Detailed information for compound 758776

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.587 | Formula: C27H28N2O5S
  • H donors: 1 H acceptors: 4 LogP: 4.14 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSCCOC(=C1C(=NC2=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)CC(C2)c1ccccc1)C)O
  • InChi: 1S/C27H28N2O5S/c1-3-35-13-12-34-27(31)24-17(2)28-22-15-20(18-8-5-4-6-9-18)16-23(30)26(22)25(24)19-10-7-11-21(14-19)29(32)33/h4-11,14,20,25,31H,3,12-13,15-16H2,1-2H3
  • InChiKey: FQJPWWSWONIRRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0229 0.0455
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0229 0.0218
Loa Loa (eye worm) TAR-binding protein 0.078 0.9658 0.9657
Echinococcus granulosus histone acetyltransferase KAT2B 0.0297 0.35 0.3624
Schistosoma mansoni hypothetical protein 0.0304 0.3596 0.3596
Leishmania major pyruvate kinase 0.0286 0.3363 1
Schistosoma mansoni hypothetical protein 0.0063 0.0523 0.0523
Entamoeba histolytica hypothetical protein 0.0152 0.1654 0.7309
Loa Loa (eye worm) pyruvate kinase 0.0286 0.3363 0.3356
Loa Loa (eye worm) hypothetical protein 0.0058 0.0458 0.0447
Schistosoma mansoni survival motor neuron protein 0.0051 0.0368 0.0368
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0202 0.0209
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0672 0.1972
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0075 0.0287
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0076 0.0681 0.0671
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0202 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0672 0.0672
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0076 0.0681 0.1832
Brugia malayi beta-lactamase family protein 0.0075 0.0672 0.0662
Schistosoma mansoni smad 0.0026 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0182 0.2039 0.2039
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0001
Loa Loa (eye worm) RNA binding protein 0.078 0.9658 0.9657
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0075 0.0193
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0584 0.171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0361 0.0374
Echinococcus multilocularis pyruvate kinase 0.0147 0.1588 0.1644
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.2267 0.2259
Brugia malayi Inositol-1 0.0038 0.0202 0.0192
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0523 0.0542
Schistosoma mansoni hypothetical protein 0.0152 0.1654 0.1654
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.0861 0.238
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0063 0.0523 0.0513
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.1654 0.1713
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0681 0.0671
Trypanosoma brucei pyruvate kinase 1 0.0286 0.3363 1
Mycobacterium ulcerans lipase LipD 0.0075 0.0672 0.0662
Mycobacterium leprae Probable pyruvate kinase PykA 0.0286 0.3363 1
Mycobacterium ulcerans pyruvate kinase 0.0286 0.3363 0.3356
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0202 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.0861 0.0891
Loa Loa (eye worm) glutaminase 0.0807 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.3363 0.5995
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0523 0.0513
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0584 0.171
Entamoeba histolytica pyruvate kinase, putative 0.0199 0.2259 1
Brugia malayi RNA recognition motif domain containing protein 0.078 0.9658 0.9657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0251 0.2916 0.2908
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0079 0.0082
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0672 0.1137
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0584 0.0604
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0681 0.0671
Schistosoma mansoni alpha-glucosidase 0.0294 0.3459 0.3459
Leishmania major pyruvate kinase 0.0286 0.3363 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0672 0.0662
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0229 0.0455
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.035 0.1011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0042 0.0044
Brugia malayi pyruvate kinase, muscle isozyme 0.006 0.0484 0.0474
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0075 0.0065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0523 0.0513
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0042 0.0044
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.5823 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0458 0.1152
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.3363 1
Schistosoma mansoni smad1 5 8 and 0.0026 0.0042 0.0042
Brugia malayi acetyltransferase, GNAT family protein 0.0305 0.3609 0.3602
Echinococcus granulosus importin subunit beta 1 0.0029 0.0079 0.0082
Brugia malayi hypothetical protein 0.0032 0.0125 0.0114
Plasmodium falciparum pyruvate kinase 2 0.0147 0.1588 0.4594
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.8315 0.861
Loa Loa (eye worm) hypothetical protein 0.01 0.0994 0.0985
Schistosoma mansoni inositol monophosphatase 0.0038 0.0202 0.0202
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0672 0.1137
Echinococcus multilocularis tar DNA binding protein 0.078 0.9658 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0681 0.0671
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0042 0.0042
Schistosoma mansoni importin beta-1 0.0029 0.0079 0.0079
Echinococcus multilocularis pyruvate kinase 0.0286 0.3363 0.3482
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0075 0.0065
Loa Loa (eye worm) pyruvate kinase-PB 0.0199 0.2259 0.2251
Brugia malayi MH2 domain containing protein 0.0026 0.0042 0.0032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0202 0.0192
Entamoeba histolytica hypothetical protein 0.0152 0.1654 0.7309
Brugia malayi Pre-SET motif family protein 0.0058 0.0458 0.0447
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0681 0.0671
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0368 0.0358
Echinococcus granulosus neutral alpha glucosidase AB 0.0076 0.0681 0.0705
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0286 0.3363 0.5768
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0584 0.0584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0458 0.0458
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0075 0.0065
Echinococcus granulosus pyruvate kinase 0.0147 0.1588 0.1644
Leishmania major alpha glucosidase II subunit, putative 0.0076 0.0681 0.1999
Toxoplasma gondii ABC1 family protein 0.0075 0.0672 0.1804
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0075 0.0065
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0229 0.0218
Mycobacterium leprae Probable lipase LipE 0.0075 0.0672 0.1972
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0305 0.3609 0.3609
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0672 0.0695
Brugia malayi pyruvate kinase 0.006 0.0484 0.0474
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0075 0.0065
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0075 0.0115
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.0861 0.0851
Loa Loa (eye worm) acetyltransferase 0.0305 0.3609 0.3602
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0458 0.0474
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0137 0.146 0.1451
Brugia malayi Pyruvate kinase, M2 isozyme 0.0286 0.3363 0.3356
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0458 0.0474
Giardia lamblia Pyruvate kinase 0.0147 0.1588 0.3166
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0042 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0069
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0001
Echinococcus multilocularis neutral alpha glucosidase AB 0.0076 0.0681 0.0705
Echinococcus multilocularis GPCR, family 2 0.0063 0.0523 0.0542
Plasmodium vivax pyruvate kinase, putative 0.0286 0.3363 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.2267 0.2259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0361 0.0374
Mycobacterium tuberculosis Conserved protein 0.0075 0.0672 0.1137
Trichomonas vaginalis set domain proteins, putative 0.0462 0.5602 0.5598
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0458 0.0458
Schistosoma mansoni pyruvate kinase 0.0147 0.1588 0.1588
Brugia malayi MH1 domain containing protein 0.0026 0.0042 0.0032
Loa Loa (eye worm) hypothetical protein 0.0075 0.0672 0.0662
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0672 0.1804
Brugia malayi Glycosyl hydrolases family 31 protein 0.0341 0.4064 0.4058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0361 0.0374
Echinococcus granulosus Smad4 0.0026 0.0042 0.0044
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0229 0.0455
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.035 0.0823
Mycobacterium ulcerans beta-lactamase 0.0075 0.0672 0.0662
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.035 0.0823
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.3363 0.5995
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0087 0.0819 0.0809
Trypanosoma brucei glucosidase, putative 0.0076 0.0681 0.1842
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0584 0.0574
Schistosoma mansoni glutaminase 0.0807 1 1
Brugia malayi TAR-binding protein 0.078 0.9658 0.9657
Mycobacterium tuberculosis Conserved protein 0.0075 0.0672 0.1137
Mycobacterium tuberculosis Conserved protein 0.0075 0.0672 0.1137
Brugia malayi RNA binding protein 0.078 0.9658 0.9657
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3596 0.359
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0523 0.0542
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0011 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.1654 0.1713
Onchocerca volvulus Pyruvate kinase homolog 0.0286 0.3363 0.5995
Trypanosoma cruzi pyruvate kinase 2, putative 0.0286 0.3363 1
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0672 0.1972
Schistosoma mansoni hypothetical protein 0.0051 0.0368 0.0368
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0151 0.0242
Echinococcus multilocularis snurportin 1 0.0304 0.3596 0.3724
Schistosoma mansoni tar DNA-binding protein 0.078 0.9658 0.9658
Schistosoma mansoni inositol monophosphatase 0.0038 0.0202 0.0202
Mycobacterium ulcerans hypothetical protein 0.0075 0.0672 0.0662
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0202 0.0572
Plasmodium vivax SET domain protein, putative 0.0058 0.0458 0.1152
Loa Loa (eye worm) hypothetical protein 0.0199 0.2259 0.2251
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0075 0.0065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0523 0.0542
Trichomonas vaginalis glutaminase, putative 0.0807 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.035 0.0823
Loa Loa (eye worm) hypothetical protein 0.02 0.2267 0.2259
Echinococcus granulosus snurportin 1 0.0304 0.3596 0.3724
Loa Loa (eye worm) pyruvate kinase 0.0286 0.3363 0.3356
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.005 0.035 0.0339
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.035 0.0823
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.0861 0.238
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.4507 0.4501
Schistosoma mansoni smad1 5 8 and 0.0026 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0075 0.0065
Echinococcus multilocularis pyruvate kinase 0.0286 0.3363 0.3482
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0202 0.0375
Leishmania major hypothetical protein, conserved 0.005 0.035 0.1011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0202 0.0853
Leishmania major hypothetical protein, conserved 0.0075 0.0672 0.1972
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0672 0.0672
Loa Loa (eye worm) Smad1 0.0026 0.0042 0.0032
Echinococcus granulosus pyruvate kinase 0.0286 0.3363 0.3482
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0672 0.0662
Trypanosoma brucei pyruvate kinase 1, putative 0.0286 0.3363 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0681 0.1999
Schistosoma mansoni Smad4 0.0026 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0152 0.1654 0.7309
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.2267 0.2259
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0681 0.298
Brugia malayi beta-lactamase 0.0075 0.0672 0.0662
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0361 0.0374
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0681 0.0671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0361 0.0361
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0305 0.3609 0.3737
Echinococcus multilocularis lysosomal alpha glucosidase 0.0341 0.4064 0.4208
Schistosoma mansoni hypothetical protein 0.0063 0.0523 0.0523
Echinococcus multilocularis geminin 0.0182 0.2039 0.2111
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0151 0.0419
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0584 0.1547
Brugia malayi MH2 domain containing protein 0.0026 0.0042 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0672 0.1972
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0202 0.0192
Giardia lamblia Pyruvate kinase 0.0286 0.3363 1
Schistosoma mansoni alpha glucosidase 0.0076 0.0681 0.0681
Schistosoma mansoni pyruvate kinase 0.0286 0.3363 0.3363
Loa Loa (eye worm) hypothetical protein 0.004 0.0229 0.0218
Echinococcus granulosus microtubule associated protein 2 0.0674 0.8315 0.861
Schistosoma mansoni tar DNA-binding protein 0.078 0.9658 0.9658
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0672 0.0662
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0584 0.0604
Onchocerca volvulus 0.0197 0.2231 0.397
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0218 0.0226
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0458 0.0474
Brugia malayi Glycosyl hydrolases family 31 protein 0.0076 0.0681 0.0671
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0076 0.0681 0.0671
Echinococcus granulosus tar DNA binding protein 0.078 0.9658 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0672 0.0662
Brugia malayi hypothetical protein 0.0152 0.1654 0.1645
Brugia malayi Pyruvate kinase, muscle isozyme 0.0286 0.3363 0.3356
Echinococcus granulosus GPCR family 2 0.0063 0.0523 0.0542
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0584 0.2549
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0011 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.035 0.1011
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.146 0.1451
Schistosoma mansoni alpha-glucosidase 0.0294 0.3459 0.3459
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0672 0.0662
Echinococcus multilocularis Smad4 0.0026 0.0042 0.0044
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0229 0.0218
Onchocerca volvulus 0.0462 0.5602 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0584 0.0574
Echinococcus granulosus pyruvate kinase 0.0286 0.3363 0.3482
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.3363 0.3356
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.078 0.9658 0.9657
Loa Loa (eye worm) hypothetical protein 0.0075 0.0672 0.0662
Echinococcus multilocularis smad 0.0026 0.0042 0.0044
Onchocerca volvulus 0.0051 0.0368 0.064
Echinococcus multilocularis pyruvate kinase 0.0226 0.2594 0.2686
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0672 0.1814
Echinococcus multilocularis pyruvate kinase 0.0147 0.1588 0.1644
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0341 0.4064 0.4058
Trichomonas vaginalis esterase, putative 0.0075 0.0672 0.0662
Schistosoma mansoni hypothetical protein 0.0063 0.0523 0.0523
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0229 0.0237
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0075 0.0193
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0672 0.0695
Brugia malayi Pre-SET motif family protein 0.0406 0.4888 0.4882
Brugia malayi hypothetical protein 0.005 0.035 0.0339
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0672 0.1137
Trichomonas vaginalis maltase-glucoamylase, putative 0.0076 0.0681 0.0671
Plasmodium falciparum pyruvate kinase 0.0286 0.3363 1
Brugia malayi hypothetical protein 0.0036 0.0179 0.0168
Trichomonas vaginalis pyruvate kinase, putative 0.0286 0.3363 0.3356
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0361 0.0351
Plasmodium vivax pyruvate kinase 2, putative 0.0147 0.1588 0.4594
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0672 0.0662
Brugia malayi Importin beta-1 subunit 0.0029 0.0079 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0063 0.0523 0.0523
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0202 0.0572
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0042 0.0044
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.4507 0.4501
Brugia malayi RNA, U transporter 1 0.0081 0.0749 0.074
Onchocerca volvulus 0.01 0.0994 0.1759
Echinococcus multilocularis pyruvate kinase 0.0147 0.1588 0.1644
Echinococcus multilocularis tumor protein p63 0.0685 0.8452 0.8751
Loa Loa (eye worm) hypothetical protein 0.0075 0.0672 0.0662
Brugia malayi hypothetical protein 0.0036 0.0179 0.0168
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0042 0.0032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.043 0.0446
Mycobacterium ulcerans glutaminase 0.0807 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0361 0.0351
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0584 0.171
Schistosoma mansoni hypothetical protein 0.0137 0.146 0.146
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0075 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0361 0.0361
Echinococcus granulosus tumor protein p63 0.0685 0.8452 0.8751
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0076 0.0681 0.298
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0202 0.0572
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0075 0.0065
Echinococcus granulosus pyruvate kinase 0.0147 0.1588 0.1644
Onchocerca volvulus 0.0075 0.0672 0.1182
Loa Loa (eye worm) inositol-1 0.0038 0.0202 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0361 0.0361
Trichomonas vaginalis sucrase-isomaltase, putative 0.0076 0.0681 0.0671
Onchocerca volvulus 0.0075 0.0672 0.1182
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0075 0.0065
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0075 0.0065
Schistosoma mansoni tar DNA-binding protein 0.078 0.9658 0.9658
Toxoplasma gondii pyruvate kinase PyK1 0.0286 0.3363 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0672 0.1137
Loa Loa (eye worm) hypothetical protein 0.0286 0.3363 0.3356
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0523 0.0513
Schistosoma mansoni tar DNA-binding protein 0.078 0.9658 0.9658
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0672 0.1137
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0681 0.1999
Brugia malayi beta-lactamase family protein 0.0075 0.0672 0.0662
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.8315 0.8315
Loa Loa (eye worm) pyruvate kinase 0.006 0.0484 0.0474
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0406 0.4888 0.4882
Schistosoma mansoni tar DNA-binding protein 0.078 0.9658 0.9658
Loa Loa (eye worm) beta-lactamase 0.0075 0.0672 0.0662
Chlamydia trachomatis pyruvate kinase 0.0286 0.3363 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.0672 0.0662
Trichomonas vaginalis alpha-glucosidase, putative 0.0076 0.0681 0.0671
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0672 0.0662
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.035 0.0835
Schistosoma mansoni smad1 5 8 and 0.0026 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0152 0.1654 0.7309
Schistosoma mansoni hypothetical protein 0.0182 0.2039 0.2039
Echinococcus granulosus pyruvate kinase 0.0147 0.1588 0.1644
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0202 0.0192
Schistosoma mansoni hypothetical protein 0.004 0.0229 0.0229
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.2916 0.3019
Schistosoma mansoni pyruvate kinase 0.0286 0.3363 0.3363
Brugia malayi hypothetical protein 0.0251 0.2916 0.2908
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0202 0.0387
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.0861 0.238
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0765 0.2089
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0994 0.0994
Echinococcus granulosus smad 0.0026 0.0042 0.0044
Brugia malayi MH2 domain containing protein 0.0376 0.4507 0.4501
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0523 0.0542
Toxoplasma gondii pyruvate kinase PyKII 0.0147 0.1588 0.4594
Onchocerca volvulus 0.0058 0.0458 0.0799
Echinococcus granulosus lysosomal alpha glucosidase 0.0341 0.4064 0.4208
Echinococcus multilocularis lysosomal alpha glucosidase 0.0341 0.4064 0.4208
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.0861 0.0851
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0218 0.0226
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0011 0.0001
Brugia malayi MH1 domain containing protein 0.0026 0.0042 0.0032
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.2916 0.3019
Echinococcus granulosus geminin 0.0182 0.2039 0.2111
Brugia malayi Smad1 0.0026 0.0042 0.0032
Brugia malayi glutaminase DH11.1 0.0807 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0765 0.3357
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0672 0.0662
Onchocerca volvulus 0.0075 0.0672 0.1182
Loa Loa (eye worm) pyruvate kinase 0.0286 0.3363 0.3356
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0672 0.0662
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0672 0.1137
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0672 0.1137
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0202 0.0209
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0672 0.0662
Loa Loa (eye worm) hypothetical protein 0.0075 0.0672 0.0662

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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