Detailed information for compound 758744

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.361 | Formula: C23H26BrNO3
  • H donors: 1 H acceptors: 2 LogP: 4.67 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1=C(C)N=C2C(=C(O)CCC2)C1c1ccccc1Br)OC1CCCCC1
  • InChi: 1S/C23H26BrNO3/c1-14-20(23(27)28-15-8-3-2-4-9-15)21(16-10-5-6-11-17(16)24)22-18(25-14)12-7-13-19(22)26/h5-6,10-11,15,21,26H,2-4,7-9,12-13H2,1H3
  • InChiKey: BLWGNCNYWHUPNT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0053 0.0067
Brugia malayi hypothetical protein 0.0051 0.0312 0.0395
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0238 0.0301
Schistosoma mansoni hypothetical protein 0.0043 0.0238 0.0301
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0077 0.0575 0.2102
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0524 0.12
Loa Loa (eye worm) hypothetical protein 0.0072 0.0524 0.0662
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0053 0.0297
Brugia malayi MH2 domain containing protein 0.0373 0.3508 0.4435
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0016 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.6612 0.8359
Loa Loa (eye worm) hypothetical protein 0.0072 0.0524 0.0662
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0044 0.0056
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0063 0.0063
Brugia malayi pyruvate kinase 0.006 0.0409 0.0517
Schistosoma mansoni hypothetical protein 0.0156 0.1356 0.1714
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0095 0.036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0067
Brugia malayi RNA, U transporter 1 0.0083 0.0629 0.0795
Echinococcus multilocularis pyruvate kinase 0.0286 0.2649 0.2649
Brugia malayi beta-lactamase family protein 0.0072 0.0524 0.0662
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0312 0.1103
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.1841 0.2327
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0044 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0016 0.002
Brugia malayi acetyltransferase, GNAT family protein 0.0311 0.2894 0.3659
Brugia malayi nuclear hormone receptor 0.0021 0.0016 0.002
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0196 0.074
Schistosoma mansoni alpha glucosidase 0.0077 0.0575 0.0727
Loa Loa (eye worm) RNA binding protein 0.0794 0.7684 0.9714
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0196 0.0248
Echinococcus multilocularis pyruvate kinase 0.0286 0.2649 0.2649
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.0067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Entamoeba histolytica hypothetical protein 0.0156 0.1356 0.7572
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.2649 0.3903
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0098 0.0372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0322 0.0407
Trichomonas vaginalis maltase-glucoamylase, putative 0.0077 0.0575 0.0727
Trichomonas vaginalis esterase, putative 0.0072 0.0524 0.0662
Schistosoma mansoni tar DNA-binding protein 0.0794 0.7684 0.9714
Loa Loa (eye worm) beta-lactamase 0.0072 0.0524 0.0662
Echinococcus granulosus snurportin 1 0.031 0.2881 0.2881
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0575 0.0727
Loa Loa (eye worm) glutaminase 0.0817 0.791 1
Echinococcus granulosus tar DNA binding protein 0.0794 0.7684 0.7684
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0524 0.0662
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0016 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Onchocerca volvulus 0.0024 0.0053 0.0055
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0095 0.0121
Brugia malayi Pyruvate kinase, M2 isozyme 0.0286 0.2649 0.3349
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.0301
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0718 0.0907
Loa Loa (eye worm) hypothetical protein 0.0087 0.0678 0.0857
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0016 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0453 0.0453
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0016 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0297
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0095 0.036
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.0642 0.2359
Giardia lamblia Pyruvate kinase 0.0147 0.1268 0.4785
Loa Loa (eye worm) hypothetical protein 0.0072 0.0524 0.0662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0687 0.0869
Schistosoma mansoni ran 0.0021 0.0023 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0322 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0016 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0687 0.0869
Mycobacterium leprae Probable pyruvate kinase PykA 0.0286 0.2649 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0524 0.0662
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.1841 0.2327
Loa Loa (eye worm) pyruvate kinase 0.0286 0.2649 0.3349
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0095 0.0121
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0063 0.0063
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0156 0.0357
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0453 0.0573
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0156 0.1356 0.1356
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.0201
Schistosoma mansoni smad1 5 8 and 0.0025 0.0063 0.0079
Brugia malayi Importin beta-1 subunit 0.0029 0.0098 0.0124
Echinococcus multilocularis pyruvate kinase 0.0147 0.1268 0.1268
Schistosoma mansoni hypothetical protein 0.0065 0.0453 0.0573
Schistosoma mansoni alpha-glucosidase 0.0299 0.2774 0.3507
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0016 0.002
Echinococcus granulosus pyruvate kinase 0.0147 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Schistosoma mansoni smad1 5 8 and 0.0025 0.0063 0.0079
Plasmodium vivax importin-beta 2, putative 0.0029 0.0098 0.0289
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0718 0.2646
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0347 0.3253 0.4113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0053 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0453 0.0573
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0524 0.0662
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0311 0.2894 0.2894
Trichomonas vaginalis sucrase-isomaltase, putative 0.0077 0.0575 0.0727
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0098 0.0098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0453 0.0453
Schistosoma mansoni importin beta-1 0.0029 0.0098 0.0124
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0238 0.0301
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0087 0.067 0.0847
Onchocerca volvulus 0.0072 0.0524 0.0753
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0524 0.1976
Giardia lamblia Pyruvate kinase 0.0286 0.2649 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0016 0.002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0016 0.0016
Schistosoma mansoni alpha-glucosidase 0.0299 0.2774 0.3507
Echinococcus multilocularis tar DNA binding protein 0.0794 0.7684 0.7684
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0286 0.2649 0.3349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0067
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0095 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0053 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0016 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0016 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0016 0.002
Schistosoma mansoni pyruvate kinase 0.0286 0.2649 0.3349
Loa Loa (eye worm) hypothetical protein 0.0065 0.0453 0.0573
Loa Loa (eye worm) glutaminase 2 0.0817 0.791 1
Loa Loa (eye worm) hypothetical protein 0.02 0.179 0.2263
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0524 0.0662
Onchocerca volvulus 0.015 0.1302 0.1907
Schistosoma mansoni hypothetical protein 0.014 0.1198 0.1515
Brugia malayi hypothetical protein 0.0033 0.0135 0.017
Trichomonas vaginalis set domain proteins, putative 0.0702 0.6763 0.855
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0016 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0016 0.0016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0088 0.0687 0.0687
Schistosoma mansoni tar DNA-binding protein 0.0794 0.7684 0.9714
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0524 0.0662
Echinococcus granulosus Smad4 0.0025 0.0063 0.0063
Leishmania major pyruvate kinase 0.0286 0.2649 1
Loa Loa (eye worm) acetyltransferase 0.0311 0.2894 0.3659
Echinococcus granulosus importin subunit beta 1 0.0029 0.0098 0.0098
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0098 0.0289
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0016 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0016 0.002
Echinococcus granulosus smad 0.0025 0.0063 0.0063
Brugia malayi ecdysteroid receptor 0.0021 0.0016 0.002
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.6612 0.6612
Echinococcus multilocularis GPCR, family 2 0.0065 0.0453 0.0453
Mycobacterium ulcerans hypothetical protein 0.0024 0.0053 0.0067
Brugia malayi nuclear receptor NHR-88 0.0021 0.0016 0.002
Echinococcus granulosus GPCR family 2 0.0065 0.0453 0.0453
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0063 0.0063
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0312 0.1103
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0196 0.066
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0575 0.0727
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0016 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0095 0.0121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0524 0.0662
Brugia malayi MH1 domain containing protein 0.0025 0.0063 0.0079
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0575 0.0727
Leishmania major alpha glucosidase II subunit, putative 0.0077 0.0575 0.217
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.7788 0.7788
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0067
Schistosoma mansoni hypothetical protein 0.0172 0.1511 0.191
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0016 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0095 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0524 0.0662
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0156 0.0395
Schistosoma mansoni ran 0.0021 0.0023 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0016 0.002
Mycobacterium ulcerans beta-lactamase 0.0072 0.0524 0.0662
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0095 0.0121
Schistosoma mansoni inositol monophosphatase 0.0039 0.0196 0.0248
Loa Loa (eye worm) hypothetical protein 0.0072 0.0524 0.0662
Brugia malayi hypothetical protein 0.0087 0.0678 0.0857
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0044 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.0067
Schistosoma mansoni hypothetical protein 0.031 0.2881 0.3642
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.2649 0.3903
Schistosoma mansoni hypothetical protein 0.0065 0.0453 0.0573
Trypanosoma brucei pyruvate kinase 1, putative 0.0286 0.2649 1
Entamoeba histolytica hypothetical protein 0.0156 0.1356 0.7572
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0016 0.002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0453 0.0453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0322 0.0322
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0196 0.074
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0238 0.082
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0085
Echinococcus multilocularis snurportin 1 0.031 0.2881 0.2881
Brugia malayi RNA binding protein 0.0794 0.7684 0.9714
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Loa Loa (eye worm) pyruvate kinase 0.0286 0.2649 0.3349
Brugia malayi hypothetical protein 0.0039 0.0196 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0718 0.0718
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0016 0.002
Brugia malayi beta-lactamase family protein 0.0072 0.0524 0.0662
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.2649 0.3903
Schistosoma mansoni pyruvate kinase 0.0286 0.2649 0.3349
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0016 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0156 0.1356 0.1356
Mycobacterium leprae Probable lipase LipE 0.0072 0.0524 0.1812
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1198 0.1515
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0524 0.0662
Schistosoma mansoni transcription factor LCR-F1 0.0156 0.1356 0.1714
Brugia malayi MH1 domain containing protein 0.0025 0.0063 0.0079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0088 0.0687 0.253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.0395
Plasmodium vivax pyruvate kinase 2, putative 0.0147 0.1268 0.4741
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0297
Loa Loa (eye worm) hypothetical protein 0.0205 0.1841 0.2327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0016 0.002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0196 0.0248
Loa Loa (eye worm) Smad1 0.0025 0.0063 0.0079
Entamoeba histolytica pyruvate kinase, putative 0.02 0.179 1
Plasmodium falciparum pyruvate kinase 2 0.0147 0.1268 0.4741
Entamoeba histolytica hypothetical protein 0.0156 0.1356 0.7572
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0016 0.0016
Schistosoma mansoni inositol monophosphatase 0.0039 0.0196 0.0248
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0043 0.0238 0.082
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0575 0.0727
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.0642 0.3586
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Onchocerca volvulus 0.0702 0.6763 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0453 0.0573
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0575 0.0727
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Brugia malayi TAR-binding protein 0.0794 0.7684 0.9714
Brugia malayi Pre-SET motif family protein 0.0616 0.5919 0.7483
Leishmania major pyruvate kinase 0.0286 0.2649 1
Onchocerca volvulus 0.0072 0.0524 0.0753
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0575 0.217
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0095 0.0533
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0085
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0524 0.12
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0794 0.7684 0.9714
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0524 0.0662
Loa Loa (eye worm) pyruvate kinase 0.0286 0.2649 0.3349
Brugia malayi Pre-SET motif family protein 0.0088 0.0687 0.0869
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0524 0.12
Schistosoma mansoni hypothetical protein 0.0065 0.0453 0.0573
Mycobacterium ulcerans pyruvate kinase 0.0286 0.2649 0.3349
Mycobacterium ulcerans glutaminase 0.0817 0.791 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0524 0.12
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0524 0.1976
Loa Loa (eye worm) hypothetical protein 0.0072 0.0524 0.0662
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0575 0.0727
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0172 0.1511 0.191
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0016 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0016 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0524 0.12
Echinococcus granulosus histone lysine methyltransferase setb 0.0088 0.0687 0.0687
Brugia malayi glutaminase DH11.1 0.0817 0.791 1
Echinococcus multilocularis smad 0.0025 0.0063 0.0063
Brugia malayi Glycosyl hydrolases family 31 protein 0.0077 0.0575 0.0727
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.0067
Brugia malayi beta-lactamase 0.0072 0.0524 0.0662
Chlamydia trachomatis pyruvate kinase 0.0286 0.2649 0.5
Loa Loa (eye worm) pyruvate kinase 0.006 0.0409 0.0517
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0085
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0524 0.0524
Echinococcus granulosus pyruvate kinase 0.0147 0.1268 0.1268
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0718 0.0907
Echinococcus multilocularis lysosomal alpha glucosidase 0.0347 0.3253 0.3253
Brugia malayi Glycosyl hydrolases family 31 protein 0.0347 0.3253 0.4113
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0067
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0196 0.0248
Loa Loa (eye worm) hypothetical protein 0.0246 0.2246 0.284
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0063 0.0079
Brugia malayi hypothetical protein 0.0246 0.2246 0.284
Brugia malayi Pyruvate kinase, muscle isozyme 0.0286 0.2649 0.3349
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0196 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2246 0.2246
Brugia malayi hypothetical protein 0.0039 0.0196 0.0248
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0718 0.2646
Loa Loa (eye worm) hypothetical protein 0.014 0.1198 0.1515
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0088 0.0687 0.0869
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0095 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.4364 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0053 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0312 0.1103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0016 0.002
Toxoplasma gondii pyruvate kinase PyKII 0.0147 0.1268 0.4741
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0095 0.0121
Trypanosoma brucei glucosidase, putative 0.0077 0.0575 0.217
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0016 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0088 0.0687 0.0869
Plasmodium falciparum pyruvate kinase 0.0286 0.2649 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0016 0.002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0053 0.0122
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.2649 0.3349
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0095 0.0118
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0238 0.0301
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0453 0.0453
Plasmodium falciparum importin beta, putative 0.0029 0.0098 0.0289
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0616 0.5919 0.7483
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0524 0.0662
Schistosoma mansoni survival motor neuron protein 0.005 0.0308 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0016 0.002
Mycobacterium ulcerans hypothetical protein 0.0072 0.0524 0.0662
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0016 0.002
Schistosoma mansoni pyruvate kinase 0.0147 0.1268 0.1603
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0524 0.1976
Echinococcus multilocularis lysosomal alpha glucosidase 0.0347 0.3253 0.3253
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0196 0.0248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0687 0.0869
Mycobacterium tuberculosis Conserved protein 0.0072 0.0524 0.12
Loa Loa (eye worm) hypothetical protein 0.015 0.1302 0.1646
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0095 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0322 0.0407
Schistosoma mansoni coup transcription factor 0.0021 0.0016 0.002
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0098 0.0372
Onchocerca volvulus 0.0088 0.0687 0.0995
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0016 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0312 0.1179
Echinococcus multilocularis pyruvate kinase 0.0147 0.1268 0.1268
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0524 0.0662
Echinococcus multilocularis tumor protein p63 0.1028 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0322 0.0407
Brugia malayi MH2 domain containing protein 0.0025 0.0063 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0322 0.0322
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0063 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0794 0.7684 0.9714
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0016 0.002
Loa Loa (eye worm) transcription factor SMAD2 0.0373 0.3508 0.4435
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0088 0.0687 0.0687
Schistosoma mansoni cellular tumor antigen P53 0.015 0.1302 0.1646
Echinococcus granulosus pyruvate kinase 0.0147 0.1268 0.1268
Schistosoma mansoni tar DNA-binding protein 0.0794 0.7684 0.9714
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0524 0.12
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0095 0.036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0016 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0524 0.1812
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0322 0.0407
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0063 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0196 0.074
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0322 0.0322
Schistosoma mansoni hypothetical protein 0.0023 0.0036 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0655 0.0655
Plasmodium vivax SET domain protein, putative 0.0088 0.0687 0.253
Mycobacterium tuberculosis Conserved protein 0.0072 0.0524 0.12
Schistosoma mansoni tar DNA-binding protein 0.0794 0.7684 0.9714
Brugia malayi hypothetical protein 0.0156 0.1356 0.1714
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0524 0.12
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0077 0.0575 0.0727
Leishmania major GTP-binding protein, putative 0.0021 0.0023 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0016 0.0016
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0196 0.0196
Loa Loa (eye worm) pyruvate kinase-PB 0.02 0.179 0.2263
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0023 0.0029
Plasmodium vivax pyruvate kinase, putative 0.0286 0.2649 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0238 0.082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0016 0.0016
Trichomonas vaginalis glutaminase, putative 0.0817 0.791 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0016 0.002
Schistosoma mansoni tar DNA-binding protein 0.0794 0.7684 0.9714
Leishmania major hypothetical protein, conserved 0.0072 0.0524 0.1976
Schistosoma mansoni smad 0.0025 0.0063 0.0079
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0196 0.1095
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0575 0.321
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.0642 0.2424
Toxoplasma gondii pyruvate kinase PyK1 0.0286 0.2649 1
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0312 0.1103
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0063 0.0079
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2246 0.2246
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0575 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0016 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0016 0.0016
Toxoplasma gondii ABC1 family protein 0.0072 0.0524 0.1908
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0016 0.0016
Trypanosoma brucei pyruvate kinase 1 0.0286 0.2649 1
Loa Loa (eye worm) TAR-binding protein 0.0794 0.7684 0.9714
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.2649 0.3349
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0524 0.12
Echinococcus granulosus neutral alpha glucosidase AB 0.0077 0.0575 0.0575
Brugia malayi Smad1 0.0025 0.0063 0.0079
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0053 0.0067
Echinococcus granulosus microtubule associated protein 2 0.0686 0.6612 0.6612
Loa Loa (eye worm) inositol-1 0.0039 0.0196 0.0248
Entamoeba histolytica hypothetical protein 0.0024 0.0044 0.0246
Echinococcus granulosus pyruvate kinase 0.0286 0.2649 0.2649
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0524 0.0524
Onchocerca volvulus 0.0072 0.0524 0.0753
Echinococcus granulosus histone acetyltransferase KAT2B 0.0302 0.2808 0.2808
Echinococcus multilocularis pyruvate kinase 0.0147 0.1268 0.1268
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0308 0.0389
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0373 0.3508 0.4435
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0016 0.002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0718 0.2646
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0044 0.0056
Echinococcus multilocularis Smad4 0.0025 0.0063 0.0063
Echinococcus granulosus pyruvate kinase 0.0286 0.2649 0.2649
Schistosoma mansoni smad1 5 8 and 0.0025 0.0063 0.0079
Brugia malayi Inositol-1 0.0039 0.0196 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0016 0.002
Onchocerca volvulus 0.005 0.0308 0.0433
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0016 0.002
Echinococcus multilocularis pyruvate kinase 0.0226 0.2051 0.2051
Schistosoma mansoni hypothetical protein 0.005 0.0308 0.0389
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.2649 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.2881 0.3642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0016 0.002
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0238 0.0238
Echinococcus granulosus geminin 0.0172 0.1511 0.1511
Trichomonas vaginalis ran, putative 0.0021 0.0023 0.0029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Brugia malayi steroid hormone receptor 0.0021 0.0016 0.002
Onchocerca volvulus 0.0201 0.1802 0.2647
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0121
Brugia malayi pyruvate kinase, muscle isozyme 0.006 0.0409 0.0517
Schistosoma mansoni glutaminase 0.0817 0.791 1
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0524 0.1908
Leishmania major importin beta-1 subunit, putative 0.0024 0.0044 0.0166
Schistosoma mansoni eyes absent homolog 0.0087 0.0678 0.0857
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0311 0.2894 0.3659
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0312 0.1179
Schistosoma mansoni hypothetical protein 0.0065 0.0453 0.0573
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.002
Echinococcus granulosus lysosomal alpha glucosidase 0.0347 0.3253 0.3253
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0095 0.036
Echinococcus multilocularis geminin 0.0172 0.1511 0.1511
Entamoeba histolytica hypothetical protein 0.0156 0.1356 0.7572
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.1841 0.2327
Brugia malayi MH2 domain containing protein 0.0025 0.0063 0.0079
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0575 0.321
Entamoeba histolytica Ran family GTPase 0.0021 0.0023 0.0126
Leishmania major hypothetical protein, conserved 0.0051 0.0312 0.1179
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0524 0.0662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0016 0.002
Mycobacterium ulcerans lipase LipD 0.0072 0.0524 0.0662
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.2649 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0678 0.0857
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0016 0.002
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0312 0.1179
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0575 0.217
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0196 0.074
Echinococcus multilocularis neutral alpha glucosidase AB 0.0077 0.0575 0.0575
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0016 0.0016
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0286 0.2649 0.607
Schistosoma mansoni Smad4 0.0025 0.0063 0.0079

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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