Detailed information for compound 756689

Basic information

Technical information
  • TDR Targets ID: 756689
  • Name: 5-(furan-2-ylmethylidene)-2-(4-propan-2-yloxy phenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6- one
  • MW: 357.427 | Formula: C18H19N3O3S
  • H donors: 0 H acceptors: 3 LogP: 4.19 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Oc1ccc(cc1)C1NC2N(N1)C(=O)C(=Cc1ccco1)S2)C
  • InChi: 1S/C18H15N3O3S/c1-11(2)24-13-7-5-12(6-8-13)16-19-18-21(20-16)17(22)15(25-18)10-14-4-3-9-23-14/h3-11H,1-2H3/b15-10-
  • InChiKey: UIXOQBWVAFUJKS-GDNBJRDFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-(furan-2-ylmethylidene)-2-(4-propan-2-yloxyphenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 5-(2-furylmethylene)-2-(4-isopropoxyphenyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-5-(2-furylmethylene)-2-(4-isopropoxyphenyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • 5-(2-furylmethylene)-2-(4-isopropoxyphenyl)-6-thiazolo[2,3-e][1,2,4]triazolone
  • (5Z)-5-(2-furylmethylene)-2-(4-isopropoxyphenyl)-6-thiazolo[2,3-e][1,2,4]triazolone
  • STOCK2S-65702
  • ZINC01103764

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.034 0.4223 0.7467
Echinococcus granulosus carbonic anhydrase 0.0181 0.2028 0.3206
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0325 0.0574
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.0558 0.0547
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.069 0.1078
Loa Loa (eye worm) hypothetical protein 0.0181 0.2028 0.2018
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0443 0.5652 0.897
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.027 0.0258
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2866 0.7851
Leishmania major carbonic anhydrase-like protein 0.0443 0.5652 1
Trichomonas vaginalis rotamase, putative 0.0036 0.0012 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3651 0.5
Schistosoma mansoni alpha-glucosidase 0.0293 0.3567 0.5654
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3651 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0325 0.0555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0558 0.1528
Echinococcus granulosus leukotriene A 4 hydrolase 0.049 0.63 1
Echinococcus multilocularis geminin 0.0171 0.1879 0.2968
Schistosoma mansoni carbonic anhydrase-related 0.0181 0.2028 0.3206
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0443 0.5652 1
Brugia malayi glutaminase DH11.1 0.0279 0.3383 0.5976
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.0558 0.1528
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3651 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0181 0.2028 0.2018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.0558 0.0968
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0325 0.0497
Echinococcus multilocularis lysosomal alpha glucosidase 0.034 0.4223 0.6697
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0325 0.0497
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.2028 0.3574
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0558 0.1528
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0012 0.0032
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.0558 0.0868
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0443 0.5652 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.049 0.63 0.6296
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0558 0.1528
Echinococcus multilocularis carbonic anhydrase 0.0181 0.2028 0.3206
Echinococcus multilocularis leukotriene A 4 hydrolase 0.049 0.63 1
Trypanosoma brucei glucosidase, putative 0.0075 0.0558 0.0987
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.0558 0.1528
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0443 0.5652 1
Echinococcus multilocularis carbonic anhydrase II 0.0443 0.5652 0.897
Onchocerca volvulus 0.0242 0.2866 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.0558 0.0868
Loa Loa (eye worm) glutaminase 0.0279 0.3383 0.3375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.016 0.0236
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.0558 0.0987
Schistosoma mansoni carbonic anhydrase-related 0.0181 0.2028 0.3206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.016 0.0236
Schistosoma mansoni carbonic anhydrase 0.0181 0.2028 0.3206
Brugia malayi hypothetical protein 0.0225 0.2633 0.4647
Schistosoma mansoni glutaminase 0.0279 0.3383 0.5361
Echinococcus multilocularis lysosomal alpha glucosidase 0.034 0.4223 0.6697
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0558 0.1528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.016 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0558 0.0987
Loa Loa (eye worm) glutaminase 2 0.0279 0.3383 0.3375
Echinococcus multilocularis carbonic anhydrase 0.0181 0.2028 0.3206
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0443 0.5652 0.5647
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.016 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0558 0.1528
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0181 0.2028 0.3574
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.0558 0.2751
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0325 0.0497
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0558 0.1528
Echinococcus multilocularis carbonic anhydrase 0.0181 0.2028 0.3206
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0558 0.0987
Echinococcus granulosus carbonic anhydrase II 0.0443 0.5652 0.897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.016 0.0236
Schistosoma mansoni alpha glucosidase 0.0075 0.0558 0.0868
Brugia malayi Pre-SET motif family protein 0.0213 0.2459 0.4339
Loa Loa (eye worm) hypothetical protein 0.0181 0.2028 0.2018
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.2028 0.3574
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0181 0.2028 0.3574
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.016 0.0236
Schistosoma mansoni carbonic anhydrase-related 0.0181 0.2028 0.3206
Schistosoma mansoni alpha-glucosidase 0.0293 0.3567 0.5654
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.069 0.1202
Trypanosoma brucei carbonic anhydrase-like protein 0.0443 0.5652 1
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3651 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0558 0.1528
Echinococcus granulosus lysosomal alpha glucosidase 0.034 0.4223 0.6697
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.049 0.63 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.069 0.0679
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.2028 0.3574
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1534 0.3954
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1534 0.5
Loa Loa (eye worm) carbonic anhydrase 3 0.0443 0.5652 0.5647
Trichomonas vaginalis glutaminase, putative 0.0279 0.3383 0.9267
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.069 0.1078
Schistosoma mansoni hypothetical protein 0.0171 0.1879 0.2968
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.016 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1534 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.069 0.1078
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.016 0.0263
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3651 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0558 0.1528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.016 0.0236
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0443 0.5652 1
Echinococcus granulosus geminin 0.0171 0.1879 0.2968
Mycobacterium ulcerans glutaminase 0.0279 0.3383 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0558 0.1528
Onchocerca volvulus 0.0197 0.2237 0.711
Echinococcus granulosus carbonic anhydrase 0.0181 0.2028 0.3206
Toxoplasma gondii hypothetical protein 0.0181 0.2028 1
Schistosoma mansoni hypothetical protein 0.0181 0.2028 0.3206
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0443 0.5652 0.897
Echinococcus granulosus carbonic anhydrase 0.0181 0.2028 0.3206
Plasmodium falciparum carbonic anhydrase 0.0181 0.2028 0.5
Schistosoma mansoni hypothetical protein 0.0171 0.1879 0.2968
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.034 0.4223 0.4217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2459 0.245

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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