Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0137 | 0.3803 | 1 |
Schistosoma mansoni | protein kinase | 0.0077 | 0.1039 | 0.1913 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0064 | 0.0467 | 0.3869 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0137 | 0.3803 | 0.3803 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0077 | 0.1039 | 0.1913 |
Schistosoma mansoni | patched 1 | 0.0056 | 0.0106 | 0.0196 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.0056 | 0.0106 | 0.0196 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0056 | 0.0106 | 0.0196 |
Echinococcus multilocularis | geminin | 0.0172 | 0.5432 | 1 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0077 | 0.1039 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0137 | 0.3803 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0056 | 0.0106 | 0.0106 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0077 | 0.1039 | 0.1039 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0056 | 0.0106 | 0.0196 |
Entamoeba histolytica | casein kinase, putative | 0.0077 | 0.1039 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0137 | 0.3803 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0064 | 0.0467 | 0.3869 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0056 | 0.0106 | 0.0196 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0064 | 0.0467 | 0.3869 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0077 | 0.1039 | 0.1913 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.5432 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0054 | 0 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0137 | 0.3803 | 0.7001 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0077 | 0.1039 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Plasmodium vivax | unspecified product | 0.0077 | 0.1039 | 0.5 |
Brugia malayi | Casein kinase II, alpha chain | 0.0077 | 0.1039 | 0.1039 |
Echinococcus granulosus | geminin | 0.0172 | 0.5432 | 1 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0137 | 0.3803 | 0.7001 |
Brugia malayi | CHE-14 protein | 0.0056 | 0.0106 | 0.0106 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0137 | 0.3803 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0056 | 0.0106 | 0.0196 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0077 | 0.1039 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0077 | 0.1039 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0077 | 0.1039 | 0.5 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0056 | 0.0106 | 0.0196 |
Echinococcus multilocularis | protein dispatched 1 | 0.0056 | 0.0106 | 0.0196 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0077 | 0.1039 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0137 | 0.3803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3803 | 0.3803 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0106 | 0.0106 |
Echinococcus multilocularis | protein patched | 0.0056 | 0.0106 | 0.0196 |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Onchocerca volvulus | 0.0054 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.5432 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0137 | 0.3803 | 0.7001 |
Loa Loa (eye worm) | STAT protein | 0.0272 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 14.91 uM | Antifungal activity against Candida albicans using twofold microbroth dilution technique. | ChEMBL. | 10969966 |
MIC (functional) | = 14.39 uM | Lowest concentration of compound that substantially inhibited the growth of Cryptococcus neoformans after 48 hr | ChEMBL. | 10969966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.