Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | snurportin 1 | 0.0321 | 0.5108 | 0.5943 |
Schistosoma mansoni | hypothetical protein | 0.0519 | 0.857 | 0.8565 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.1514 | 0.3932 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0388 | 0.0354 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.0389 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.1514 | 0.3932 |
Brugia malayi | mbt repeat family protein | 0.0099 | 0.1236 | 0.3182 |
Leishmania major | trypanothione reductase | 0.005 | 0.0389 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.0805 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1116 | 0.1085 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.1514 | 0.3932 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0099 | 0.1236 | 0.2368 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0159 | 0.008 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0131 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0159 | 0.0244 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0131 | 0.0152 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0113 | 0.1475 | 0.3815 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.0389 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0321 | 0.5108 | 0.509 |
Onchocerca volvulus | 0.0037 | 0.0159 | 0.0684 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0159 | 0.1092 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0159 | 0.0327 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0168 | 0.2442 | 0.282 |
Onchocerca volvulus | 0.0099 | 0.1236 | 1 | |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.0805 | 0.0772 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0159 | 0.172 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0159 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0236 | 0.0396 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0159 | 0.008 |
Onchocerca volvulus | 0.0037 | 0.0159 | 0.0684 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.1116 | 0.1266 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.0389 | 0.0698 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0159 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0159 | 0.0244 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.0389 | 0.0415 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0036 | 0.0131 | 0.2692 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0113 | 0.1475 | 0.1721 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0099 | 0.1236 | 0.1407 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0159 | 0.0327 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0159 | 0.349 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.0805 | 0.0939 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.0389 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.0389 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.2034 | 0.2006 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0159 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.1514 | 0.3932 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0159 | 0.008 |
Brugia malayi | RNA, U transporter 1 | 0.0085 | 0.1002 | 0.256 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0131 | 0.0152 |
Brugia malayi | glutathione reductase | 0.005 | 0.0389 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1475 | 0.2839 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0159 | 0.008 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0161 | 0.1754 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0099 | 0.1236 | 0.1205 |
Schistosoma mansoni | hypothetical protein | 0.0519 | 0.857 | 0.8565 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.0131 | 0.1358 |
Loa Loa (eye worm) | RNA binding protein | 0.0199 | 0.2979 | 0.5803 |
Echinococcus multilocularis | snurportin 1 | 0.0321 | 0.5108 | 0.596 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0099 | 0.1236 | 0.1407 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.0389 | 0.0698 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.0805 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.008 | 0.0087 |
Loa Loa (eye worm) | TAR-binding protein | 0.0199 | 0.2979 | 0.5803 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0159 | 0.172 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.365 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.0389 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0161 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.0161 | 0.0127 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0113 | 0.1475 | 0.1687 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0159 | 0.0185 |
Brugia malayi | mbt repeat family protein | 0.0099 | 0.1236 | 0.3182 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0131 | 0.044 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0159 | 0.008 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.0131 | 0.0096 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0161 | 0.1195 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.1514 | 0.3932 |
Plasmodium vivax | pyruvate kinase, putative | 0.0036 | 0.0131 | 0.2692 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0159 | 0.0176 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0113 | 0.1475 | 0.1687 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0199 | 0.2979 | 0.5803 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.2979 | 0.2954 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0161 | 0.1754 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.0161 | 0.0334 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.1116 | 0.2863 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0321 | 0.5108 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.1738 | 0.4567 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1236 | 0.2368 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.1116 | 0.2131 |
Echinococcus multilocularis | importin subunit beta 1 | 0.003 | 0.0035 | 0.0041 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.0131 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.381 | 0.7442 |
Onchocerca volvulus | 0.0037 | 0.0159 | 0.0684 | |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0159 | 0.0244 |
Echinococcus granulosus | tar DNA binding protein | 0.0199 | 0.2979 | 0.3449 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.0161 | 0.0188 |
Echinococcus granulosus | chromobox protein 1 | 0.0074 | 0.0805 | 0.0902 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.0389 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0145 | 0.2034 | 0.2006 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0161 | 0.0249 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0236 | 0.1355 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0388 | 0.0934 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0159 | 0.172 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0161 | 0.1754 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.2979 | 0.2954 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.1116 | 0.1302 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0074 | 0.0805 | 0.1517 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0036 | 0.0131 | 0.2692 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0099 | 0.1236 | 0.1205 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0099 | 0.1236 | 0.1443 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1116 | 0.1085 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0159 | 0.008 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0159 | 0.1092 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.0161 | 0.3566 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.0131 | 0.0112 |
Brugia malayi | chromobox protein homolog 3 | 0.0042 | 0.0236 | 0.0533 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0161 | 0.1754 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0159 | 0.008 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.0291 | 0.3419 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0199 | 0.2979 | 0.7798 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0036 | 0.0131 | 0.0252 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0161 | 0.3566 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.0291 | 0.1831 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.2442 | 0.285 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.0161 | 0.1754 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0159 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.1738 | 0.4567 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0159 | 0.0244 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.2979 | 0.2954 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.1738 | 0.4567 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0036 | 0.0131 | 0.2692 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0159 | 0.0244 |
Echinococcus multilocularis | geminin | 0.0519 | 0.857 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0161 | 0.1195 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0159 | 0.0124 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0236 | 0.2714 |
Loa Loa (eye worm) | MBCTL1 | 0.0113 | 0.1475 | 0.2839 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.0389 | 0.0938 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.0131 | 0.0096 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.0161 | 0.1195 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0159 | 0.0176 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.039 | 0.631 | 0.7352 |
Echinococcus multilocularis | chromobox protein 1 | 0.0074 | 0.0805 | 0.0939 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.1116 | 0.1302 |
Giardia lamblia | Pyruvate kinase | 0.0036 | 0.0131 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0159 | 0.008 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0113 | 0.1475 | 0.1721 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0113 | 0.1475 | 0.1445 |
Chlamydia trachomatis | pyruvate kinase | 0.0036 | 0.0131 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0246 | 0.381 | 0.4446 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0159 | 0.349 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0131 | 0.044 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0388 | 0.0354 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0161 | 0.1754 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.1116 | 0.1085 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0131 | 0.0188 |
Echinococcus multilocularis | tar DNA binding protein | 0.0199 | 0.2979 | 0.3476 |
Brugia malayi | hypothetical protein | 0.0246 | 0.381 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0159 | 0.172 |
Brugia malayi | TAR-binding protein | 0.0199 | 0.2979 | 0.7798 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.2979 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0131 | 0.0188 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.2442 | 0.285 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0159 | 0.008 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0161 | 0.1754 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0131 | 0.0188 |
Plasmodium falciparum | pyruvate kinase | 0.0036 | 0.0131 | 0.2692 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0159 | 0.172 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.0389 | 0.0454 |
Onchocerca volvulus | 0.005 | 0.0388 | 0.2665 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0236 | 0.2714 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0168 | 0.2442 | 0.4745 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0159 | 0.1092 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0159 | 0.008 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0159 | 0.0124 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0159 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0099 | 0.1236 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0159 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0099 | 0.1236 | 0.1443 |
Trichomonas vaginalis | chromobox protein, putative | 0.0074 | 0.0805 | 1 |
Schistosoma mansoni | chromobox protein | 0.0074 | 0.0805 | 0.0772 |
Brugia malayi | Heterochromatin protein 1 | 0.0074 | 0.0805 | 0.2039 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.2979 | 0.2954 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.1738 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.039 | 0.631 | 0.7363 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0168 | 0.2442 | 0.6376 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0246 | 0.381 | 0.4423 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.1514 | 0.3932 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0131 | 0.0188 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0159 | 0.0244 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0161 | 0.1754 |
Trichomonas vaginalis | chromobox protein, putative | 0.0045 | 0.0291 | 0.3419 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.0131 | 0.1358 |
Onchocerca volvulus | 0.0097 | 0.1206 | 0.974 | |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.0161 | 0.0148 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0161 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0159 | 0.172 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.1116 | 0.1266 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0159 | 0.0244 |
Echinococcus granulosus | geminin | 0.0519 | 0.857 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.005 | 0.0389 | 0.0735 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.0389 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0099 | 0.1236 | 0.1205 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.0161 | 0.1754 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0159 | 0.0327 |
Brugia malayi | RNA binding protein | 0.0199 | 0.2979 | 0.7798 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0159 | 0.349 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0159 | 0.0244 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0036 | 0.0131 | 0.0252 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0115 | 0.1514 | 0.8609 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.