Detailed information for compound 758825

Basic information

Technical information
  • TDR Targets ID: 758825
  • Name: 1-(1,3-benzodioxol-5-ylmethyl)-4-(4-nitrophen yl)sulfonylpiperazine
  • MW: 405.425 | Formula: C18H19N3O6S
  • H donors: 0 H acceptors: 4 LogP: 2.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)Cc1ccc2c(c1)OCO2
  • InChi: 1S/C18H19N3O6S/c22-21(23)15-2-4-16(5-3-15)28(24,25)20-9-7-19(8-10-20)12-14-1-6-17-18(11-14)27-13-26-17/h1-6,11H,7-10,12-13H2
  • InChiKey: RWHXEFMQPUXCPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(1,3-benzodioxol-5-ylmethyl)-4-(4-nitrophenyl)sulfonyl-piperazine
  • STK100388
  • EU-0009560
  • Oprea1_777528

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0453 0.5599 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0139 0.0066
Brugia malayi hypothetical protein 0.0036 0.0127 0.0219
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0312 0.055
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0111 0.0454
Onchocerca volvulus Pyruvate kinase homolog 0.0206 0.2355 0.726
Echinococcus multilocularis tar DNA binding protein 0.0453 0.5599 0.5567
Mycobacterium tuberculosis Conserved protein 0.0035 0.0111 0.0092
Trichomonas vaginalis pyruvate kinase, putative 0.0206 0.2355 0.7347
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0299 0.3571 0.3524
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0111 0.0346
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0196 0.0832
Brugia malayi beta-lactamase family protein 0.0035 0.0111 0.0191
Loa Loa (eye worm) pyruvate kinase 0.0206 0.2355 0.4201
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0196 0.0611
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0453 0.5599 1
Trichomonas vaginalis set domain proteins, putative 0.0271 0.3205 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0073 0.0123
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0196 0.0611
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0196 0.0611
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0845 0.0778
Giardia lamblia Pyruvate kinase 0.0106 0.104 0.2008
Schistosoma mansoni pyruvate kinase 0.0106 0.104 0.0974
Entamoeba histolytica hypothetical protein 0.0072 0.0599 0.3893
Schistosoma mansoni alpha-glucosidase 0.016 0.1756 0.1696
Echinococcus multilocularis pyruvate kinase 0.0162 0.1786 0.1725
Trypanosoma cruzi pyruvate kinase 2, putative 0.0206 0.2355 1
Brugia malayi glutaminase DH11.1 0.0264 0.3124 0.5576
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0806 0.341
Entamoeba histolytica hypothetical protein 0.0072 0.0599 0.3893
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0599 0.0529
Trichomonas vaginalis glutaminase, putative 0.0264 0.3124 0.9747
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.3 0.5354
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0101 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0845 0.1503
Mycobacterium leprae Probable lipase LipE 0.0035 0.0111 0.0101
Brugia malayi Glycosyl hydrolases family 31 protein 0.0186 0.2097 0.374
Plasmodium vivax pyruvate kinase 2, putative 0.0106 0.104 0.4407
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0178 0.031
Mycobacterium ulcerans pyruvate kinase 0.0206 0.2355 0.7447
Schistosoma mansoni inositol monophosphatase 0.0037 0.0139 0.0066
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0599 0.0529
Echinococcus multilocularis tumor protein p63 0.0701 0.8847 0.8838
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0178 0.031
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0139 0.0433
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0196 0.1274
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0139 0.0066
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0139 0.059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0845 0.0778
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0139 0.5
Schistosoma mansoni glutaminase 0.0264 0.3124 0.3074
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0004 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0111 0.0038
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0139 0.059
Onchocerca volvulus 0.0271 0.3205 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0139 0.0573
Plasmodium vivax importin-beta 2, putative 0.0033 0.0081 0.0325
Schistosoma mansoni hypothetical protein 0.0069 0.0559 0.049
Trypanosoma cruzi pyruvate kinase 2, putative 0.0206 0.2355 1
Onchocerca volvulus Pyruvate kinase homolog 0.0206 0.2355 0.726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0845 0.0778
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0081 0.0325
Loa Loa (eye worm) hypothetical protein 0.004 0.0178 0.031
Onchocerca volvulus 0.0035 0.0111 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0101 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0845 0.0778
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0806 0.2514
Loa Loa (eye worm) glutaminase 2 0.0264 0.3124 0.5576
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0599 0.0529
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0111 0.0092
Echinococcus granulosus snurportin 1 0.0347 0.4211 0.4168
Schistosoma mansoni importin beta-1 0.0033 0.0081 0.0008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0806 0.2514
Leishmania major hypothetical protein, conserved 0.0035 0.0111 0.0471
Schistosoma mansoni microtubule-associated protein tau 0.0788 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0101 0.0029
Echinococcus multilocularis snurportin 1 0.0347 0.4211 0.4168
Brugia malayi Pre-SET motif family protein 0.0034 0.0101 0.0174
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0139 0.0433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0845 0.0778
Schistosoma mansoni hypothetical protein 0.0072 0.0599 0.0529
Schistosoma mansoni survival motor neuron protein 0.005 0.0312 0.0241
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0101 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0111 0.0471
Schistosoma mansoni alpha glucosidase 0.0041 0.0196 0.0124
Brugia malayi Pyruvate kinase, M2 isozyme 0.0206 0.2355 0.4201
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0196 0.0611
Toxoplasma gondii pyruvate kinase PyK1 0.0206 0.2355 1
Loa Loa (eye worm) TAR-binding protein 0.0453 0.5599 1
Schistosoma mansoni hypothetical protein 0.0347 0.4211 0.4168
Schistosoma mansoni hypothetical protein 0.004 0.0178 0.0105
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0111 0.0092
Plasmodium falciparum pyruvate kinase 2 0.0106 0.104 0.4407
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0196 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0101 0.0029
Brugia malayi Inositol-1 0.0037 0.0139 0.0241
Loa Loa (eye worm) hypothetical protein 0.0103 0.0999 0.1779
Brugia malayi RNA recognition motif domain containing protein 0.0453 0.5599 1
Onchocerca volvulus 0.005 0.0312 0.0679
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0191
Loa Loa (eye worm) hypothetical protein 0.0206 0.2355 0.4201
Echinococcus granulosus pyruvate kinase 0.0206 0.2355 0.2299
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0806 0.341
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0073 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0191
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0178 0.0737
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.3461 0.3413
Brugia malayi Pyruvate kinase, muscle isozyme 0.0206 0.2355 0.4201
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0111 0.0471
Loa Loa (eye worm) inositol-1 0.0037 0.0139 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0453 0.5599 0.5567
Leishmania major pyruvate kinase 0.0206 0.2355 1
Schistosoma mansoni alpha-glucosidase 0.016 0.1756 0.1696
Plasmodium vivax SET domain protein, putative 0.0034 0.0101 0.0413
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0196 0.0124
Echinococcus granulosus tumor protein p63 0.0701 0.8847 0.8838
Brugia malayi beta-lactamase 0.0035 0.0111 0.0191
Echinococcus multilocularis pyruvate kinase 0.0106 0.104 0.0974
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0191
Loa Loa (eye worm) hypothetical protein 0.0144 0.1538 0.2741
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0073 0.0123
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0004 0.0018
Echinococcus multilocularis pyruvate kinase 0.0106 0.104 0.0974
Echinococcus multilocularis pyruvate kinase 0.0206 0.2355 0.2299
Brugia malayi Pre-SET motif family protein 0.0238 0.2774 0.4951
Echinococcus granulosus importin subunit beta 1 0.0033 0.0081 0.0008
Loa Loa (eye worm) glutaminase 0.0264 0.3124 0.5576
Brugia malayi hypothetical protein 0.0072 0.0599 0.1062
Trypanosoma brucei pyruvate kinase 1, putative 0.0206 0.2355 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0196 0.1274
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0081 0.0325
Leishmania major pyruvate kinase 0.0206 0.2355 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0178 0.031
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0139 0.059
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0196 0.0343
Echinococcus granulosus lysosomal alpha glucosidase 0.0186 0.2097 0.2038
Trypanosoma brucei glucosidase, putative 0.0041 0.0196 0.0815
Loa Loa (eye worm) pyruvate kinase-PB 0.0144 0.1538 0.2741
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0978 0.1741
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0085 0.0012
Mycobacterium tuberculosis Conserved protein 0.0035 0.0111 0.0092
Loa Loa (eye worm) hypothetical protein 0.0246 0.2881 0.5142
Plasmodium falciparum importin beta, putative 0.0033 0.0081 0.0325
Brugia malayi pyruvate kinase, muscle isozyme 0.0043 0.0223 0.0391
Echinococcus granulosus pyruvate kinase 0.0106 0.104 0.0974
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0111 0.0346
Brugia malayi MH2 domain containing protein 0.0255 0.3 0.5354
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0196 0.0611
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0137
Entamoeba histolytica pyruvate kinase, putative 0.0144 0.1538 1
Trypanosoma brucei pyruvate kinase 1 0.0206 0.2355 1
Brugia malayi beta-lactamase family protein 0.0035 0.0111 0.0191
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0111 0.0038
Brugia malayi acetyltransferase, GNAT family protein 0.0299 0.3571 0.6376
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0978 0.1741
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0191
Brugia malayi hypothetical protein 0.0036 0.0127 0.0219
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0139 0.0573
Mycobacterium ulcerans glutaminase 0.0264 0.3124 1
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0081 0.0325
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0178 0.0737
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0073 0.0123
Leishmania major hypothetical protein, conserved 0.0027 0.0004 0.0018
Schistosoma mansoni pyruvate kinase 0.0206 0.2355 0.2299
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0196 0.0611
Entamoeba histolytica hypothetical protein 0.0072 0.0599 0.3893
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0196 0.0611
Echinococcus granulosus tar DNA binding protein 0.0453 0.5599 0.5567
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0111 0.0191
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.2774 0.4951
Schistosoma mansoni tar DNA-binding protein 0.0453 0.5599 0.5567
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.4211 0.7518
Onchocerca volvulus 0.0035 0.0111 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0111 0.0346
Trichomonas vaginalis pyruvate kinase, putative 0.0206 0.2355 0.7347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0978 0.1741
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0101 0.0029
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0196 0.0124
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0206 0.2355 0.9118
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2881 0.2829
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0178 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0453 0.5599 0.5567
Echinococcus granulosus pyruvate kinase 0.0106 0.104 0.0974
Plasmodium falciparum pyruvate kinase 0.0206 0.2355 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0111 0.0454
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0999 0.0933
Loa Loa (eye worm) hypothetical protein 0.0069 0.0559 0.0992
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0101 0.0029
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0062 0.0471 0.0834
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0111 0.0092
Loa Loa (eye worm) pyruvate kinase 0.0206 0.2355 0.4201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0111 0.0038
Onchocerca volvulus 0.0035 0.0111 0.0031
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0196 0.0611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0845 0.0778
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0111 0.0191
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2881 0.2829
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0139 0.0066
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0196 0.0343
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.071 0.3002
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0111 0.0346
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.3 0.5354
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0191
Chlamydia trachomatis pyruvate kinase 0.0206 0.2355 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0806 0.341
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0845 0.1503
Echinococcus multilocularis microtubule associated protein 2 0.0788 1 1
Loa Loa (eye worm) pyruvate kinase 0.0206 0.2355 0.4201
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0191
Echinococcus multilocularis pyruvate kinase 0.0106 0.104 0.0974
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0111 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0101 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0453 0.5599 0.5567
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0186 0.2097 0.374
Echinococcus multilocularis pyruvate kinase 0.0206 0.2355 0.2299
Echinococcus granulosus pyruvate kinase 0.0206 0.2355 0.2299
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0111 0.0092
Brugia malayi pyruvate kinase 0.0043 0.0223 0.0391
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0139 0.0433
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0111 0.0038
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0081 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0196 0.0832
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0111 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0111 0.0346
Loa Loa (eye worm) acetyltransferase 0.0299 0.3571 0.6376
Brugia malayi hypothetical protein 0.0246 0.2881 0.5142
Onchocerca volvulus Pyruvate kinase homolog 0.0206 0.2355 0.726
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0806 0.0738
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0299 0.3571 0.3524
Brugia malayi RNA, U transporter 1 0.0092 0.0868 0.1543
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0559 0.0992
Brugia malayi TAR-binding protein 0.0453 0.5599 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0111 0.0092
Plasmodium vivax pyruvate kinase, putative 0.0206 0.2355 1
Brugia malayi RNA binding protein 0.0453 0.5599 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.2097 0.2038
Toxoplasma gondii pyruvate kinase PyKII 0.0106 0.104 0.4407
Mycobacterium leprae Probable pyruvate kinase PykA 0.0206 0.2355 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2574 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0111 0.0191
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.0174
Trichomonas vaginalis esterase, putative 0.0035 0.0111 0.0346
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0139 0.0093
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0139 0.0903
Loa Loa (eye worm) pyruvate kinase 0.0043 0.0223 0.0391
Schistosoma mansoni tar DNA-binding protein 0.0453 0.5599 0.5567
Echinococcus granulosus pyruvate kinase 0.0106 0.104 0.0974
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0196 0.0832
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0196 0.0815
Mycobacterium tuberculosis Conserved protein 0.0035 0.0111 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0845 0.0778
Brugia malayi Importin beta-1 subunit 0.0033 0.0081 0.0137
Onchocerca volvulus 0.0108 0.1067 0.311
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.071 0.4617
Loa Loa (eye worm) hypothetical protein 0.0101 0.0978 0.1741
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0111 0.0454
Schistosoma mansoni hypothetical protein 0.005 0.0312 0.0241
Onchocerca volvulus 0.0103 0.0999 0.2893
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0111 0.0101
Giardia lamblia Pyruvate kinase 0.0206 0.2355 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0178 0.0737
Schistosoma mansoni pyruvate kinase 0.0206 0.2355 0.2299
Entamoeba histolytica hypothetical protein 0.0072 0.0599 0.3893
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.2097 0.2038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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