Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0137 | 0.0137 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.3648 | 0.3648 |
Echinococcus multilocularis | acetylcholinesterase | 0.0103 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.043 | 0.043 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0337 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0017 | 0.0137 | 0.0008 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0308 | 0.0182 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0968 | 0.0843 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0308 | 0.021 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.043 | 0.043 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3648 | 0.356 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0137 | 0.0137 |
Schistosoma mansoni | lamin | 0.0027 | 0.043 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0308 | 0.0308 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0017 | 0.0137 | 0.0037 |
Echinococcus granulosus | acetylcholinesterase | 0.0103 | 0.2783 | 0.2783 |
Echinococcus granulosus | acetylcholinesterase | 0.0103 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0968 | 0.0968 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0676 | 0.0676 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0281 | 0.8277 | 0.8253 |
Brugia malayi | Carboxylesterase family protein | 0.0017 | 0.0137 | 0.0093 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.1634 | 0.8133 |
Loa Loa (eye worm) | acetyltransferase | 0.0281 | 0.8277 | 0.8277 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0076 | 0.1938 | 1 |
Echinococcus multilocularis | neuroligin | 0.0017 | 0.0137 | 0.0137 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3648 | 0.356 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0103 | 0.2783 | 0.2783 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0308 | 0.021 |
Echinococcus granulosus | thymidylate synthase | 0.0337 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0308 | 0.0182 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.1474 | 0.1363 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1043 | 0.1003 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0129 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0676 | 0.0546 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0017 | 0.0137 | 0.0137 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0968 | 0.0928 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.043 | 0.0297 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0968 | 0.0968 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0777 | 0.0777 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.043 | 0.043 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0676 | 0.2254 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0676 | 0.2254 |
Echinococcus multilocularis | lamin | 0.0027 | 0.043 | 0.043 |
Onchocerca volvulus | 0.0047 | 0.1043 | 0.0918 | |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1634 | 0.1518 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0308 | 0.0182 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0676 | 0.2254 |
Loa Loa (eye worm) | carboxylesterase | 0.0103 | 0.2783 | 0.2783 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0083 | 0.2151 | 0.0794 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0337 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0676 | 0.0634 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0044 | 0.0044 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.1474 | 0.1388 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0308 | 0.0265 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.016 | 0.4547 | 0.3482 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.1474 | 0.1356 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2783 | 0.2783 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0676 | 0.0676 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.3648 | 0.3648 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0676 | 0.0546 |
Mycobacterium tuberculosis | Hypothetical protein | 0.016 | 0.4547 | 0.4492 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.043 | 0.043 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0777 | 0.0777 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0103 | 0.2783 | 0.2683 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3648 | 0.356 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0083 | 0.2151 | 0.2048 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0308 | 0.0308 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0083 | 0.2151 | 0.2151 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0968 | 0.0968 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0308 | 0.0182 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0308 | 0.0265 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.043 | 0.043 |
Loa Loa (eye worm) | carboxylesterase | 0.0017 | 0.0137 | 0.0137 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0281 | 0.8277 | 0.8269 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0017 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.3648 | 0.3648 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0017 | 0.0137 | 0.0137 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3648 | 0.356 |
Echinococcus granulosus | carboxylesterase 5A | 0.0103 | 0.2783 | 0.2783 |
Brugia malayi | Carboxylesterase family protein | 0.0017 | 0.0137 | 0.0093 |
Brugia malayi | hypothetical protein | 0.0229 | 0.6677 | 0.6663 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0017 | 0.0137 | 0.0037 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0308 | 0.0182 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0137 | 0.0093 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.043 | 0.043 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 0.6677 | 0.6677 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0308 | 0.0182 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0308 | 0.0265 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.1474 | 0.1363 |
Schistosoma mansoni | lamin | 0.0027 | 0.043 | 0.0297 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0968 | 0.0968 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0337 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0337 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0337 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0337 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.1474 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0137 | 0.0137 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0968 | 0.0968 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0017 | 0.0137 | 0.0137 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0083 | 0.2151 | 0.0794 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0337 | 1 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.1634 | 0.1597 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.1474 | 0.1474 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0676 | 0.2254 |
Echinococcus multilocularis | musashi | 0.0027 | 0.043 | 0.043 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0076 | 0.1938 | 0.1833 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0129 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0017 | 0.0137 | 0.0137 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 0.6677 | 0.6677 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.6677 | 0.6677 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.3648 | 0.3648 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0415 | 0.0415 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.043 | 0.0388 |
Onchocerca volvulus | 0.0023 | 0.0308 | 0.0174 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.016 | 0.4547 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0017 | 0.0137 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.4123 | 0.4123 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1634 | 0.1634 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0137 | 0.0137 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.043 | 0.0388 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.1474 | 0.1356 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.3648 | 0.3648 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2783 | 0.2783 |
Echinococcus granulosus | lamin | 0.0027 | 0.043 | 0.043 |
Loa Loa (eye worm) | thymidylate synthase | 0.0337 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0103 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | carboxylesterase | 0.0017 | 0.0137 | 0.0137 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0103 | 0.2783 | 0.2783 |
Brugia malayi | RNA binding protein | 0.0131 | 0.3648 | 0.362 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0308 | 0.0308 |
Onchocerca volvulus | 0.0027 | 0.043 | 0.0297 | |
Echinococcus multilocularis | thymidylate synthase | 0.0337 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0337 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0281 | 0.8277 | 0.8277 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0017 | 0.0137 | 0.0037 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1634 | 0.1634 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0308 | 0.0182 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0083 | 0.2151 | 0.4567 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3648 | 0.356 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1043 | 0.0918 |
Onchocerca volvulus | 0.0146 | 0.4123 | 0.4041 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0968 | 0.0843 |
Onchocerca volvulus | 0.0337 | 1 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0017 | 0.0137 | 0.0137 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1634 | 0.1634 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1043 | 0.0918 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.2783 | 0.2751 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.1634 | 0.1368 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0273 | 0.8033 | 0.8033 |
Onchocerca volvulus | 0.0027 | 0.043 | 0.0297 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0083 | 0.2151 | 0.4567 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.1474 | 0.1203 |
Brugia malayi | hypothetical protein | 0.0146 | 0.4123 | 0.4097 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.3648 | 0.362 |
Brugia malayi | hypothetical protein | 0.016 | 0.4547 | 0.4523 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0129 | 0.0129 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0076 | 0.1938 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0337 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0129 | 0.0129 |
Brugia malayi | Carboxylesterase family protein | 0.0017 | 0.0137 | 0.0093 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0968 | 0.0843 |
Echinococcus granulosus | neuroligin | 0.0017 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0129 | 0.0129 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.3648 | 0.362 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0308 | 0.0182 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.1474 | 0.1363 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.2783 | 0.2751 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0129 | 0.0129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.