Detailed information for compound 757315

Basic information

Technical information
  • TDR Targets ID: 757315
  • Name: propan-2-yl 7-(difluoromethyl)-5-(4-methylphe nyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
  • MW: 345.343 | Formula: C18H17F2N3O2
  • H donors: 0 H acceptors: 3 LogP: 3.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)c1cnn2c1nc(cc2C(F)F)c1ccc(cc1)C)C
  • InChi: 1S/C18H17F2N3O2/c1-10(2)25-18(24)13-9-21-23-15(16(19)20)8-14(22-17(13)23)12-6-4-11(3)5-7-12/h4-10,16H,1-3H3
  • InChiKey: ZASBWCMOZYLOBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isopropyl 7-(difluoromethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
  • 7-(difluoromethyl)-5-(4-methylphenyl)-3-pyrazolo[1,5-a]pyrimidinecarboxylic acid isopropyl ester
  • 7-(difluoromethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid isopropyl ester
  • ST5029440
  • ZINC00616429
  • BAS 09530713

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0023 0.0176 0.0222
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0023 0.0176 0.0141
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.332 0.6123
Schistosoma mansoni cpg binding protein 0.0032 0.0289 0.0289
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0685 0.0685
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0173 0.0131
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0023 0.0176 0.0293
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0023 0.0176 0.0017
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0086 0.0982 0.1844
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.332 0.5378
Giardia lamblia Glutamate synthase 0.0023 0.0176 0.0034
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0135 0.0253
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0023 0.0176 0.1792
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0086 0.0982 0.23
Loa Loa (eye worm) hypothetical protein 0.0023 0.0176 0.0293
Brugia malayi glutathione reductase 0.025 0.3052 0.5625
Echinococcus granulosus mothers against decapentaplegic 2 0.0012 0.004 0.0076
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0086 0.0982 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0176 0.0285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0217
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0023 0.0176 0.0285
Schistosoma mansoni ran 0.0023 0.0173 0.0173
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.1809 0.1809
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.2264 0.4165
Schistosoma mansoni ran 0.0023 0.0173 0.0173
Schistosoma mansoni glutamate synthase 0.0023 0.0176 0.0176
Mycobacterium ulcerans dehydrogenase 0.0023 0.0176 0.0932
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0023 0.0176 0.1792
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0086 0.0982 0.1241
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0012 0.004 0.0036
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Trichomonas vaginalis glutamate synthase, putative 0.0023 0.0176 0.0285
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0086 0.0982 0.52
Brugia malayi N-terminal motif family protein 0.0213 0.2591 0.477
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0233 0.0437
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0023 0.0176 0.0293
Schistosoma mansoni Smad4 0.0012 0.004 0.004
Schistosoma mansoni rab6-interacting 0.002 0.0135 0.0135
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0173 0.0325
Brugia malayi RNA binding protein 0.0069 0.0758 0.1372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Brugia malayi CXXC zinc finger family protein 0.003 0.0267 0.0461
Echinococcus granulosus c-Jun N-terminal kinases 0.0231 0.2811 0.5277
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0023 0.0176 0.0141
Brugia malayi TAR-binding protein 0.0069 0.0758 0.1372
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0086 0.0982 0.52
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0233 0.0437
Trichomonas vaginalis set domain proteins, putative 0.0496 0.6174 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0685 0.1285
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0233 0.0399
Loa Loa (eye worm) glutathione reductase 0.025 0.3052 0.5625
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.5326 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0569 0.7109 0.8981
Brugia malayi MH2 domain containing protein 0.0027 0.0233 0.0399
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0032 0.0026
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0023 0.0176 0.0017
Treponema pallidum oxidoreductase 0.0023 0.0176 0.1792
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0231 0.2811 0.5277
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0135 0.0253
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0086 0.0982 0.2905
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.2264 0.4165
Echinococcus granulosus glutamate synthase 0.0023 0.0176 0.033
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0176 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0685 0.0685
Echinococcus granulosus thioredoxin glutathione reductase 0.0251 0.3067 0.5758
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0018 0.0034
Schistosoma mansoni lipoxygenase 0.0055 0.0586 0.0586
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0023 0.0176 0.0932
Schistosoma mansoni hypothetical protein 0.0429 0.5326 0.5326
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0023 0.0176 0.0932
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0023 0.0176 0.0017
Entamoeba histolytica thioredoxin reductase, putative 0.0023 0.0176 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0724 0.0724
Plasmodium falciparum glutathione reductase 0.025 0.3052 1
Brugia malayi MH1 domain containing protein 0.0027 0.0233 0.0399
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.0176 0.033
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0217
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.1809 0.3397
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0018 0.0034
Echinococcus granulosus snurportin 1 0.033 0.4071 0.7644
Onchocerca volvulus 0.003 0.0267 0.0404
Schistosoma mansoni polycystin 1-related 0.002 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0023 0.0176 0.0176
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0176 0.0008
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0086 0.0982 0.2905
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0277 0.0854
Plasmodium vivax importin-beta 2, putative 0.0031 0.0277 0.0486
Schistosoma mansoni hypothetical protein 0.002 0.0135 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.332 0.5378
Trichomonas vaginalis ran, putative 0.0023 0.0173 0.0281
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0023 0.0176 0.0008
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0173 0.0131
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0023 0.0176 0.0222
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0586 0.1099
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0176 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0086 0.0982 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0135 0.0253
Entamoeba histolytica hypothetical protein 0.0152 0.1809 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0023 0.0176 0.0932
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0086 0.0982 0.0982
Schistosoma mansoni smad 0.0012 0.004 0.004
Schistosoma mansoni smad1 5 8 and 0.0027 0.0233 0.0233
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0086 0.0982 0.23
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0086 0.0982 0.1844
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0233 0.0233
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0176 0.0521
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0758 0.0758
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0537 0.1034
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0231 0.2811 0.5178
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.025 0.3052 0.3856
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2139 0.3465
Mycobacterium ulcerans NADH dehydrogenase 0.0023 0.0176 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Mycobacterium ulcerans hypothetical protein 0.0023 0.0176 0.0932
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0023 0.0176 0.0222
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0016
Plasmodium vivax glutathione reductase, putative 0.025 0.3052 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0569 0.7109 0.8981
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0135 0.0253
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0135 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.2264 0.2264
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0203 0.0328
Plasmodium vivax thioredoxin reductase, putative 0.025 0.3052 1
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2139 0.3465
Plasmodium falciparum thioredoxin reductase 0.0086 0.0982 0.2905
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.004 0.0042
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0023 0.0176 0.0008
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0023 0.0176 0.0008
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0023 0.0176 0.0008
Schistosoma mansoni cpg binding protein 0.0032 0.0289 0.0289
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0023 0.0176 0.0222
Brugia malayi Importin beta-1 subunit 0.0031 0.0277 0.048
Leishmania major hypothetical protein, conserved 0.0023 0.0176 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0758 0.1372
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0176 0.0285
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0064 0.0691 0.1248
Brugia malayi Pre-SET motif family protein 0.0063 0.0685 0.1236
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0023 0.0176 0.0034
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0569 0.7109 0.8981
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1685 0.43
Schistosoma mansoni disulfide oxidoreductase 0.0023 0.0176 0.0176
Loa Loa (eye worm) Smad1 0.0027 0.0233 0.0399
Schistosoma mansoni dep domain containing protein 0.001 0.0018 0.0018
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0176 0.0285
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0023 0.0176 0.1792
Schistosoma mansoni regulator of G protein signaling 0.001 0.0018 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0176 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0685 0.1285
Leishmania major NADH dehydrogenase, putative 0.0023 0.0176 0.0008
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0023 0.0176 0.0222
Schistosoma mansoni Smad4 0.0027 0.0233 0.0233
Echinococcus multilocularis mothers against decapentaplegic 2 0.0012 0.004 0.0076
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0023 0.0176 0.0285
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0009 0.0016
Echinococcus multilocularis snurportin 1 0.033 0.4071 0.7644
Trypanosoma cruzi NADH dehydrogenase, putative 0.0023 0.0176 0.0008
Schistosoma mansoni lipoxygenase 0.002 0.0135 0.0135
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0023 0.0176 0.033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.2264 0.4252
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.332 0.5378
Schistosoma mansoni glutamate synthase 0.0023 0.0176 0.0176
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0018 0.0034
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0023 0.0176 0.033
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0086 0.0982 0.2905
Leishmania major hypothetical protein, conserved 0.0023 0.0176 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0982 0.23
Echinococcus multilocularis tumor protein p63 0.0362 0.448 0.8412
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0086 0.0982 0.23
Onchocerca volvulus 0.0496 0.6174 1
Echinococcus multilocularis Smad4 0.0027 0.0233 0.0437
Mycobacterium tuberculosis Probable oxidoreductase 0.0633 0.7915 1
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.2811 0.2811
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0203 0.0084
Echinococcus granulosus smad 0.0027 0.0233 0.0437
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.1809 0.3397
Schistosoma mansoni dishevelled 0.001 0.0018 0.0018
Echinococcus multilocularis RUN 0.002 0.0135 0.0253
Brugia malayi Doublecortin family protein 0.002 0.0135 0.0217
Echinococcus granulosus dnaJ subfamily B 0.0429 0.5326 1
Brugia malayi hypothetical protein 0.002 0.0135 0.0217
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0176 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2139 0.3465
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0023 0.0176 0.0017
Treponema pallidum thioredoxin reductase (trxB) 0.0023 0.0176 0.1792
Echinococcus granulosus Smad4 0.0027 0.0233 0.0437
Loa Loa (eye worm) RNA binding protein 0.0069 0.0758 0.1372
Echinococcus granulosus importin subunit beta 1 0.0031 0.0277 0.052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0077 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.2264 0.4252
Toxoplasma gondii thioredoxin reductase 0.025 0.3052 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0018 0.0034
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0233 0.0437
Echinococcus multilocularis glutamate synthase 0.0023 0.0176 0.033
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0023 0.0176 0.0285
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0023 0.0176 0.0932
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.369 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0086 0.0982 0.2905
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Brugia malayi MH2 domain containing protein 0.0403 0.4995 0.9229
Schistosoma mansoni cpg binding protein 0.003 0.0267 0.0267
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0023 0.0176 0.033
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0018 0.0034
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0032 0.006
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0135 0.0253
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0018 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0633 0.7915 1
Brugia malayi MH1 domain containing protein 0.0027 0.0233 0.0399
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0173 0.0325
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0176 0.0008
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0023 0.0176 0.0222
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0023 0.0176 0.0521
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0023 0.0176 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0403 0.4995 0.9229
Mycobacterium ulcerans ferredoxin reductase 0.0023 0.0176 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0277 0.052
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0086 0.0982 0.3178
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.0176 0.033
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0023 0.0176 0.0285
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0023 0.0176 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0758 0.0758
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0086 0.0982 0.23
Toxoplasma gondii hypothetical protein 0.0048 0.0498 0.1584
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.332 0.6123
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0023 0.0176 0.0222
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0203 0.0328
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0173 0.0512
Schistosoma mansoni hypothetical protein 0.033 0.4071 0.4071
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0277 0.0294
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0176 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0042
Echinococcus multilocularis cpg binding protein 0.0032 0.0289 0.0542
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0086 0.0982 0.23
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.226 0.3661
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0032 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.2264 0.2264
Schistosoma mansoni loxhd1 0.002 0.0135 0.0135
Schistosoma mansoni sulfide quinone reductase 0.0023 0.0176 0.0176
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0023 0.0176 0.033
Plasmodium falciparum glutathione reductase 0.0086 0.0982 0.2905
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0023 0.0176 0.0222
Loa Loa (eye worm) hypothetical protein 0.0053 0.0557 0.1
Mycobacterium ulcerans hypothetical protein 0.0158 0.1889 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0213 0.2591 0.418
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0023 0.0176 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2139 0.3465
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0023 0.0176 0.0932
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0086 0.0982 0.23
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0086 0.0982 0.23
Trichomonas vaginalis mercuric reductase, putative 0.0086 0.0982 0.1591
Toxoplasma gondii selenide, water dikinase 0.0023 0.0176 0.0521
Leishmania major mitochondrial DNA polymerase beta 0.03 0.369 1
Plasmodium falciparum ferrodoxin reductase-like protein 0.0023 0.0176 0.0141
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0173 0.0288
Schistosoma mansoni dishevelled 0.001 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0025 0.0203 0.018
Treponema pallidum NADH oxidase 0.0086 0.0982 1
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.332 0.5378
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0086 0.0982 1
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.332 0.5378
Giardia lamblia Thioredoxin reductase 0.0023 0.0176 0.0034
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0023 0.0176 0.0932
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0176 0.0285
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.2139 0.3446
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1685 0.43
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0018 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0633 0.7915 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0086 0.0982 0.1788
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0557 0.0557
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0023 0.0176 0.0017
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0586 0.1099
Brugia malayi hypothetical protein 0.002 0.0135 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.2264 0.4252
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.042 0.0701
Loa Loa (eye worm) hypothetical protein 0.0031 0.0277 0.048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.042 0.0701
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0018 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0685 0.1285
Leishmania major hypothetical protein, conserved 0.0023 0.0176 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.042 0.0701
Schistosoma mansoni sulfide quinone reductase 0.0023 0.0176 0.0176
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0031 0.0023
Schistosoma mansoni importin beta-1 0.0031 0.0277 0.0277
Plasmodium vivax ferrodoxin reductase, putative 0.0023 0.0176 0.0141
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.5411 1
Brugia malayi MH2 domain containing protein 0.0027 0.0233 0.0399
Trypanosoma brucei trypanothione reductase 0.025 0.3052 0.8186
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0277 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0758 0.0758
Leishmania major importin beta-1 subunit, putative 0.0025 0.0203 0.0084
Mycobacterium tuberculosis Probable reductase 0.0569 0.7109 0.8981
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.226 0.3661
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0018 0.0018
Echinococcus granulosus tumor protein p63 0.0362 0.448 0.8412
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0173 0.0288
Plasmodium vivax SET domain protein, putative 0.0063 0.0685 0.1884
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0569 0.7109 0.8981
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.369 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0267 0.0461
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2139 0.3465
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0685 0.0685
Onchocerca volvulus 0.0023 0.0176 0.0257
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0685 0.2197
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0758 0.1423
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0176 0.0521
Trichomonas vaginalis glutathione reductase, putative 0.0086 0.0982 0.1591
Brugia malayi hypothetical protein 0.0152 0.1809 0.3321
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0086 0.0982 0.52
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0023 0.0176 0.0008
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0023 0.0176 0.033
Mycobacterium ulcerans monoxygenase 0.0023 0.0176 0.0932
Onchocerca volvulus 0.0063 0.0685 0.1083
Echinococcus granulosus mothers against decapentaplegic 6 0.0012 0.004 0.0076
Onchocerca volvulus 0.0053 0.0557 0.0876
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.2264 0.2264
Schistosoma mansoni glutamate synthase 0.0023 0.0176 0.0176
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.042 0.0701
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2139 0.3465
Schistosoma mansoni Smad4 0.0012 0.004 0.004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0758 0.1372
Entamoeba histolytica hypothetical protein 0.0152 0.1809 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0086 0.0982 1
Trichomonas vaginalis glutamate synthase, putative 0.0023 0.0176 0.0285
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0064 0.0691 0.1248
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0023 0.0176 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0233 0.0399
Onchocerca volvulus 0.002 0.0135 0.019
Echinococcus multilocularis thioredoxin glutathione reductase 0.0251 0.3067 0.5758
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0758 0.0758
Loa Loa (eye worm) programmed cell death 8 0.0023 0.0176 0.0293
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0018 0.0018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0203 0.0328
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.332 0.5378
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1685 0.43
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0023 0.0176 0.0521
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0009 0.0016
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0023 0.0176 0.033
Brugia malayi MH1 domain containing protein 0.0015 0.0077 0.011
Entamoeba histolytica hypothetical protein 0.0152 0.1809 1
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0176 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0633 0.7915 1
Schistosoma mansoni smad 0.0027 0.0233 0.0233
Entamoeba histolytica hypothetical protein 0.0152 0.1809 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0023 0.0176 0.0222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.2264 0.4252
Trypanosoma cruzi trypanothione reductase, putative 0.025 0.3052 0.8186
Loa Loa (eye worm) nuclear factor I 0.0015 0.0077 0.011
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0023 0.0176 0.0141
Brugia malayi RNA, U transporter 1 0.0088 0.1 0.1821
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.0176 0.033
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.369 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0012 0.004 0.0076
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0086 0.0982 0.23
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.0176 0.033
Loa Loa (eye worm) doublecortin family protein 0.002 0.0135 0.0217
Leishmania major trypanothione reductase 0.025 0.3052 0.8186
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0176 0.0521
Entamoeba histolytica disulphide oxidoreductase, putative 0.0023 0.0176 0.0017
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0018 0.0034
Echinococcus granulosus RUN 0.002 0.0135 0.0253
Plasmodium falciparum thioredoxin reductase 0.025 0.3052 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0233 0.0233
Echinococcus multilocularis smad 0.0027 0.0233 0.0437
Brugia malayi Thioredoxin reductase 0.025 0.3052 0.5625
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0086 0.0982 0.23
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.0176 0.0293
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0023 0.0176 0.0222
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0647 0.1215
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0176 0.0285
Schistosoma mansoni rab6-interacting 0.002 0.0135 0.0135
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.4071 0.7515
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0023 0.0176 0.0932
Brugia malayi Smad1 0.0027 0.0233 0.0399
Loa Loa (eye worm) hypothetical protein 0.0213 0.2591 0.477
Brugia malayi mothers against decapentaplegic homolog 3 0.0012 0.004 0.0042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0569 0.7109 0.8981
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.2139 0.3465
Plasmodium falciparum importin beta, putative 0.0031 0.0277 0.0486
Trypanosoma cruzi NADH dehydrogenase, putative 0.0023 0.0176 0.0008
Trichomonas vaginalis apoptosis inducing factor, putative 0.0023 0.0176 0.0285
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1889 0.2386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0685 0.0685
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0018 0.0034
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0233 0.0437
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.0176 0.0293
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0023 0.0176 0.033
Loa Loa (eye worm) hypothetical protein 0.0063 0.0685 0.1236
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0758 0.1372
Loa Loa (eye worm) thioredoxin reductase 0.025 0.3052 0.5625
Brugia malayi Stress-activated protein kinase jnk-1 0.0231 0.2811 0.5178
Trypanosoma brucei NADH dehydrogenase 0.0023 0.0176 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.004 0.0042
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0569 0.7109 0.8981
Loa Loa (eye worm) transcription factor SMAD2 0.0403 0.4995 0.9229
Schistosoma mansoni smad1 5 8 and 0.0027 0.0233 0.0233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0638 0.2043
Brugia malayi MH2 domain containing protein 0.0012 0.004 0.0042
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0023 0.0176 0.0932
Schistosoma mansoni hypothetical protein 0.0152 0.1809 0.1809
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0016
Brugia malayi glutamate synthase 0.0023 0.0176 0.0293
Brugia malayi MH1 domain containing protein 0.0015 0.0077 0.011
Onchocerca volvulus 0.002 0.0135 0.019
Echinococcus granulosus tar DNA binding protein 0.0069 0.0758 0.1423
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0758 0.0758
Brugia malayi Pre-SET motif family protein 0.0435 0.5411 1
Echinococcus granulosus cpg binding protein 0.0032 0.0289 0.0542
Toxoplasma gondii NADPH-glutathione reductase 0.0086 0.0982 0.3178

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.