Detailed information for compound 758894

Basic information

Technical information
  • TDR Targets ID: 758894
  • Name: N-[4-(acetylsulfamoyl)phenyl]-5-chloro-2-meth oxybenzamide
  • MW: 382.819 | Formula: C16H15ClN2O5S
  • H donors: 2 H acceptors: 4 LogP: 2.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)Nc1ccc(cc1)S(=O)(=O)NC(=O)C)Cl
  • InChi: 1S/C16H15ClN2O5S/c1-10(20)19-25(22,23)13-6-4-12(5-7-13)18-16(21)14-9-11(17)3-8-15(14)24-2/h3-9H,1-2H3,(H,18,21)(H,19,20)
  • InChiKey: HRUXNIFHPJNTOG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(acetylsulfamoyl)phenyl]-5-chloro-2-methoxy-benzamide
  • 5-chloro-N-[4-(ethanoylsulfamoyl)phenyl]-2-methoxy-benzamide
  • ST5324565
  • EU-0009539
  • ZINC04387435
  • CBMicro_028569
  • BIM-0028480.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyruvate kinase 0.0288 0.2449 0.2536
Toxoplasma gondii pyruvate kinase PyK1 0.0288 0.2449 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0021 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0546 0.0566
Echinococcus multilocularis pyruvate kinase 0.0148 0.1158 0.12
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0026 0.0107
Onchocerca volvulus Pyruvate kinase homolog 0.0288 0.2449 0.2766
Loa Loa (eye worm) pyruvate kinase 0.0061 0.0356 0.0356
Leishmania major importin beta-1 subunit, putative 0.0024 0.0021 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0471 0.1091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.2164 0.2164
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0149 0.1174 0.1174
Onchocerca volvulus 0.0073 0.0471 0.0507
Entamoeba histolytica hypothetical protein 0.0024 0.0021 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.093 0.093
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0084 0.0066
Loa Loa (eye worm) hypothetical protein 0.0201 0.1647 0.1647
Echinococcus multilocularis neutral alpha glucosidase AB 0.0079 0.0523 0.0541
Echinococcus multilocularis pyruvate kinase 0.0148 0.1158 0.12
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0079 0.0523 0.0523
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0177 0.1426 0.1426
Brugia malayi Pre-SET motif family protein 0.0123 0.093 0.093
Brugia malayi hypothetical protein 0.0072 0.0462 0.0462
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0526 0.0526
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0108 0.0108
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.008 0.0533 0.2178
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0026 0.0107
Schistosoma mansoni smad1 5 8 and 0.0034 0.0108 0.0108
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0079 0.0523 0.2134
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0084 0.0087
Entamoeba histolytica hypothetical protein 0.0227 0.189 1
Onchocerca volvulus 0.0976 0.8785 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0084 0.0084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0655 0.2674
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0655 0.2674
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0084 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0916 0.8231 0.8231
Echinococcus multilocularis snurportin 1 0.0319 0.2738 0.2835
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0067 0.0275
Brugia malayi beta-lactamase 0.0073 0.0471 0.0471
Mycobacterium leprae Probable lipase LipE 0.0073 0.0471 0.1835
Loa Loa (eye worm) beta-lactamase 0.0073 0.0471 0.0471
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0503 0.2054
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0084 0.0084
Onchocerca volvulus 0.0205 0.1688 0.1897
Trypanosoma brucei pyruvate kinase 1, putative 0.0288 0.2449 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.2738 0.2738
Leishmania major hypothetical protein, conserved 0.0077 0.0503 0.2054
Chlamydia trachomatis pyruvate kinase 0.0288 0.2449 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0084 0.0087
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0084 0.0087
Schistosoma mansoni hypothetical protein 0.0034 0.0114 0.0114
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0067 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0108 0.0108
Brugia malayi Glycosyl hydrolases family 31 protein 0.0355 0.3066 0.3066
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0288 0.2449 0.5947
Onchocerca volvulus 0.0031 0.0084 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0916 0.8231 0.8231
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0523 0.0523
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1097 0.1136
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0026 0.0139
Echinococcus granulosus tar DNA binding protein 0.0916 0.8231 0.8524
Plasmodium falciparum pyruvate kinase 2 0.0148 0.1158 0.473
Schistosoma mansoni Smad4 0.0034 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0176 0.1415 0.1415
Schistosoma mansoni inositol monophosphatase 0.0079 0.0526 0.0526
Brugia malayi Smad1 0.0034 0.0108 0.0108
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0067 0.0047
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0655 0.0678
Brugia malayi beta-lactamase family protein 0.0073 0.0471 0.0471
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0471 0.0471
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0084 0.0087
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0503 0.2054
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0067 0.0275
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Mycobacterium ulcerans beta-lactamase 0.0073 0.0471 0.0446
Schistosoma mansoni importin beta-1 0.003 0.0073 0.0073
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0857 0.7694 0.7694
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0084 0.0087
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0084 0.0084
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0108 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0084 0.0087
Echinococcus granulosus pyruvate kinase 0.0288 0.2449 0.2536
Mycobacterium tuberculosis Conserved protein 0.0073 0.0471 0.1091
Schistosoma mansoni tar DNA-binding protein 0.0916 0.8231 0.8231
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0084 0.0087
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0317 0.2714 0.2714
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0067 0.0067
Onchocerca volvulus Pyruvate kinase homolog 0.0288 0.2449 0.2766
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0084 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0523 0.0523
Echinococcus granulosus histone lysine methyltransferase setb 0.0123 0.093 0.0963
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0526 0.2147
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0526 0.0545
Schistosoma mansoni hypothetical protein 0.0227 0.189 0.189
Plasmodium falciparum pyruvate kinase 0.0288 0.2449 1
Schistosoma mansoni glutaminase 0.1108 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0523 0.2134
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0026 0.0026
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0021 0.0021
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0084 0.0087
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0067 0.0067
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0084 0.0087
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0503 0.2054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Brugia malayi nuclear hormone receptor 0.0031 0.0084 0.0084
Echinococcus multilocularis lysosomal alpha glucosidase 0.0355 0.3066 0.3175
Giardia lamblia Pyruvate kinase 0.0148 0.1158 0.473
Echinococcus granulosus smad 0.0034 0.0108 0.0112
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0084 0.0084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0026 0.0139
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.1174 0.1174
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0317 0.2714 0.2811
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0503 0.2054
Schistosoma mansoni pyruvate kinase 0.0148 0.1158 0.1158
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0471 0.0487
Brugia malayi steroid hormone receptor 0.0031 0.0084 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0503 0.2054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0084 0.0084
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0584 0.2383
Echinococcus multilocularis lysosomal alpha glucosidase 0.0355 0.3066 0.3175
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.008 0.0533 0.0533
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0526 0.5
Brugia malayi Pyruvate kinase, M2 isozyme 0.0288 0.2449 0.2449
Plasmodium vivax SET domain protein, putative 0.0123 0.093 0.3797
Trichomonas vaginalis esterase, putative 0.0073 0.0471 0.0471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0084 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1097 0.1136
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0526 0.0526
Schistosoma mansoni survival motor neuron protein 0.0149 0.1174 0.1174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0123 0.093 0.0963
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0084 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0084 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0084 0.0084
Mycobacterium ulcerans lipase LipD 0.0073 0.0471 0.0446
Loa Loa (eye worm) Smad1 0.0034 0.0108 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Loa Loa (eye worm) pyruvate kinase-PB 0.0201 0.1647 0.1647
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0471 0.0446
Schistosoma mansoni smad 0.0034 0.0108 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0084 0.0084
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0108 0.0112
Mycobacterium leprae Probable pyruvate kinase PykA 0.0288 0.2449 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0227 0.189 0.1957
Brugia malayi RNA, U transporter 1 0.0085 0.0581 0.0581
Brugia malayi MH2 domain containing protein 0.0034 0.0108 0.0108
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0471 0.1091
Leishmania major pyruvate kinase 0.0288 0.2449 1
Schistosoma mansoni hypothetical protein 0.0177 0.1426 0.1426
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0084 0.0084
Plasmodium vivax pyruvate kinase, putative 0.0288 0.2449 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0471 0.1091
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0916 0.8231 0.8231
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0546 0.0546
Mycobacterium tuberculosis Conserved protein 0.0073 0.0471 0.1091
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0067 0.0067
Echinococcus granulosus lysosomal alpha glucosidase 0.0355 0.3066 0.3175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1097 0.1097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.093 0.093
Schistosoma mansoni pyruvate kinase 0.0288 0.2449 0.2449
Brugia malayi beta-lactamase family protein 0.0073 0.0471 0.0471
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0108 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0084 0.0084
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0084 0.0084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0079 0.0523 0.0523
Brugia malayi RNA binding protein 0.0916 0.8231 0.8231
Mycobacterium ulcerans glutaminase 0.1108 1 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0584 0.2383
Schistosoma mansoni hypothetical protein 0.0319 0.2738 0.2738
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0526 0.2782
Loa Loa (eye worm) RNA binding protein 0.0916 0.8231 0.8231
Brugia malayi Inositol-1 0.0079 0.0526 0.0526
Echinococcus granulosus survival motor neuron protein 1 0.0733 0.6547 0.678
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0084 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0523 0.0523
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0526 0.2147
Echinococcus granulosus GPCR family 2 0.0081 0.0546 0.0566
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0471 0.1922
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0471 0.1922
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0084 0.0084
Onchocerca volvulus 0.0073 0.0471 0.0507
Loa Loa (eye worm) hypothetical protein 0.0073 0.0471 0.0471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0084 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0067 0.0067
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.2164 0.2164
Leishmania major alpha glucosidase II subunit, putative 0.0079 0.0523 0.2134
Onchocerca volvulus Pyruvate kinase homolog 0.0288 0.2449 0.2766
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0655 0.2674
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0108 0.0112
Mycobacterium ulcerans hypothetical protein 0.0073 0.0471 0.0446
Echinococcus granulosus geminin 0.0177 0.1426 0.1477
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0084 0.0084
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0084 0.0084
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.7054 0.7306
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0523 0.2765
Trypanosoma brucei glucosidase, putative 0.0079 0.0523 0.2134
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0073 0.0471 0.0471
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0655 0.0655
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0026 0.0026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0084 0.0087
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.2164 0.2164
Echinococcus multilocularis geminin 0.0177 0.1426 0.1477
Echinococcus multilocularis pyruvate kinase 0.0227 0.189 0.1958
Echinococcus multilocularis Smad4 0.0034 0.0108 0.0112
Brugia malayi MH2 domain containing protein 0.0495 0.4358 0.4358
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0503 0.2054
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0067 0.0067
Onchocerca volvulus 0.0123 0.093 0.1032
Loa Loa (eye worm) hypothetical protein 0.0073 0.0471 0.0471
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0355 0.3066 0.3066
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0084 0.0066
Mycobacterium ulcerans pyruvate kinase 0.0288 0.2449 0.2429
Schistosoma mansoni hypothetical protein 0.0081 0.0546 0.0546
Brugia malayi hypothetical protein 0.0072 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0081 0.0546 0.0546
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0123 0.093 0.093
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0084 0.0084
Trichomonas vaginalis pyruvate kinase, putative 0.0288 0.2449 0.2449
Loa Loa (eye worm) hypothetical protein 0.008 0.0533 0.0533
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0471 0.1091
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0067 0.0067
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.045 0.1039
Echinococcus granulosus histone acetyltransferase KAT2B 0.0308 0.2632 0.2726
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0084 0.0084
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0084 0.0087
Toxoplasma gondii pyruvate kinase PyKII 0.0148 0.1158 0.473
Brugia malayi Importin beta-1 subunit 0.003 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0733 0.6547 0.6547
Schistosoma mansoni alpha glucosidase 0.0079 0.0523 0.0523
Trichomonas vaginalis glutaminase, putative 0.1108 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0471 0.0471
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0084 0.0084
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0108 0.0112
Entamoeba histolytica hypothetical protein 0.0227 0.189 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0227 0.189 0.1957
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0471 0.1922
Echinococcus granulosus snurportin 1 0.0319 0.2738 0.2835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0084 0.0084
Schistosoma mansoni pyruvate kinase 0.0288 0.2449 0.2449
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0471 0.1922
Loa Loa (eye worm) hypothetical protein 0.0257 0.2164 0.2164
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0523 0.0523
Trypanosoma cruzi pyruvate kinase 2, putative 0.0288 0.2449 1
Trichomonas vaginalis set domain proteins, putative 0.0976 0.8785 0.8785
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0073 0.0297
Giardia lamblia Pyruvate kinase 0.0288 0.2449 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0523 0.2134
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0026 0.0026
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0067 0.0275
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0087 0.06 0.06
Trichomonas vaginalis pyruvate kinase, putative 0.0288 0.2449 0.2449
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0084 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0471 0.0471
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0471 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0084 0.0084
Brugia malayi acetyltransferase, GNAT family protein 0.0317 0.2714 0.2714
Echinococcus multilocularis pyruvate kinase 0.0148 0.1158 0.12
Loa Loa (eye worm) inositol-1 0.0079 0.0526 0.0526
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0526 0.0501
Schistosoma mansoni alpha-glucosidase 0.0305 0.2611 0.2611
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0084 0.0084
Mycobacterium tuberculosis Conserved protein 0.0073 0.0471 0.1091
Echinococcus multilocularis microtubule associated protein 2 0.0755 0.6753 0.6994
Schistosoma mansoni coup transcription factor 0.0031 0.0084 0.0084
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0084 0.0087
Schistosoma mansoni hypothetical protein 0.0081 0.0546 0.0546
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0067 0.0275
Schistosoma mansoni transcription factor LCR-F1 0.0227 0.189 0.189
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0471 0.1091
Plasmodium vivax importin-beta 2, putative 0.003 0.0073 0.0297
Echinococcus multilocularis GPCR, family 2 0.0081 0.0546 0.0566
Schistosoma mansoni inositol monophosphatase 0.0079 0.0526 0.0526
Echinococcus multilocularis tar DNA binding protein 0.0916 0.8231 0.8524
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.008 0.0533 0.0552
Entamoeba histolytica pyruvate kinase, putative 0.0201 0.1647 0.8712
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.093 0.0963
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.093 0.093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0084 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0084 0.0084
Onchocerca volvulus 0.0073 0.0471 0.0507
Loa Loa (eye worm) acetyltransferase 0.0317 0.2714 0.2714
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0888 0.092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0546 0.0546
Brugia malayi pyruvate kinase, muscle isozyme 0.0061 0.0356 0.0356
Brugia malayi nuclear receptor NHR-88 0.0031 0.0084 0.0084
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0526 0.2147
Brugia malayi TAR-binding protein 0.0916 0.8231 0.8231
Echinococcus multilocularis tumor protein p63 0.107 0.9656 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0073 0.0075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0288 0.2449 0.2449
Schistosoma mansoni tar DNA-binding protein 0.0916 0.8231 0.8231
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0471 0.0487
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0471 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0084 0.0084
Brugia malayi glutaminase DH11.1 0.1108 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0526 0.0545
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0471 0.0471
Echinococcus granulosus pyruvate kinase 0.0148 0.1158 0.12
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0067 0.0357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0084 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.093 0.093
Brugia malayi MH1 domain containing protein 0.0034 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0073 0.0471 0.0471
Schistosoma mansoni smad1 5 8 and 0.0034 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0176 0.1415 0.1415
Echinococcus granulosus neutral alpha glucosidase AB 0.0079 0.0523 0.0541
Echinococcus multilocularis smad 0.0034 0.0108 0.0112
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1097 0.1097
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.045 0.1747
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0084 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0471 0.0471
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0526 0.2147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0067
Echinococcus multilocularis importin subunit beta 1 0.003 0.0073 0.0075
Schistosoma mansoni smad1 5 8 and 0.0034 0.0108 0.0108
Brugia malayi RNA recognition motif domain containing protein 0.0916 0.8231 0.8231
Trichomonas vaginalis maltase-glucoamylase, putative 0.0079 0.0523 0.0523
Plasmodium vivax pyruvate kinase 2, putative 0.0148 0.1158 0.473
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.1415 0.1415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1097 0.1097
Echinococcus multilocularis survival motor neuron protein 1 0.0733 0.6547 0.678
Brugia malayi MH2 domain containing protein 0.0034 0.0108 0.0108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0084 0.0084
Brugia malayi Pyruvate kinase, muscle isozyme 0.0288 0.2449 0.2449
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0073 0.0297
Trypanosoma brucei pyruvate kinase 1 0.0288 0.2449 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1097 0.1097
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0546 0.0546
Brugia malayi MH1 domain containing protein 0.0034 0.0108 0.0108
Onchocerca volvulus 0.0157 0.124 0.1386
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0471 0.0446
Loa Loa (eye worm) MH2 domain-containing protein 0.0495 0.4358 0.4358
Schistosoma mansoni hypothetical protein 0.008 0.0533 0.0533
Onchocerca volvulus 0.0149 0.1174 0.131
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.008 0.0533 0.2178
Schistosoma mansoni microtubule-associated protein tau 0.0755 0.6753 0.6753
Loa Loa (eye worm) hypothetical protein 0.0073 0.0471 0.0471
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0073 0.0297
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0523 0.0523
Echinococcus granulosus Smad4 0.0034 0.0108 0.0112
Brugia malayi hypothetical protein 0.0077 0.0503 0.0503
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0471 0.0471
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.008 0.0533 0.0533
Echinococcus multilocularis pyruvate kinase 0.0288 0.2449 0.2536
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0546 0.0566
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0084 0.0087
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0084 0.0087
Loa Loa (eye worm) glutaminase 0.1108 1 1
Schistosoma mansoni hypothetical protein 0.0081 0.0546 0.0546
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1097 0.1136
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.0227 0.189 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.008 0.0533 0.2178
Brugia malayi hypothetical protein 0.0049 0.0253 0.0253
Schistosoma mansoni hypothetical protein 0.0081 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.008 0.0533 0.0533
Trichomonas vaginalis sucrase-isomaltase, putative 0.0079 0.0523 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0084 0.0084
Brugia malayi hypothetical protein 0.0733 0.6547 0.6547
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0114 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1097 0.1136
Echinococcus granulosus pyruvate kinase 0.0148 0.1158 0.12
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1097 0.1097
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0471 0.1091
Leishmania major hypothetical protein, conserved 0.0073 0.0471 0.1922
Loa Loa (eye worm) pyruvate kinase 0.0288 0.2449 0.2449
Echinococcus granulosus pyruvate kinase 0.0288 0.2449 0.2536
Loa Loa (eye worm) pyruvate kinase 0.0288 0.2449 0.2449
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0084 0.0087
Loa Loa (eye worm) pyruvate kinase 0.0288 0.2449 0.2449
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0471 0.1835
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0084 0.0087
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.41 1
Loa Loa (eye worm) transcription factor SMAD2 0.0495 0.4358 0.4358
Echinococcus granulosus pyruvate kinase 0.0148 0.1158 0.12
Loa Loa (eye worm) hypothetical protein 0.0157 0.124 0.124
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0526 0.2147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0471 0.0471
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0026 0.0139
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0546 0.0566
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0655 0.0655
Toxoplasma gondii ABC1 family protein 0.0073 0.0471 0.1922
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0021 0.0084
Brugia malayi pyruvate kinase 0.0061 0.0356 0.0356
Brugia malayi hypothetical protein 0.0227 0.189 0.189
Schistosoma mansoni cellular tumor antigen P53 0.0157 0.124 0.124
Entamoeba histolytica hypothetical protein 0.0227 0.189 1
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0084 0.0066
Trypanosoma cruzi pyruvate kinase 2, putative 0.0288 0.2449 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0503 0.0503
Echinococcus granulosus tumor protein p63 0.107 0.9656 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0526 0.0526
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.093 0.3797
Schistosoma mansoni alpha-glucosidase 0.0305 0.2611 0.2611
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0523 0.0523
Brugia malayi ecdysteroid receptor 0.0031 0.0084 0.0084
Loa Loa (eye worm) TAR-binding protein 0.0916 0.8231 0.8231
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0523 0.0523
Plasmodium falciparum importin beta, putative 0.003 0.0073 0.0297
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0114 0.0118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0546 0.0566
Leishmania major pyruvate kinase 0.0288 0.2449 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0523 0.2765
Echinococcus granulosus microtubule associated protein 2 0.0755 0.6753 0.6994
Schistosoma mansoni tar DNA-binding protein 0.0916 0.8231 0.8231
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0503 0.2054
Brugia malayi Pre-SET motif family protein 0.0857 0.7694 0.7694
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0584 0.3087
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0026 0.0107
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0067 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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