Detailed information for compound 758682

Basic information

Technical information
  • TDR Targets ID: 758682
  • Name: 4-ethyl-N-(4-imidazo[1,2-a]pyridin-2-ylphenyl )benzenesulfonamide
  • MW: 377.459 | Formula: C21H19N3O2S
  • H donors: 1 H acceptors: 3 LogP: 4.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)c1nc2n(c1)cccc2
  • InChi: 1S/C21H19N3O2S/c1-2-16-6-12-19(13-7-16)27(25,26)23-18-10-8-17(9-11-18)20-15-24-14-4-3-5-21(24)22-20/h3-15,23H,2H2,1H3
  • InChiKey: RAXDHXRBGZAAFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-ethyl-N-[4-(2-imidazo[1,2-a]pyridinyl)phenyl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysosomal alpha glucosidase 0.0341 0.2967 0.3147
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0166 0.0176
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0079 0.0542 0.0575
Brugia malayi pyruvate kinase, muscle isozyme 0.006 0.0364 0.0364
Loa Loa (eye worm) TAR-binding protein 0.0905 0.8184 0.8184
Loa Loa (eye worm) pyruvate kinase 0.0286 0.2454 0.2454
Onchocerca volvulus 0.0023 0.0021 0.0033
Schistosoma mansoni hypothetical protein 0.0154 0.1234 0.1234
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0154 0.0164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0502 0.0502
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0592 0.2383
Mycobacterium leprae Probable pyruvate kinase PykA 0.0286 0.2454 1
Schistosoma mansoni hypothetical protein 0.0317 0.2744 0.2744
Brugia malayi TAR-binding protein 0.0905 0.8184 0.8184
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0508 0.0499
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0592 0.3544
Schistosoma mansoni tar DNA-binding protein 0.0905 0.8184 0.8184
Brugia malayi glutaminase DH11.1 0.1101 1 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0076 0.0508 0.0539
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0068 0.0059
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0123 0.013
Onchocerca volvulus 0.0075 0.0502 0.0781
Brugia malayi hypothetical protein 0.0072 0.0471 0.0471
Echinococcus multilocularis pyruvate kinase 0.0286 0.2454 0.2603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0693 0.0693
Brugia malayi Pre-SET motif family protein 0.009 0.0641 0.0641
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0502 0.1137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0068 0.0059
Schistosoma mansoni hypothetical protein 0.0079 0.0535 0.0535
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0408 0.0408
Brugia malayi beta-lactamase family protein 0.0075 0.0502 0.0502
Leishmania major alpha glucosidase II subunit, putative 0.0076 0.0508 0.204
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0508 0.0499
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.425 1
Echinococcus granulosus microtubule associated protein 2 0.0703 0.6313 0.6696
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0512 0.2056
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0114 0.0121
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0502 0.1137
Entamoeba histolytica hypothetical protein 0.0154 0.1234 0.7452
Leishmania major importin beta-1 subunit, putative 0.0024 0.003 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0028 0.0068 0.0068
Brugia malayi MH1 domain containing protein 0.0033 0.0114 0.0114
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.003 0.0084
Loa Loa (eye worm) hypothetical protein 0.0249 0.2108 0.2108
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0502 0.0482
Echinococcus granulosus pyruvate kinase 0.0286 0.2454 0.2603
Loa Loa (eye worm) hypothetical protein 0.0075 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0075 0.0502 0.0502
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0315 0.2719 0.2884
Giardia lamblia Pyruvate kinase 0.0147 0.1165 0.473
Plasmodium vivax importin-beta 2, putative 0.003 0.0082 0.0297
Echinococcus granulosus pyruvate kinase 0.0147 0.1165 0.1236
Schistosoma mansoni hypothetical protein 0.0097 0.0701 0.0701
Schistosoma mansoni smad1 5 8 and 0.0033 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0068 0.024
Mycobacterium tuberculosis Conserved protein 0.0075 0.0502 0.1137
Brugia malayi Glycosyl hydrolases family 31 protein 0.0341 0.2967 0.2967
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0114 0.0121
Onchocerca volvulus 0.0075 0.0502 0.0781
Echinococcus multilocularis lysosomal alpha glucosidase 0.0341 0.2967 0.3147
Schistosoma mansoni hypothetical protein 0.0079 0.0535 0.0535
Brugia malayi RNA, U transporter 1 0.0085 0.0589 0.0589
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0408 0.163
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0114 0.0114
Loa Loa (eye worm) Smad1 0.0033 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0075 0.0502 0.0502
Trichomonas vaginalis importin beta-1, putative 0.0024 0.003 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0508 0.0499
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0641 0.068
Echinococcus multilocularis pyruvate kinase 0.0147 0.1165 0.1236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0693 0.0735
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0009 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0502 0.0502
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0663 0.2675
Schistosoma mansoni alpha glucosidase 0.0076 0.0508 0.0508
Brugia malayi Pyruvate kinase, muscle isozyme 0.0286 0.2454 0.2454
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0068 0.0059
Echinococcus multilocularis pyruvate kinase 0.0226 0.1896 0.2011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0114 0.0121
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0286 0.2454 0.5753
Leishmania major hypothetical protein, conserved 0.0075 0.0502 0.2016
Brugia malayi hypothetical protein 0.0154 0.1234 0.1234
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0166 0.064
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0128 0.0253
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0068 0.0059
Toxoplasma gondii pyruvate kinase PyKII 0.0147 0.1165 0.473
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0166 0.5
Onchocerca volvulus 0.0715 0.6428 1
Schistosoma mansoni transcription factor LCR-F1 0.0154 0.1234 0.1234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0693 0.0735
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0512 0.2056
Echinococcus granulosus tar DNA binding protein 0.0905 0.8184 0.868
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0341 0.2967 0.2967
Schistosoma mansoni smad1 5 8 and 0.0033 0.0114 0.0114
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.2454 1
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0154 0.0164
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0128 0.044
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0068 0.0105
Trichomonas vaginalis esterase, putative 0.0075 0.0502 0.0493
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0068 0.0059
Schistosoma mansoni microtubule-associated protein tau 0.0703 0.6313 0.6313
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0502 0.1137
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0082 0.0297
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0408 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0502 0.2016
Loa Loa (eye worm) hypothetical protein 0.009 0.0641 0.0641
Trichomonas vaginalis maltase-glucoamylase, putative 0.0076 0.0508 0.0499
Schistosoma mansoni smad1 5 8 and 0.0033 0.0114 0.0114
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0009 0.0009
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.2454 0.3818
Loa Loa (eye worm) acetyltransferase 0.0315 0.2719 0.2719
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0512 0.2056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0641 0.0641
Brugia malayi hypothetical protein 0.0076 0.0512 0.0512
Mycobacterium leprae Probable lipase LipE 0.0075 0.0502 0.1977
Echinococcus multilocularis tar DNA binding protein 0.0905 0.8184 0.868
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0049
Brugia malayi MH1 domain containing protein 0.0033 0.0114 0.0114
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.2454 0.2447
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0068 0.0068
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0021
Schistosoma mansoni pyruvate kinase 0.0286 0.2454 0.2454
Schistosoma mansoni glutaminase 0.1101 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0502 0.0493
Echinococcus multilocularis neutral alpha glucosidase AB 0.0076 0.0508 0.0539
Entamoeba histolytica pyruvate kinase, putative 0.0199 0.1653 1
Schistosoma mansoni survival motor neuron protein 0.0097 0.0701 0.0701
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0166 0.0952
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.2454 0.3818
Brugia malayi Pyruvate kinase, M2 isozyme 0.0286 0.2454 0.2454
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0079 0.0542 0.0542
Plasmodium vivax pyruvate kinase, putative 0.0286 0.2454 1
Echinococcus multilocularis pyruvate kinase 0.0147 0.1165 0.1236
Entamoeba histolytica hypothetical protein 0.0154 0.1234 0.7452
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0512 0.2056
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0663 0.0655
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0502 0.1137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0154 0.1234 0.1309
Schistosoma mansoni smad 0.0033 0.0114 0.0114
Schistosoma mansoni pyruvate kinase 0.0147 0.1165 0.1165
Brugia malayi beta-lactamase family protein 0.0075 0.0502 0.0502
Brugia malayi hypothetical protein 0.0049 0.0262 0.0262
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0021 0.0073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.2108 0.2108
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0068 0.024
Schistosoma mansoni tar DNA-binding protein 0.0905 0.8184 0.8184
Echinococcus granulosus geminin 0.0188 0.1545 0.1639
Brugia malayi Importin beta-1 subunit 0.003 0.0082 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0641 0.0641
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0087 0.0608 0.0608
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0512 0.2056
Echinococcus multilocularis Smad4 0.0033 0.0114 0.0121
Schistosoma mansoni Smad4 0.0033 0.0114 0.0114
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0535 0.0567
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0166 0.0157
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0166 0.0145
Trypanosoma brucei glucosidase, putative 0.0076 0.0508 0.204
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0641 0.0641
Loa Loa (eye worm) pyruvate kinase 0.0286 0.2454 0.2454
Schistosoma mansoni hypothetical protein 0.017 0.138 0.138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0021
Echinococcus granulosus snurportin 1 0.0317 0.2744 0.2911
Plasmodium falciparum pyruvate kinase 0.0286 0.2454 1
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0502 0.2016
Mycobacterium ulcerans beta-lactamase 0.0075 0.0502 0.0482
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0502 0.0493
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0408 0.163
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0408 0.0432
Echinococcus multilocularis snurportin 1 0.0317 0.2744 0.2911
Loa Loa (eye worm) RNA binding protein 0.0905 0.8184 0.8184
Leishmania major hypothetical protein, conserved 0.0076 0.0512 0.2056
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0166 0.064
Schistosoma mansoni hypothetical protein 0.0079 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0079 0.0542 0.0542
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0535 0.0567
Schistosoma mansoni hypothetical protein 0.0188 0.1545 0.1545
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0079 0.0542 0.0542
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0021 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0535 0.0535
Chlamydia trachomatis pyruvate kinase 0.0286 0.2454 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0693 0.0693
Loa Loa (eye worm) glutaminase 0.1101 1 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0079 0.0542 0.0542
Echinococcus granulosus importin subunit beta 1 0.003 0.0082 0.0087
Onchocerca volvulus 0.0097 0.0701 0.1091
Loa Loa (eye worm) hypothetical protein 0.0474 0.4192 0.4192
Echinococcus granulosus survival motor neuron protein 1 0.0474 0.4192 0.4446
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0502 0.1977
Loa Loa (eye worm) hypothetical protein 0.0152 0.1215 0.1215
Loa Loa (eye worm) hypothetical protein 0.0075 0.0502 0.0502
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.2454 0.3818
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0082 0.0297
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0068 0.0059
Loa Loa (eye worm) pyruvate kinase 0.006 0.0364 0.0364
Brugia malayi pyruvate kinase 0.006 0.0364 0.0364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0693 0.0693
Leishmania major pyruvate kinase 0.0286 0.2454 1
Trypanosoma brucei pyruvate kinase 1 0.0286 0.2454 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0408 0.0408
Loa Loa (eye worm) pyruvate kinase 0.0286 0.2454 0.2454
Loa Loa (eye worm) transcription factor SMAD2 0.0488 0.4324 0.4324
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0123 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0068 0.0059
Echinococcus multilocularis pyruvate kinase 0.0147 0.1165 0.1236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0693 0.0693
Onchocerca volvulus 0.0152 0.1215 0.189
Onchocerca volvulus 0.0197 0.1634 0.2543
Loa Loa (eye worm) hypothetical protein 0.017 0.138 0.138
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0114 0.0114
Schistosoma mansoni inositol monophosphatase 0.0039 0.0166 0.0166
Brugia malayi beta-lactamase 0.0075 0.0502 0.0502
Schistosoma mansoni hypothetical protein 0.0079 0.0542 0.0542
Plasmodium vivax SET domain protein, putative 0.009 0.0641 0.2585
Mycobacterium tuberculosis Conserved protein 0.0075 0.0502 0.1137
Trichomonas vaginalis set domain proteins, putative 0.0715 0.6428 0.6425
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0592 0.2383
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0508 0.204
Loa Loa (eye worm) hypothetical protein 0.0286 0.2454 0.2454
Echinococcus granulosus GPCR family 2 0.0079 0.0535 0.0567
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0905 0.8184 0.8184
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0628 0.5624 0.5624
Brugia malayi MH2 domain containing protein 0.0033 0.0114 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0905 0.8184 0.8184
Brugia malayi Smad1 0.0033 0.0114 0.0114
Trichomonas vaginalis sucrase-isomaltase, putative 0.0076 0.0508 0.0499
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0508 0.0499
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0663 0.0655
Echinococcus multilocularis tumor protein p63 0.1039 0.9428 1
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.2454 0.2447
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0502 0.0493
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0508 0.0499
Schistosoma mansoni alpha-glucosidase 0.0294 0.2527 0.2527
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0508 0.3034
Echinococcus multilocularis smad 0.0033 0.0114 0.0121
Entamoeba histolytica hypothetical protein 0.0154 0.1234 0.7452
Loa Loa (eye worm) inositol-1 0.0039 0.0166 0.0166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0693 0.0735
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0663 0.2675
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0502 0.0482
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0166 0.0157
Plasmodium vivax pyruvate kinase 2, putative 0.0147 0.1165 0.473
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0502 0.0502
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0508 0.204
Mycobacterium ulcerans glutaminase 0.1101 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0082 0.0082
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0502 0.2016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0021
Brugia malayi RNA binding protein 0.0905 0.8184 0.8184
Mycobacterium ulcerans hypothetical protein 0.0075 0.0502 0.0482
Echinococcus granulosus smad 0.0033 0.0114 0.0121
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0154 0.1234 0.1309
Echinococcus granulosus pyruvate kinase 0.0147 0.1165 0.1236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0693 0.0693
Brugia malayi MH2 domain containing protein 0.0488 0.4324 0.4324
Brugia malayi Inositol-1 0.0039 0.0166 0.0166
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0508 0.3034
Schistosoma mansoni tar DNA-binding protein 0.0905 0.8184 0.8184
Loa Loa (eye worm) hypothetical protein 0.0076 0.0512 0.0512
Toxoplasma gondii ABC1 family protein 0.0075 0.0502 0.2016
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0068 0.024
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0166 0.064
Schistosoma mansoni cellular tumor antigen P53 0.0152 0.1215 0.1215
Mycobacterium tuberculosis Conserved protein 0.0075 0.0502 0.1137
Schistosoma mansoni hypothetical protein 0.0034 0.0123 0.0123
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0079 0.0542 0.2181
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0693 0.0735
Echinococcus granulosus pyruvate kinase 0.0286 0.2454 0.2603
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0021 0.0073
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0166 0.064
Trypanosoma brucei pyruvate kinase 1, putative 0.0286 0.2454 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0114 0.0121
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0408 0.0432
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0502 0.1137
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0079 0.0542 0.2181
Brugia malayi Glycosyl hydrolases family 31 protein 0.0076 0.0508 0.0508
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0502 0.1137
Brugia malayi Pre-SET motif family protein 0.0628 0.5624 0.5624
Plasmodium falciparum pyruvate kinase 2 0.0147 0.1165 0.473
Echinococcus multilocularis GPCR, family 2 0.0079 0.0535 0.0567
Brugia malayi hypothetical protein 0.0474 0.4192 0.4192
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.2454 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0502 0.0532
Plasmodium falciparum importin beta, putative 0.003 0.0082 0.0297
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.061 0.0647
Schistosoma mansoni pyruvate kinase 0.0286 0.2454 0.2454
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0508 0.0499
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0512 0.2056
Schistosoma mansoni tar DNA-binding protein 0.0905 0.8184 0.8184
Giardia lamblia Pyruvate kinase 0.0286 0.2454 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0068 0.024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0535 0.0567
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0068 0.0357
Echinococcus multilocularis microtubule associated protein 2 0.0703 0.6313 0.6696
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0408 0.163
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0502 0.0493
Schistosoma mansoni alpha-glucosidase 0.0294 0.2527 0.2527
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0125
Echinococcus granulosus pyruvate kinase 0.0147 0.1165 0.1236
Brugia malayi acetyltransferase, GNAT family protein 0.0315 0.2719 0.2719
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0068 0.0059
Loa Loa (eye worm) hypothetical protein 0.0075 0.0502 0.0502
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0076 0.0508 0.204
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0009 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0641 0.068
Schistosoma mansoni ran 0.0022 0.0009 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0502 0.0502
Schistosoma mansoni hypothetical protein 0.0079 0.0535 0.0535
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.138 0.138
Brugia malayi RNA recognition motif domain containing protein 0.0905 0.8184 0.8184
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0663 0.0703
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0512 0.2056
Loa Loa (eye worm) hypothetical protein 0.0079 0.0535 0.0535
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0408 0.163
Loa Loa (eye worm) pyruvate kinase-PB 0.0199 0.1653 0.1653
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0408 0.2425
Mycobacterium ulcerans pyruvate kinase 0.0286 0.2454 0.2438
Echinococcus granulosus tumor protein p63 0.1039 0.9428 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.7059 0.7487
Schistosoma mansoni importin beta-1 0.003 0.0082 0.0082
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0508 0.0499
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0641 0.068
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0315 0.2719 0.2719
Schistosoma mansoni inositol monophosphatase 0.0039 0.0166 0.0166
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0535 0.0567
Echinococcus granulosus lysosomal alpha glucosidase 0.0341 0.2967 0.3147
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0663 0.2675
Mycobacterium ulcerans lipase LipD 0.0075 0.0502 0.0482
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0188 0.1545 0.1545
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0166 0.064
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0502 0.1137
Echinococcus multilocularis survival motor neuron protein 1 0.0474 0.4192 0.4446
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0641 0.2585
Entamoeba histolytica hypothetical protein 0.0154 0.1234 0.7452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.2108 0.2108
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0082 0.0297
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0502 0.0493
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0076 0.0508 0.0508
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0535 0.0535
Onchocerca volvulus 0.009 0.0641 0.0997
Leishmania major pyruvate kinase 0.0286 0.2454 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0166 0.0157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0075 0.0502 0.0502
Toxoplasma gondii pyruvate kinase PyK1 0.0286 0.2454 1
Echinococcus granulosus Smad4 0.0033 0.0114 0.0121
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0079 0.0542 0.2181
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0049
Echinococcus multilocularis importin subunit beta 1 0.003 0.0082 0.0087
Loa Loa (eye worm) MH2 domain-containing protein 0.0488 0.4324 0.4324
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0701 0.0701
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0166 0.0176
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0114 0.0114
Echinococcus granulosus histone acetyltransferase KAT2B 0.0306 0.2637 0.2797
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0502 0.2016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.2108 0.2108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0502 0.0532
Brugia malayi hypothetical protein 0.0072 0.0471 0.0471
Echinococcus multilocularis geminin 0.0188 0.1545 0.1639
Echinococcus multilocularis pyruvate kinase 0.0286 0.2454 0.2603
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0009 0.001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.2744 0.2744
Trichomonas vaginalis glutaminase, putative 0.1101 1 1
Loa Loa (eye worm) beta-lactamase 0.0075 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0199 0.1653 0.1653
Brugia malayi MH2 domain containing protein 0.0033 0.0114 0.0114
Schistosoma mansoni ran 0.0022 0.0009 0.0009
Onchocerca volvulus 0.0075 0.0502 0.0781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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