcus multilocularis	protein dispatched 1	0.0048	0.1221	0.2646
Schistosoma mansoni	ferritin	0.0027	0.0538	0.1167
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0229	0.0064
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.4313	0.935
Loa Loa (eye worm)	hypothetical protein	0.005	0.1304	0.2678
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0739	0.3192
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0145	0.4398	0.974
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0424	0.04
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0159	0.4869	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0395	0.0876
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1027	0.2108
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0027	0.0538	0.0694
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0739	0.1518
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0424	0.0871
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.1027	0.2274
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0713	0.0565
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.2853	0.6185
Brugia malayi	CHE-14 protein	0.0042	0.1027	0.2108
Schistosoma mansoni	hypothetical protein	0.0015	0.0157	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0229	0.0471
Mycobacterium ulcerans	bacterioferritin BfrB	0.0027	0.0538	0.0634
Brugia malayi	latrophilin 2 splice variant baaae	0.0109	0.3219	0.6611
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.2853	0.5859
Schistosoma mansoni	patched 1	0.0042	0.1027	0.2226
Echinococcus multilocularis	expressed protein	0.0033	0.0739	0.1602
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0142	0.4313	0.935
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0027	0.0538	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0424	0.04
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.1304	0.2827
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.1109	0.0967
Echinococcus multilocularis	expressed conserved protein	0.0092	0.2659	0.5764
Schistosoma mansoni	apoferritin-2	0.0027	0.0538	0.1167
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.2902	0.6292
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.1109	0.0967
Treponema pallidum	bacterioferrin (TpF1)	0.0027	0.0538	0.5
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0215	0.0466
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.1737	0.3848
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.097	0.5
Schistosoma mansoni	hypothetical protein	0.005	0.1304	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0916	0.1882
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0148	0.4515	0.9789
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0424	0.04
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0713	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0071	0.198	0.4068
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0424	0.0461
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.455	0.4463
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0159	0.4869	1
Schistosoma mansoni	zinc finger protein	0.0015	0.0157	0.0341
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0424	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0424	0.0871
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0166	0.5103	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.1167	0.2585
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.1167	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0424	0.0871
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.1167	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0134	0.4033	0.8283
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0229	0.0471
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0148	0.4515	1
Schistosoma mansoni	ferritin	0.0027	0.0538	0.1167
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0132	0.3966	0.8599
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1176	0.2416
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0424	0.0271
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.1304	0.2827
Echinococcus multilocularis	GPCR, family 2	0.005	0.1304	0.2827
Schistosoma mansoni	hypothetical protein	0.004	0.0977	0.2118
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0027	0.0538	0.0694
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0333	0.0683
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0132	0.3966	0.8785
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0151	0.4613	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0424	0.0871
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0355	0.0728
Schistosoma mansoni	hypothetical protein	0.005	0.1304	0.2827
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.2853	0.5936
Brugia malayi	Bromodomain containing protein	0.0079	0.2241	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0229	0.0471
Toxoplasma gondii	hypothetical protein	0.0051	0.1323	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0424	0.0271
Schistosoma mansoni	thyroid hormone receptor	0.0142	0.4313	0.935
Entamoeba histolytica	hypothetical protein	0.0148	0.4515	1
Schistosoma mansoni	rotamase	0.0033	0.0739	0.1602
Brugia malayi	acetyltransferase, GNAT family protein	0.0151	0.4613	0.9474
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0395	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2853	0.5859
Entamoeba histolytica	hypothetical protein	0.0148	0.4515	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0215	0.0476
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.1027	0.2274
Echinococcus multilocularis	zinc finger protein	0.0023	0.0417	0.0905
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0316	1	1
Schistosoma mansoni	hypothetical protein	0.005	0.1304	0.2827
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.1027	0.7766
Trichomonas vaginalis	rotamase, putative	0.0033	0.0739	0.3192
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0424	0.04
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.097	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0215	0.0441
Onchocerca volvulus		0.0023	0.0424	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0836	0.1812
Echinococcus granulosus	ferritin	0.0027	0.0538	0.1193
Schistosoma mansoni	transcription factor LCR-F1	0.0148	0.4515	0.9789
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0215	0.0476
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0316	1	1
Echinococcus multilocularis	expressed protein	0.0027	0.0538	0.1167
Schistosoma mansoni	hypothetical protein	0.004	0.0977	0.2118
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.097	1
Mycobacterium ulcerans	bacterioferritin BfrA	0.0027	0.0538	0.0634
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0316	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1335	0.2743
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0424	0.04
Schistosoma mansoni	ferritin light chain	0.0027	0.0538	0.1167
Schistosoma mansoni	hypothetical protein	0.005	0.1304	0.2827
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0424	0.04
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.1027	0.2226
Schistosoma mansoni	ferritin	0.0027	0.0538	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0159	0.4869	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.455	0.4463
Schistosoma mansoni	hypothetical protein	0.0109	0.3219	0.6978
Brugia malayi	Bromodomain containing protein	0.0042	0.1033	0.2122
Entamoeba histolytica	hypothetical protein	0.0148	0.4515	1
Echinococcus granulosus	expressed protein	0.0033	0.0739	0.1637
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.1304	0.2678
Schistosoma mansoni	zinc finger protein	0.0023	0.0417	0.0905
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0027	0.0538	0.5
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0713	0.0565
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0229	0.5
Mycobacterium ulcerans	hypothetical protein	0.0166	0.5103	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0215	0.0466
Echinococcus multilocularis	ferritin	0.0027	0.0538	0.1167
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.2853	0.6318
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0713	0.0565
Loa Loa (eye worm)	acetyltransferase	0.0151	0.4613	0.9474
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.1737	0.3767
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.1027	0.2108
Schistosoma mansoni	hypothetical protein	0.0132	0.3966	0.8599
Echinococcus granulosus	GPCR family 2	0.005	0.1304	0.2888
Schistosoma mansoni	apoferritin-2	0.0027	0.0538	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0229	0.0471
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.1167	0.7447
Echinococcus granulosus	zinc finger protein	0.0023	0.0417	0.0924
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0215	0.0466
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.4226	0.9359
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0424	0.0271
Schistosoma mansoni	hypothetical protein	0.004	0.0977	0.2118
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0215	0.0466
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.1304	0.2888
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.1167	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0424	0.04
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0215	0.0466
Brugia malayi	hypothetical protein	0.0148	0.4515	0.9274
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0424	0.0871
Echinococcus granulosus	expressed protein	0.0027	0.0538	0.1193
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0713	0.0707
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.1109	0.0967
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.1167	0.7447
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0739	0.1518
Brugia malayi	Latrophilin receptor protein 2	0.005	0.1304	0.2678
Echinococcus granulosus	expressed conserved protein	0.0092	0.2659	0.5889
Schistosoma mansoni	ferritin light chain	0.0027	0.0538	0.1167
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0424	0.04
Loa Loa (eye worm)	MH2 domain-containing protein	0.0134	0.4033	0.8283
Schistosoma mansoni	hypothetical protein	0.004	0.0977	0.2118
Trichomonas vaginalis	rotamase, putative	0.0032	0.0713	0.2785
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.1304	0.2678
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.1304	0.2888
Entamoeba histolytica	hypothetical protein	0.0148	0.4515	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0151	0.4613	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 756461