Detailed information for compound 758498

Basic information

Technical information
  • TDR Targets ID: 758498
  • Name: 4-[4-(4-chlorophenoxy)-3,5,6-trifluoropyridin -2-yl]morpholine
  • MW: 344.716 | Formula: C15H12ClF3N2O2
  • H donors: 0 H acceptors: 1 LogP: 3.73 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Oc1c(F)c(F)nc(c1F)N1CCOCC1
  • InChi: 1S/C15H12ClF3N2O2/c16-9-1-3-10(4-2-9)23-13-11(17)14(19)20-15(12(13)18)21-5-7-22-8-6-21/h1-4H,5-8H2
  • InChiKey: NQDUTINJZRLVAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-(4-chlorophenoxy)-3,5,6-trifluoro-2-pyridyl]morpholine
  • 4-[4-(4-chlorophenoxy)-3,5,6-trifluoro-pyridin-2-yl]morpholine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cdc25b, putative 0.0166 0.1577 0.2558
Entamoeba histolytica hypothetical protein 0.0079 0.0667 0.4061
Trypanosoma brucei protein kinase, putative 0.005 0.0353 0.1134
Loa Loa (eye worm) hypothetical protein 0.0165 0.1567 0.1567
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0353 0.0353
Brugia malayi CXXC zinc finger family protein 0.0059 0.0455 0.0455
Schistosoma mansoni hypothetical protein 0.0197 0.1904 0.2179
Brugia malayi Muscleblind-like protein 0.0158 0.1497 0.1497
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0045 0.0045
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0249 0.0342
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0835 0.0835
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0249 0.0342
Schistosoma mansoni hypothetical protein 0.0844 0.8737 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.004 0.0249 0.0413
Echinococcus multilocularis zinc finger protein 0.0024 0.0078 0.0078
Loa Loa (eye worm) oxidoreductase 0.004 0.0249 0.0249
Leishmania major 3-oxoacyl-ACP reductase, putative 0.004 0.0249 0.08
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0023 0.0023
Onchocerca volvulus 0.0166 0.1577 0.8022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0029 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0353 0.0516
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0166 0.1577 0.1577
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0249 0.0342
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0588 0.6032 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0249 0.0249
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0353 0.0586
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.104 0.1724
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Brugia malayi hypothetical protein 0.0165 0.1567 0.1567
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.004 0.0249 0.0249
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0835 0.0956
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0469 0.0469
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.3116 1
Entamoeba histolytica hypothetical protein 0.0079 0.0667 0.4061
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0291 0.0935
Leishmania major oxidoreductase-like protein 0.004 0.0249 0.08
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Echinococcus multilocularis dna polymerase kappa 0.002 0.0045 0.0045
Mycobacterium ulcerans oxidoreductase 0.004 0.0249 0.0342
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0353 0.1134
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0353 0.0353
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0835 0.0835
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0166 0.1577 0.2558
Mycobacterium ulcerans hypothetical protein 0.0164 0.1561 0.2532
Brugia malayi MAP kinase sur-1 0.005 0.0353 0.0353
Trichomonas vaginalis cdc25b, putative 0.0166 0.1577 0.2558
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0001
Loa Loa (eye worm) hypothetical protein 0.0166 0.1577 0.1577
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0046 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0111 0.0355
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0111 0.0184
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0526 0.0526
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0368 0.0368
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0368 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0353 0.0405
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0052
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Onchocerca volvulus 0.0166 0.1577 0.8022
Trypanosoma brucei oxidoreductase-like protein 0.004 0.0249 0.08
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0111 0.0355
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0111 0.0184
Schistosoma mansoni cpg binding protein 0.0065 0.0511 0.0585
Echinococcus granulosus dnaJ subfamily B 0.0844 0.8737 0.8737
Loa Loa (eye worm) retinol dehydrogenase 12 0.004 0.0249 0.0249
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.004 0.0249 0.034
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0353 0.0516
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.004 0.0249 0.0342
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0667 0.0667
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0015 0.0017
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0056 0.0056
Echinococcus granulosus zinc finger protein 0.0024 0.0078 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0144
Onchocerca volvulus 0.0166 0.1577 0.8022
Schistosoma mansoni dihydropteridine reductase 0.004 0.0249 0.0285
Echinococcus granulosus dna polymerase kappa 0.002 0.0045 0.0045
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.004 0.0249 0.0249
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0046 0.0001
Brugia malayi Rhodanese-like domain containing protein 0.0166 0.1577 0.1577
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0515 0.0515
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0052
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.004 0.0249 0.0342
Leishmania major DNA polymerase eta, putative 0.002 0.0045 0.0144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0153 0.144 0.144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.0146
Loa Loa (eye worm) hypothetical protein 0.0051 0.0368 0.0368
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0353 0.0353
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0353 0.0516
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.004 0.0249 0.0413
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0353 1
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0054 0.0054
Brugia malayi PHD-finger family protein 0.0029 0.0136 0.0136
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0111 0.0184
Trichomonas vaginalis hypothetical protein 0.0588 0.6032 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0481 0.4907 0.4907
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0835 0.0835
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.004 0.0249 0.08
Leishmania major dehydrogenase/oxidoreductase-like protein 0.004 0.0249 0.08
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0198 0.0198
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.004 0.0249 0.0413
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.004 0.0249 0.0342
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0588 0.6032 1
Onchocerca volvulus 0.0197 0.1904 1
Loa Loa (eye worm) hypothetical protein 0.0964 1 1
Schistosoma mansoni cpg binding protein 0.0059 0.0455 0.052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0526 0.0602
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0197 0.1904 0.1904
Echinococcus granulosus dna polymerase eta 0.002 0.0045 0.0045
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.022 0.022
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0291 0.0935
Schistosoma mansoni hypothetical protein 0.0035 0.0198 0.0226
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0111 0.0355
Loa Loa (eye worm) hypothetical protein 0.004 0.0247 0.0247
Brugia malayi jmjC domain containing protein 0.0061 0.0469 0.0469
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0515 0.0515
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0353 0.1134
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0353 0.1134
Echinococcus multilocularis survival motor neuron protein 1 0.0964 1 1
Echinococcus multilocularis cpg binding protein 0.0065 0.0511 0.0511
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.004 0.0249 0.0249
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0526 0.0526
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0588 0.6032 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.0588 0.6032 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0353 0.0353
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1385 0.4444
Loa Loa (eye worm) hypothetical protein 0.0158 0.1497 0.1497
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0023 0.0023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0368 0.0368
Toxoplasma gondii hypothetical protein 0.005 0.0359 0.0596
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.011 0.011
Entamoeba histolytica rodhanase-like domain containing protein 0.0166 0.1577 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0835 0.0835
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.004 0.0249 0.0342
Brugia malayi hypothetical protein 0.0079 0.0667 0.0667
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0526 0.0602
Leishmania major DNA polymerase kappa, putative 0.002 0.0045 0.0144
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.004 0.0249 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0144
Echinococcus multilocularis dna polymerase eta 0.002 0.0045 0.0045
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0469 0.0537
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1385 0.4444
Trypanosoma cruzi oxidoreductase-like protein, putative 0.004 0.0249 0.08
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0469 0.0469
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.004 0.0249 0.0249
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0353 0.1134
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Onchocerca volvulus 0.0165 0.1567 0.7964
Brugia malayi hypothetical protein 0.0027 0.0111 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0144
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0588 0.6032 1
Brugia malayi Bromodomain containing protein 0.0081 0.0681 0.0681
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Leishmania major dehydrogenase/oxidoreductase-like protein 0.004 0.0249 0.08
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0588 0.6032 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0835 0.0956
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.004 0.0249 0.08
Schistosoma mansoni survival motor neuron protein 0.0197 0.1904 0.2179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0835 0.0956
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0166 0.1577 0.2558
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0469 0.0469
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Leishmania major hypothetical protein, conserved 0.0027 0.0111 0.0355
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1497 0.1497
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0045 0.0144
Entamoeba histolytica rodhanase-like domain containing protein 0.0166 0.1577 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0046 0.0046
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0022 0.0022
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0046 0.0046
Trypanosoma brucei unspecified product 0.002 0.0045 0.0144
Echinococcus multilocularis muscleblind protein 0.0158 0.1497 0.1497
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0249 0.0342
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0015 0.0015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0046 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0079 0.0667 0.4061
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.004 0.0249 0.0342
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0166 0.1577 0.2558
Brugia malayi follicle stimulating hormone receptor 0.0481 0.4907 0.4907
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0198 0.0198
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0166 0.1577 0.1577
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.0076
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0588 0.6032 1
Brugia malayi jmjC domain containing protein 0.0066 0.0526 0.0526
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.1156 0.1323
Onchocerca volvulus 0.0059 0.0455 0.1242
Echinococcus multilocularis dnaJ subfamily B 0.0844 0.8737 0.8737
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.022 0.022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0046 0.0025
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.004 0.0249 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Schistosoma mansoni hypothetical protein 0.0021 0.0054 0.0062
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0046 0.0046
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0045 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0249 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Loa Loa (eye worm) hypothetical protein 0.0166 0.1577 0.1577
Loa Loa (eye worm) hypothetical protein 0.0042 0.0273 0.0273
Schistosoma mansoni cpg binding protein 0.0065 0.0511 0.0585
Entamoeba histolytica rodhanase-like domain containing protein 0.0166 0.1577 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0353 0.1134
Leishmania major pteridine reductase 1 0.004 0.0249 0.08
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0015 0.0015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0046 0.0146
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0045 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.0146
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0588 0.6032 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1561 0.2532
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.011 0.011
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0353 0.0353
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0353 0.1134
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0023 0.0023
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0291 0.0935
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0667 0.0763
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0029 0.0029
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0166 0.1577 0.2558
Loa Loa (eye worm) hypothetical protein 0.0153 0.144 0.144
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.004 0.0249 0.08
Schistosoma mansoni DNA polymerase eta 0.002 0.0045 0.0051
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0047 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0079 0.0667 0.0763
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.004 0.0249 0.0249
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.3116 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0045 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.0079 0.0667 0.4061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0667 0.0667
Echinococcus granulosus cpg binding protein 0.0065 0.0511 0.0511
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0835 0.0835
Trichomonas vaginalis cdc25c, putative 0.0166 0.1577 0.2558
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0835 0.0835
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0166 0.1577 0.1804
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0045 0.0144
Toxoplasma gondii exonuclease III APE 0.0021 0.0046 0.0076
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0029 0.0029
Schistosoma mansoni zinc finger protein 0.0024 0.0078 0.0089
Loa Loa (eye worm) hypothetical protein 0.0158 0.1497 0.1497
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0249 0.0342
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0111
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Onchocerca volvulus 0.0166 0.1577 0.8022
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.004 0.0249 0.0413
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.004 0.0249 0.0342
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0393 0.126
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0166 0.1577 0.2558
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1385 0.4444
Trypanosoma brucei pteridine reductase 1 0.004 0.0249 0.08
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0001
Loa Loa (eye worm) hypothetical protein 0.0073 0.0599 0.0599
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0045 0.0144
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.3116 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0455 0.0455
Mycobacterium tuberculosis Probable oxidoreductase 0.004 0.0249 0.0342
Mycobacterium ulcerans short chain dehydrogenase 0.004 0.0249 0.0342
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0046 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0015 0.0017
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0045
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0353 0.0516
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0046 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0045 0.0144
Echinococcus granulosus survival motor neuron protein 1 0.0964 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0111 0.0184
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0291 0.0935
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0029 0.0033
Echinococcus granulosus muscleblind protein 0.0158 0.1497 0.1497
Brugia malayi hypothetical protein 0.0017 0.0011 0.0011
Brugia malayi Rhodanese-like domain containing protein 0.0166 0.1577 0.1577
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0041 0.0041
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0045 0.0144
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.011 0.0126
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.004 0.0249 0.0413
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.004 0.0249 0.0342
Schistosoma mansoni bromodomain containing protein 0.0069 0.0554 0.0634
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0353 0.1134
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.004 0.0249 0.0342
Brugia malayi Bromodomain containing protein 0.004 0.0246 0.0246
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.004 0.0249 0.1336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0029
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0046 0.0005
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.3116 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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