TDR Targets

Basic information

Technical information

TDR Targets ID: 757762
Name: ethyl 5-[(4-diethylamino-2-methoxyphenyl)meth ylidene]-2-[(4-methoxyphenyl)amino]-4-oxothio phene-3-carboxylate
MW: 482.592 | Formula: C26H30N2O5S
H donors: 1 H acceptors: 2 LogP: 6.25 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=C(Nc2ccc(cc2)OC)SC(=Cc2ccc(cc2OC)N(CC)CC)C1=O
InChi: 1S/C26H30N2O5S/c1-6-28(7-2)19-12-9-17(21(16-19)32-5)15-22-24(29)23(26(30)33-8-3)25(34-22)27-18-10-13-20(31-4)14-11-18/h9-16,27H,6-8H2,1-5H3/b22-15-
InChiKey: VUICROGKRHGOTQ-JCMHNJIXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl (5Z)-5-[(4-diethylamino-2-methoxyphenyl)methylidene]-2-[(4-methoxyphenyl)amino]-4-oxothiophene-3-carboxylate
ethyl 5-[(4-diethylamino-2-methoxy-phenyl)methylene]-2-[(4-methoxyphenyl)amino]-4-oxo-thiophene-3-carboxylate
ethyl (5Z)-5-[(4-diethylamino-2-methoxy-phenyl)methylene]-2-[(4-methoxyphenyl)amino]-4-oxo-thiophene-3-carboxylate
5-[(4-diethylamino-2-methoxyphenyl)methylene]-2-[(4-methoxyphenyl)amino]-4-oxo-3-thiophenecarboxylic acid ethyl ester
(5Z)-5-[(4-diethylamino-2-methoxyphenyl)methylene]-2-[(4-methoxyphenyl)amino]-4-oxo-3-thiophenecarboxylic acid ethyl ester
5-(4-diethylamino-2-methoxy-benzylidene)-4-keto-2-[(4-methoxyphenyl)amino]thiophene-3-carboxylic acid ethyl ester
(5Z)-5-(4-diethylamino-2-methoxy-benzylidene)-4-keto-2-[(4-methoxyphenyl)amino]thiophene-3-carboxylic acid ethyl ester
ethyl 5-[(4-diethylamino-2-methoxy-phenyl)methylidene]-2-[(4-methoxyphenyl)amino]-4-oxo-thiophene-3-carboxylate
ethyl (5Z)-5-[(4-diethylamino-2-methoxy-phenyl)methylidene]-2-[(4-methoxyphenyl)amino]-4-oxo-thiophene-3-carboxylate
AN-989/14669058
ZINC08438418

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	snurportin 1	0.0321	0.5108	0.5943
Schistosoma mansoni	hypothetical protein	0.0519	0.857	0.8565
Mycobacterium tuberculosis	Probable reductase	0.0115	0.1514	0.3932
Schistosoma mansoni	survival motor neuron protein	0.005	0.0388	0.0354
Trypanosoma brucei	trypanothione reductase	0.005	0.0389	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.1514	0.3932
Brugia malayi	mbt repeat family protein	0.0099	0.1236	0.3182
Leishmania major	trypanothione reductase	0.005	0.0389	1
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0805	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.1116	0.1085
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.1514	0.3932
Loa Loa (eye worm)	mbt repeat family protein	0.0099	0.1236	0.2368
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0159	0.008
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0131	0.044
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0244
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0131	0.0152
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0113	0.1475	0.3815
Plasmodium falciparum	thioredoxin reductase	0.005	0.0389	1
Schistosoma mansoni	hypothetical protein	0.0321	0.5108	0.509
Onchocerca volvulus		0.0037	0.0159	0.0684
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0159	0.1092
Brugia malayi	beta-lactamase family protein	0.0037	0.0159	0.0327
Echinococcus granulosus	lysosomal alpha glucosidase	0.0168	0.2442	0.282
Onchocerca volvulus		0.0099	0.1236	1
Schistosoma mansoni	chromobox protein	0.0074	0.0805	0.0772
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0159	0.172
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0159	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0236	0.0396
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0159	0.008
Onchocerca volvulus		0.0037	0.0159	0.0684
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.1116	0.1266
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0389	0.0698
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0159	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0244
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0389	0.0415
Toxoplasma gondii	pyruvate kinase PyK1	0.0036	0.0131	0.2692
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0113	0.1475	0.1721
Echinococcus granulosus	SAM and MBT domain containing protein	0.0099	0.1236	0.1407
Brugia malayi	beta-lactamase family protein	0.0037	0.0159	0.0327
Toxoplasma gondii	ABC1 family protein	0.0037	0.0159	0.349
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0805	0.0939
Plasmodium falciparum	glutathione reductase	0.005	0.0389	1
Toxoplasma gondii	thioredoxin reductase	0.005	0.0389	1
Schistosoma mansoni	alpha-glucosidase	0.0145	0.2034	0.2006
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0159	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.1514	0.3932
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0159	0.008
Brugia malayi	RNA, U transporter 1	0.0085	0.1002	0.256
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0131	0.0152
Brugia malayi	glutathione reductase	0.005	0.0389	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1475	0.2839
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0159	0.008
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0161	0.1754
Schistosoma mansoni	sex comb on midleg homolog	0.0099	0.1236	0.1205
Schistosoma mansoni	hypothetical protein	0.0519	0.857	0.8565
Trichomonas vaginalis	pyruvate kinase, putative	0.0036	0.0131	0.1358
Loa Loa (eye worm)	RNA binding protein	0.0199	0.2979	0.5803
Echinococcus multilocularis	snurportin 1	0.0321	0.5108	0.596
Echinococcus granulosus	polycomb protein SCMH1	0.0099	0.1236	0.1407
Loa Loa (eye worm)	glutathione reductase	0.005	0.0389	0.0698
Echinococcus granulosus	chromobox protein 1	0.0074	0.0805	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0033	0.008	0.0087
Loa Loa (eye worm)	TAR-binding protein	0.0199	0.2979	0.5803
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0159	0.172
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.365	1
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0389	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0161	0.5
Schistosoma mansoni	alpha glucosidase	0.0037	0.0161	0.0127
Echinococcus granulosus	histone acetyltransferase MYST2	0.0113	0.1475	0.1687
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0159	0.0185
Brugia malayi	mbt repeat family protein	0.0099	0.1236	0.3182
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0131	0.044
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0159	0.008
Schistosoma mansoni	pyruvate kinase	0.0036	0.0131	0.0096
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0161	0.1195
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.1514	0.3932
Plasmodium vivax	pyruvate kinase, putative	0.0036	0.0131	0.2692
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0159	0.0176
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0113	0.1475	0.1687
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0199	0.2979	0.5803
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2979	0.2954
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0161	0.1754
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0161	0.0334
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.1116	0.2863
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0321	0.5108	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.1738	0.4567
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1236	0.2368
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.1116	0.2131
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0035	0.0041
Echinococcus granulosus	pyruvate kinase	0.0036	0.0131	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0246	0.381	0.7442
Onchocerca volvulus		0.0037	0.0159	0.0684
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0159	0.0244
Echinococcus granulosus	tar DNA binding protein	0.0199	0.2979	0.3449
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0161	0.0188
Echinococcus granulosus	chromobox protein 1	0.0074	0.0805	0.0902
Plasmodium vivax	glutathione reductase, putative	0.005	0.0389	1
Schistosoma mansoni	alpha-glucosidase	0.0145	0.2034	0.2006
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0161	0.0249
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0236	0.1355
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0388	0.0934
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0159	0.172
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0161	0.1754
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2979	0.2954
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.1116	0.1302
Loa Loa (eye worm)	heterochromatin protein 1	0.0074	0.0805	0.1517
Trypanosoma brucei	pyruvate kinase 1	0.0036	0.0131	0.2692
Schistosoma mansoni	sex comb on midleg homolog	0.0099	0.1236	0.1205
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0099	0.1236	0.1443
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.1116	0.1085
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0159	0.008
Leishmania major	hypothetical protein, conserved	0.0037	0.0159	0.1092
Trypanosoma brucei	glucosidase, putative	0.0037	0.0161	0.3566
Echinococcus granulosus	pyruvate kinase	0.0036	0.0131	0.0112
Brugia malayi	chromobox protein homolog 3	0.0042	0.0236	0.0533
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0161	0.1754
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0159	0.008
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.0291	0.3419
Brugia malayi	RNA recognition motif domain containing protein	0.0199	0.2979	0.7798
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0036	0.0131	0.0252
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0161	0.3566
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.0291	0.1831
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0168	0.2442	0.285
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0161	0.1754
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0159	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.1738	0.4567
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0244
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2979	0.2954
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.1738	0.4567
Trypanosoma brucei	pyruvate kinase 1, putative	0.0036	0.0131	0.2692
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0244
Echinococcus multilocularis	geminin	0.0519	0.857	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0161	0.1195
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0159	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0236	0.2714
Loa Loa (eye worm)	MBCTL1	0.0113	0.1475	0.2839
Brugia malayi	Thioredoxin reductase	0.005	0.0389	0.0938
Schistosoma mansoni	pyruvate kinase	0.0036	0.0131	0.0096
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0161	0.1195
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0159	0.0176
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.039	0.631	0.7352
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0805	0.0939
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.1116	0.1302
Giardia lamblia	Pyruvate kinase	0.0036	0.0131	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0159	0.008
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0113	0.1475	0.1721
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0113	0.1475	0.1445
Chlamydia trachomatis	pyruvate kinase	0.0036	0.0131	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0246	0.381	0.4446
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0159	0.349
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0131	0.044
Schistosoma mansoni	hypothetical protein	0.005	0.0388	0.0354
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0161	0.1754
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.1116	0.1085
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0131	0.0188
Echinococcus multilocularis	tar DNA binding protein	0.0199	0.2979	0.3476
Brugia malayi	hypothetical protein	0.0246	0.381	1
Trichomonas vaginalis	esterase, putative	0.0037	0.0159	0.172
Brugia malayi	TAR-binding protein	0.0199	0.2979	0.7798
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2979	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0131	0.0188
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0168	0.2442	0.285
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0159	0.008
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0161	0.1754
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0131	0.0188
Plasmodium falciparum	pyruvate kinase	0.0036	0.0131	0.2692
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0159	0.172
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0389	0.0454
Onchocerca volvulus		0.005	0.0388	0.2665
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0236	0.2714
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0168	0.2442	0.4745
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0159	0.1092
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0159	0.008
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0159	0.0124
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0159	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0099	0.1236	1
Mycobacterium ulcerans	lipase LipD	0.0037	0.0159	1
Echinococcus multilocularis	polycomb protein SCMH1	0.0099	0.1236	0.1443
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0805	1
Schistosoma mansoni	chromobox protein	0.0074	0.0805	0.0772
Brugia malayi	Heterochromatin protein 1	0.0074	0.0805	0.2039
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.2979	0.2954
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.1738	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.039	0.631	0.7363
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0168	0.2442	0.6376
Echinococcus granulosus	survival motor neuron protein 1	0.0246	0.381	0.4423
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.1514	0.3932
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0131	0.0188
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0159	0.0244
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0161	0.1754
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.0291	0.3419
Trichomonas vaginalis	pyruvate kinase, putative	0.0036	0.0131	0.1358
Onchocerca volvulus		0.0097	0.1206	0.974
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0161	0.0148
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0161	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0159	0.172
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.1116	0.1266
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0159	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0244
Echinococcus granulosus	geminin	0.0519	0.857	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0389	0.0735
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0389	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0099	0.1236	0.1205
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0161	0.1754
Brugia malayi	beta-lactamase	0.0037	0.0159	0.0327
Brugia malayi	RNA binding protein	0.0199	0.2979	0.7798
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0159	0.349
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0159	0.0244
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0036	0.0131	0.0252
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.1514	0.8609

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 757762