Detailed information for compound 758736

Basic information

Technical information
  • TDR Targets ID: 758736
  • Name: 1,3-benzodioxol-5-ylmethyl 4-(2-chlorophenyl) -6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-c arboxylate
  • MW: 400.812 | Formula: C20H17ClN2O5
  • H donors: 2 H acceptors: 2 LogP: 2.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=C(C(N1)c1ccccc1Cl)C(=O)OCc1ccc2c(c1)OCO2)C
  • InChi: 1S/C20H17ClN2O5/c1-11-17(18(23-20(25)22-11)13-4-2-3-5-14(13)21)19(24)26-9-12-6-7-15-16(8-12)28-10-27-15/h2-8,18H,9-10H2,1H3,(H2,22,23,25)
  • InChiKey: NYBLZVYGXMXTMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 1,3-benzodioxol-5-ylmethyl ester
  • 4-(2-chlorophenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid 1,3-benzodioxol-5-ylmethyl ester
  • STK046671
  • Oprea1_144020

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-glucosidase 0.028 0.3251 0.3238
Mycobacterium ulcerans pyruvate kinase 0.0272 0.3151 0.3062
Toxoplasma gondii pyruvate kinase PyKII 0.014 0.1449 0.4567
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0053 0.0041
Loa Loa (eye worm) hypothetical protein 0.019 0.2093 0.2093
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0179 0.1951 0.1936
Brugia malayi pyruvate kinase 0.0057 0.0391 0.0391
Schistosoma mansoni glutaminase 0.0805 1 1
Schistosoma mansoni pyruvate kinase 0.0272 0.3151 0.3138
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0785 0.0785
Brugia malayi Glycosyl hydrolases family 31 protein 0.0325 0.3832 0.3832
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0053 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.2751 0.2751
Loa Loa (eye worm) hypothetical protein 0.0072 0.0575 0.0575
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0582 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0575 0.1825
Echinococcus multilocularis pyruvate kinase 0.0272 0.3151 0.3763
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0129 0.041
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0575 0.0452
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.3541 0.3541
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0294 0.0877
Echinococcus multilocularis pyruvate kinase 0.014 0.1449 0.1718
Schistosoma mansoni inositol monophosphatase 0.0037 0.0129 0.0111
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0299 0.3498 0.418
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0582 0.0582
Schistosoma mansoni hypothetical protein 0.0067 0.0516 0.0498
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0129 0.5
Plasmodium vivax pyruvate kinase 2, putative 0.014 0.1449 0.4567
Entamoeba histolytica pyruvate kinase, putative 0.019 0.2093 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0575 0.0908
Loa Loa (eye worm) TAR-binding protein 0.0566 0.6928 0.6928
Echinococcus granulosus tumor protein p63 0.0676 0.8344 1
Plasmodium vivax pyruvate kinase, putative 0.0272 0.3151 1
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.0582 0.0582
Giardia lamblia Pyruvate kinase 0.0272 0.3151 1
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0575 0.1825
Loa Loa (eye worm) hypothetical protein 0.0058 0.0403 0.0403
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0072 0.0582 0.0582
Echinococcus multilocularis pyruvate kinase 0.014 0.1449 0.1718
Toxoplasma gondii ABC1 family protein 0.0072 0.0575 0.1776
Brugia malayi RNA recognition motif domain containing protein 0.0566 0.6928 0.6928
Schistosoma mansoni hypothetical protein 0.0048 0.0267 0.0249
Loa Loa (eye worm) beta-lactamase 0.0072 0.0575 0.0575
Schistosoma mansoni hypothetical protein 0.0179 0.1951 0.1936
Brugia malayi Importin beta-1 subunit 0.0028 0.0019 0.0019
Mycobacterium ulcerans beta-lactamase 0.0072 0.0575 0.0452
Brugia malayi Pre-SET motif family protein 0.0058 0.0403 0.0403
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.5535 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0019 0.006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0575 0.0452
Plasmodium vivax SET domain protein, putative 0.0058 0.0403 0.1225
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0053 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0914 0.0914
Schistosoma mansoni pyruvate kinase 0.0272 0.3151 0.3138
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0294 0.0877
Trichomonas vaginalis pyruvate kinase, putative 0.0272 0.3151 0.3151
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0575 0.0908
Schistosoma mansoni inositol monophosphatase 0.0037 0.0129 0.0111
Echinococcus multilocularis pyruvate kinase 0.0215 0.2415 0.2878
Loa Loa (eye worm) hypothetical protein 0.0272 0.3151 0.3151
Schistosoma mansoni microtubule-associated protein tau 0.067 0.8267 0.8264
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0582 0.2779
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0403 0.0384
Onchocerca volvulus Pyruvate kinase homolog 0.0272 0.3151 0.5639
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0575 0.0668
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0406 0.4868 0.4868
Brugia malayi hypothetical protein 0.0032 0.0067 0.0067
Echinococcus granulosus neutral alpha glucosidase AB 0.0072 0.0582 0.0676
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0294 0.0932
Echinococcus granulosus GPCR family 2 0.0031 0.0053 0.0041
Echinococcus multilocularis snurportin 1 0.0303 0.3541 0.4231
Onchocerca volvulus 0.0072 0.0575 0.1029
Onchocerca volvulus 0.0099 0.0927 0.1658
Echinococcus multilocularis neutral alpha glucosidase AB 0.0072 0.0582 0.0676
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0129 0.041
Schistosoma mansoni hypothetical protein 0.0112 0.1099 0.1082
Onchocerca volvulus Pyruvate kinase homolog 0.0272 0.3151 0.5639
Leishmania major pyruvate kinase 0.0272 0.3151 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0575 0.0575
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0582 0.2779
Brugia malayi RNA binding protein 0.0566 0.6928 0.6928
Brugia malayi beta-lactamase 0.0072 0.0575 0.0575
Echinococcus multilocularis lysosomal alpha glucosidase 0.0325 0.3832 0.4581
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0785 0.2446
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.1099 0.1082
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0267 0.0267
Brugia malayi pyruvate kinase, muscle isozyme 0.0057 0.0391 0.0391
Brugia malayi Inositol-1 0.0037 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0072 0.0575 0.0575
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.0582 0.0582
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.1099 0.1298
Trypanosoma brucei glucosidase, putative 0.0072 0.0582 0.1846
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0129 0.0618
Brugia malayi TAR-binding protein 0.0566 0.6928 0.6928
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0129 0.041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0403 0.0384
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0914 0.0914
Mycobacterium ulcerans glutaminase 0.0805 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0129 0.0133
Brugia malayi Pre-SET motif family protein 0.0406 0.4868 0.4868
Schistosoma mansoni tar DNA-binding protein 0.0566 0.6928 0.6922
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0575 0.0668
Loa Loa (eye worm) pyruvate kinase 0.0272 0.3151 0.3151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0575 0.0557
Loa Loa (eye worm) hypothetical protein 0.005 0.0294 0.0294
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0575 0.0908
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0566 0.6928 0.6928
Echinococcus granulosus pyruvate kinase 0.0272 0.3151 0.3763
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0516 0.0516
Echinococcus multilocularis tumor protein p63 0.0676 0.8344 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0272 0.3151 0.3151
Brugia malayi hypothetical protein 0.005 0.0294 0.0294
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0575 0.0575
Trichomonas vaginalis esterase, putative 0.0072 0.0575 0.0575
Brugia malayi beta-lactamase family protein 0.0072 0.0575 0.0575
Schistosoma mansoni tar DNA-binding protein 0.0566 0.6928 0.6922
Echinococcus granulosus pyruvate kinase 0.014 0.1449 0.1718
Schistosoma mansoni pyruvate kinase 0.014 0.1449 0.1433
Brugia malayi hypothetical protein 0.0112 0.1099 0.1099
Leishmania major hypothetical protein, conserved 0.0072 0.0575 0.1825
Mycobacterium tuberculosis Conserved protein 0.0072 0.0575 0.0908
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0053 0.0041
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0019
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2658 0.317
Leishmania major hypothetical protein, conserved 0.005 0.0294 0.0932
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.1099 0.1298
Onchocerca volvulus 0.0048 0.0267 0.0478
Schistosoma mansoni hypothetical protein 0.0303 0.3541 0.3529
Echinococcus granulosus lysosomal alpha glucosidase 0.0325 0.3832 0.4581
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0082 0.0713 0.0713
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0582 0.0582
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0785 0.2446
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0325 0.3832 0.3832
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2658 0.317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0053 0.0041
Mycobacterium leprae Probable pyruvate kinase PykA 0.0272 0.3151 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.2658 0.2658
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0691 0.2145
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0582 0.0582
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0582 0.0582
Mycobacterium ulcerans lipase LipD 0.0072 0.0575 0.0452
Schistosoma mansoni alpha glucosidase 0.0072 0.0582 0.0564
Loa Loa (eye worm) glutaminase 0.0805 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0582 0.1846
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0575 0.0575
Trichomonas vaginalis sucrase-isomaltase, putative 0.0072 0.0582 0.0582
Echinococcus multilocularis pyruvate kinase 0.0272 0.3151 0.3763
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0575 0.1825
Plasmodium falciparum pyruvate kinase 2 0.014 0.1449 0.4567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0283 0.0318
Loa Loa (eye worm) inositol-1 0.0037 0.0129 0.0129
Leishmania major pyruvate kinase 0.0272 0.3151 1
Schistosoma mansoni alpha-glucosidase 0.028 0.3251 0.3238
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0294 0.0932
Echinococcus multilocularis pyruvate kinase 0.014 0.1449 0.1718
Brugia malayi MH2 domain containing protein 0.0241 0.2751 0.2751
Echinococcus multilocularis microtubule associated protein 2 0.067 0.8267 0.9908
Brugia malayi Pyruvate kinase, M2 isozyme 0.0272 0.3151 0.3151
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0019 0.006
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0053 0.0053
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0403 0.0461
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0575 0.0908
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0575 0.0908
Giardia lamblia Pyruvate kinase 0.014 0.1449 0.3083
Echinococcus granulosus microtubule associated protein 2 0.067 0.8267 0.9908
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0575 0.0575
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0575 0.0575
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0575 0.0557
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0294 0.0877
Echinococcus granulosus pyruvate kinase 0.014 0.1449 0.1718
Mycobacterium tuberculosis Conserved protein 0.0072 0.0575 0.0908
Onchocerca volvulus 0.0058 0.0403 0.072
Entamoeba histolytica hypothetical protein 0.0112 0.1099 0.525
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0785 0.092
Onchocerca volvulus 0.0188 0.2071 0.3706
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0129 0.0129
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0927 0.0909
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.2751 0.2751
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0691 0.33
Trypanosoma brucei pyruvate kinase 1, putative 0.0272 0.3151 1
Leishmania major alpha glucosidase II subunit, putative 0.0072 0.0582 0.1846
Trichomonas vaginalis pyruvate kinase, putative 0.0272 0.3151 0.3151
Echinococcus granulosus geminin 0.0179 0.1951 0.2321
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0403 0.0461
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0294 0.0877
Loa Loa (eye worm) pyruvate kinase 0.0272 0.3151 0.3151
Trichomonas vaginalis glutaminase, putative 0.0805 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0582 0.0582
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0403 0.0461
Loa Loa (eye worm) hypothetical protein 0.0072 0.0575 0.0575
Chlamydia trachomatis pyruvate kinase 0.0272 0.3151 0.5
Trypanosoma cruzi pyruvate kinase 2, putative 0.0272 0.3151 1
Brugia malayi hypothetical protein 0.0234 0.2658 0.2658
Schistosoma mansoni tar DNA-binding protein 0.0566 0.6928 0.6922
Schistosoma mansoni survival motor neuron protein 0.0048 0.0267 0.0249
Trichomonas vaginalis set domain proteins, putative 0.0462 0.5589 0.5589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0283 0.0265
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0403 0.1225
Mycobacterium tuberculosis Conserved protein 0.0072 0.0575 0.0908
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0129 0.0133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0283 0.0318
Echinococcus granulosus tar DNA binding protein 0.0566 0.6928 0.8299
Loa Loa (eye worm) hypothetical protein 0.0067 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0072 0.0575 0.0575
Entamoeba histolytica hypothetical protein 0.0112 0.1099 0.525
Schistosoma mansoni tar DNA-binding protein 0.0566 0.6928 0.6922
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0785 0.2446
Plasmodium falciparum pyruvate kinase 0.0272 0.3151 1
Brugia malayi acetyltransferase, GNAT family protein 0.0299 0.3498 0.3498
Echinococcus granulosus pyruvate kinase 0.014 0.1449 0.1718
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0283 0.0318
Loa Loa (eye worm) pyruvate kinase 0.0272 0.3151 0.3151
Echinococcus multilocularis geminin 0.0179 0.1951 0.2321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0914 0.0914
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0575 0.0575
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0575 0.0575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0283 0.0265
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0272 0.3151 0.5631
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0403 0.0384
Loa Loa (eye worm) hypothetical protein 0.0072 0.0575 0.0575
Brugia malayi beta-lactamase family protein 0.0072 0.0575 0.0575
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0129 0.0353
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0575 0.0908
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0575 0.1776
Loa Loa (eye worm) acetyltransferase 0.0299 0.3498 0.3498
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0294 0.0932
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0035
Loa Loa (eye worm) hypothetical protein 0.0099 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0098 0.0914 0.0914
Trypanosoma brucei pyruvate kinase 1 0.0272 0.3151 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0283 0.0283
Echinococcus granulosus snurportin 1 0.0303 0.3541 0.4231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0283 0.0318
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0785 0.0785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0283 0.0265
Entamoeba histolytica hypothetical protein 0.0112 0.1099 0.525
Onchocerca volvulus 0.0462 0.5589 1
Mycobacterium leprae Probable lipase LipE 0.0072 0.0575 0.1613
Loa Loa (eye worm) pyruvate kinase 0.0057 0.0391 0.0391
Toxoplasma gondii pyruvate kinase PyK1 0.0272 0.3151 1
Loa Loa (eye worm) pyruvate kinase-PB 0.019 0.2093 0.2093
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0129 0.0129
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0575 0.0908
Schistosoma mansoni hypothetical protein 0.0031 0.0053 0.0035
Echinococcus multilocularis GPCR, family 2 0.0031 0.0053 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0582 0.1846
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0129 0.041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0325 0.3832 0.4581
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0575 0.1613
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0575 0.0575
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0375 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0403 0.0384
Brugia malayi glutaminase DH11.1 0.0805 1 1
Loa Loa (eye worm) RNA binding protein 0.0566 0.6928 0.6928
Onchocerca volvulus 0.0072 0.0575 0.1029
Echinococcus granulosus histone acetyltransferase KAT2B 0.0291 0.3391 0.405
Schistosoma mansoni tar DNA-binding protein 0.0566 0.6928 0.6922
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0072 0.0582 0.1797
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0582 0.0582
Brugia malayi RNA, U transporter 1 0.0081 0.069 0.069
Trypanosoma cruzi pyruvate kinase 2, putative 0.0272 0.3151 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0053 0.0053
Echinococcus multilocularis tar DNA binding protein 0.0566 0.6928 0.8299
Mycobacterium ulcerans hypothetical protein 0.0072 0.0575 0.0452
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0299 0.3498 0.3486
Onchocerca volvulus Pyruvate kinase homolog 0.0272 0.3151 0.5639
Onchocerca volvulus 0.0072 0.0575 0.1029
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0129 0.0129
Entamoeba histolytica hypothetical protein 0.0112 0.1099 0.525
Echinococcus granulosus pyruvate kinase 0.0272 0.3151 0.3763

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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