Detailed information for compound 75896

Basic information

Technical information
  • TDR Targets ID: 75896
  • Name: 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[3,4-c]pyri dine-1,6-dione
  • MW: 154.166 | Formula: C7H10N2O2
  • H donors: 2 H acceptors: 2 LogP: -1.44 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCC2C(C1)C(=O)NC2
  • InChi: 1S/C7H10N2O2/c10-6-1-5-4(2-8-6)3-9-7(5)11/h4-5H,1-3H2,(H,8,10)(H,9,11)
  • InChiKey: YDLPCUTTXVWMBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[3,4-c]pyridine-1,6-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0009 0.0041 0.0022
Onchocerca volvulus 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0115 0.1476 0.2537
Brugia malayi diacylglycerol kinase 0.0065 0.0792 0.1346
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0247 0.2554
Brugia malayi Inositol-1 0.0074 0.0912 0.1556
Loa Loa (eye worm) hypothetical protein 0.0065 0.0792 0.1346
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0065 0.0792 0.146
Entamoeba histolytica hypothetical protein 0.0065 0.0792 0.4228
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0432 0.0414
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.027 0.0438
Onchocerca volvulus 0.0231 0.305 0.5278
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0389 0.0699
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0026 0.0082
Schistosoma mansoni inositol monophosphatase 0.0074 0.0912 0.1687
Schistosoma mansoni inositol monophosphatase 0.0074 0.0912 0.1687
Schistosoma mansoni neuropeptide receptor 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus protein kinase c iota type 0.0227 0.2987 0.2974
Loa Loa (eye worm) hypothetical protein 0.023 0.3036 0.5254
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0912 1
Brugia malayi Protein kinase domain containing protein 0.0082 0.1021 0.1745
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0432 0.0781
Brugia malayi CXXC zinc finger family protein 0.0028 0.0293 0.0478
Brugia malayi Protein kinase domain containing protein 0.0108 0.1373 0.2357
Entamoeba histolytica hypothetical protein 0.0038 0.0432 0.226
Brugia malayi intermediate filament protein 0.0026 0.027 0.0438
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0067 0.0822 0.0805
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0431 0.2255
Trypanosoma cruzi NIMA-related kinase, putative 0.0008 0.0025 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0082 0.1021 0.3347
Loa Loa (eye worm) AGC/PKN protein kinase 0.0082 0.1021 0.1745
Schistosoma mansoni apoferritin-2 0.0008 0.0026 0.0014
Loa Loa (eye worm) hypothetical protein 0.003 0.0316 0.0519
Brugia malayi larval opioid receptor 0.0009 0.0041 0.0039
Onchocerca volvulus 0.0009 0.0041 0.0039
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0432 0.0781
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.001 0.0051 0.0236
Echinococcus multilocularis cpg binding protein 0.003 0.0315 0.0297
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0041 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0316 0.0298
Echinococcus granulosus bloom syndrome protein 0.0021 0.0196 0.0177
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0462 0.0772
Schistosoma mansoni vav2 0.0071 0.0873 0.1614
Trypanosoma cruzi NIMA-related kinase, putative 0.0008 0.0025 0.0073
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0716 0.5478
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0462 0.0837
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0065 0.0212
Schistosoma mansoni ferritin 0.0008 0.0026 0.0014
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0008 0.0025 0.0048
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0185 0.0166
Echinococcus multilocularis N chimaerin 0.0065 0.0792 0.0775
Schistosoma mansoni atypical protein kinase C 0.0233 0.3067 0.5756
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0041 0.0042
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0041 0.0039
Toxoplasma gondii protein kinase domain-containing protein 0.0008 0.0025 0.0051
Schistosoma mansoni hypothetical protein 0.0009 0.0041 0.0042
Schistosoma mansoni ferritin 0.0008 0.0026 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.072
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0022 0.0215 0.0196
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus multilocularis protein kinase c epsilon type 0.0287 0.3804 0.3792
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0082 0.1021 0.1004
Onchocerca volvulus 0.0071 0.0875 0.1491
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0041 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0041 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0041 0.0022
Schistosoma mansoni survival motor neuron protein 0.0047 0.0551 0.1005
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0008 0.0019 0.5
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0432 0.0414
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0008 0.0025 0.0048
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0912 0.0895
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Onchocerca volvulus 0.0009 0.0041 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0196 0.0642
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0105 0.015
Schistosoma mansoni adenoreceptor 0.0009 0.0041 0.0042
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0041 0.0022
Onchocerca volvulus 0.0269 0.3558 0.6163
Entamoeba histolytica diacylglycerol kinase, putative 0.0065 0.0792 0.4228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus granulosus orexin receptor type 2 0.0009 0.0041 0.0022
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.003 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0432 0.1417
Loa Loa (eye worm) hypothetical protein 0.0119 0.1522 0.2617
Entamoeba histolytica protein kinase, putative 0.0008 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Leishmania major protein kinase, putative 0.0008 0.0025 0.0073
Onchocerca volvulus 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0019 0.0061
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0041 0.0022
Echinococcus granulosus Rac GTPase activating protein 1 0.0065 0.0792 0.0775
Schistosoma mansoni hypothetical protein 0.0035 0.0389 0.0699
Entamoeba histolytica protein kinase, putative 0.0008 0.0025 0.0036
Brugia malayi Pre-SET motif family protein 0.003 0.0316 0.0519
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0065 0.0792 0.1346
Echinococcus granulosus serine:threonine protein kinase N2 0.0137 0.1766 0.1751
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0078 0.0104
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0041 0.0022
Brugia malayi hypothetical protein 0.0432 0.5762 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0041 0.0022
Leishmania major serine/threonine-protein kinase a, putative 0.0008 0.0025 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0432 0.1417
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0185 0.0166
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0041 0.0039
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0153 0.199 0.3433
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0247 0.4896
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0041 0.0042
Echinococcus granulosus intermediate filament protein 0.0026 0.027 0.0252
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0041 0.0022
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0041 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0792 0.146
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0432 0.072
Loa Loa (eye worm) hypothetical protein 0.0026 0.027 0.0438
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0041 0.0039
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0041 0.0042
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0196 0.0308
Echinococcus multilocularis Diacylglycerol kinase theta 0.0065 0.0792 0.0775
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0041 0.0022
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.003 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0822 0.1516
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.072
Mycobacterium tuberculosis TRK system potassium uptake protein CeoB 0.0022 0.0216 0.2506
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0041 0.0039
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0065 0.0792 0.1346
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0008 0.0025 0.0073
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0041 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0296 0.0523
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1832 0.3157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0269 0.3558 0.6163
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0022 0.0215 0.0196
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0106
Echinococcus multilocularis rac serine:threonine kinase 0.0028 0.0296 0.0278
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0041 0.0022
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0082 0.1021 0.1004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0041 0.0022
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.001 0.0051 0.0358
Entamoeba histolytica hypothetical protein 0.0008 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Brugia malayi Pleckstrin Homology Domain 0.0071 0.0873 0.1488
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0432 0.0414
Echinococcus multilocularis serine threonine protein kinase 0.0203 0.2665 0.2652
Mycobacterium ulcerans TRK system potassium uptake protein CeoC 0.0022 0.0216 0.2213
Echinococcus multilocularis protein kinase c iota type 0.0227 0.2987 0.2974
Schistosoma mansoni diacylglycerol kinase theta 0.0065 0.0792 0.146
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0041 0.0022
Echinococcus granulosus g protein coupled receptor 0.0009 0.0041 0.0022
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0215 0.2192
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0041 0.0022
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0432 0.0781
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0041 0.0039
Echinococcus multilocularis protein kinase c eta type 0.0065 0.0792 0.0775
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0065 0.0792 0.1346
Echinococcus multilocularis unc 13 (munc13) 0.0071 0.0875 0.0858
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0008 0.0024 0.0009
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0041 0.0039
Brugia malayi G protein-coupled receptor 0.0009 0.0041 0.0039
Echinococcus granulosus hypothetical protein 0.0009 0.0041 0.0022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.002
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0041 0.0022
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0196 0.0642
Onchocerca volvulus 0.0008 0.0024 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0231 0.305 1
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0432 0.0414
Echinococcus granulosus allatostatin A receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0183 0.2399 0.4145
Brugia malayi RE15519p 0.0009 0.0041 0.0039
Echinococcus granulosus g protein coupled receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.6115 0.6108
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Treponema pallidum hypothetical protein 0.0022 0.0216 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0023 0.0004
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0025 0.0255 0.0412
Loa Loa (eye worm) acetyltransferase 0.0142 0.1832 0.3157
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.2026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.0092
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0008 0.0025 0.0073
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0041 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0432 0.0781
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0041 0.0042
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0432 0.0414
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Brugia malayi PXA domain containing protein 0.0038 0.0432 0.072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1778 0.1763
Echinococcus granulosus somatostatin receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0041 0.0022
Schistosoma mansoni opsin-like receptor 0.0009 0.0041 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0912 0.6599
Echinococcus granulosus neuropeptide s receptor 0.0458 0.6115 0.6108
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0716 0.0698
Schistosoma mansoni rac gtpase activating protein 0.0065 0.0792 0.146
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0041 0.0039
Onchocerca volvulus 0.0189 0.2481 0.4287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0389 0.0371
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0041 0.0042
Giardia lamblia Kinase, AGC PKA 0.0022 0.0215 0.475
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0478 0.1567
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0065 0.0792 0.0775
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0026 0.0093
Loa Loa (eye worm) RasGEF domain-containing protein 0.0065 0.0792 0.1346
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0041 0.0039
Echinococcus granulosus survival motor neuron protein 1 0.023 0.3036 0.3023
Loa Loa (eye worm) intermediate filament protein 0.0026 0.027 0.0438
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus granulosus raf serine:threonine protein kinase 0.0065 0.0792 0.0775
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0432 0.0414
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0822 0.1516
Brugia malayi Melatonin receptor type 1A 0.0009 0.0041 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.027 0.0438
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0478 0.1567
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0041 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0143 0.1847 1
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.3543 0.6656
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0716 0.1316
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0044 0.0045
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0082 0.1021 0.1004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0264 0.0426
Schistosoma mansoni neuropeptide receptor 0.0009 0.0041 0.0042
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0912 1
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0462 0.0837
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0023 0.0004
Echinococcus granulosus expressed protein 0.0008 0.0026 0.0007
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0186 0.2429 0.4197
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0462 0.0772
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.003 0.0128
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0117
Brugia malayi Hr1 repeat family protein 0.0082 0.1021 0.1745
Echinococcus multilocularis potassium large conductance calcium activated 0.0038 0.0428 0.041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0316 0.0298
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0041 0.0039
Echinococcus granulosus N chimaerin 0.0065 0.0792 0.0775
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0041 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus granulosus g protein coupled receptor 0.0009 0.0041 0.0022
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0008 0.0025 0.0073
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0041 0.0022
Schistosoma mansoni protein kinase C 0.0071 0.0875 0.1617
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0071 0.0875 0.0858
Plasmodium vivax potassium channel, putative 0.001 0.0051 0.0563
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0008 0.0025 0.0036
Plasmodium vivax SET domain protein, putative 0.003 0.0316 0.6433
Echinococcus granulosus sex peptide receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0255 0.0412
Treponema pallidum potassium transporter peripheral membrane component 0.0022 0.0216 1
Brugia malayi PXA domain containing protein 0.0038 0.0432 0.072
Brugia malayi Serotonin receptor 0.0009 0.0041 0.0039
Schistosoma mansoni cpg binding protein 0.0028 0.0293 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0316 0.0562
Schistosoma mansoni serine/threonine kinase 0.0082 0.1021 0.1892
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0431 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0041 0.0022
Entamoeba histolytica hypothetical protein 0.0038 0.0432 0.226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Onchocerca volvulus 0.0009 0.0041 0.0039
Brugia malayi Pre-SET motif family protein 0.0203 0.267 0.4617
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0041 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0316 0.0298
Schistosoma mansoni hypothetical protein 0.0009 0.0041 0.0042
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0008 0.0025 0.0073
Schistosoma mansoni calcium-activated potassium channel 0.0035 0.0392 0.0705
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0041 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0041 0.0039
Brugia malayi sulfakinin receptor protein 0.0009 0.0041 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0432 0.0781
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0082 0.1021 0.1004
Loa Loa (eye worm) hypothetical protein 0.0351 0.4665 0.809
Schistosoma mansoni unc-13 (munc13) 0.0071 0.0875 0.1617
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0106
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus granulosus potassium large conductance calcium activated 0.0038 0.0428 0.041
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0065 0.0792 0.0775
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0432 0.0414
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0296 0.3102
Onchocerca volvulus 0.0047 0.0551 0.0927
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Echinococcus granulosus lamin dm0 0.0026 0.027 0.0252
Mycobacterium ulcerans transmembrane cation transporter 0.0022 0.0216 0.2213
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0432 0.0414
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0268 0.3543 0.3531
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Entamoeba histolytica protein kinase, putative 0.0008 0.0025 0.0036
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0432 0.072
Entamoeba histolytica protein kinase, putative 0.0008 0.0025 0.0036
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.2026
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0137 0.0223
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0041 0.0042
Brugia malayi RhoGAP domain containing protein 0.0065 0.0792 0.1346
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0716 0.8837
Loa Loa (eye worm) hypothetical protein 0.0071 0.0873 0.1488
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0478 0.046
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1832 0.1816
Schistosoma mansoni DNA helicase recq5 0.0009 0.003 0.0022
Onchocerca volvulus 0.0009 0.0041 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0247 0.2554
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus multilocularis serotonin receptor 0.0009 0.0041 0.0022
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1832 0.3424
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0065 0.0514
Schistosoma mansoni hypothetical protein 0.0011 0.0063 0.0084
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0041 0.0039
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0432 0.0781
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0063 0.0045
Schistosoma mansoni opsin-like receptor 0.0009 0.0041 0.0042
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0247 0.1793
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0041 0.0042
Entamoeba histolytica protein kinase, putative 0.0008 0.0027 0.0044
Mycobacterium ulcerans TRK system potassium uptake protein CeoB 0.0022 0.0216 0.2213
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0071 0.0875 0.0858
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0041 0.0042
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0008 0.0025 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0316 0.0562
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0082 0.1021 0.1004
Schistosoma mansoni calcium-activated potassium channel 0.0032 0.0353 0.0631
Brugia malayi diacylglycerol kinase 0.0065 0.0792 0.1346
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0065 0.0514
Entamoeba histolytica protein kinase, putative 0.0008 0.0027 0.0044
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Echinococcus granulosus myotubularin protein 13 0.0071 0.0873 0.0856
Brugia malayi Protein kinase domain containing protein 0.0082 0.1021 0.1745
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0432 0.5762 1
Echinococcus granulosus lamin 0.0026 0.027 0.0252
Echinococcus granulosus Diacylglycerol kinase theta 0.0065 0.0792 0.0775
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0808 1
Schistosoma mansoni serine/threonine-protein kinase 0.0028 0.0296 0.0523
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0041 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0316 0.0562
Schistosoma mansoni ferritin light chain 0.0008 0.0026 0.0014
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.072
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0431 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0041 0.0039
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0186 0.2429 0.4197
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.1021 0.1892
Trichomonas vaginalis AGC family protein kinase 0.0108 0.1373 0.4501
Brugia malayi Protein kinase c protein 2 0.0188 0.2466 0.4262
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0462 0.0444
Loa Loa (eye worm) hypothetical protein 0.0025 0.0247 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0432 0.1417
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0462 0.0444
Brugia malayi neuropeptide F receptor 0.0009 0.0041 0.0039
Echinococcus granulosus nervana 2 0.002 0.0185 0.0166
Echinococcus granulosus serine:threonine protein kinase N2 0.0082 0.1021 0.1004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0041 0.0022
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0023 0.0004
Echinococcus multilocularis raf serine:threonine protein kinase 0.0065 0.0792 0.0775
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0041 0.0022
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0296 0.1515
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0065 0.0792 0.1346
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.6115 0.6108
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0065 0.0792 0.1346
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0432 0.072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus multilocularis nervana 2 0.002 0.0185 0.0166
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0041 0.0022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0912 1
Trichomonas vaginalis AGC family protein kinase 0.0108 0.1373 0.4501
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0432 0.072
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0121 0.1551 0.2669
Entamoeba histolytica protein kinase, putative 0.0102 0.1291 0.6959
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0041 0.0042
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0478 0.3609
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0078 0.0104
Schistosoma mansoni amine GPCR 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni diacylglycerol kinase theta 0.0065 0.0792 0.146
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.0092
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0008 0.0025 0.0073
Echinococcus granulosus ferritin 0.0008 0.0026 0.0007
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0082 0.1021 0.1004
Trypanosoma brucei protein kinase, putative 0.0008 0.0025 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Leishmania major hypothetical protein, conserved 0.001 0.0051 0.0358
Echinococcus granulosus serotonin receptor 0.0009 0.0041 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Loa Loa (eye worm) hypothetical protein 0.0334 0.4436 0.7692
Loa Loa (eye worm) hypothetical protein 0.0065 0.0792 0.1346
Loa Loa (eye worm) hypothetical protein 0.0432 0.5762 1
Entamoeba histolytica protein kinase, putative 0.0108 0.1373 0.7404
Entamoeba histolytica PH domain containing protein kinase, putative 0.0008 0.0025 0.0036
Brugia malayi RhoGAP domain containing protein 0.0065 0.0792 0.1346
Entamoeba histolytica PH domain containing protein kinase, putative 0.0008 0.0025 0.0036
Echinococcus multilocularis expressed protein 0.0008 0.0026 0.0007
Loa Loa (eye worm) hypothetical protein 0.018 0.2354 0.4066
Loa Loa (eye worm) hypothetical protein 0.0269 0.3558 0.6163
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0041 0.0022
Echinococcus granulosus protein kinase c eta type 0.0065 0.0792 0.0775
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0041 0.0039
Trichomonas vaginalis ferritin, putative 0.0008 0.0026 0.0085
Loa Loa (eye worm) hypothetical protein 0.0065 0.0792 0.1346
Entamoeba histolytica protein kinase, putative 0.0108 0.1373 0.7404
Schistosoma mansoni hypothetical protein 0.0399 0.5314 1
Schistosoma mansoni ferritin 0.0008 0.0026 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0028 0.0296 0.1515
Loa Loa (eye worm) hypothetical protein 0.0038 0.0432 0.072
Schistosoma mansoni biogenic amine receptor 0.0009 0.0041 0.0042
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0912 0.0895
Echinococcus multilocularis expressed protein 0.0744 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0716 0.1316
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0162 0.3361
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0041 0.0022
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0432 0.1417
Entamoeba histolytica p21-activated kinase 0.0008 0.0025 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0316 0.0562
Onchocerca volvulus 0.003 0.0316 0.0519
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0008 0.0025 0.0073
Entamoeba histolytica diacylglycerol kinase, putative 0.0065 0.0792 0.4228
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0432 0.0414
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.003 0.0012
Schistosoma mansoni unc-13 (munc13) 0.0071 0.0875 0.1617
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0432 0.0781
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0432 0.072
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0008 0.0019 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0432 0.0414
Echinococcus multilocularis lamin dm0 0.0026 0.027 0.0252
Loa Loa (eye worm) inositol-1 0.0074 0.0912 0.1556
Schistosoma mansoni amine GPCR 0.0009 0.0041 0.0042
Schistosoma mansoni ferritin light chain 0.0008 0.0026 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.1021 0.1892
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.3036 0.3023
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0041 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0046 0.0027
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0019 0.0061
Echinococcus granulosus calcium activated potassium channel variant 0.0035 0.0392 0.0374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0041 0.0042
Echinococcus granulosus unc 13 munc13 0.0071 0.0875 0.0858
Brugia malayi Serotonin receptor 0.0009 0.0041 0.0039
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0022 0.0215 0.4182
Loa Loa (eye worm) RecQ helicase 0.0021 0.0196 0.0308
Trichomonas vaginalis AGC family protein kinase 0.0108 0.1373 0.4501
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.1021 0.1892
Schistosoma mansoni histamine h1 receptor 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0079 0.0991 0.3249
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0008 0.0025 0.0048
Brugia malayi hypothetical protein 0.023 0.3036 0.5254
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0041 0.0022
Brugia malayi Ras association domain family 1 isoform A 0.0065 0.0792 0.1346
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0462 0.0772
Entamoeba histolytica hypothetical protein 0.0038 0.0432 0.226
Brugia malayi RhoGEF domain containing protein 0.0065 0.0792 0.1346
Onchocerca volvulus 0.0009 0.0041 0.0039
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0041 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0432 0.1417
Echinococcus granulosus Protein kinase C brain isozyme 0.0268 0.3543 0.3531
Mycobacterium ulcerans TRK system potassium uptake protein CeoC1 0.0022 0.0216 0.2213
Entamoeba histolytica protein kinase 2, putative 0.0022 0.0215 0.1071
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0041 0.0042
Schistosoma mansoni hypothetical protein 0.005 0.0597 0.1092
Brugia malayi Variant SH3 domain containing protein 0.0065 0.0792 0.1346
Echinococcus multilocularis somatostatin receptor 0.0009 0.0041 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0108 0.1373 0.4501
Onchocerca volvulus 0.0009 0.0041 0.0039
Toxoplasma gondii AGC kinase 0.0102 0.1291 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0041 0.0039
Onchocerca volvulus 0.0028 0.0293 0.0478
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0041 0.0042
Loa Loa (eye worm) raf kinase 0.0065 0.0792 0.1346
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0478 0.3609
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0041 0.0042
Brugia malayi hypothetical protein 0.0038 0.0432 0.072
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0008 0.0025 0.0083
Brugia malayi C1-like domain containing protein 0.0186 0.2429 0.4197
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0912 0.2991
Loa Loa (eye worm) runx1 0.0054 0.0648 0.1095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0041 0.0022
Onchocerca volvulus 0.0026 0.027 0.0438
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.3543 0.6656
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni lozenge 0.0054 0.0648 0.1188
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0102 0.0657
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0082 0.1021 0.1745
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0432 0.0414
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0046 0.0027
Onchocerca volvulus 0.0009 0.0041 0.0039
Trypanosoma brucei TrkA-N domain containing protein, putative 0.0022 0.0216 0.146
Echinococcus granulosus NDR protein kinase 0.0082 0.1021 0.1004
Echinococcus granulosus protein kinase c epsilon type 0.0287 0.3804 0.3792
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0041 0.0042
Brugia malayi putative neuropeptide receptor 0.0009 0.0041 0.0039
Echinococcus multilocularis myotubularin protein 13 0.0071 0.0873 0.0856
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0694 0.5306
Brugia malayi GnHR receptor homolog 0.0009 0.0041 0.0039
Onchocerca volvulus 0.0183 0.2399 0.4145
Brugia malayi Protein kinase domain containing protein 0.0067 0.0822 0.1398
Schistosoma mansoni protein kinase C mu 0.0065 0.0792 0.146
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0432 0.0781
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0432 0.072
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Brugia malayi neuropeptide F receptor 0.0009 0.0041 0.0039
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.001 0.0051 0.0358
Onchocerca volvulus 0.0432 0.5762 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0808 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0102 0.1291 0.2216
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0716 0.7802
Brugia malayi ORL1-like opioid receptor 0.0009 0.0041 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0082 0.1021 0.1745
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.2026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0041 0.0022
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0008 0.0025 0.0073
Echinococcus multilocularis calcium activated potassium channel 0.004 0.0458 0.044
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0105 0.015
Brugia malayi hypothetical protein 0.0038 0.0432 0.072
Schistosoma mansoni cpg binding protein 0.003 0.0315 0.0559
Onchocerca volvulus 0.0119 0.1522 0.2617
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0041 0.0022
Wolbachia endosymbiont of Brugia malayi Kef-type K+ transport system, membrane component 0.0022 0.0216 0.2148
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0108 0.1373 0.4501
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0041 0.0022
Toxoplasma gondii ion channel protein 0.001 0.0051 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0432 0.1417
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0041 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0023 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0293 0.0478
Leishmania major hypothetical protein, conserved 0.0025 0.0247 0.2554
Brugia malayi G-protein coupled receptor 0.0009 0.0041 0.0039
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0912 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0139 0.0209
Echinococcus granulosus cpg binding protein 0.003 0.0315 0.0297
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0063 0.0045
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0086 0.0067
Schistosoma mansoni hypothetical protein 0.0047 0.0551 0.1005
Schistosoma mansoni apoferritin-2 0.0008 0.0026 0.0014
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0432 0.072
Brugia malayi G-protein coupled receptor 0.0009 0.0041 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0316 0.234
Trichomonas vaginalis AGC family protein kinase 0.0082 0.1021 0.3347
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0432 0.0414
Brugia malayi p70 ribosomal S6 kinase beta 0.0102 0.1291 0.2216
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0008 0.0025 0.0073
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.1021 0.1004
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0432 0.0781
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Loa Loa (eye worm) hypothetical protein 0.0189 0.2481 0.4287
Mycobacterium tuberculosis TRK system potassium uptake protein CeoC 0.0022 0.0216 0.2506
Loa Loa (eye worm) hypothetical protein 0.0119 0.1522 0.2617
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0082 0.1021 0.1745
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0065 0.0339
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0041 0.0022
Echinococcus multilocularis Rac GTPase activating protein 1 0.0065 0.0792 0.0775
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0432 0.0414
Echinococcus multilocularis RNA directed DNA polymerase 0.0115 0.1476 0.146
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0185 0.0166
Schistosoma mansoni biogenic amine receptor 0.0009 0.0041 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.267 0.4617
Schistosoma mansoni neuropeptide receptor 0.0009 0.0041 0.0042
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0287 0.3804 0.659
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0065 0.0792 0.146
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0026 0.0093
Onchocerca volvulus 0.0009 0.0041 0.0039
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0071 0.0875 0.1491
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.3804 0.7147
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus dnaJ subfamily B 0.0399 0.5314 0.5306
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0716 0.7802
Schistosoma mansoni lamin 0.0026 0.027 0.0475
Toxoplasma gondii ion channel protein 0.001 0.0051 0.0251
Schistosoma mansoni hypothetical protein 0.0009 0.0041 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0247 0.5463
Onchocerca volvulus 0.0009 0.0041 0.0039
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0432 0.0781
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0041 0.0022
Schistosoma mansoni calcium-activated potassium channel 0.0038 0.0428 0.0773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0041 0.0042
Echinococcus granulosus neuropeptide receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis musashi 0.0026 0.027 0.0252
Leishmania major folate/biopterin transporter, putative 0.0008 0.0025 0.0073
Echinococcus multilocularis calcium activated potassium channel variant 0.0035 0.0392 0.0374
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0008 0.0025 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0088 0.1102 0.3613
Brugia malayi Dopamine receptor protein 1 0.0009 0.0041 0.0039
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0432 0.0414
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0185 0.0166
Schistosoma mansoni opsin-like receptor 0.0009 0.0041 0.0042
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0432 0.0414
Echinococcus granulosus serine/threonine protein kinase 0.0028 0.0296 0.0278
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0035 0.0392 0.065
Brugia malayi hypothetical protein 0.0025 0.0247 0.0397
Schistosoma mansoni intermediate filament proteins 0.0026 0.027 0.0475
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis serine:threonine protein kinase N2 0.0216 0.2843 0.2829
Schistosoma mansoni amine GPCR 0.0009 0.0041 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0912 1
Trypanosoma cruzi Protein kinase B 0.0028 0.0296 0.3102
Echinococcus granulosus serine threonine protein kinase nrc 0.0022 0.0215 0.0196
Echinococcus multilocularis ferritin 0.0008 0.0026 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Schistosoma mansoni cpg binding protein 0.003 0.0315 0.0559
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Onchocerca volvulus 0.0009 0.0041 0.0039
Brugia malayi Dopamine receptor protein 2 0.0009 0.0041 0.0039
Schistosoma mansoni ferritin 0.0008 0.0026 0.0014
Echinococcus granulosus calcium activated potassium channel 0.004 0.0458 0.044
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus granulosus protein kinase C gamma type 0.0203 0.2665 0.2652
Toxoplasma gondii diacylglycerol kinase, putative 0.0065 0.0792 0.6076
Treponema pallidum hypothetical protein 0.0022 0.0216 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0432 0.072
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0023 0.0004
Onchocerca volvulus 0.0009 0.0041 0.0039
Schistosoma mansoni biogenic amine receptor 0.0009 0.0041 0.0042
Echinococcus multilocularis Protein lozenge 0.0054 0.0648 0.063
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0041 0.0039
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0124 0.1589 0.2734
Echinococcus multilocularis sex peptide receptor 0.0009 0.0041 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0733 0.1349
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0912 0.2991
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0067 0.0822 0.0805
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0389 0.0371
Onchocerca volvulus 0.0026 0.027 0.0438
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.003 0.0012
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0294 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0108 0.1373 0.4501
Onchocerca volvulus 0.0009 0.0041 0.0039
Loa Loa (eye worm) AGC/NDR protein kinase 0.0082 0.1021 0.1745
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Trypanosoma brucei rac serine-threonine kinase, putative 0.0108 0.1373 1
Entamoeba histolytica hypothetical protein 0.0035 0.0389 0.2026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0086 0.0067
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0269 0.3558 0.6163
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0041 0.0039
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0912 0.4886
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0041 0.0022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0716 0.0698
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Brugia malayi hypothetical protein 0.0016 0.0129 0.0192
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0462 0.0837
Loa Loa (eye worm) hypothetical protein 0.0009 0.003 0.002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0041 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0041 0.0022
Echinococcus granulosus nervana 2 0.002 0.0185 0.0166
Schistosoma mansoni amine GPCR 0.0009 0.0041 0.0042
Brugia malayi hypothetical protein 0.0035 0.0389 0.0645
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0008 0.0019 0.0061
Schistosoma mansoni neuropeptide receptor 0.0009 0.0041 0.0042
Entamoeba histolytica hypothetical protein 0.0008 0.0025 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0025 0.0083
Echinococcus multilocularis lamin 0.0026 0.027 0.0252
Schistosoma mansoni amine GPCR 0.0009 0.0041 0.0042
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0008 0.0025 0.0073
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0196 0.0177
Onchocerca volvulus 0.0009 0.0041 0.0039
Brugia malayi protein kinase C II. 0.0287 0.3804 0.659
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.0025 0.0255 0.0412
Brugia malayi hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni lamin 0.0026 0.027 0.0475
Trichomonas vaginalis AGC family protein kinase 0.0108 0.1373 0.4501
Schistosoma mansoni protein kinase C mu 0.0186 0.2429 0.4552
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0022 0.0215 0.4666
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0115 0.1476 0.146
Schistosoma mansoni hypothetical protein 0.0009 0.0041 0.0042
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0041 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.6115 0.6108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0716 0.7802
Trichomonas vaginalis AGC family protein kinase 0.0082 0.1021 0.3347
Onchocerca volvulus 0.0009 0.0041 0.0039
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0247 0.1686
Onchocerca volvulus 0.0009 0.0041 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Schistosoma mansoni DNA helicase recq1 0.0009 0.003 0.0022
Echinococcus multilocularis nervana 2 0.002 0.0185 0.0166
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0039
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0065 0.0251
Leishmania major calcium/potassium channel (CAKC), putative 0.001 0.0051 0.0358
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0008 0.0025 0.0048
Brugia malayi AKH receptor 0.0009 0.0041 0.0039
Brugia malayi protein kinase C3,putative 0.0147 0.191 0.3294
Loa Loa (eye worm) hypothetical protein 0.0065 0.0792 0.1346
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.003 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0912 0.2991
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0432 0.0414
Echinococcus multilocularis serotonin receptor 0.0009 0.0041 0.0022
Loa Loa (eye worm) AGC/AKT protein kinase 0.0108 0.1373 0.2357
Loa Loa (eye worm) histone methyltransferase 0.001 0.0046 0.0047
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0008 0.0025 0.0051
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0041 0.0022
Entamoeba histolytica protein kinase, putative 0.0082 0.1021 0.5479
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.003 0.0284
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0056
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0432 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.1021 0.1892
Leishmania major protein kinase, putative 0.0008 0.0025 0.0073
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0912 0.7021
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.003 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0551 0.0927
Echinococcus multilocularis serine:threonine protein kinase 38 0.0082 0.1021 0.1004
Schistosoma mansoni myosin xvIII 0.0009 0.0041 0.0042
Echinococcus granulosus neuropeptide receptor 0.0009 0.0041 0.0022
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0478 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0041 0.0022
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0041 0.0022
Plasmodium falciparum potassium channel 0.001 0.0051 0.0628
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0432 0.0414
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0026 0.0093
Schistosoma mansoni hypothetical protein 0.0065 0.0792 0.146
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0432 0.1417
Brugia malayi Dopamine receptor 0.0009 0.0041 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0716 0.7802
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0041 0.0039
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0105 0.1753
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0026 0.0082
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0041 0.0039
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.5314 0.5306
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0041 0.0042
Echinococcus granulosus RNA directed DNA polymerase 0.0115 0.1476 0.146
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0247 0.5463
Entamoeba histolytica protein kinase, putative 0.0008 0.0025 0.0036
Brugia malayi Protein kinase domain containing protein 0.0008 0.0024 0.0009
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0022 0.0216 0.2506

Activities

Activity type Activity value Assay description Source Reference
clogP = -2.8 Calculated partition coefficient (clogP) ChEMBL. 7837228
logP (ADMET) = -2.11 Partition coefficient (logP) ChEMBL. 7837228
logP (ADMET) = -2 Partition coefficient (logP) ChEMBL. 7837228

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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