Detailed information for compound 758677

Basic information

Technical information
  • TDR Targets ID: 758677
  • Name: 1-[(3-methoxyphenyl)methylideneamino]-4,6-dim ethyl-2-oxopyridine-3-carbonitrile
  • MW: 281.309 | Formula: C16H15N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C=Nn1c(C)cc(c(c1=O)C#N)C
  • InChi: 1S/C16H15N3O2/c1-11-7-12(2)19(16(20)15(11)9-17)18-10-13-5-4-6-14(8-13)21-3/h4-8,10H,1-3H3/b18-10+
  • InChiKey: YAKNSQDVXSMFPB-VCHYOVAHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(3-methoxyphenyl)methyleneamino]-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile
  • 1-[(3-methoxyphenyl)methyleneamino]-4,6-dimethyl-2-oxo-3-pyridinecarbonitrile
  • 2-keto-1-[(3-methoxybenzylidene)amino]-4,6-dimethyl-nicotinonitrile
  • 1-[(3-methoxyphenyl)methylideneamino]-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile
  • Oprea1_711406
  • Oprea1_777281
  • AN-329/11445930
  • ST040215
  • ARONIS003665

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0498 0.1091
Entamoeba histolytica hypothetical protein 0.0151 0.1294 0.7372
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0092 0.0703 0.2696
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.0071 0.0498 0.063
Brugia malayi hypothetical protein 0.0151 0.1294 0.1636
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.069 0.069
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0388 0.0388
Echinococcus granulosus pyruvate kinase 0.0145 0.1236 0.1236
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.1813 0.2292
Loa Loa (eye worm) hypothetical protein 0.004 0.0188 0.0237
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.2323 0.2937
Brugia malayi Inositol-1 0.0038 0.0172 0.0218
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0703 0.2696
Toxoplasma gondii pyruvate kinase PyK1 0.0283 0.2608 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0548 0.0693
Brugia malayi Pyruvate kinase, M2 isozyme 0.0283 0.2608 0.3298
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0498 0.063
Schistosoma mansoni alpha-glucosidase 0.0295 0.2732 0.3455
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0283 0.2608 0.6017
Entamoeba histolytica hypothetical protein 0.0151 0.1294 0.7372
Brugia malayi MH2 domain containing protein 0.0254 0.2323 0.2937
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0498 0.1909
Brugia malayi pyruvate kinase, muscle isozyme 0.006 0.0384 0.0485
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0283 0.0358
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0291 0.1116
Echinococcus multilocularis microtubule associated protein 2 0.0809 0.7851 0.7851
Trichomonas vaginalis pyruvate kinase, putative 0.0283 0.2608 0.3298
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0086 0.0643 0.0812
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0668 0.0845
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0091
Echinococcus multilocularis geminin 0.017 0.1479 0.1479
Schistosoma mansoni microtubule-associated protein tau 0.0809 0.7851 0.9927
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.003 0.0174
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0075 0.0289
Mycobacterium ulcerans beta-lactamase 0.0071 0.0498 0.0593
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0172 0.066
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0498 0.1091
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0032 0.0104 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0668 0.0845
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0498 0.063
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0188 0.0237
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.003 0.0174
Onchocerca volvulus 0.0699 0.6759 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0021 0.0082
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.043 0.0544
Leishmania major hypothetical protein, conserved 0.005 0.0291 0.1116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0297 0.0376
Onchocerca volvulus 0.0088 0.0668 0.0948
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0072 0.0277
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0498 0.063
Toxoplasma gondii hypothetical protein 0.0032 0.0104 0.04
Loa Loa (eye worm) beta-lactamase 0.0071 0.0498 0.063
Onchocerca volvulus 0.015 0.1284 0.1863
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0781 0.7567 0.9568
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.1173 0.1483
Schistosoma mansoni inositol monophosphatase 0.0038 0.0172 0.0218
Brugia malayi beta-lactamase family protein 0.0071 0.0498 0.063
Brugia malayi TAR-binding protein 0.0781 0.7567 0.9568
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0703 0.2696
Plasmodium falciparum pyruvate kinase 0.0283 0.2608 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0072 0.0091
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.284 0.3591
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0172 0.066
Loa Loa (eye worm) inositol-1 0.0038 0.0172 0.0218
Mycobacterium leprae Probable lipase LipE 0.0071 0.0498 0.1814
Trypanosoma brucei pyruvate kinase 1, putative 0.0283 0.2608 1
Loa Loa (eye worm) glutaminase 0.0815 0.7908 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0498 0.0593
Loa Loa (eye worm) hypothetical protein 0.0197 0.1755 0.222
Mycobacterium tuberculosis Conserved protein 0.0071 0.0498 0.1091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0088 0.0668 0.0668
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0498 0.1909
Trichomonas vaginalis pyruvate kinase, putative 0.0283 0.2608 0.3298
Trypanosoma cruzi pyruvate kinase 2, putative 0.0283 0.2608 1
Brugia malayi RNA binding protein 0.0781 0.7567 0.9568
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.043 0.043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0243 0.2209 0.2793
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0132 0.0394
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.0615 0.3504
Schistosoma mansoni hypothetical protein 0.0306 0.284 0.3591
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0548 0.0693
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0498 0.063
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0075 0.0289
Brugia malayi Importin beta-1 subunit 0.0029 0.0075 0.0095
Schistosoma mansoni survival motor neuron protein 0.005 0.0283 0.0358
Toxoplasma gondii pyruvate kinase PyKII 0.0145 0.1236 0.474
Schistosoma mansoni pyruvate kinase 0.0283 0.2608 0.3298
Brugia malayi Latrophilin receptor protein 2 0.0064 0.043 0.0544
Echinococcus granulosus pyruvate kinase 0.0145 0.1236 0.1236
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0072 0.0277
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0104 0.04
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0703 0.2696
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0307 0.2851 0.3605
Schistosoma mansoni hypothetical protein 0.0064 0.043 0.0544
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.003 0.0117
Loa Loa (eye worm) hypothetical protein 0.0283 0.2608 0.3298
Plasmodium vivax importin-beta 2, putative 0.0029 0.0075 0.0289
Onchocerca volvulus 0.0198 0.1767 0.2581
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0039
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0172 0.0218
Entamoeba histolytica hypothetical protein 0.0151 0.1294 0.7372
Echinococcus multilocularis GPCR, family 2 0.0064 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0039
Entamoeba histolytica hypothetical protein 0.0023 0.0021 0.0122
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0172 0.066
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0018
Echinococcus granulosus GPCR family 2 0.0064 0.043 0.043
Plasmodium falciparum importin beta, putative 0.0029 0.0075 0.0289
Echinococcus multilocularis pyruvate kinase 0.0145 0.1236 0.1236
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0088 0.0668 0.0668
Onchocerca volvulus 0.0071 0.0498 0.0695
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.069 0.2646
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0703 0.0854
Schistosoma mansoni hypothetical protein 0.0064 0.043 0.0544
Trypanosoma cruzi pyruvate kinase 2, putative 0.0283 0.2608 1
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0498 0.0593
Loa Loa (eye worm) hypothetical protein 0.0071 0.0498 0.063
Schistosoma mansoni glutaminase 0.0815 0.7908 1
Schistosoma mansoni tar DNA-binding protein 0.0781 0.7567 0.9568
Brugia malayi RNA, U transporter 1 0.0082 0.0602 0.0761
Schistosoma mansoni tar DNA-binding protein 0.0781 0.7567 0.9568
Mycobacterium tuberculosis Conserved protein 0.0071 0.0498 0.1091
Echinococcus granulosus histone acetyltransferase KAT2B 0.0299 0.2765 0.2765
Mycobacterium tuberculosis Conserved protein 0.0071 0.0498 0.1091
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0132 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0039
Chlamydia trachomatis pyruvate kinase 0.0283 0.2608 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0291 0.1116
Brugia malayi Pre-SET motif family protein 0.0088 0.0668 0.0845
Brugia malayi Probable ClpP-like protease 0.0092 0.0703 0.0889
Echinococcus multilocularis snurportin 1 0.0306 0.284 0.284
Echinococcus multilocularis tar DNA binding protein 0.0781 0.7567 0.7567
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0188 0.0188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0548 0.3124
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0188 0.072
Schistosoma mansoni hypothetical protein 0.0151 0.1294 0.1636
Brugia malayi Pyruvate kinase, muscle isozyme 0.0283 0.2608 0.3298
Onchocerca volvulus Pyruvate kinase homolog 0.0283 0.2608 0.3831
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.0615 0.2358
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0172 0.066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.043 0.043
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0498 0.1091
Trichomonas vaginalis set domain proteins, putative 0.0699 0.6759 0.8546
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0027
Schistosoma mansoni cellular tumor antigen P53 0.015 0.1284 0.1624
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.043 0.043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0072 0.0091
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0032 0.0104 0.04
Loa Loa (eye worm) hypothetical protein 0.0088 0.0668 0.0845
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0498 0.1091
Giardia lamblia Pyruvate kinase 0.0283 0.2608 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0021 0.0027
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0388 0.1389
Loa Loa (eye worm) hypothetical protein 0.0203 0.1813 0.2292
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0297 0.0297
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0291 0.1116
Schistosoma mansoni hypothetical protein 0.005 0.0283 0.0358
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0076 0.0548 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0498 0.063
Leishmania major importin beta-1 subunit, putative 0.0023 0.0021 0.0082
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0498 0.063
Echinococcus multilocularis lysosomal alpha glucosidase 0.0343 0.3208 0.3208
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0076 0.0548 0.2102
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.2323 0.2937
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0088 0.0668 0.2561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0297 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0548 0.2102
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0188 0.072
Brugia malayi Glycosyl hydrolases family 31 protein 0.0076 0.0548 0.0693
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0072 0.0091
Mycobacterium ulcerans pyruvate kinase 0.0283 0.2608 0.3272
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.069 0.0872
Echinococcus granulosus snurportin 1 0.0306 0.284 0.284
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0388 0.0836
Brugia malayi acetyltransferase, GNAT family protein 0.0307 0.2851 0.3605
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0498 0.0498
Echinococcus granulosus geminin 0.017 0.1479 0.1479
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0172 0.0172
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0072 0.0277
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0151 0.1294 0.1294
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.1813 0.2292
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0088 0.0668 0.0845
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0498 0.1091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0297 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0297 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.1813 0.2292
Schistosoma mansoni alpha-glucosidase 0.0295 0.2732 0.3455
Echinococcus multilocularis pyruvate kinase 0.0283 0.2608 0.2608
Entamoeba histolytica hypothetical protein 0.0151 0.1294 0.7372
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0291 0.1116
Loa Loa (eye worm) hypothetical protein 0.0064 0.043 0.0544
Entamoeba histolytica pyruvate kinase, putative 0.0197 0.1755 1
Brugia malayi hypothetical protein 0.0032 0.0113 0.0143
Loa Loa (eye worm) hypothetical protein 0.0071 0.0498 0.063
Brugia malayi glutaminase DH11.1 0.0815 0.7908 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0092 0.0703 0.0703
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0343 0.3208 0.4057
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0072 0.0091
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0072 0.0091
Trypanosoma brucei pyruvate kinase 1 0.0283 0.2608 1
Schistosoma mansoni hypothetical protein 0.004 0.0188 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0297 0.0376
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0548 0.0693
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.003 0.0117
Brugia malayi hypothetical protein 0.005 0.0291 0.0368
Brugia malayi Pre-SET motif family protein 0.0615 0.5913 0.7477
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0015 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0498 0.1909
Echinococcus granulosus pyruvate kinase 0.0283 0.2608 0.2608
Mycobacterium ulcerans lipase LipD 0.0071 0.0498 0.0593
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0297 0.0297
Plasmodium vivax pyruvate kinase, putative 0.0283 0.2608 1
Plasmodium falciparum pyruvate kinase 2 0.0145 0.1236 0.474
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0072 0.0091
Loa Loa (eye worm) pyruvate kinase 0.006 0.0384 0.0485
Echinococcus multilocularis pyruvate kinase 0.0223 0.2014 0.2014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0071 0.0498 0.063
Loa Loa (eye worm) pyruvate kinase 0.0283 0.2608 0.3298
Onchocerca volvulus Pyruvate kinase homolog 0.0283 0.2608 0.3831
Echinococcus granulosus microtubule associated protein 2 0.0809 0.7851 0.7851
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0498 0.0498
Echinococcus multilocularis pyruvate kinase 0.0283 0.2608 0.2608
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0291 0.1116
Schistosoma mansoni tar DNA-binding protein 0.0781 0.7567 0.9568
Loa Loa (eye worm) glutaminase 2 0.0815 0.7908 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0498 0.1909
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0072 0.0277
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0548 0.0693
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0172 0.018
Echinococcus granulosus pyruvate kinase 0.0283 0.2608 0.2608
Echinococcus granulosus histone lysine methyltransferase setb 0.0088 0.0668 0.0668
Schistosoma mansoni hypothetical protein 0.0064 0.043 0.0544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0668 0.0845
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.069 0.2646
Loa Loa (eye worm) RNA binding protein 0.0781 0.7567 0.9568
Schistosoma mansoni transcription factor LCR-F1 0.0151 0.1294 0.1636
Brugia malayi beta-lactamase family protein 0.0071 0.0498 0.063
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0548 0.2102
Mycobacterium ulcerans hypothetical protein 0.0071 0.0498 0.0593
Loa Loa (eye worm) pyruvate kinase-PB 0.0197 0.1755 0.222
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0291 0.1116
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0703 0.0854
Echinococcus granulosus lysosomal alpha glucosidase 0.0343 0.3208 0.3208
Loa Loa (eye worm) hypothetical protein 0.0139 0.1173 0.1483
Giardia lamblia Pyruvate kinase 0.0145 0.1236 0.474
Onchocerca volvulus 0.0071 0.0498 0.0695
Schistosoma mansoni tar DNA-binding protein 0.0781 0.7567 0.9568
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0172 0.0218
Schistosoma mansoni hypothetical protein 0.0064 0.043 0.0544
Loa Loa (eye worm) hypothetical protein 0.0071 0.0498 0.063
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0188 0.072
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.003 0.0117
Schistosoma mansoni inositol monophosphatase 0.0038 0.0172 0.0218
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0092 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.015 0.1284 0.1624
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0075 0.0289
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0498 0.1091
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0172 0.066
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0388 0.0836
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.069 0.2646
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.043 0.0544
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0072 0.0091
Plasmodium vivax pyruvate kinase 2, putative 0.0145 0.1236 0.474
Loa Loa (eye worm) hypothetical protein 0.0071 0.0498 0.063
Echinococcus multilocularis tumor protein p63 0.1025 1 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0388 0.0388
Brugia malayi pyruvate kinase 0.006 0.0384 0.0485
Echinococcus granulosus importin subunit beta 1 0.0029 0.0075 0.0075
Loa Loa (eye worm) TAR-binding protein 0.0781 0.7567 0.9568
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0498 0.1814
Loa Loa (eye worm) hypothetical protein 0.005 0.0291 0.0368
Schistosoma mansoni importin beta-1 0.0029 0.0075 0.0095
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0498 0.1091
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0615 0.5913 0.7477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0297 0.0376
Trypanosoma brucei glucosidase, putative 0.0076 0.0548 0.2102
Echinococcus granulosus pyruvate kinase 0.0145 0.1236 0.1236
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0307 0.2851 0.2851
Echinococcus granulosus neutral alpha glucosidase AB 0.0076 0.0548 0.0548
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0297 0.0376
Schistosoma mansoni pyruvate kinase 0.0145 0.1236 0.1563
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0548 0.3124
Brugia malayi hypothetical protein 0.0036 0.0149 0.0189
Schistosoma mansoni peptidase Clp (S14 family) 0.0092 0.0703 0.0889
Onchocerca volvulus Pyruvate kinase homolog 0.0283 0.2608 0.3831
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0172 0.0218
Leishmania major pyruvate kinase 0.0283 0.2608 1
Echinococcus multilocularis pyruvate kinase 0.0145 0.1236 0.1236
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0498 0.063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.043 0.043
Loa Loa (eye worm) acetyltransferase 0.0307 0.2851 0.3605
Echinococcus multilocularis lysosomal alpha glucosidase 0.0343 0.3208 0.3208
Loa Loa (eye worm) hypothetical protein 0.0092 0.0703 0.0889
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0188 0.0237
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.003 0.0174
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0072 0.0412
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2209 0.2209
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0291 0.1116
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2209 0.2209
Leishmania major pyruvate kinase 0.0283 0.2608 1
Brugia malayi hypothetical protein 0.0243 0.2209 0.2793
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0703 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0188 0.0237
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0092 0.0703 1
Schistosoma mansoni hypothetical protein 0.0139 0.1173 0.1483
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0039
Brugia malayi hypothetical protein 0.0036 0.0149 0.0189
Brugia malayi Glycosyl hydrolases family 31 protein 0.0343 0.3208 0.4057
Trichomonas vaginalis esterase, putative 0.0071 0.0498 0.063
Leishmania major alpha glucosidase II subunit, putative 0.0076 0.0548 0.2102
Schistosoma mansoni alpha glucosidase 0.0076 0.0548 0.0693
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0172 0.0172
Trichomonas vaginalis sucrase-isomaltase, putative 0.0076 0.0548 0.0693
Schistosoma mansoni hypothetical protein 0.017 0.1479 0.187
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0072 0.0091
Trichomonas vaginalis maltase-glucoamylase, putative 0.0076 0.0548 0.0693
Mycobacterium ulcerans glutaminase 0.0815 0.7908 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0092 0.0703 0.261
Mycobacterium leprae Probable pyruvate kinase PykA 0.0283 0.2608 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0076 0.0548 0.0548
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0548 0.0693
Echinococcus granulosus tar DNA binding protein 0.0781 0.7567 0.7567
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.0615 0.2358
Toxoplasma gondii ABC1 family protein 0.0071 0.0498 0.1909
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.4315 1
Brugia malayi RNA recognition motif domain containing protein 0.0781 0.7567 0.9568
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0548 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0498 0.063
Loa Loa (eye worm) pyruvate kinase 0.0283 0.2608 0.3298
Leishmania major hypothetical protein, conserved 0.0071 0.0498 0.1909
Loa Loa (eye worm) hypothetical protein 0.0029 0.0075 0.0095
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0075 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0781 0.7567 0.9568
Schistosoma mansoni pyruvate kinase 0.0283 0.2608 0.3298
Brugia malayi beta-lactamase 0.0071 0.0498 0.063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0498 0.063
Trichomonas vaginalis glutaminase, putative 0.0815 0.7908 1
Loa Loa (eye worm) pyruvate kinase 0.0283 0.2608 0.3298
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.069 0.0872
Onchocerca volvulus 0.0071 0.0498 0.0695
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0072 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0151 0.1294 0.1294
Echinococcus multilocularis pyruvate kinase 0.0145 0.1236 0.1236
Schistosoma mansoni hypothetical protein 0.017 0.1479 0.187
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0172 0.0981
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0548 0.0693
Plasmodium vivax SET domain protein, putative 0.0088 0.0668 0.2561
Onchocerca volvulus 0.005 0.0283 0.0376

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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