Detailed information for compound 756734

Basic information

Technical information
  • TDR Targets ID: 756734
  • Name: 5-(4-tert-butylphenyl)-3-hydroxy-4-(5-methylf uran-2-carbonyl)-1-(pyridin-3-ylmethyl)-5H-py rrol-2-one
  • MW: 430.496 | Formula: C26H26N2O4
  • H donors: 1 H acceptors: 4 LogP: 4.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(o1)C(=O)C1=C(O)C(=O)N(C1c1ccc(cc1)C(C)(C)C)Cc1cccnc1
  • InChi: 1S/C26H26N2O4/c1-16-7-12-20(32-16)23(29)21-22(18-8-10-19(11-9-18)26(2,3)4)28(25(31)24(21)30)15-17-6-5-13-27-14-17/h5-14,22,30H,15H2,1-4H3
  • InChiKey: GQNKIKRBGGKUKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-tert-butylphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(3-pyridylmethyl)-5H-pyrrol-2-one
  • 5-(4-tert-butylphenyl)-3-hydroxy-4-[(5-methyl-2-furyl)-oxomethyl]-1-(3-pyridylmethyl)-5H-pyrrol-2-one
  • 5-(4-tert-butylphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(3-pyridylmethyl)-3-pyrrolin-2-one
  • 5-(4-tert-butylphenyl)-3-hydroxy-4-(5-methylfuran-2-yl)carbonyl-1-(pyridin-3-ylmethyl)-5H-pyrrol-2-one
  • ST5040647
  • EU-0044230
  • Oprea1_525813

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0146 0.3499
Schistosoma mansoni ap endonuclease 0.0037 0.017 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0165 0.544
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0322 0.0485
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0165 0.1722
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.035 0.0932
Echinococcus multilocularis peroxidasin 0.0402 0.4366 0.4331
Echinococcus multilocularis tumor protein p63 0.033 0.3535 0.3495
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.021 0.015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.071 0.2581
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.2512 0.3109
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.017 0.011
Onchocerca volvulus Arrow homolog 0.0038 0.0182 0.0071
Plasmodium vivax importin-beta 2, putative 0.0028 0.0061 0.0006
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0038 0.0182 0.0274
Plasmodium falciparum importin beta, putative 0.0028 0.0061 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.021 0.015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.071 0.2581
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0038 0.0182 0.0071
Brugia malayi Animal haem peroxidase family protein 0.0401 0.4354 0.6561
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.071 0.2581
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0146 0.1127
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.071 0.2581
Echinococcus granulosus geminin 0.0175 0.1755 0.2149
Onchocerca volvulus Peroxidase homolog 0.0401 0.4354 0.8428
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.067 1
Schistosoma mansoni hypothetical protein 0.0175 0.1755 0.2149
Loa Loa (eye worm) blistered cuticle protein 3 0.0401 0.4354 0.6561
Toxoplasma gondii thioredoxin reductase 0.0037 0.0165 0.1722
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0146 0.0108
Schistosoma mansoni ap endonuclease 0.0037 0.017 0.0138
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Echinococcus multilocularis snurportin 1 0.0297 0.3164 0.3122
Loa Loa (eye worm) animal heme peroxidase 0.0401 0.4354 0.6561
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0061 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.021 0.0316
Onchocerca volvulus Peroxidase homolog 0.0401 0.4354 0.8428
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0038 0.0182 0.0274
Echinococcus granulosus low density lipoprotein receptor ldl 0.0038 0.0182 0.0153
Plasmodium vivax SET domain protein, putative 0.0059 0.0421 0.5909
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.067 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.021 0.0189
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0138 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.2512 0.3109
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.017 0.0458
Onchocerca volvulus 0.0038 0.0182 0.0071
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Leishmania major trypanothione reductase 0.0037 0.0165 0.544
Brugia malayi Blistered cuticle protein 3 0.0401 0.4354 0.6561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0421 0.0456
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0146 0.0283
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.7946 0.7934
Brugia malayi beta-lactamase family protein 0.0035 0.0146 0.022
Loa Loa (eye worm) hypothetical protein 0.0051 0.0322 0.0485
Trypanosoma brucei trypanothione reductase 0.0037 0.0165 0.4302
Schistosoma mansoni hypothetical protein 0.0297 0.3164 0.3935
Plasmodium vivax glutathione reductase, putative 0.0037 0.0165 0.1722
Brugia malayi Smad1 0.0041 0.021 0.0316
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0038 0.0182 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.017 0.5587
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.067 0.0772
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0146 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0146 0.4798
Brugia malayi Animal haem peroxidase family protein 0.0401 0.4354 0.6561
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0304 0.3994
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0182 0.0153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Loa Loa (eye worm) glutathione reductase 0.0037 0.0165 0.0249
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.021 0.0316
Loa Loa (eye worm) animal heme peroxidase 0.0401 0.4354 0.6561
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2333 1
Mycobacterium tuberculosis Probable reductase 0.0084 0.071 0.2581
Brugia malayi MH1 domain containing protein 0.0041 0.021 0.0316
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0146 0.0108
Loa Loa (eye worm) hypothetical protein 0.0081 0.067 0.1009
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0146 0.1402
Loa Loa (eye worm) hypothetical protein 0.0048 0.0296 0.0445
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.017 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.2512 0.2466
Onchocerca volvulus 0.0038 0.0182 0.0071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0421 0.0362
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0146 0.022
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0146 0.0108
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0421 0.0362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.022
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.017 0.033
Schistosoma mansoni smad1 5 8 and 0.0041 0.021 0.0189
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.035 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.022
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Brugia malayi Peroxidasin 0.0402 0.4366 0.6577
Schistosoma mansoni smad1 5 8 and 0.0041 0.021 0.0189
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Trichomonas vaginalis set domain proteins, putative 0.0469 0.514 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.071 0.2581
Brugia malayi Animal haem peroxidase family protein 0.0401 0.4354 0.6561
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0818 1
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0038 0.0182 0.0071
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0818 0.3076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.2512 0.3109
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.017 0.1795
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0146 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0421 0.0456
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0146 0.0283
Onchocerca volvulus Peroxidasin homolog 0.0401 0.4354 0.8428
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0171 0.0111
Onchocerca volvulus 0.0038 0.0182 0.0071
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0146 0.0283
Echinococcus granulosus snurportin 1 0.0297 0.3164 0.3935
Brugia malayi glutathione reductase 0.0037 0.0165 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0146 0.4798
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.067 1
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0038 0.0182 0.0121
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.017 0.4486
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Echinococcus granulosus peroxidasin 0.0402 0.4366 0.5459
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.017 0.5587
Onchocerca volvulus 0.0469 0.514 1
Brugia malayi Probable ClpP-like protease 0.0081 0.067 0.1009
Schistosoma mansoni hypothetical protein 0.0038 0.0182 0.0153
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.2512 0.3785
Onchocerca volvulus 0.0059 0.0421 0.055
Brugia malayi MH2 domain containing protein 0.0041 0.021 0.0316
Leishmania major hypothetical protein, conserved 0.0035 0.0146 0.4798
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0038 0.0182 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0138 0.0208
Brugia malayi MH2 domain containing protein 0.0599 0.6637 1
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.017 0.0256
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.017 0.0256
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.022
Brugia malayi hypothetical protein 0.0032 0.0104 0.0157
Onchocerca volvulus 0.0401 0.4354 0.8428
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0092
Echinococcus multilocularis Smad4 0.0041 0.021 0.015
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.067 0.5
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0304 0.3994
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0038 0.0182 0.0153
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.035 0.0366
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0038 0.0182 0.0121
Loa Loa (eye worm) MH2 domain-containing protein 0.0599 0.6637 1
Onchocerca volvulus 0.0038 0.0182 0.0071
Brugia malayi beta-lactamase 0.0035 0.0146 0.022
Onchocerca volvulus Dual oxidase homolog 0.0401 0.4354 0.8428
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0165 0.0089
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.067 0.0772
Plasmodium falciparum thioredoxin reductase 0.0037 0.0165 0.1722
Plasmodium falciparum glutathione reductase 0.0037 0.0165 0.1722
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0038 0.0182 0.0121
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0146 0.0283
Echinococcus granulosus Smad4 0.0041 0.021 0.0189
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.017 0.033
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0038 0.0182 0.0153
Trichomonas vaginalis esterase, putative 0.0035 0.0146 0.0283
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.067 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.017 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.022
Schistosoma mansoni smad1 5 8 and 0.0041 0.021 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.2512 0.3109
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.035 0.3814
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0421 0.0456
Echinococcus multilocularis low density lipoprotein receptor protein 0.0038 0.0182 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0304 1
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0038 0.0182 0.0274
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.035 0.0932
Brugia malayi Animal haem peroxidase family protein 0.0401 0.4354 0.6561
Echinococcus multilocularis geminin 0.0175 0.1755 0.1705
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0038 0.0182 0.0274
Brugia malayi basement membrane proteoglycan precursor 0.0038 0.0182 0.0274
Loa Loa (eye worm) beta-lactamase 0.0035 0.0146 0.022
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.017 0.1795
Brugia malayi Pre-SET motif family protein 0.0412 0.4484 0.6756
Schistosoma mansoni hypothetical protein 0.0038 0.0182 0.0153
Echinococcus granulosus basement membrane specific heparan sulfate 0.0038 0.0182 0.0153
Echinococcus granulosus basement membrane specific heparan sulfate 0.0038 0.0182 0.0153
Schistosoma mansoni Smad4 0.0041 0.021 0.0189
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0038 0.0182 0.0153
Loa Loa (eye worm) hypothetical protein 0.0402 0.4366 0.6577
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Mycobacterium leprae Probable lipase LipE 0.0035 0.0146 0.1127
Onchocerca volvulus 0.0038 0.0182 0.0071
Echinococcus granulosus microtubule associated protein 2 0.0713 0.7946 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.067 0.804
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0421 0.5909
Brugia malayi RNA, U transporter 1 0.0079 0.0652 0.0983
Brugia malayi MH2 domain containing protein 0.0041 0.021 0.0316
Echinococcus granulosus low density lipoprotein receptor ldl 0.0038 0.0182 0.0153
Brugia malayi Calcium binding EGF domain containing protein 0.0038 0.0182 0.0274
Echinococcus granulosus smad 0.0041 0.021 0.0189
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.017 1
Onchocerca volvulus 0.0038 0.0182 0.0071
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.067 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0322 0.0485
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.7946 1
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.067 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0304 0.0458
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0304 0.3994
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.2512 0.2466
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.067 0.0613
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.4484 0.6756
Schistosoma mansoni peroxidasin 0.0402 0.4366 0.5459
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.022
Loa Loa (eye worm) hypothetical protein 0.0059 0.0421 0.0634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.2512 0.3109
Leishmania major hypothetical protein, conserved 0.0049 0.0304 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0421 0.0456
Brugia malayi hypothetical protein 0.0049 0.0304 0.0458
Onchocerca volvulus 0.0401 0.4354 0.8428
Brugia malayi hypothetical protein 0.0401 0.4354 0.6561
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.067 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3164 0.4767
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Echinococcus multilocularis smad 0.0041 0.021 0.015
Echinococcus granulosus low density lipoprotein receptor protein 0.0038 0.0182 0.0153
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0146 0.022
Brugia malayi Importin beta-1 subunit 0.0028 0.0061 0.0092
Toxoplasma gondii exonuclease III APE 0.0037 0.017 0.1795
Brugia malayi beta-lactamase family protein 0.0035 0.0146 0.022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0146 0.022
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0038 0.0182 0.0121
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.021 0.0189
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.017 0.1795
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0038 0.0182 0.0121
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0818 0.3076
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Loa Loa (eye worm) transcription factor SMAD2 0.0599 0.6637 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0304 1
Loa Loa (eye worm) animal heme peroxidase 0.0401 0.4354 0.6561
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.2512 0.3785
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.021 0.0189
Loa Loa (eye worm) animal heme peroxidase 0.0401 0.4354 0.6561
Loa Loa (eye worm) Smad1 0.0041 0.021 0.0316
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Onchocerca volvulus Peroxidasin homolog 0.0402 0.4366 0.845
Onchocerca volvulus 0.0048 0.0296 0.03
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Schistosoma mansoni hypothetical protein 0.0175 0.1755 0.2149
Brugia malayi CUB domain containing protein 0.0038 0.0182 0.0274
Toxoplasma gondii ABC1 family protein 0.0035 0.0146 0.1402
Onchocerca volvulus 0.0401 0.4354 0.8428
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.071 0.8572
Brugia malayi MH1 domain containing protein 0.0041 0.021 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0421 0.0456
Brugia malayi Animal haem peroxidase family protein 0.0401 0.4354 0.6561
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Schistosoma mansoni hypothetical protein 0.0035 0.0138 0.0098
Schistosoma mansoni smad 0.0041 0.021 0.0189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0322 0.0485
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0038 0.0182 0.0121
Echinococcus granulosus tumor protein p63 0.033 0.3535 0.4405
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0304 0.3994
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0818 0.3076
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0304 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Loa Loa (eye worm) hypothetical protein 0.0401 0.4354 0.6561
Brugia malayi Thioredoxin reductase 0.0037 0.0165 0.0249
Schistosoma mansoni peroxidasin 0.0401 0.4354 0.5445
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.017 0.5
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0171 0.014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.017 0.5587
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.067 0.5
Brugia malayi Pre-SET motif family protein 0.0059 0.0421 0.0634
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0296 0.0298
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0396 0.0424
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0038 0.0182 0.0274
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0038 0.0182 0.0153
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.067 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0165 0.0249
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0274
Onchocerca volvulus Chorion peroxidase homolog 0.0401 0.4354 0.8428
Brugia malayi enteropeptidase precursor 0.0038 0.0182 0.0274

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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