Detailed information for compound 756700

Basic information

Technical information
  • TDR Targets ID: 756700
  • Name: (5Z)-5-[(3-methoxy-4-pentoxyphenyl)methyliden e]-2-thiophen-2-yl-[1,3]thiazolo[2,3-e][1,2,4 ]triazol-6-one
  • MW: 431.572 | Formula: C21H25N3O3S2
  • H donors: 0 H acceptors: 3 LogP: 5.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOc1ccc(cc1OC)C=C1SC2N(C1=O)NC(N2)c1cccs1
  • InChi: 1S/C21H21N3O3S2/c1-3-4-5-10-27-15-9-8-14(12-16(15)26-2)13-18-20(25)24-21(29-18)22-19(23-24)17-7-6-11-28-17/h6-9,11-13H,3-5,10H2,1-2H3/b18-13-
  • InChiKey: QFOMEXWLYPHVPK-AQTBWJFISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(3-methoxy-4-pentoxyphenyl)methylidene]-2-thiophen-2-yl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 5-[(3-methoxy-4-pentoxy-phenyl)methylene]-2-(2-thienyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-5-[(3-methoxy-4-pentoxy-phenyl)methylene]-2-(2-thienyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • 5-[(3-methoxy-4-pentoxyphenyl)methylene]-2-(2-thienyl)-6-thiazolo[2,3-e][1,2,4]triazolone
  • (5Z)-5-[(3-methoxy-4-pentoxyphenyl)methylene]-2-(2-thienyl)-6-thiazolo[2,3-e][1,2,4]triazolone
  • 5-(4-amoxy-3-methoxy-benzylidene)-2-(2-thienyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-5-(4-amoxy-3-methoxy-benzylidene)-2-(2-thienyl)thiazolo[2,3-e][1,2,4]triazol-6-one
  • 5-[(3-methoxy-4-pentoxy-phenyl)methylidene]-2-thiophen-2-yl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-5-[(3-methoxy-4-pentoxy-phenyl)methylidene]-2-thiophen-2-yl-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica pyruvate kinase, putative 0.02 0.1332 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0046 0.0157
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0384 0.1131
Loa Loa (eye worm) TAR-binding protein 0.0922 0.6763 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0384 0.0567
Leishmania major pyruvate kinase 0.0286 0.1982 1
Brugia malayi acetyltransferase, GNAT family protein 0.0332 0.2326 0.3439
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0199 0.0295
Schistosoma mansoni hypothetical protein 0.0172 0.1126 0.1665
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1631 0.1631
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0248 0.1183
Leishmania major hypothetical protein, conserved 0.0055 0.0248 0.1229
Echinococcus granulosus pyruvate kinase 0.0286 0.1982 0.1982
Schistosoma mansoni smad1 5 8 and 0.0027 0.0036 0.0054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0117 0.0166
Brugia malayi MH2 domain containing protein 0.0398 0.2823 0.4173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0588 0.0588
Loa Loa (eye worm) Smad1 0.0027 0.0036 0.0054
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0431 0.0431
Chlamydia trachomatis pyruvate kinase 0.0286 0.1982 0.5
Schistosoma mansoni smad1 5 8 and 0.0027 0.0036 0.0054
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0248 0.1183
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0084 0.0463 0.2277
Loa Loa (eye worm) inositol-1 0.0038 0.0117 0.0173
Loa Loa (eye worm) hypothetical protein 0.0286 0.1982 0.2931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0518 0.0765
Schistosoma mansoni hypothetical protein 0.008 0.0431 0.0638
Loa Loa (eye worm) pyruvate kinase 0.006 0.0285 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0406 0.1987
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0944 0.0944
Loa Loa (eye worm) hypothetical protein 0.0239 0.1631 0.2412
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0036 0.0036
Giardia lamblia Histone acetyltransferase GCN5 0.0089 0.0505 0.2488
Brugia malayi beta-lactamase family protein 0.0073 0.0384 0.0567
Echinococcus granulosus snurportin 1 0.0353 0.2484 0.2484
Echinococcus multilocularis geminin 0.0172 0.1122 0.1122
Echinococcus granulosus importin subunit beta 1 0.0033 0.0081 0.0081
Plasmodium vivax SET domain protein, putative 0.0091 0.0518 0.2553
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0344 0.2417 0.3574
Mycobacterium leprae Probable lipase LipE 0.0073 0.0384 0.1916
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0087 0.0245
Loa Loa (eye worm) hypothetical protein 0.0084 0.0463 0.0685
Brugia malayi Pre-SET motif family protein 0.0091 0.0518 0.0765
Echinococcus granulosus pyruvate kinase 0.0286 0.1982 0.1982
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0384 0.0602
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0922 0.6763 1
Echinococcus multilocularis microtubule associated protein 2 0.0732 0.5335 0.5335
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.1982 0.3213
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0117 0.5
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0117 0.0516
Onchocerca volvulus 0.0199 0.1327 0.252
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0431 0.0431
Brugia malayi beta-lactamase 0.0073 0.0384 0.0567
Brugia malayi RNA, U transporter 1 0.0094 0.0539 0.0797
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0406 0.0638
Echinococcus granulosus geminin 0.0172 0.1122 0.1122
Loa Loa (eye worm) glutaminase 0.0839 0.6136 0.9072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0384 0.0567
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0518 0.0765
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0384 0.0618
Schistosoma mansoni pyruvate kinase 0.0147 0.0936 0.1384
Schistosoma mansoni alpha-glucosidase 0.0296 0.2057 0.3042
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0019 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0248 0.1183
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0007
Trichomonas vaginalis esterase, putative 0.0073 0.0384 0.0602
Trypanosoma brucei pyruvate kinase 1 0.0286 0.1982 1
Entamoeba histolytica Ran family GTPase 0.0024 0.0015 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0636 0.4609 0.6814
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0516
Schistosoma mansoni hypothetical protein 0.008 0.0431 0.0638
Leishmania major importin beta-1 subunit, putative 0.0027 0.0034 0.0147
Echinococcus granulosus tar DNA binding protein 0.0922 0.6763 0.6763
Loa Loa (eye worm) pyruvate kinase 0.0286 0.1982 0.2931
Leishmania major alpha glucosidase II subunit, putative 0.0076 0.0406 0.2029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0384 0.0567
Brugia malayi Pyruvate kinase, muscle isozyme 0.0286 0.1982 0.2931
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0084 0.0463 0.0685
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0384 0.1131
Brugia malayi MH1 domain containing protein 0.0027 0.0036 0.0054
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1631 0.1631
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0431 0.0638
Schistosoma mansoni hypothetical protein 0.0353 0.2484 0.3673
Giardia lamblia Pyruvate kinase 0.0147 0.0936 0.468
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0248 0.1183
Brugia malayi hypothetical protein 0.0076 0.0402 0.0594
Brugia malayi Pre-SET motif family protein 0.0636 0.4609 0.6814
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0406 0.0638
Schistosoma mansoni survival motor neuron protein 0.0049 0.0199 0.0295
Onchocerca volvulus 0.0073 0.0384 0.0729
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0068
Leishmania major pyruvate kinase 0.0286 0.1982 1
Echinococcus multilocularis pyruvate kinase 0.0286 0.1982 0.1982
Brugia malayi Importin beta-1 subunit 0.0033 0.0081 0.012
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0098 0.0566 0.2799
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0046 0.005
Echinococcus granulosus GPCR family 2 0.008 0.0431 0.0431
Brugia malayi hypothetical protein 0.0055 0.0248 0.0367
Brugia malayi hypothetical protein 0.0148 0.0944 0.1396
Echinococcus multilocularis smad 0.0027 0.0036 0.0036
Schistosoma mansoni inositol monophosphatase 0.0038 0.0117 0.0173
Loa Loa (eye worm) hypothetical protein 0.0073 0.0384 0.0567
Onchocerca volvulus 0.0073 0.0384 0.0729
Brugia malayi hypothetical protein 0.0076 0.0402 0.0594
Brugia malayi glutaminase DH11.1 0.0839 0.6136 0.9072
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0081 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0098 0.0566 0.0899
Loa Loa (eye worm) MH2 domain-containing protein 0.0398 0.2823 0.4173
Entamoeba histolytica hypothetical protein 0.0148 0.0944 0.7079
Echinococcus granulosus pyruvate kinase 0.0147 0.0936 0.0936
Schistosoma mansoni smad1 5 8 and 0.0027 0.0036 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0384 0.0602
Loa Loa (eye worm) glutaminase 2 0.0839 0.6136 0.9072
Toxoplasma gondii pyruvate kinase PyKII 0.0147 0.0936 0.468
Echinococcus multilocularis tumor protein p63 0.1353 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0384 0.0602
Brugia malayi pyruvate kinase, muscle isozyme 0.006 0.0285 0.0422
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0036 0.0054
Toxoplasma gondii ABC1 family protein 0.0073 0.0384 0.1873
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0384 0.1916
Plasmodium falciparum importin beta, putative 0.0033 0.0081 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0518 0.0765
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0081 0.0333
Echinococcus granulosus histone acetyltransferase KAT2B 0.0098 0.0566 0.0566
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0406 0.3024
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0046 0.005
Entamoeba histolytica hypothetical protein 0.0148 0.0944 0.7079
Echinococcus multilocularis neutral alpha glucosidase AB 0.0076 0.0406 0.0406
Loa Loa (eye worm) pyruvate kinase 0.0286 0.1982 0.2931
Loa Loa (eye worm) hypothetical protein 0.0091 0.0518 0.0765
Brugia malayi Glycosyl hydrolases family 31 protein 0.0076 0.0406 0.06
Schistosoma mansoni tar DNA-binding protein 0.0922 0.6763 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0384 0.0384
Echinococcus multilocularis pyruvate kinase 0.0286 0.1982 0.1982
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0046 0.0068
Trichomonas vaginalis maltase-glucoamylase, putative 0.0076 0.0406 0.0638
Echinococcus granulosus smad 0.0027 0.0036 0.0036
Loa Loa (eye worm) RNA binding protein 0.0922 0.6763 1
Brugia malayi TAR-binding protein 0.0922 0.6763 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.3355 1
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.1982 0.3762
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0406 0.1987
Schistosoma mansoni hypothetical protein 0.0084 0.0463 0.0685
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0384 0.1873
Schistosoma mansoni microtubule-associated protein tau 0.0732 0.5335 0.7888
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0084 0.0463 0.0463
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0248 0.1183
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0084 0.0463 0.2277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0518 0.0765
Brugia malayi hypothetical protein 0.0036 0.0101 0.0149
Brugia malayi MH1 domain containing protein 0.0027 0.0036 0.0054
Schistosoma mansoni cellular tumor antigen P53 0.0198 0.1321 0.1953
Echinococcus multilocularis pyruvate kinase 0.0147 0.0936 0.0936
Schistosoma mansoni hypothetical protein 0.0172 0.1122 0.1658
Echinococcus multilocularis pyruvate kinase 0.0147 0.0936 0.0936
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0588 0.0869
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0046 0.0088
Loa Loa (eye worm) transcription factor SMAD2 0.0398 0.2823 0.4173
Schistosoma mansoni hypothetical protein 0.0025 0.0019 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.0252 0.1725 0.255
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.1982 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0252 0.1725 0.255
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0117 0.0183
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0117 0.0844
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0588 0.0869
Schistosoma mansoni ran 0.0024 0.0015 0.0023
Brugia malayi Inositol-1 0.0038 0.0117 0.0173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0252 0.1725 0.255
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0034 0.003
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0384 0.1131
Loa Loa (eye worm) beta-lactamase 0.0073 0.0384 0.0567
Entamoeba histolytica hypothetical protein 0.0148 0.0944 0.7079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0588 0.0869
Echinococcus multilocularis snurportin 1 0.0353 0.2484 0.2484
Echinococcus granulosus lysosomal alpha glucosidase 0.0344 0.2417 0.2417
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0588 0.0869
Brugia malayi RNA recognition motif domain containing protein 0.0922 0.6763 1
Echinococcus multilocularis GPCR, family 2 0.008 0.0431 0.0431
Entamoeba histolytica hypothetical protein 0.0027 0.0034 0.0219
Loa Loa (eye worm) hypothetical protein 0.008 0.0431 0.0638
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.1982 0.3762
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0198 0.1321 0.1953
Brugia malayi Latrophilin receptor protein 2 0.008 0.0431 0.0638
Echinococcus granulosus neutral alpha glucosidase AB 0.0076 0.0406 0.0406
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0081 0.0333
Schistosoma mansoni hypothetical protein 0.008 0.0431 0.0638
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0406 0.0638
Echinococcus granulosus histone acetyltransferase KAT2B 0.0323 0.2256 0.2256
Brugia malayi RNA binding protein 0.0922 0.6763 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0117 0.0117
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0567
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0384 0.1131
Brugia malayi beta-lactamase family protein 0.0073 0.0384 0.0567
Plasmodium falciparum pyruvate kinase 0.0286 0.1982 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0332 0.2326 0.3439
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0384 0.1873
Loa Loa (eye worm) pyruvate kinase 0.0286 0.1982 0.2931
Schistosoma mansoni hypothetical protein 0.0172 0.1122 0.1658
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0117 0.0166
Trypanosoma brucei glucosidase, putative 0.0076 0.0406 0.1987
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0518 0.0518
Plasmodium vivax importin-beta 2, putative 0.0033 0.0081 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0046 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0406 0.0638
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0036 0.0036
Mycobacterium ulcerans beta-lactamase 0.0073 0.0384 0.0618
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0034 0.0095
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0087 0.0483 0.0714
Entamoeba histolytica acetyltransferase, GNAT family 0.0089 0.0505 0.3767
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0922 0.6763 1
Onchocerca volvulus 0.0198 0.1321 0.2507
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0007
Echinococcus multilocularis pyruvate kinase 0.0226 0.1529 0.1529
Schistosoma mansoni inositol monophosphatase 0.0038 0.0117 0.0173
Brugia malayi pyruvate kinase 0.006 0.0285 0.0422
Plasmodium falciparum pyruvate kinase 2 0.0147 0.0936 0.468
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0384 0.0618
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.1126 0.1665
Brugia malayi Smad1 0.0027 0.0036 0.0054
Onchocerca volvulus 0.0091 0.0518 0.0982
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0944 0.1396
Loa Loa (eye worm) hypothetical protein 0.0073 0.0384 0.0567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0588 0.0588
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0431 0.0431
Schistosoma mansoni pyruvate kinase 0.0286 0.1982 0.2931
Toxoplasma gondii pyruvate kinase PyK1 0.0286 0.1982 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0087 0.0416
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.1982 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0588 0.0588
Mycobacterium ulcerans hypothetical protein 0.0073 0.0384 0.0618
Loa Loa (eye worm) hypothetical protein 0.02 0.1332 0.1969
Mycobacterium ulcerans lipase LipD 0.0073 0.0384 0.0618
Echinococcus multilocularis tar DNA binding protein 0.0922 0.6763 0.6763
Brugia malayi Pyruvate kinase, M2 isozyme 0.0286 0.1982 0.2931
Loa Loa (eye worm) hypothetical protein 0.0252 0.1725 0.255
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0015 0.0015
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0046 0.0157
Mycobacterium ulcerans glutaminase 0.0839 0.6136 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0384 0.0384
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0518 0.2553
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0384 0.0602
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0406 0.3024
Mycobacterium ulcerans pyruvate kinase 0.0286 0.1982 0.3225
Schistosoma mansoni alpha-glucosidase 0.0296 0.2057 0.3042
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0384 0.0567
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0384 0.1131
Brugia malayi MH2 domain containing protein 0.0027 0.0036 0.0054
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0516
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0248 0.1183
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0492 0.0492
Onchocerca volvulus 0.0723 0.5268 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0384 0.1131
Leishmania major GTP-binding protein, putative 0.0024 0.0015 0.0053
Echinococcus granulosus Smad4 0.0027 0.0036 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0046 0.005
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0046 0.0157
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0036 0.0054
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0286 0.1982 0.5903
Echinococcus multilocularis lysosomal alpha glucosidase 0.0344 0.2417 0.2417
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0098 0.0566 0.2799
Trichomonas vaginalis sucrase-isomaltase, putative 0.0076 0.0406 0.0638
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0922 0.6763 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0944 0.0944
Echinococcus multilocularis pyruvate kinase 0.0147 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.012
Echinococcus granulosus microtubule associated protein 2 0.0732 0.5335 0.5335
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0015 0.0023
Brugia malayi MH2 domain containing protein 0.0027 0.0036 0.0054
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0046 0.0311
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0081 0.0333
Onchocerca volvulus 0.0073 0.0384 0.0729
Loa Loa (eye worm) hypothetical protein 0.0172 0.1126 0.1665
Loa Loa (eye worm) pyruvate kinase-PB 0.02 0.1332 0.1969
Mycobacterium leprae Probable pyruvate kinase PykA 0.0286 0.1982 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0046 0.005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0034 0.003
Schistosoma mansoni pyruvate kinase 0.0286 0.1982 0.2931
Loa Loa (eye worm) hypothetical protein 0.0073 0.0384 0.0567
Leishmania major hypothetical protein, conserved 0.0073 0.0384 0.1916
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0098 0.0566 0.0899
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0098 0.0566 0.2799
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0518 0.0518
Echinococcus granulosus pyruvate kinase 0.0147 0.0936 0.0936
Schistosoma mansoni alpha glucosidase 0.0076 0.0406 0.06
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0384 0.1131
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0007
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0036 0.0036
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0117 0.0516
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0036 0.0054
Echinococcus multilocularis lysosomal alpha glucosidase 0.0344 0.2417 0.2417
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0406 0.0638
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0084 0.0463 0.0685
Schistosoma mansoni Smad4 0.0027 0.0036 0.0054
Mycobacterium tuberculosis Conserved protein 0.0073 0.0384 0.1131
Brugia malayi Glycosyl hydrolases family 31 protein 0.0344 0.2417 0.3574
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0015 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0384 0.1131
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0046 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0588 0.0588
Echinococcus granulosus pyruvate kinase 0.0147 0.0936 0.0936
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0034 0.003
Plasmodium vivax pyruvate kinase 2, putative 0.0147 0.0936 0.468
Mycobacterium tuberculosis Conserved protein 0.0073 0.0384 0.1131
Giardia lamblia Pyruvate kinase 0.0286 0.1982 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0286 0.1982 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0384 0.0567
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0384 0.1873
Onchocerca volvulus 0.0023 0.0005 0.0009
Brugia malayi hypothetical protein 0.0239 0.1631 0.2412
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0046 0.0209
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0015 0.0023
Plasmodium falciparum histone acetyltransferase GCN5 0.0089 0.0505 0.2488
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0007
Schistosoma mansoni smad 0.0027 0.0036 0.0054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0384 0.0567
Entamoeba histolytica hypothetical protein 0.0148 0.0944 0.7079
Trichomonas vaginalis set domain proteins, putative 0.0723 0.5268 0.8582
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0406 0.0638
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0353 0.2484 0.3673
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0076 0.0406 0.06
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0406 0.0638
Onchocerca volvulus 0.0049 0.0199 0.0379
Loa Loa (eye worm) hypothetical protein 0.0055 0.0248 0.0367
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0431 0.0638
Echinococcus multilocularis Smad4 0.0027 0.0036 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0248 0.1183
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0518 0.0518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0588 0.0869
Schistosoma mansoni hypothetical protein 0.0049 0.0199 0.0295
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.1982 0.3213
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0384 0.1873
Schistosoma mansoni ran 0.0024 0.0015 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0046 0.005
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0384 0.0602
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0084 0.0463 0.2277
Schistosoma mansoni tar DNA-binding protein 0.0922 0.6763 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0076 0.0406 0.1987
Loa Loa (eye worm) acetyltransferase 0.0332 0.2326 0.3439
Schistosoma mansoni glutaminase 0.0839 0.6136 0.9072
Schistosoma mansoni tar DNA-binding protein 0.0922 0.6763 1
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.1982 0.3762
Schistosoma mansoni importin beta-1 0.0033 0.0081 0.012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0384 0.0567
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0084 0.0463 0.0685
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0007
Plasmodium vivax pyruvate kinase, putative 0.0286 0.1982 1
Schistosoma mansoni hypothetical protein 0.0148 0.0944 0.1396
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.008 0.0431 0.0638
Trichomonas vaginalis glutaminase, putative 0.0839 0.6136 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0117 0.0166
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0332 0.2326 0.2326

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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