Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | protease, serine, 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0187 | 0.24 | 0.535 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0246 | 0.3484 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0246 | 0.3484 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0244 | 0.3457 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0161 | 0.1916 | 0.0831 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0122 | 0.1183 | 0.3423 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0246 | 0.3484 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.5316 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0187 | 0.24 | 0.2944 |
Brugia malayi | Protein kinase domain containing protein | 0.027 | 0.3932 | 0.7396 |
Echinococcus granulosus | dihydrofolate reductase | 0.0244 | 0.3457 | 1 |
Brugia malayi | Trypsin family protein | 0.0344 | 0.5316 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0344 | 0.5316 | 0.4687 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.3932 | 0.665 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.5316 | 1 |
Onchocerca volvulus | 0.0344 | 0.5316 | 1 | |
Onchocerca volvulus | 0.0319 | 0.4848 | 0.8932 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0344 | 0.5316 | 0.4687 |
Brugia malayi | thymidylate synthase | 0.0122 | 0.1183 | 0.2226 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0244 | 0.3457 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0246 | 0.3484 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0187 | 0.24 | 0.4514 |
Schistosoma mansoni | alpha-glucosidase | 0.0161 | 0.1916 | 0.0831 |
Brugia malayi | Dihydrofolate reductase | 0.0244 | 0.3457 | 0.6503 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0244 | 0.3457 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0244 | 0.3457 | 0.5501 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0244 | 0.3457 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0244 | 0.3457 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0244 | 0.3457 | 0.6503 |
Onchocerca volvulus | 0.0122 | 0.1183 | 0.0566 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0187 | 0.24 | 0.535 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0187 | 0.24 | 0.535 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0244 | 0.3457 | 0.2579 |
Trypanosoma brucei | RNA helicase, putative | 0.0597 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0246 | 0.3484 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 96 nM | Inhibitory activity against human thrombin (using Chromozym TH as the substrate) | ChEMBL. | 10794696 |
Ki (binding) | = 96 nM | Inhibitory activity against human thrombin (using Chromozym TH as the substrate) | ChEMBL. | 10794696 |
Ki (binding) | = 1235 nM | Inhibitory activity against human trypsin (using Chromozym TH as the substrate) | ChEMBL. | 10794696 |
Ki (binding) | = 1235 nM | Inhibitory activity against human trypsin (using Chromozym TH as the substrate) | ChEMBL. | 10794696 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.