TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 300.438 | Formula: C19H28N2O
H donors: 0 H acceptors: 0 LogP: 3.68 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(Oc1ccc(cc1)C1N2CC3(CN1CC(C2)(C3)C)C)C
InChi: 1S/C19H28N2O/c1-14(2)22-16-7-5-15(6-8-16)17-20-10-18(3)9-19(4,12-20)13-21(17)11-18/h5-8,14,17H,9-13H2,1-4H3
InChiKey: UKMSPUNRBGVRKA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0014	0.0103	0.0096
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0286	0.0308
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0014	0.0103	0.0121
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0051	0.0915	0.1351
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0051	0.0915	0.1351
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0377	0.7902	1
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0029	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1252	0.1252
Schistosoma mansoni	glutamate synthase	0.0014	0.0103	0.0103
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0458	0.0536
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0051	0.0915	0.1351
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0014	0.0103	0.025
Plasmodium vivax	importin-beta 2, putative	0.003	0.0458	0.1224
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0014	0.0103	0.0104
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.019	0.0222
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0196	0.0229
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0008	0.001
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0029	0.0034
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0149	0.3001	0.3798
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.019	0.0196
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.3621	0.3657
Leishmania major	trypanothione reductase	0.0149	0.3001	0.4819
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1252	0.1252
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.3426	0.346
Mycobacterium tuberculosis	Probable oxidoreductase	0.0377	0.7902	1
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0014	0.0103	0.0121
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0014	0.0103	0.0329
Brugia malayi	glutathione reductase	0.0149	0.3001	0.3443
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0014	0.0103	0.025
Onchocerca volvulus		0.0052	0.0921	0.0904
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0644	0.0721
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0155	0.3136	0.3672
Brugia malayi	hypothetical protein	0.0155	0.3136	0.3599
Brugia malayi	RNA binding protein	0.0067	0.1252	0.1423
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0196	0.0229
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0014	0.0103	0.1125
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.1252	0.1423
Schistosoma mansoni	ran	0.0022	0.0286	0.0286
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.103	0.1167
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0029	0.0034
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1808	0.2117
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0014	0.0103	0.013
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.019	0.0222
Brugia malayi	Pre-SET motif family protein	0.006	0.1093	0.1239
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0051	0.0915	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0286	0.0336
Schistosoma mansoni	cpg binding protein	0.003	0.0457	0.0457
Echinococcus granulosus	thioredoxin glutathione reductase	0.0149	0.3013	0.3529
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.3426	0.346
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.2795	0.4476
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0029	0.0034
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0014	0.0103	0.0096
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0339	0.709	0.8972
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.001
Schistosoma mansoni	smad1 5 8 and	0.0018	0.019	0.019
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0008	0.001
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0008	0.001
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.1808	0.2065
Entamoeba histolytica	Ran family GTPase	0.0022	0.0286	0.0605
Trichomonas vaginalis	set domain proteins, putative	0.047	0.9901	1
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0196	0.0203
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0155	0.3136	0.3672
Trichomonas vaginalis	mercuric reductase, putative	0.0051	0.0915	0.0925
Echinococcus granulosus	tumor protein p63	0.0353	0.7406	0.8673
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0335	0.0386
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.006	0.1093	0.1093
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0057	0.1033	0.1209
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0014	0.0103	0.025
Echinococcus granulosus	snurportin 1	0.0322	0.6729	0.7881
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0014	0.0103	0.0104
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0014	0.0103	0.0104
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0014	0.0103	0.013
Plasmodium falciparum	glutathione reductase	0.0149	0.3001	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.5321	0.5375
Schistosoma mansoni	hypothetical protein	0.0322	0.6729	0.6729
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0196	0.0203
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0029	0.001
Brugia malayi	hypothetical protein	0.001	0.0029	0.001
Trichomonas vaginalis	glutamate synthase, putative	0.0014	0.0103	0.0104
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0286	0.0867
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0014	0.0103	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0196	0.0203
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0014	0.0103	0.025
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0014	0.0103	0.013
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0051	0.0915	0.1351
Toxoplasma gondii	NADPH-glutathione reductase	0.0051	0.0915	0.2983
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.1093	0.1093
Schistosoma mansoni	cpg binding protein	0.0029	0.0422	0.0422
Loa Loa (eye worm)	Smad1	0.0018	0.019	0.0196
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0029	0.001
Schistosoma mansoni	hypothetical protein	0.0014	0.0103	0.0103
Entamoeba histolytica	hypothetical protein	0.0155	0.3136	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0286	0.0633
Trichomonas vaginalis	glutathione reductase, putative	0.0051	0.0915	0.0925
Schistosoma mansoni	smad1 5 8 and	0.0018	0.019	0.019
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0051	0.0915	1
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0014	0.0103	0.0121
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0196	0.0203
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.1252	0.1423
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1808	0.2117
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0014	0.0103	0.0104
Trypanosoma brucei	trypanothione reductase	0.0149	0.3001	0.4819
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.001
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0029	0.0029
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0029	0.001
Treponema pallidum	thioredoxin reductase (trxB)	0.0014	0.0103	0.1125
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.1093	0.1093
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0046	0.003
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.103	0.1167
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0196	0.0229
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.3426	0.346
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.5321	0.5375
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.001
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0029	0.0034
Brugia malayi	Smad1	0.0018	0.019	0.0196
Wolbachia endosymbiont of Brugia malayi	NADPH-dependent glutamate synthase beta chain	0.0014	0.0103	0.1125
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1017	0.3326
Echinococcus multilocularis	cpg binding protein	0.003	0.0457	0.0536
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.5321	0.5375
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0915	0.1351
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0014	0.0103	0.0104
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0196	0.0229
Toxoplasma gondii	selenide, water dikinase	0.0014	0.0103	0.025
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0014	0.0103	0.0104
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0014	0.0103	0.0329
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0014	0.0103	0.013
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.089	0.1309
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0029	0.0034
Schistosoma mansoni	hypothetical protein	0.0018	0.0196	0.0196
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0256	0.5321	0.6123
Brugia malayi	Importin beta-1 subunit	0.003	0.0458	0.0506
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0458	0.1443
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0029	0.001
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0029	0.0034
Mycobacterium ulcerans	dehydrogenase	0.0014	0.0103	0.0329
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1156	0.1156
Echinococcus granulosus	smad	0.0018	0.019	0.0222
Entamoeba histolytica	hypothetical protein	0.0024	0.0335	0.0765
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.6117	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.3132	0.3963
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0286	0.0305
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0029	0.0034
Schistosoma mansoni	smad1 5 8 and	0.0018	0.019	0.019
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.1808	0.2065
Echinococcus granulosus	glutamate synthase	0.0014	0.0103	0.0121
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0029	0.0029
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0014	0.0103	0.013
Toxoplasma gondii	hypothetical protein	0.0047	0.0827	0.2685
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0339	0.709	0.8972
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0014	0.0103	0.013
Brugia malayi	N-terminal motif family protein	0.0207	0.4265	0.4904
Toxoplasma gondii	thioredoxin reductase	0.0149	0.3001	1
Schistosoma mansoni	smad	0.0018	0.019	0.019
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0103	0.0096
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Schistosoma mansoni	hypothetical protein	0.0155	0.3136	0.3136
Schistosoma mansoni	dishevelled	0.001	0.0029	0.0029
Loa Loa (eye worm)	RNA binding protein	0.0067	0.1252	0.1423
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0286	0.0308
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0029	0.0034
Brugia malayi	glutamate synthase	0.0014	0.0103	0.0096
Trichomonas vaginalis	ran, putative	0.0022	0.0286	0.0289
Echinococcus multilocularis	tumor protein p63	0.0353	0.7406	0.8673
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0335	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0207	0.4265	0.4904
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0339	0.709	0.8972
Echinococcus multilocularis	dnaJ subfamily B	0.0406	0.8539	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0051	0.0915	1
Mycobacterium ulcerans	hypothetical protein	0.0155	0.3132	1
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0014	0.0103	0.0329
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0014	0.0103	0.0104
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.3426	0.346
Echinococcus multilocularis	glutamate synthase	0.0014	0.0103	0.0121
Loa Loa (eye worm)	transcription factor SMAD2	0.026	0.5394	0.6208
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0921	0.1041
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0029	0.0029
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0014	0.0103	0.0121
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0014	0.0103	0.0329
Plasmodium falciparum	thioredoxin reductase	0.0149	0.3001	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.3621	0.3657
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0014	0.0103	0.0329
Brugia malayi	TAR-binding protein	0.0067	0.1252	0.1423
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1808	0.2117
Mycobacterium ulcerans	ferredoxin reductase	0.0014	0.0103	0.0329
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0014	0.0103	0.0096
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1808	0.1808
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.019	0.0222
Brugia malayi	Pre-SET motif family protein	0.0413	0.8677	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0286	0.0305
Echinococcus multilocularis	smad	0.0018	0.019	0.0222
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.5321	0.5375
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0014	0.0103	0.0121
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1252	0.1252
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0051	0.0915	0.1034
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0196	0.0229
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0207	0.4265	0.4291
Schistosoma mansoni	hypothetical protein	0.0018	0.0196	0.0196
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0335	0.0386
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1808	0.1808
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.1252	0.1423
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0014	0.0103	0.0121
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0051	0.0915	0.1351
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0149	0.3013	0.3529
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0051	0.0915	0.2803
Schistosoma mansoni	hypothetical protein	0.0039	0.0644	0.0644
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0696	0.0987
Entamoeba histolytica	hypothetical protein	0.0155	0.3136	1
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0014	0.0103	0.0096
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0014	0.0103	0.0329
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Schistosoma mansoni	sulfide quinone reductase	0.0014	0.0103	0.0103
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0051	0.0915	0.0915
Plasmodium falciparum	importin beta, putative	0.003	0.0458	0.1224
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.1252	0.1466
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0339	0.709	0.8972
Echinococcus granulosus	GPCR family 2	0.0018	0.0196	0.0229
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0051	0.0915	1
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0014	0.0103	0.013
Brugia malayi	RNA, U transporter 1	0.0086	0.1653	0.1886
Schistosoma mansoni	ran	0.0022	0.0286	0.0286
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0051	0.0915	0.1351
Echinococcus granulosus	dnaJ subfamily B	0.0406	0.8539	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0322	0.6729	0.775
Schistosoma mansoni	transcription factor LCR-F1	0.0155	0.3136	0.3136
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0014	0.0103	0.0329
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0014	0.0103	0.0121
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0051	0.0915	0.2983
Onchocerca volvulus	Glucosylceramidase homolog	0.0168	0.3426	0.3441
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0286	0.2259
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0043	0.0027
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0051	0.0915	0.2803
Schistosoma mansoni	hypothetical protein	0.0018	0.0196	0.0196
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0046	0.0054
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1808	0.2117
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0377	0.7902	1
Loa Loa (eye worm)	thioredoxin reductase	0.0149	0.3001	0.3443
Echinococcus granulosus	importin subunit beta 1	0.003	0.0458	0.0536
Leishmania major	GTP-binding protein, putative	0.0022	0.0286	0.0305
Entamoeba histolytica	hypothetical protein	0.0155	0.3136	1
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0029	0.001
Mycobacterium ulcerans	NADH dehydrogenase	0.0014	0.0103	0.0329
Leishmania major	mitochondrial DNA polymerase beta	0.0293	0.6117	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0051	0.0915	0.2803
Schistosoma mansoni	dishevelled	0.001	0.0029	0.0029
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0286	0.0305
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.3426	0.346
Onchocerca volvulus		0.006	0.1093	0.1078
Schistosoma mansoni	disulfide oxidoreductase	0.0014	0.0103	0.0103
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0029	0.0034
Schistosoma mansoni	dep domain containing protein	0.001	0.0029	0.0029
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0286	0.0633
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.3426	0.346
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0014	0.0103	0.0121
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0696	0.0987
Echinococcus granulosus	Smad4	0.0018	0.019	0.0222
Echinococcus granulosus	histone lysine methyltransferase setb	0.006	0.1093	0.128
Plasmodium vivax	glutathione reductase, putative	0.0149	0.3001	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0149	0.3001	0.4819
Mycobacterium ulcerans	hypothetical protein	0.0014	0.0103	0.0329
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0051	0.0915	0.1072
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.6117	1
Mycobacterium ulcerans	monoxygenase	0.0014	0.0103	0.0329
Schistosoma mansoni	importin beta-1	0.003	0.0458	0.0458
Echinococcus granulosus	cpg binding protein	0.003	0.0457	0.0536
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0014	0.0103	0.025
Brugia malayi	MH1 domain containing protein	0.0018	0.019	0.0196
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0014	0.0103	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0644	0.0721
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.5321	0.5375
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.1093	0.1093
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.019	0.019
Schistosoma mansoni	sulfide quinone reductase	0.0014	0.0103	0.0103
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0051	0.0915	0.2923
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0014	0.0103	0.0121
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0915	0.2803
Schistosoma mansoni	cpg binding protein	0.003	0.0457	0.0457
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0014	0.0103	0.0104
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.006	0.1093	0.128
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0014	0.0103	0.0104
Brugia malayi	MH2 domain containing protein	0.0018	0.019	0.0196
Mycobacterium tuberculosis	Probable dehydrogenase	0.0339	0.709	0.8972
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.006	0.1093	0.128
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0335	0.0338
Onchocerca volvulus		0.047	0.9901	1
Schistosoma mansoni	Smad4	0.0018	0.019	0.019
Schistosoma mansoni	hypothetical protein	0.0018	0.0196	0.0196
Loa Loa (eye worm)	programmed cell death 8	0.0014	0.0103	0.0096
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0422	0.0465
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0339	0.709	0.8972
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0014	0.0103	0.0121
Brugia malayi	MH2 domain containing protein	0.026	0.5394	0.6208
Plasmodium falciparum	glutathione reductase	0.0051	0.0915	0.2803
Loa Loa (eye worm)	hypothetical protein	0.006	0.1093	0.1239
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.103	0.1167
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.001
Onchocerca volvulus		0.0014	0.0103	0.0075
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0286	0.0336
Brugia malayi	MH1 domain containing protein	0.0018	0.019	0.0196
Schistosoma mansoni	glutamate synthase	0.0014	0.0103	0.0103
Trichomonas vaginalis	glutamate synthase, putative	0.0014	0.0103	0.0104
Echinococcus granulosus	tar DNA binding protein	0.0067	0.1252	0.1466
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.006	0.1093	0.358
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1252	0.1252
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0014	0.0103	0.0329
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0051	0.0915	0.1351
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0051	0.0915	0.1158
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0377	0.7902	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	0.6117	1
Onchocerca volvulus		0.0029	0.0422	0.0399
Brugia malayi	Thioredoxin reductase	0.0149	0.3001	0.3443
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0051	0.0915	0.2803
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.019	0.0196
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0051	0.0915	0.1351
Echinococcus multilocularis	snurportin 1	0.0322	0.6729	0.7881
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0335	0.0338
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.3426	0.346
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0422	0.0465
Treponema pallidum	NADH oxidase	0.0051	0.0915	1
Schistosoma mansoni	hypothetical protein	0.0406	0.8539	0.8539
Echinococcus multilocularis	Smad4	0.0018	0.019	0.0222
Loa Loa (eye worm)	glutathione reductase	0.0149	0.3001	0.3443
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0014	0.0103	0.0104
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0458	0.059
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0014	0.0103	0.0104
Mycobacterium tuberculosis	Probable reductase	0.0339	0.709	0.8972
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0038	0.0622	0.0695
Schistosoma mansoni	glutamate synthase	0.0014	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.003	0.0458	0.0506
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0051	0.0915	0.1351
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0458	0.059
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0413	0.8677	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0696	0.0987
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0051	0.0915	0.2923
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0014	0.0103	0.013
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0008	0.0008
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0696	0.0987
Plasmodium vivax	thioredoxin reductase, putative	0.0149	0.3001	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0038	0.0622	0.0695
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.1252	0.1252
Brugia malayi	hypothetical protein	0.001	0.0029	0.001
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0014	0.0103	0.013
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.2795	0.4476
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0046	0.0054
Brugia malayi	MH2 domain containing protein	0.0018	0.019	0.0196
Plasmodium vivax	SET domain protein, putative	0.006	0.1093	0.3416
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.019	0.0222
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0921	0.0921
Trichomonas vaginalis	glucosylceramidase, putative	0.0256	0.5321	0.5375
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0256	0.5321	0.6123
Loa Loa (eye worm)	hypothetical protein	0.0057	0.103	0.1167
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0051	0.0915	0.1072
Loa Loa (eye worm)	MH2 domain-containing protein	0.026	0.5394	0.6208
Treponema pallidum	oxidoreductase	0.0014	0.0103	0.1125
Brugia malayi	DIX domain containing protein	0.001	0.0029	0.001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1808	0.1808
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0014	0.0103	0.0121
Entamoeba histolytica	hypothetical protein	0.0155	0.3136	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.2795	0.4476
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0014	0.0103	0.013
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0051	0.0915	0.2923

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 757411