Detailed information for compound 758644

Basic information

Technical information
  • TDR Targets ID: 758644
  • Name: N-tert-butylquinoline-8-sulfonamide
  • MW: 264.343 | Formula: C13H16N2O2S
  • H donors: 1 H acceptors: 3 LogP: 2.14 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NS(=O)(=O)c1cccc2c1nccc2)(C)C
  • InChi: 1S/C13H16N2O2S/c1-13(2,3)15-18(16,17)11-8-4-6-10-7-5-9-14-12(10)11/h4-9,15H,1-3H3
  • InChiKey: YBLRRMVHSWCNMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-tert-butyl-8-quinolinesulfonamide
  • ZINC00092757
  • BAS 07381784
  • Quinoline-8-sulfonic acid tert-butylamide
  • EU-0081022

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1501 0.0178
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0222 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.4072 0.4068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2986 0.2929
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0177 0.0648
Echinococcus multilocularis sulfhydryl oxidase 1 0.0022 0.1347 0.1276
Schistosoma mansoni tar DNA-binding protein 0.0069 0.4817 0.4813
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0177 0.0648
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.014 0.9999 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0347 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Schistosoma mansoni cpg binding protein 0.003 0.1884 0.1879
Schistosoma mansoni tar DNA-binding protein 0.0069 0.4817 0.4813
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2986 0.2929
Schistosoma mansoni cpg binding protein 0.0028 0.1767 0.1762
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.2986 0.2929
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.2485 0.5
Brugia malayi hypothetical protein 0.0016 0.0867 0.0792
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0177 0.0648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2986 0.2981
Toxoplasma gondii Erv1 / Alr family protein 0.014 0.9999 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.2737 1
Brugia malayi Augmenter of liver regeneration 0.014 0.9999 0.9999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2986 0.2981
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0222 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0347 0.0269
Loa Loa (eye worm) quiescin Q6 0.0022 0.1347 0.1276
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.2737 0.2731
Loa Loa (eye worm) Erv1/Alr family protein 0.0022 0.1347 0.1276
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.1501 0.0178
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0222 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0177 0.0648
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0177 0.0648
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.2737 0.1607
Echinococcus granulosus tar DNA binding protein 0.0069 0.4817 0.4775
Brugia malayi hypothetical protein 0.0024 0.1501 0.1432
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.1501 0.0178
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.1501 0.0178
Brugia malayi Erv1 / Alr family protein 0.0022 0.1347 0.1276
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Schistosoma mansoni bromodomain containing protein 0.0005 0.0081 0.0074
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 1 1
Echinococcus multilocularis tar DNA binding protein 0.0069 0.4817 0.4774
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.2485 0.5
Schistosoma mansoni cpg binding protein 0.003 0.1884 0.1879
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.1501 0.1494
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0514 0.0437
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.1501 0.0178
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0347 0.0269
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.2737 1
Brugia malayi RNA binding protein 0.0069 0.4817 0.4774
Loa Loa (eye worm) hepatopoietin HPO2 0.014 0.9999 0.9999
Loa Loa (eye worm) TAR-binding protein 0.0069 0.4817 0.4774
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2986 0.2929
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.2737 0.2678
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2986 0.2981
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.014 0.9999 1
Schistosoma mansoni bromodomain containing protein 0.0005 0.0081 0.0074
Brugia malayi TAR-binding protein 0.0069 0.4817 0.4774
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0514 0.0437
Schistosoma mansoni tar DNA-binding protein 0.0069 0.4817 0.4813
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2986 0.2929
Loa Loa (eye worm) hypothetical protein 0.0024 0.1501 0.1432
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Loa Loa (eye worm) hypothetical protein 0.0022 0.1347 0.1276
Trichomonas vaginalis helicase, putative 0.0006 0.0177 0.0648
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.1767 0.17
Plasmodium vivax hypothetical protein, conserved 0.0022 0.1347 0.134
Loa Loa (eye worm) hypothetical protein 0.0022 0.1347 0.1276
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0022 0.1347 0.1341
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.014 0.9999 1
Loa Loa (eye worm) acetyltransferase 0.014 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.4817 0.4774
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0339 0.0261
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.2986 0.2929
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.014 0.9999 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.014 0.9999 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.014 0.9999 0.9999
Brugia malayi CXXC zinc finger family protein 0.0028 0.1767 0.17
Toxoplasma gondii Erv1 / Alr family protein 0.014 0.9999 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0222 0.0143
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.014 0.9999 1
Echinococcus granulosus sulfhydryl oxidase 1 0.0022 0.1347 0.1277
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.2485 0.1315
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0222 0.0216
Echinococcus granulosus cpg binding protein 0.003 0.1884 0.1818
Echinococcus multilocularis cpg binding protein 0.003 0.1884 0.1818
Schistosoma mansoni tar DNA-binding protein 0.0069 0.4817 0.4813
Onchocerca volvulus 0.0028 0.1767 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.4817 0.4774
Schistosoma mansoni tar DNA-binding protein 0.0069 0.4817 0.4813
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0177 0.0648
Brugia malayi quiescin Q6 0.0022 0.1347 0.1276
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.014 0.9999 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.4817 0.4774
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.9711 0.971
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Schistosoma mansoni hypothetical protein 0.0011 0.0514 0.0508
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.3858 0.2902
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.2737 0.1607
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0177 0.0648
Schistosoma mansoni zinc finger protein 0.0005 0.0081 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0177 0.0648
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.1501 0.0178
Leishmania major hypothetical protein, conserved 0.014 0.9999 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0177 0.0648

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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