Detailed information for compound 758771

Basic information

Technical information
  • TDR Targets ID: 758771
  • Name: N-[5-[2-[(4-diethylaminophenyl)amino]-1,3-thi azol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamid e
  • MW: 463.618 | Formula: C24H25N5OS2
  • H donors: 2 H acceptors: 3 LogP: 5.98 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)Nc1scc(n1)c1sc(nc1C)NC(=O)c1ccccc1)CC
  • InChi: 1S/C24H25N5OS2/c1-4-29(5-2)19-13-11-18(12-14-19)26-23-27-20(15-31-23)21-16(3)25-24(32-21)28-22(30)17-9-7-6-8-10-17/h6-15H,4-5H2,1-3H3,(H,26,27)(H,25,28,30)
  • InChiKey: BCEIMCPLBKSXDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-[2-[(4-diethylaminophenyl)amino]thiazol-4-yl]-4-methyl-thiazol-2-yl]benzamide
  • N-[5-[2-[(4-diethylaminophenyl)amino]-4-thiazolyl]-4-methyl-2-thiazolyl]benzamide
  • Oprea1_016498
  • STK093379

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH1 domain containing protein 0.0033 0.0105 0.0133
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0532 0.068
Brugia malayi ecdysteroid receptor 0.003 0.0075 0.0095
Onchocerca volvulus 0.0037 0.0138 0.0299
Brugia malayi Pyruvate kinase, muscle isozyme 0.0245 0.2206 0.2821
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0183 0.1593 0.1593
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0138 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0006
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0075 0.0158
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0278 0.126
Loa Loa (eye worm) MH2 domain-containing protein 0.0489 0.4635 0.5929
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0075 0.0095
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.1135 0.1451
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0137 0.0137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0075 0.0095
Brugia malayi pyruvate kinase, muscle isozyme 0.0052 0.0286 0.0365
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0075 0.0095
Loa Loa (eye worm) pyruvate kinase 0.0052 0.0286 0.0365
Schistosoma mansoni hypothetical protein 0.0331 0.3066 0.3921
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0075 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0137 0.0619
Mycobacterium tuberculosis Conserved protein 0.0037 0.0138 0.0602
Mycobacterium leprae Probable lipase LipE 0.0037 0.0138 0.0602
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0404 0.0404
Trypanosoma cruzi pyruvate kinase 2, putative 0.0245 0.2206 1
Leishmania major hypothetical protein, conserved 0.0037 0.0138 0.0622
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0696 0.0696
Schistosoma mansoni inositol monophosphatase 0.0076 0.0532 0.068
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0165 0.0747
Brugia malayi TAR-binding protein 0.0644 0.6168 0.789
Schistosoma mansoni glutaminase 0.081 0.7818 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0278 0.126
Loa Loa (eye worm) pyruvate kinase 0.0245 0.2206 0.2821
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0074 0.051 0.0651
Schistosoma mansoni tar DNA-binding protein 0.0644 0.6168 0.789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0075 0.0095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0138 0.0175
Echinococcus multilocularis smad 0.0033 0.0105 0.0105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0137 0.1135 0.1451
Onchocerca volvulus Pyruvate kinase homolog 0.0245 0.2206 0.4973
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0075 0.0095
Trichomonas vaginalis pyruvate kinase, putative 0.0245 0.2206 0.2821
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0532 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0138 0.0175
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0105 0.0105
Echinococcus multilocularis pyruvate kinase 0.0245 0.2206 0.2206
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0644 0.6168 0.789
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0138 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0404 0.0404
Mycobacterium tuberculosis Conserved protein 0.0037 0.0138 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0075 0.0095
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0075 0.0075
Echinococcus granulosus smad 0.0033 0.0105 0.0105
Echinococcus granulosus pyruvate kinase 0.0245 0.2206 0.2206
Plasmodium falciparum importin beta, putative 0.0031 0.0082 0.0369
Loa Loa (eye worm) pyruvate kinase-PB 0.0171 0.147 0.188
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0075 0.0158
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0105 0.0133
Onchocerca volvulus 0.0151 0.127 0.2859
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0138 0.0602
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0665 0.3012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0665 0.3012
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0137 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0075 0.0095
Leishmania major pyruvate kinase 0.0245 0.2206 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0165 0.0211
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0075 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0075 0.0095
Mycobacterium tuberculosis Conserved protein 0.0037 0.0138 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0075 0.0095
Toxoplasma gondii pyruvate kinase PyKII 0.0126 0.1022 0.4632
Schistosoma mansoni inositol monophosphatase 0.0076 0.0532 0.068
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0278 0.126
Schistosoma mansoni importin beta-1 0.0031 0.0082 0.0105
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0137 0.0175
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0532 0.2409
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0361 0.0461
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0305 0.2804 0.2804
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0138 0.0175
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0075 0.0075
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0082 0.0369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0696 0.089
Brugia malayi acetyltransferase, GNAT family protein 0.0305 0.2804 0.3586
Mycobacterium ulcerans lipase LipD 0.0037 0.0138 0.0169
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Echinococcus granulosus FTZ F1 alpha 0.003 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0102 0.0784 0.1003
Mycobacterium ulcerans pyruvate kinase 0.0245 0.2206 0.2817
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0137 0.0175
Brugia malayi nuclear receptor NHR-88 0.003 0.0075 0.0095
Plasmodium falciparum pyruvate kinase 2 0.0126 0.1022 0.4632
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0075 0.0096
Loa Loa (eye worm) pyruvate kinase 0.0245 0.2206 0.2821
Loa Loa (eye worm) glutaminase 2 0.081 0.7818 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0137 0.0175
Schistosoma mansoni hypothetical protein 0.0166 0.1418 0.1814
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0165 0.0747
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0075 0.0095
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0644 0.6168 0.789
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0138 0.0602
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0075 0.0075
Entamoeba histolytica hypothetical protein 0.0183 0.1593 1
Echinococcus multilocularis Smad4 0.0033 0.0105 0.0105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0361 0.0361
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0165 0.0211
Loa Loa (eye worm) inositol-1 0.0076 0.0532 0.068
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0006
Schistosoma mansoni pyruvate kinase 0.0245 0.2206 0.2821
Loa Loa (eye worm) hypothetical protein 0.0245 0.2206 0.2821
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0075 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0005 0.0006
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0001 0.0001
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0532 0.0532
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0138 0.0602
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0137 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0138 0.0175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0075 0.0075
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0105 0.0134
Loa Loa (eye worm) beta-lactamase 0.0037 0.0138 0.0175
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0075 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0075 0.0095
Loa Loa (eye worm) hypothetical protein 0.0499 0.4727 0.6046
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0024 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0075 0.0075
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0138 0.0602
Echinococcus multilocularis pyruvate kinase 0.0245 0.2206 0.2206
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Loa Loa (eye worm) acetyltransferase 0.0305 0.2804 0.3586
Brugia malayi hypothetical protein 0.0033 0.0099 0.0127
Brugia malayi Smad1 0.0033 0.0105 0.0133
Schistosoma mansoni hypothetical protein 0.0137 0.1135 0.1451
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.4727 0.4727
Brugia malayi MH2 domain containing protein 0.0033 0.0105 0.0133
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0784 0.1002
Leishmania major hypothetical protein, conserved 0.0051 0.0278 0.126
Brugia malayi RNA binding protein 0.0644 0.6168 0.789
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0665 0.0665
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0138 0.0602
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0005 0.0021
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0137 0.0175
Echinococcus multilocularis tar DNA binding protein 0.0644 0.6168 0.6168
Schistosoma mansoni pyruvate kinase 0.0245 0.2206 0.2821
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0138 0.0175
Leishmania major pyruvate kinase 0.0245 0.2206 1
Echinococcus granulosus pyruvate kinase 0.0245 0.2206 0.2206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0075 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0075 0.0096
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1412 0.1412
Loa Loa (eye worm) hypothetical protein 0.02 0.1765 0.2257
Loa Loa (eye worm) hypothetical protein 0.0037 0.0138 0.0175
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0075 0.0096
Trichomonas vaginalis esterase, putative 0.0037 0.0138 0.0175
Brugia malayi MH1 domain containing protein 0.0033 0.0105 0.0133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0082 0.0104
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0361 0.1632
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0532 0.0674
Brugia malayi pyruvate kinase 0.0052 0.0286 0.0365
Brugia malayi hypothetical protein 0.0036 0.0127 0.0162
Brugia malayi Inositol-1 0.0076 0.0532 0.068
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Echinococcus multilocularis geminin 0.0166 0.1418 0.1418
Loa Loa (eye worm) RNA binding protein 0.0644 0.6168 0.789
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0075 0.0095
Echinococcus granulosus importin subunit beta 1 0.0031 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0039 0.0165 0.0211
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0137 0.0137
Echinococcus granulosus pyruvate kinase 0.0126 0.1022 0.1022
Loa Loa (eye worm) hypothetical protein 0.0171 0.147 0.188
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0075 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0138 0.0622
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0138 0.0138
Schistosoma mansoni alpha-glucosidase 0.0142 0.1184 0.1514
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0075 0.0095
Onchocerca volvulus 0.0095 0.0721 0.1618
Schistosoma mansoni coup transcription factor 0.003 0.0075 0.0096
Schistosoma mansoni cellular tumor antigen P53 0.0151 0.127 0.1625
Mycobacterium ulcerans hypothetical protein 0.0037 0.0138 0.0169
Brugia malayi RNA, U transporter 1 0.0088 0.0651 0.0831
Trypanosoma brucei pyruvate kinase 1, putative 0.0245 0.2206 1
Echinococcus multilocularis GPCR, family 2 0.0063 0.0404 0.0404
Onchocerca volvulus Pyruvate kinase homolog 0.0245 0.2206 0.4973
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0183 0.1593 0.1593
Schistosoma mansoni Smad4 0.0033 0.0105 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0696 0.0696
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0339 0.0339
Entamoeba histolytica hypothetical protein 0.0025 0.0024 0.0145
Brugia malayi Importin beta-1 subunit 0.0031 0.0082 0.0104
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0082 0.0369
Loa Loa (eye worm) TAR-binding protein 0.0644 0.6168 0.789
Plasmodium falciparum pyruvate kinase 0.0245 0.2206 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0278 0.126
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.1765 0.2257
Loa Loa (eye worm) hypothetical protein 0.0037 0.0138 0.0175
Loa Loa (eye worm) glutaminase 0.081 0.7818 1
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0278 0.126
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0591 0.2676
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0005 0.003
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.4727 0.4727
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0532 0.068
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0138 0.0169
Trichomonas vaginalis set domain proteins, putative 0.0469 0.4431 0.5667
Schistosoma mansoni tar DNA-binding protein 0.0644 0.6168 0.789
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0452 0.2032
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0278 0.126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.1765 0.2257
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0452 0.2032
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0532 0.2409
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0138 0.0176
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0075 0.0075
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1412 0.1805
Echinococcus granulosus geminin 0.0166 0.1418 0.1418
Echinococcus multilocularis pyruvate kinase 0.0126 0.1022 0.1022
Schistosoma mansoni smad 0.0033 0.0105 0.0134
Schistosoma mansoni transcription factor LCR-F1 0.0183 0.1593 0.2037
Trypanosoma cruzi pyruvate kinase 2, putative 0.0245 0.2206 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0137 0.0858
Entamoeba histolytica hypothetical protein 0.0183 0.1593 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0696 0.089
Schistosoma mansoni alpha glucosidase 0.0037 0.0137 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0696 0.0696
Schistosoma mansoni survival motor neuron protein 0.0102 0.0784 0.1003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0075 0.0075
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0105 0.0133
Onchocerca volvulus 0.0469 0.4431 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0138 0.0169
Echinococcus granulosus pyruvate kinase 0.0126 0.1022 0.1022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0137 0.0175
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0305 0.2804 0.3587
Echinococcus granulosus snurportin 1 0.0331 0.3066 0.3066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0696 0.089
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0138 0.0602
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0075 0.0075
Entamoeba histolytica hypothetical protein 0.0183 0.1593 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1412 0.1412
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0005 0.003
Brugia malayi nuclear hormone receptor 0.003 0.0075 0.0095
Trichomonas vaginalis glutaminase, putative 0.081 0.7818 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0696 0.0889
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0404 0.0516
Onchocerca volvulus 0.0059 0.0361 0.0803
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0245 0.2206 1
Schistosoma mansoni hypothetical protein 0.0063 0.0404 0.0516
Schistosoma mansoni thyroid hormone receptor 0.003 0.0075 0.0096
Brugia malayi Pre-SET motif family protein 0.0059 0.0361 0.046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0361 0.0361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0404 0.0404
Schistosoma mansoni smad1 5 8 and 0.0033 0.0105 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0361 0.0461
Schistosoma mansoni pyruvate kinase 0.0126 0.1022 0.1307
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0331 0.3066 0.3921
Echinococcus granulosus GPCR family 2 0.0063 0.0404 0.0404
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0137 0.0175
Brugia malayi beta-lactamase family protein 0.0037 0.0138 0.0175
Plasmodium vivax importin-beta 2, putative 0.0031 0.0082 0.0369
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0138 0.0622
Brugia malayi MH2 domain containing protein 0.0489 0.4635 0.5929
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0075 0.0095
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0361 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0361 0.0461
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0665 0.085
Leishmania major importin beta-1 subunit, putative 0.0025 0.0024 0.0105
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.21 0.9517
Echinococcus granulosus Smad4 0.0033 0.0105 0.0105
Plasmodium vivax pyruvate kinase, putative 0.0245 0.2206 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0075 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0138 0.0622
Echinococcus multilocularis pyruvate kinase 0.0126 0.1022 0.1022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0404 0.0516
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0037 0.0138 0.0175
Onchocerca volvulus 0.0037 0.0138 0.0299
Brugia malayi hypothetical protein 0.0036 0.0127 0.0162
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0075 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0696 0.0889
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.3866 0.4944
Onchocerca volvulus 0.0102 0.0784 0.176
Plasmodium vivax pyruvate kinase 2, putative 0.0126 0.1022 0.4632
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0644 0.6168 0.789
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0278 0.126
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0005 0.0021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0024 0.003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0105 0.0105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0075 0.0096
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0075 0.0075
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0137 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0137 0.0619
Echinococcus granulosus pyruvate kinase 0.0126 0.1022 0.1022
Echinococcus multilocularis tumor protein p63 0.103 1 1
Brugia malayi hypothetical protein 0.0051 0.0278 0.0355
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0075 0.0075
Onchocerca volvulus 0.0037 0.0138 0.0299
Brugia malayi RNA recognition motif domain containing protein 0.0644 0.6168 0.789
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0665 0.085
Loa Loa (eye worm) Smad1 0.0033 0.0105 0.0133
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0082 0.0082
Echinococcus multilocularis pyruvate kinase 0.0126 0.1022 0.1022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0361 0.0461
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0105 0.0105
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0137 0.0175
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0591 0.3706
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0165 0.0747
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0075 0.0095
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0404 0.0516
Schistosoma mansoni smad1 5 8 and 0.0033 0.0105 0.0134
Brugia malayi Pyruvate kinase, M2 isozyme 0.0245 0.2206 0.2821
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0532 0.2409
Trichomonas vaginalis pyruvate kinase, putative 0.0245 0.2206 0.2821
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0138 0.0602
Brugia malayi steroid hormone receptor 0.003 0.0075 0.0095
Brugia malayi hypothetical protein 0.0499 0.4727 0.6046
Brugia malayi glutaminase DH11.1 0.081 0.7818 1
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0024 0.003
Schistosoma mansoni hypothetical protein 0.0039 0.0165 0.0211
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0404 0.0404
Schistosoma mansoni ran 0.0023 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0166 0.1418 0.1814
Toxoplasma gondii ABC1 family protein 0.0037 0.0138 0.0622
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0138 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0075 0.0095
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0532 0.2409
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0075 0.0096
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0665 0.3012
Loa Loa (eye worm) hypothetical protein 0.0151 0.127 0.1624
Plasmodium vivax SET domain protein, putative 0.0059 0.0361 0.1632
Schistosoma mansoni tar DNA-binding protein 0.0644 0.6168 0.789
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Toxoplasma gondii pyruvate kinase PyK1 0.0245 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0138 0.0175
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0165 0.0211
Brugia malayi beta-lactamase family protein 0.0037 0.0138 0.0175
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0075 0.0075
Giardia lamblia Pyruvate kinase 0.0126 0.1022 0.4632
Giardia lamblia Pyruvate kinase 0.0245 0.2206 1
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0404 0.0516
Onchocerca volvulus 0.003 0.0075 0.0158
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0137 0.0858
Loa Loa (eye worm) transcription factor SMAD2 0.0489 0.4635 0.5929
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0075 0.0075
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0165 0.0165
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0075 0.0095
Chlamydia trachomatis pyruvate kinase 0.0245 0.2206 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.1765 0.2257
Echinococcus granulosus tar DNA binding protein 0.0644 0.6168 0.6168
Loa Loa (eye worm) hypothetical protein 0.0059 0.0361 0.046
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0138 0.0175
Schistosoma mansoni hypothetical protein 0.0183 0.1593 0.2037
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0532 0.2409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0138 0.0175
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0082 0.0369
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0075 0.0075
Entamoeba histolytica pyruvate kinase, putative 0.0171 0.147 0.9229
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0137 0.0175
Mycobacterium ulcerans glutaminase 0.081 0.7818 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0137 0.0619
Brugia malayi hypothetical protein 0.0183 0.1593 0.2037
Onchocerca volvulus Pyruvate kinase homolog 0.0245 0.2206 0.4973
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0075 0.0095
Mycobacterium leprae Probable pyruvate kinase PykA 0.0245 0.2206 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1412 0.1412
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0138 0.0602
Brugia malayi beta-lactamase 0.0037 0.0138 0.0175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0696 0.0696
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0024 0.003
Brugia malayi Pre-SET motif family protein 0.0412 0.3866 0.4944
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0075 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0075 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0075 0.0095
Loa Loa (eye worm) pyruvate kinase 0.0245 0.2206 0.2821
Schistosoma mansoni ran 0.0023 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0033 0.0105 0.0133
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0138 0.0138
Trypanosoma brucei glucosidase, putative 0.0037 0.0137 0.0619
Schistosoma mansoni hypothetical protein 0.0063 0.0404 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0075 0.0095
Schistosoma mansoni hypothetical protein 0.0063 0.0404 0.0516
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0075 0.0075
Trypanosoma brucei pyruvate kinase 1 0.0245 0.2206 1
Schistosoma mansoni hypothetical protein 0.0063 0.0404 0.0516
Echinococcus multilocularis pyruvate kinase 0.0193 0.1693 0.1693
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0532 0.3337
Schistosoma mansoni thyroid hormone receptor 0.003 0.0075 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0075 0.0075
Entamoeba histolytica hypothetical protein 0.0183 0.1593 1
Schistosoma mansoni alpha-glucosidase 0.0142 0.1184 0.1514
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0532 0.068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0278 0.0355
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0138 0.0622
Schistosoma mansoni nuclear hormone receptor 0.003 0.0075 0.0096
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.0591 0.2676
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0137 0.0619
Echinococcus granulosus histone acetyltransferase KAT2B 0.0297 0.2719 0.2719
Echinococcus multilocularis snurportin 1 0.0331 0.3066 0.3066
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0138 0.0169
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0005 0.0021
Schistosoma mansoni smad1 5 8 and 0.0033 0.0105 0.0134
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1412 0.1805

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.