Detailed information for compound 758740

Basic information

Technical information
  • TDR Targets ID: 758740
  • Name: dimethyl 4-(2-chlorophenyl)-1-(oxolan-2-ylmet hyl)-4H-pyridine-3,5-dicarboxylate
  • MW: 391.845 | Formula: C20H22ClNO5
  • H donors: 0 H acceptors: 2 LogP: 2.98 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=CN(CC2CCCO2)C=C(C1c1ccccc1Cl)C(=O)OC
  • InChi: 1S/C20H22ClNO5/c1-25-19(23)15-11-22(10-13-6-5-9-27-13)12-16(20(24)26-2)18(15)14-7-3-4-8-17(14)21/h3-4,7-8,11-13,18H,5-6,9-10H2,1-2H3
  • InChiKey: UTOSXBGWALVCRN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • dimethyl 4-(2-chlorophenyl)-1-(tetrahydrofuran-2-ylmethyl)-4H-pyridine-3,5-dicarboxylate
  • 4-(2-chlorophenyl)-1-(2-tetrahydrofuranylmethyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
  • 4-(2-chlorophenyl)-1-(tetrahydrofurfuryl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
  • BAS 04378721
  • EU-0009586
  • A2618/0111343

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0113 0.0523 0.0523
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0255 0.0852
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0321 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.0987 0.0973
Chlamydia trachomatis pyruvate kinase 0.0301 0.1681 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.0305 0.2377
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0058 0.0045
Toxoplasma gondii pyruvate kinase PyK1 0.0301 0.1681 1
Schistosoma mansoni survival motor neuron protein 0.015 0.075 0.0736
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.008 0.0321 0.2502
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0523 0.0512
Loa Loa (eye worm) transcription factor SMAD2 0.0738 0.4362 0.4362
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0113 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0082 0.0336 0.0336
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0306 0.1745
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0225 0.1275
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.4228 0.4219
Leishmania major hypothetical protein, conserved 0.0113 0.0523 0.3063
Schistosoma mansoni hypothetical protein 0.0181 0.0944 0.0931
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.0305 0.0304
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.008 0.0321 0.1834
Schistosoma mansoni hypothetical protein 0.0122 0.0581 0.0566
Onchocerca volvulus 0.015 0.075 0.1293
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.0305 0.0344
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.0987 0.0987
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0225 0.1275
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0523 0.0512
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0144 0.0254
Schistosoma mansoni alpha glucosidase 0.008 0.0321 0.0306
Schistosoma mansoni tar DNA-binding protein 0.1007 0.602 0.6014
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0321 0.1849
Echinococcus multilocularis smad 0.005 0.0138 0.0129
Schistosoma mansoni glutaminase 0.1655 1 1
Schistosoma mansoni hypothetical protein 0.0181 0.0944 0.0931
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0523 0.0602
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0321 0.0309
Schistosoma mansoni tar DNA-binding protein 0.1007 0.602 0.6014
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0523 0.1152
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0305 0.1757
Echinococcus multilocularis pyruvate kinase 0.0155 0.078 0.0802
Echinococcus multilocularis survival motor neuron protein 1 0.0735 0.4343 0.454
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.0925 0.0925
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.0987 0.0973
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0309 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0138 0.0145
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.008 0.0321 0.2502
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0096 0.0417 0.0406
Schistosoma mansoni inositol monophosphatase 0.0077 0.0305 0.0291
Echinococcus granulosus smad 0.005 0.0138 0.0145
Entamoeba histolytica hypothetical protein 0.023 0.1245 1
Brugia malayi hypothetical protein 0.023 0.1245 0.1245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.0987 0.0973
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0571 0.0557
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0523 0.0477
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0309 0.1764
Brugia malayi MH2 domain containing protein 0.0738 0.4362 0.4362
Echinococcus granulosus tar DNA binding protein 0.1007 0.602 0.7111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0523 0.1152
Plasmodium vivax pyruvate kinase, putative 0.0301 0.1681 1
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0523 0.2572
Trichomonas vaginalis set domain proteins, putative 0.0958 0.5719 0.5714
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0523 0.1152
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0336 0.038
Schistosoma mansoni alpha-glucosidase 0.031 0.1736 0.1723
Onchocerca volvulus 0.0113 0.0523 0.0896
Trypanosoma brucei pyruvate kinase 1, putative 0.0301 0.1681 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1582 0.9549 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0336 0.0336
Onchocerca volvulus 0.0113 0.0523 0.0896
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0122 0.0581 0.0581
Mycobacterium ulcerans lipase LipD 0.0113 0.0523 0.0477
Loa Loa (eye worm) pyruvate kinase 0.0063 0.0219 0.0219
Brugia malayi pyruvate kinase 0.0063 0.0219 0.0219
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1007 0.602 0.602
Loa Loa (eye worm) hypothetical protein 0.0113 0.0523 0.0523
Mycobacterium ulcerans hypothetical protein 0.0113 0.0523 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0523 0.3063
Loa Loa (eye worm) inositol-1 0.0077 0.0305 0.0305
Brugia malayi beta-lactamase family protein 0.0113 0.0523 0.0523
Brugia malayi MH2 domain containing protein 0.005 0.0138 0.0138
Mycobacterium ulcerans glutaminase 0.1655 1 1
Brugia malayi beta-lactamase family protein 0.0113 0.0523 0.0523
Echinococcus multilocularis pyruvate kinase 0.0155 0.078 0.0802
Loa Loa (eye worm) beta-lactamase 0.0113 0.0523 0.0523
Echinococcus multilocularis pyruvate kinase 0.0301 0.1681 0.1747
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0058 0.0051
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0523 0.1152
Entamoeba histolytica hypothetical protein 0.023 0.1245 1
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0306 0.1745
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0123 0.0123
Schistosoma mansoni smad 0.005 0.0138 0.0123
Trypanosoma cruzi pyruvate kinase 2, putative 0.0301 0.1681 1
Schistosoma mansoni eyes absent homolog 0.0085 0.0353 0.0338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.0987 0.115
Brugia malayi Glycosyl hydrolases family 31 protein 0.008 0.0321 0.0321
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.4228 0.4418
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0722 0.4265 1
Echinococcus multilocularis pyruvate kinase 0.0155 0.078 0.0802
Echinococcus granulosus pyruvate kinase 0.0155 0.078 0.0905
Plasmodium vivax pyruvate kinase 2, putative 0.0155 0.078 0.4589
Schistosoma mansoni Smad4 0.005 0.0138 0.0123
Loa Loa (eye worm) hypothetical protein 0.0735 0.4343 0.4343
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0255 0.0518
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0309 0.5
Leishmania major pyruvate kinase 0.0301 0.1681 1
Plasmodium falciparum pyruvate kinase 0.0301 0.1681 1
Schistosoma mansoni pyruvate kinase 0.0301 0.1681 0.1668
Echinococcus granulosus pyruvate kinase 0.0155 0.078 0.0905
Brugia malayi hypothetical protein 0.0078 0.0306 0.0306
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0144 0.0152
Echinococcus granulosus histone acetyltransferase KAT2B 0.0316 0.1774 0.2082
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0309 0.1764
Giardia lamblia Pyruvate kinase 0.0155 0.078 0.3133
Echinococcus granulosus survival motor neuron protein 1 0.0735 0.4343 0.5126
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0138 0.0129
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0123 0.0662
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0309 0.0262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0049
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0326 0.183 0.1903
Echinococcus multilocularis pyruvate kinase 0.0301 0.1681 0.1747
Entamoeba histolytica hypothetical protein 0.023 0.1245 1
Leishmania major hypothetical protein, conserved 0.0078 0.0306 0.1759
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0306 0.1745
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0261 0.1431 0.1431
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0336 0.0337
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0049 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.023 0.1245 0.1232
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0225 0.021
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0091 0.0389 0.0389
Loa Loa (eye worm) glutaminase 0.1655 1 1
Echinococcus granulosus microtubule associated protein 2 0.0716 0.4228 0.4989
Loa Loa (eye worm) hypothetical protein 0.0085 0.0353 0.0353
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0305 0.1757
Entamoeba histolytica hypothetical protein 0.023 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0049
Echinococcus granulosus neutral alpha glucosidase AB 0.008 0.0321 0.0362
Echinococcus granulosus lysosomal alpha glucosidase 0.036 0.2044 0.2403
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0122 0.0581 0.0581
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0523 0.0509
Trichomonas vaginalis sucrase-isomaltase, putative 0.008 0.0321 0.0309
Schistosoma mansoni smad1 5 8 and 0.005 0.0138 0.0123
Brugia malayi Calcitonin receptor-like protein seb-1 0.0261 0.1431 0.1431
Onchocerca volvulus 0.0206 0.1092 0.1893
Loa Loa (eye worm) hypothetical protein 0.0121 0.0571 0.0571
Onchocerca volvulus Pyruvate kinase homolog 0.0301 0.1681 0.2924
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.0122 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0113 0.0523 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0523 0.3063
Brugia malayi MH2 domain containing protein 0.005 0.0138 0.0138
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0301 0.1681 0.3889
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0321 0.0309
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0306 0.1745
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0523 0.0533
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0015
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0122 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0113 0.0523 0.0523
Loa Loa (eye worm) RNA binding protein 0.1007 0.602 0.602
Entamoeba histolytica pyruvate kinase, putative 0.021 0.1121 0.8989
Echinococcus multilocularis neutral alpha glucosidase AB 0.008 0.0321 0.032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0049
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0049 0.0199
Onchocerca volvulus 0.0121 0.0571 0.098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.023 0.1245 0.129
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0309 0.1597
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0523 0.3063
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0096 0.0417 0.2415
Schistosoma mansoni tar DNA-binding protein 0.1007 0.602 0.6014
Echinococcus multilocularis tumor protein p63 0.1404 0.8459 0.8856
Trichomonas vaginalis pyruvate kinase, putative 0.0301 0.1681 0.1671
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0306 0.1759
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0523 0.0477
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0305 0.1757
Schistosoma mansoni hypothetical protein 0.0323 0.1816 0.1803
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0121 0.0571 0.0583
Brugia malayi hypothetical protein 0.011 0.0508 0.0508
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0138 0.0138
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0571 0.3339
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0138 0.0123
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.008 0.0321 0.0309
Onchocerca volvulus Pyruvate kinase homolog 0.0301 0.1681 0.2924
Loa Loa (eye worm) pyruvate kinase 0.0301 0.1681 0.1681
Schistosoma mansoni tar DNA-binding protein 0.1007 0.602 0.6014
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0523 0.0512
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0096 0.0417 0.2415
Brugia malayi Pyruvate kinase, muscle isozyme 0.0301 0.1681 0.1681
Loa Loa (eye worm) MH2 domain-containing protein 0.0738 0.4362 0.4362
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0309 0.0308
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0123 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0523 0.0523
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0138 0.0138
Brugia malayi hypothetical protein 0.011 0.0508 0.0508
Schistosoma mansoni smad1 5 8 and 0.005 0.0138 0.0123
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0309 0.0262
Echinococcus granulosus geminin 0.0181 0.0944 0.11
Echinococcus multilocularis snurportin 1 0.0323 0.1816 0.1888
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0123 0.0075
Brugia malayi RNA, U transporter 1 0.0086 0.0358 0.0358
Schistosoma mansoni alpha-glucosidase 0.031 0.1736 0.1723
Echinococcus multilocularis geminin 0.0181 0.0944 0.0975
Plasmodium vivax SET domain protein, putative 0.0121 0.0571 0.3339
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0523 0.0523
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0123 0.0075
Schistosoma mansoni hypothetical protein 0.0082 0.0336 0.0321
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0043 0.0033
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0144 0.0135
Mycobacterium ulcerans pyruvate kinase 0.0301 0.1681 0.164
Echinococcus granulosus histone acetyltransferase KAT2B 0.0096 0.0417 0.0476
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0122 0.0581 0.0593
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.075 0.075
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.008 0.0321 0.0321
Brugia malayi Inositol-1 0.0077 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.021 0.1121 0.1121
Schistosoma mansoni hypothetical protein 0.0082 0.0336 0.0321
Trichomonas vaginalis pyruvate kinase, putative 0.0301 0.1681 0.1671
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0225 0.022
Echinococcus multilocularis pyruvate kinase 0.0238 0.1291 0.1338
Brugia malayi MH1 domain containing protein 0.005 0.0138 0.0138
Schistosoma mansoni smad1 5 8 and 0.005 0.0138 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0123 0.0075
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.0305 0.0293
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0015 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.0987 0.1019
Echinococcus granulosus Smad4 0.005 0.0138 0.0145
Schistosoma mansoni hypothetical protein 0.0178 0.0925 0.0911
Echinococcus granulosus snurportin 1 0.0323 0.1816 0.2132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0336 0.0337
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.036 0.2044 0.2044
Schistosoma mansoni hypothetical protein 0.0082 0.0336 0.0321
Loa Loa (eye worm) hypothetical protein 0.0048 0.0123 0.0123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0123 0.0204
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0225 0.1725
Toxoplasma gondii pyruvate kinase PyKII 0.0155 0.078 0.4589
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0544 0.0626
Echinococcus multilocularis lysosomal alpha glucosidase 0.036 0.2044 0.2128
Mycobacterium ulcerans beta-lactamase 0.0113 0.0523 0.0477
Echinococcus granulosus GPCR family 2 0.0082 0.0336 0.038
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0144 0.0254
Loa Loa (eye worm) hypothetical protein 0.0078 0.0306 0.0306
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0144 0.0135
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0309 0.0348
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0309 0.1764
Mycobacterium tuberculosis Conserved protein 0.0113 0.0523 0.1152
Brugia malayi Smad1 0.005 0.0138 0.0138
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.008 0.0321 0.0309
Brugia malayi hypothetical protein 0.0735 0.4343 0.4343
Loa Loa (eye worm) hypothetical protein 0.0113 0.0523 0.0523
Mycobacterium leprae Probable lipase LipE 0.0113 0.0523 0.2572
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0048 0.0123 0.0123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.0987 0.0987
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0336 0.0336
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0138 0.0129
Brugia malayi Pre-SET motif family protein 0.0842 0.5004 0.5004
Onchocerca volvulus 0.0113 0.0523 0.0896
Entamoeba histolytica acetyltransferase, GNAT family 0.0088 0.0368 0.2889
Echinococcus granulosus pyruvate kinase 0.0301 0.1681 0.1973
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0321 0.0309
Loa Loa (eye worm) hypothetical protein 0.0261 0.1431 0.1431
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0123 0.0075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0225 0.0225
Mycobacterium ulcerans hypothetical protein 0.0048 0.0123 0.0075
Echinococcus granulosus histone lysine methyltransferase setb 0.0121 0.0571 0.0659
Brugia malayi RNA recognition motif domain containing protein 0.1007 0.602 0.602
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0523 0.1152
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0309 0.1196
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0309 0.1764
Brugia malayi Glycosyl hydrolases family 31 protein 0.036 0.2044 0.2044
Echinococcus granulosus pyruvate kinase 0.0301 0.1681 0.1973
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0571 0.0583
Schistosoma mansoni inositol monophosphatase 0.0077 0.0305 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0321 0.1849
Schistosoma mansoni cellular tumor antigen P53 0.0206 0.1092 0.1079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0123 0.0075
Schistosoma mansoni pyruvate kinase 0.0301 0.1681 0.1668
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0015 0.0018
Plasmodium falciparum histone acetyltransferase GCN5 0.0088 0.0368 0.2121
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0225 0.1275
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0123 0.0204
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0523 0.1152
Schistosoma mansoni tar DNA-binding protein 0.1007 0.602 0.6014
Trichomonas vaginalis glutaminase, putative 0.1655 1 1
Brugia malayi TAR-binding protein 0.1007 0.602 0.602
Mycobacterium tuberculosis Conserved protein 0.0113 0.0523 0.1152
Mycobacterium tuberculosis Conserved protein 0.0113 0.0523 0.1152
Loa Loa (eye worm) acetyltransferase 0.0326 0.183 0.183
Echinococcus granulosus pyruvate kinase 0.0155 0.078 0.0905
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0571 0.0557
Brugia malayi Probable ClpP-like protease 0.0078 0.0309 0.0309
Onchocerca volvulus Pyruvate kinase homolog 0.0301 0.1681 0.2924
Brugia malayi pyruvate kinase, muscle isozyme 0.0063 0.0219 0.0219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0523 0.0509
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.0571 0.0557
Brugia malayi Pre-SET motif family protein 0.0121 0.0571 0.0571
Brugia malayi MH1 domain containing protein 0.005 0.0138 0.0138
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.023 0.1245 0.1457
Echinococcus granulosus tumor protein p63 0.1404 0.8459 1
Onchocerca volvulus 0.0048 0.0123 0.0193
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0122 0.0581 0.3394
Loa Loa (eye worm) hypothetical protein 0.0078 0.0309 0.0309
Trichomonas vaginalis esterase, putative 0.0113 0.0523 0.0512
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0305 0.0293
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0523 0.0512
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0225 0.0248
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0336 0.038
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0012
Leishmania major alpha glucosidase II subunit, putative 0.008 0.0321 0.1849
Brugia malayi Pyruvate kinase, M2 isozyme 0.0301 0.1681 0.1681
Echinococcus multilocularis GPCR, family 2 0.0082 0.0336 0.0337
Brugia malayi acetyltransferase, GNAT family protein 0.0326 0.183 0.183
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0123 0.0662
Loa Loa (eye worm) hypothetical protein 0.0048 0.0123 0.0123
Loa Loa (eye worm) pyruvate kinase-PB 0.021 0.1121 0.1121
Loa Loa (eye worm) hypothetical protein 0.0301 0.1681 0.1681
Brugia malayi RNA binding protein 0.1007 0.602 0.602
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0326 0.183 0.1817
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0309 0.1597
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0309 0.0294
Trypanosoma cruzi pyruvate kinase 2, putative 0.0301 0.1681 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.0305 0.0258
Schistosoma mansoni pyruvate kinase 0.0155 0.078 0.0765
Leishmania major pyruvate kinase 0.0301 0.1681 1
Brugia malayi beta-lactamase 0.0113 0.0523 0.0523
Loa Loa (eye worm) pyruvate kinase 0.0301 0.1681 0.1681
Echinococcus multilocularis Smad4 0.005 0.0138 0.0129
Onchocerca volvulus 0.0208 0.111 0.1924
Brugia malayi hypothetical protein 0.0085 0.0353 0.0353
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0122 0.0581 0.3394
Trichomonas vaginalis bromodomain-containing protein, putative 0.0096 0.0417 0.0406
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0028
Loa Loa (eye worm) hypothetical protein 0.0206 0.1092 0.1092
Plasmodium falciparum pyruvate kinase 2 0.0155 0.078 0.4589
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0261 0.1431 0.1431
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0123 0.0075
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0306 0.1759
Trichomonas vaginalis maltase-glucoamylase, putative 0.008 0.0321 0.0309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.0987 0.1019
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0523 0.0512
Toxoplasma gondii ABC1 family protein 0.0113 0.0523 0.3051
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0122 0.0581 0.3394
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.1816 0.1816
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0049 0.0199
Trypanosoma brucei pyruvate kinase 1 0.0301 0.1681 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0123 0.0123
Giardia lamblia Pyruvate kinase 0.0301 0.1681 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0225 0.1275
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0123 0.0896
Echinococcus multilocularis tar DNA binding protein 0.1007 0.602 0.6298
Trypanosoma brucei glucosidase, putative 0.008 0.0321 0.1849
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0123 0.0662
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0123 0.0896
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0523 0.1152
Schistosoma mansoni hypothetical protein 0.023 0.1245 0.1232
Loa Loa (eye worm) hypothetical protein 0.0085 0.0353 0.0353
Brugia malayi glutaminase DH11.1 0.1655 1 1
Loa Loa (eye worm) pyruvate kinase 0.0301 0.1681 0.1681
Loa Loa (eye worm) TAR-binding protein 0.1007 0.602 0.602
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0523 0.3051
Schistosoma mansoni hypothetical protein 0.015 0.075 0.0736
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.0987 0.115
Onchocerca volvulus 0.0958 0.5719 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0305 0.1757
Loa Loa (eye worm) hypothetical protein 0.0178 0.0925 0.0925
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0305 0.0293
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.0305 0.1742
Mycobacterium leprae Probable pyruvate kinase PykA 0.0301 0.1681 1
Brugia malayi hypothetical protein 0.005 0.0137 0.0137
Echinococcus multilocularis lysosomal alpha glucosidase 0.036 0.2044 0.2128
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0842 0.5004 0.5004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0123 0.0896
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0336 0.0336
Loa Loa (eye worm) Smad1 0.005 0.0138 0.0138
Brugia malayi Importin beta-1 subunit 0.003 0.0015 0.0015
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0225 0.0225
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0096 0.0417 0.2415
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0321 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0571 0.0557
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0306 0.1759
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0138 0.0145
Schistosoma mansoni hypothetical protein 0.0082 0.0336 0.0321

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.