Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0094 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.5538 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.5538 | 0.5162 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0067 | 0.6166 | 0.6071 |
Plasmodium falciparum | pyruvate kinase | 0.0032 | 0.1327 | 0.093 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.1327 | 0.1157 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0032 | 0.1327 | 0.0597 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0094 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.1327 | 1 |
Leishmania major | pyruvate kinase | 0.0032 | 0.1327 | 0.0597 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0094 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.1327 | 0.1327 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0028 | 0.0776 | 0.0546 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0028 | 0.0776 | 0.0546 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0028 | 0.0776 | 0.0546 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.1327 | 0.1157 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0776 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6699 | 0.6699 |
Mycobacterium ulcerans | hypothetical protein | 0.0094 | 1 | 1 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0028 | 0.0776 | 0.0546 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.1327 | 0.1799 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1536 | 0.1536 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0094 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0094 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0067 | 0.6166 | 0.6071 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0776 | 0.0776 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.1327 | 0.0597 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.5538 | 0.5162 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.3663 | 0.313 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.1327 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0028 | 0.0776 | 0.0546 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.1327 | 0.1157 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.1327 | 0.0597 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0028 | 0.0776 | 0.0776 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.1327 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.1327 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0776 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0776 | 0.0776 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6699 | 0.6699 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0028 | 0.0776 | 0.0546 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0032 | 0.1327 | 0.0597 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.5538 | 0.5538 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.007 | 0.6699 | 1 |
Onchocerca volvulus | 0.0094 | 1 | 1 | |
Leishmania major | pyruvate kinase | 0.0032 | 0.1327 | 0.0597 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5538 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.1327 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6699 | 0.6699 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0028 | 0.0776 | 0.0776 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0032 | 0.1327 | 0.1111 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0032 | 0.1327 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6699 | 0.6699 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1536 | 0.1597 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5538 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1536 | 0.0824 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.1327 | 0.1327 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0067 | 0.6166 | 0.6071 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0094 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.5538 | 0.5162 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.007 | 0.6699 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.007 | 0.6699 | 0.6617 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1327 | 0.1327 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0776 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5538 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5538 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0028 | 0.0776 | 0.0776 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0028 | 0.0776 | 0.0726 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3663 | 0.3663 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0032 | 0.1327 | 0.0597 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.5538 | 0.5538 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0067 | 0.6166 | 0.6071 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.3663 | 0.313 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.3663 | 0.3663 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.5538 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0776 | 0.0546 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.1327 | 0.1799 |
Plasmodium vivax | pyruvate kinase, putative | 0.0032 | 0.1327 | 0.093 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0032 | 0.1327 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5538 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0032 | 0.1327 | 0.0597 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.5538 | 0.5538 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.007 | 0.6699 | 0.6421 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0028 | 0.0776 | 0.0546 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0028 | 0.0776 | 0.0776 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0094 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0032 | 0.1327 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6699 | 0.6699 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0032 | 0.1327 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.007 | 0.6699 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.1327 | 0.1327 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.1327 | 0.1157 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0094 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.